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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SYT14-HSD11B1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SYT14-HSD11B1
FusionPDB ID: 88534
FusionGDB2.0 ID: 88534
HgeneTgene
Gene symbol

SYT14

HSD11B1

Gene ID

255928

3290

Gene namesynaptotagmin 14hydroxysteroid 11-beta dehydrogenase 1
SynonymsSCAR11|sytXIV11-DH|11-beta-HSD1|CORTRD2|HDL|HSD11|HSD11B|HSD11L|SDR26C1
Cytomap

1q32.2

1q32.2

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-14synaptotagmin XIVcorticosteroid 11-beta-dehydrogenase isozyme 1short chain dehydrogenase/reductase family 26C member 1
Modification date2020031320200313
UniProtAcc.

Q7Z5J1

Ensembl transtripts involved in fusion geneENST idsENST00000271745, ENST00000367015, 
ENST00000537238, ENST00000422431, 
ENST00000367019, ENST00000399639, 
ENST00000472886, ENST00000534859, 
ENST00000261465, ENST00000367027, 
ENST00000367028, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=273 X 4 X 3=36
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SYT14 [Title/Abstract] AND HSD11B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SYT14(210126101)-HSD11B1(209905781), # samples:1
Anticipated loss of major functional domain due to fusion event.SYT14-HSD11B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYT14-HSD11B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYT14-HSD11B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SYT14-HSD11B1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SYT14-HSD11B1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SYT14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSD11B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-AAP1-01ASYT14chr1

210126101

-HSD11B1chr1

209905781

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534859SYT14chr1210126101-ENST00000367028HSD11B1chr1209905781+92413372494140
ENST00000534859SYT14chr1210126101-ENST00000261465HSD11B1chr1209905781+92413372494140
ENST00000534859SYT14chr1210126101-ENST00000367027HSD11B1chr1209905781+83813372494140
ENST00000399639SYT14chr1210126101-ENST00000367028HSD11B1chr1209905781+92413372494140
ENST00000399639SYT14chr1210126101-ENST00000261465HSD11B1chr1209905781+92413372494140
ENST00000399639SYT14chr1210126101-ENST00000367027HSD11B1chr1209905781+83813372494140
ENST00000367019SYT14chr1210126101-ENST00000367028HSD11B1chr1209905781+8869534456140
ENST00000367019SYT14chr1210126101-ENST00000261465HSD11B1chr1209905781+8869534456140
ENST00000367019SYT14chr1210126101-ENST00000367027HSD11B1chr1209905781+8009534456140
ENST00000472886SYT14chr1210126101-ENST00000367028HSD11B1chr1209905781+8667514436140
ENST00000472886SYT14chr1210126101-ENST00000261465HSD11B1chr1209905781+8667514436140
ENST00000472886SYT14chr1210126101-ENST00000367027HSD11B1chr1209905781+7807514436140

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534859ENST00000367028SYT14chr1210126101-HSD11B1chr1209905781+0.0135113130.98648876
ENST00000534859ENST00000261465SYT14chr1210126101-HSD11B1chr1209905781+0.0135113130.98648876
ENST00000534859ENST00000367027SYT14chr1210126101-HSD11B1chr1209905781+0.0128182560.98718166
ENST00000399639ENST00000367028SYT14chr1210126101-HSD11B1chr1209905781+0.0135113130.98648876
ENST00000399639ENST00000261465SYT14chr1210126101-HSD11B1chr1209905781+0.0135113130.98648876
ENST00000399639ENST00000367027SYT14chr1210126101-HSD11B1chr1209905781+0.0128182560.98718166
ENST00000367019ENST00000367028SYT14chr1210126101-HSD11B1chr1209905781+0.0127891410.98721087
ENST00000367019ENST00000261465SYT14chr1210126101-HSD11B1chr1209905781+0.0127891410.98721087
ENST00000367019ENST00000367027SYT14chr1210126101-HSD11B1chr1209905781+0.0127600770.9872399
ENST00000472886ENST00000367028SYT14chr1210126101-HSD11B1chr1209905781+0.0108226090.9891774
ENST00000472886ENST00000261465SYT14chr1210126101-HSD11B1chr1209905781+0.0108226090.9891774
ENST00000472886ENST00000367027SYT14chr1210126101-HSD11B1chr1209905781+0.0110156130.98898435

