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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TANC2-CRB3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TANC2-CRB3
	FusionPDB ID: 88937
	FusionGDB2.0 ID: 88937
		Hgene	Tgene
	Gene symbol	TANC2	CRB3
	Gene ID	26115	92359
	Gene name	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	crumbs cell polarity complex component 3
	Synonyms	ROLSA\|rols	-
	Cytomap	17q23.2-q23.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2	protein crumbs homolog 3crumbs 3, cell polarity complex componentcrumbs family member 3
	Modification date	20200313	20200313
	UniProtAcc	.	Q9BUF7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000389520, ENST00000424789,	ENST00000308243, ENST00000356762, ENST00000598494, ENST00000600229,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	39 X 25 X 15=14625	4 X 5 X 2=40
	# samples	45	5
	** MAII score	log2(45/14625*10)=-5.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TANC2 [Title/Abstract] AND CRB3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TANC2(61345234)-CRB3(6465556), # samples:5
Anticipated loss of major functional domain due to fusion event.	TANC2-CRB3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TANC2-CRB3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CRB3	GO:0072659	protein localization to plasma membrane	17332497

Fusion gene breakpoints across TANC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CRB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-50-5946-01A	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+
ChimerDB4	LUAD	TCGA-50-5946-01A	TANC2	chr17	61345234	-	CRB3	chr19	6465556	+
ChimerDB4	LUAD	TCGA-50-5946-01A	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+
ChimerDB4	LUAD	TCGA-50-5946-02A	TANC2	chr17	61345234	-	CRB3	chr19	6465556	+
ChimerDB4	LUAD	TCGA-50-5946-02A	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+
ChimerDB4	LUAD	TCGA-50-5946	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000424789	TANC2	chr17	61345234	+	ENST00000598494	CRB3	chr19	6465556	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345234	+	ENST00000600229	CRB3	chr19	6465556	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345234	+	ENST00000356762	CRB3	chr19	6465556	+	1430	941	4	1230	408
ENST00000424789	TANC2	chr17	61345234	+	ENST00000308243	CRB3	chr19	6465556	+	1319	941	4	1221	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000598494	CRB3	chr19	6465556	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000600229	CRB3	chr19	6465556	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000356762	CRB3	chr19	6465556	+	1426	937	0	1226	408
ENST00000389520	TANC2	chr17	61345234	+	ENST00000308243	CRB3	chr19	6465556	+	1315	937	0	1217	405
ENST00000424789	TANC2	chr17	61345234	+	ENST00000598494	CRB3	chr19	6465555	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345234	+	ENST00000600229	CRB3	chr19	6465555	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345234	+	ENST00000356762	CRB3	chr19	6465555	+	1430	941	4	1230	408
ENST00000424789	TANC2	chr17	61345234	+	ENST00000308243	CRB3	chr19	6465555	+	1319	941	4	1221	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000598494	CRB3	chr19	6465555	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000600229	CRB3	chr19	6465555	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345234	+	ENST00000356762	CRB3	chr19	6465555	+	1426	937	0	1226	408
ENST00000389520	TANC2	chr17	61345234	+	ENST00000308243	CRB3	chr19	6465555	+	1315	937	0	1217	405
ENST00000424789	TANC2	chr17	61345233	+	ENST00000598494	CRB3	chr19	6465555	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345233	+	ENST00000600229	CRB3	chr19	6465555	+	1771	941	4	1221	405
ENST00000424789	TANC2	chr17	61345233	+	ENST00000356762	CRB3	chr19	6465555	+	1430	941	4	1230	408
ENST00000424789	TANC2	chr17	61345233	+	ENST00000308243	CRB3	chr19	6465555	+	1319	941	4	1221	405
ENST00000389520	TANC2	chr17	61345233	+	ENST00000598494	CRB3	chr19	6465555	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345233	+	ENST00000600229	CRB3	chr19	6465555	+	1767	937	0	1217	405
ENST00000389520	TANC2	chr17	61345233	+	ENST00000356762	CRB3	chr19	6465555	+	1426	937	0	1226	408
ENST00000389520	TANC2	chr17	61345233	+	ENST00000308243	CRB3	chr19	6465555	+	1315	937	0	1217	405

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000424789	ENST00000598494	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.011717723	0.98828226
ENST00000424789	ENST00000600229	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.011717723	0.98828226
ENST00000424789	ENST00000356762	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.007887423	0.9921125
ENST00000424789	ENST00000308243	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.011931476	0.9880685
ENST00000389520	ENST00000598494	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.011980759	0.98801917
ENST00000389520	ENST00000600229	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.011980759	0.98801917
ENST00000389520	ENST00000356762	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.008043137	0.99195683
ENST00000389520	ENST00000308243	TANC2	chr17	61345234	+	CRB3	chr19	6465556	+	0.01254087	0.9874592
ENST00000424789	ENST00000598494	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.011717723	0.98828226
ENST00000424789	ENST00000600229	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.011717723	0.98828226
ENST00000424789	ENST00000356762	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.007887423	0.9921125
ENST00000424789	ENST00000308243	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.011931476	0.9880685
ENST00000389520	ENST00000598494	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.011980759	0.98801917
ENST00000389520	ENST00000600229	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.011980759	0.98801917
ENST00000389520	ENST00000356762	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.008043137	0.99195683
ENST00000389520	ENST00000308243	TANC2	chr17	61345234	+	CRB3	chr19	6465555	+	0.01254087	0.9874592
ENST00000424789	ENST00000598494	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.011717723	0.98828226
ENST00000424789	ENST00000600229	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.011717723	0.98828226
ENST00000424789	ENST00000356762	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.007887423	0.9921125
ENST00000424789	ENST00000308243	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.011931476	0.9880685
ENST00000389520	ENST00000598494	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.011980759	0.98801917
ENST00000389520	ENST00000600229	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.011980759	0.98801917
ENST00000389520	ENST00000356762	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.008043137	0.99195683
ENST00000389520	ENST00000308243	TANC2	chr17	61345233	+	CRB3	chr19	6465555	+	0.01254087	0.9874592

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88937_88937_1_TANC2-CRB3_TANC2_chr17_61345233_ENST00000389520_CRB3_chr19_6465555_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_2_TANC2-CRB3_TANC2_chr17_61345233_ENST00000389520_CRB3_chr19_6465555_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_3_TANC2-CRB3_TANC2_chr17_61345233_ENST00000389520_CRB3_chr19_6465555_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_4_TANC2-CRB3_TANC2_chr17_61345233_ENST00000389520_CRB3_chr19_6465555_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_5_TANC2-CRB3_TANC2_chr17_61345233_ENST00000424789_CRB3_chr19_6465555_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_6_TANC2-CRB3_TANC2_chr17_61345233_ENST00000424789_CRB3_chr19_6465555_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_7_TANC2-CRB3_TANC2_chr17_61345233_ENST00000424789_CRB3_chr19_6465555_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_8_TANC2-CRB3_TANC2_chr17_61345233_ENST00000424789_CRB3_chr19_6465555_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_9_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465555_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_10_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465555_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_11_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465555_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_12_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465555_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_13_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465556_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_14_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465556_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_15_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465556_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_16_TANC2-CRB3_TANC2_chr17_61345234_ENST00000389520_CRB3_chr19_6465556_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_17_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465555_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_18_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465555_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_19_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465555_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_20_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465555_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_21_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465556_ENST00000308243_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_22_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465556_ENST00000356762_length(amino acids)=408AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_23_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465556_ENST00000598494_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

>88937_88937_24_TANC2-CRB3_TANC2_chr17_61345234_ENST00000424789_CRB3_chr19_6465556_ENST00000600229_length(amino acids)=405AA_BP=312
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL
MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG
IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA
ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:61345234/chr19:6465556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CRB3 Q9BUF7
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250\|UniProtKB:Q8QZT4, ECO:0000269\|PubMed:12771187, ECO:0000269\|PubMed:14718572}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000308243

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000308243

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000356762

27_59

27.333333333333332

124.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000356762

81_120

27.333333333333332

124.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000598494

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000598494

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000600229

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000600229

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000308243

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000308243

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000356762

27_59

27.333333333333332

124.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000356762

81_120

27.333333333333332

124.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000598494

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000598494

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000600229

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000600229

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000308243

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000308243

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000356762

27_59

27.333333333333332

124.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000356762

81_120

27.333333333333332

124.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000598494

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000598494

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000600229

27_59

27.333333333333332

121.0

Topological domain

Extracellular

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000600229

81_120

27.333333333333332

121.0

Topological domain

Cytoplasmic

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000308243

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000356762

60_80

27.333333333333332

124.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000598494

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345233

chr19:6465555

ENST00000600229

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000308243

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000356762

60_80

27.333333333333332

124.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000598494

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465555

ENST00000600229

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000308243

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000356762

60_80

27.333333333333332

124.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000598494

60_80

27.333333333333332

121.0

Transmembrane

Helical

Tgene

CRB3

chr17:61345234

chr19:6465556

ENST00000600229

60_80

27.333333333333332

121.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1033_1062

312.3333333333333

2001.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1066_1095

312.3333333333333

2001.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1099_1128

312.3333333333333

2001.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1132_1161

312.3333333333333

2001.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1165_1194

312.3333333333333

2001.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1198_1227

312.3333333333333

2001.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1244_1277

312.3333333333333

2001.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1291_1324

312.3333333333333

2001.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

1325_1358

312.3333333333333

2001.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

846_878

312.3333333333333

2001.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

884_913

312.3333333333333

2001.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

917_946

312.3333333333333

2001.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

950_979

312.3333333333333

2001.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000389520

990_1019

312.3333333333333

2001.0

Repeat

Note=ANK 5

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1033_1062

312.3333333333333

1991.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1066_1095

312.3333333333333

1991.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1099_1128

312.3333333333333

1991.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1132_1161

312.3333333333333

1991.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1165_1194

312.3333333333333

1991.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1198_1227

312.3333333333333

1991.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1244_1277

312.3333333333333

1991.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1291_1324

312