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88534_88534_1_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000367019_HSD11B1_chr1_209905781_ENST00000261465_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_2_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000367019_HSD11B1_chr1_209905781_ENST00000367027_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_3_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000367019_HSD11B1_chr1_209905781_ENST00000367028_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_4_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000399639_HSD11B1_chr1_209905781_ENST00000261465_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_5_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000399639_HSD11B1_chr1_209905781_ENST00000367027_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_6_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000399639_HSD11B1_chr1_209905781_ENST00000367028_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_7_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000472886_HSD11B1_chr1_209905781_ENST00000261465_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_8_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000472886_HSD11B1_chr1_209905781_ENST00000367027_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_9_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000472886_HSD11B1_chr1_209905781_ENST00000367028_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_10_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000534859_HSD11B1_chr1_209905781_ENST00000261465_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_11_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000534859_HSD11B1_chr1_209905781_ENST00000367027_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

>88534_88534_12_SYT14-HSD11B1_SYT14_chr1_210126101_ENST00000534859_HSD11B1_chr1_209905781_ENST00000367028_length(amino acids)=140AA_BP=20
MAIEGGERTCGVHELICIRKGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:210126101/chr1:209905781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSD11B1

Q7Z5J1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYT14chr1:210126101chr1:209905781ENST00000422431-2101_2425.0620.0Topological domainExtracellular
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000026146547183_187172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000026146547218_222172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702736183_187172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702736218_222172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702847183_187172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702847218_222172.33333333333334293.0Nucleotide bindingNADP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYT14chr1:210126101chr1:209905781ENST00000367015-18260_3790518.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000367015-18415_5500518.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000367019-29260_37920.333333333333332575.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000367019-29415_55020.333333333333332575.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000422431-210260_37925.0620.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000422431-210415_55025.0620.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000472886-28260_37920.333333333333332556.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000472886-28415_55020.333333333333332556.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000534859-29260_37920.333333333333332582.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000534859-29415_55020.333333333333332582.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000537238-29260_3790518.0DomainC2 1
HgeneSYT14chr1:210126101chr1:209905781ENST00000537238-29415_5500518.0DomainC2 2
HgeneSYT14chr1:210126101chr1:209905781ENST00000367015-181_240518.0Topological domainExtracellular
HgeneSYT14chr1:210126101chr1:209905781ENST00000367015-1848_5550518.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000367019-291_2420.333333333333332575.0Topological domainExtracellular
HgeneSYT14chr1:210126101chr1:209905781ENST00000367019-2948_55520.333333333333332575.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000422431-21048_55525.0620.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000472886-281_2420.333333333333332556.0Topological domainExtracellular
HgeneSYT14chr1:210126101chr1:209905781ENST00000472886-2848_55520.333333333333332556.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000534859-291_2420.333333333333332582.0Topological domainExtracellular
HgeneSYT14chr1:210126101chr1:209905781ENST00000534859-2948_55520.333333333333332582.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000537238-291_240518.0Topological domainExtracellular
HgeneSYT14chr1:210126101chr1:209905781ENST00000537238-2948_5550518.0Topological domainCytoplasmic
HgeneSYT14chr1:210126101chr1:209905781ENST00000367015-1825_470518.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSYT14chr1:210126101chr1:209905781ENST00000367019-2925_4720.333333333333332575.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSYT14chr1:210126101chr1:209905781ENST00000422431-21025_4725.0620.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSYT14chr1:210126101chr1:209905781ENST00000472886-2825_4720.333333333333332556.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSYT14chr1:210126101chr1:209905781ENST00000534859-2925_4720.333333333333332582.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneSYT14chr1:210126101chr1:209905781ENST00000537238-2925_470518.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000026146547119_121172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000002614654741_67172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000002614654792_93172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702736119_121172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670273641_67172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670273692_93172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST0000036702847119_121172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670284741_67172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670284792_93172.33333333333334293.0Nucleotide bindingNADP
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000261465471_7172.33333333333334293.0Topological domainCytoplasmic
TgeneHSD11B1chr1:210126101chr1:209905781ENST000002614654725_292172.33333333333334293.0Topological domainLumenal
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000367027361_7172.33333333333334293.0Topological domainCytoplasmic
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670273625_292172.33333333333334293.0Topological domainLumenal
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000367028471_7172.33333333333334293.0Topological domainCytoplasmic
TgeneHSD11B1chr1:210126101chr1:209905781ENST000003670284725_292172.33333333333334293.0Topological domainLumenal
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000261465478_24172.33333333333334293.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000367027368_24172.33333333333334293.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneHSD11B1chr1:210126101chr1:209905781ENST00000367028478_24172.33333333333334293.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SYT14
HSD11B1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SYT14-HSD11B1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SYT14-HSD11B1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource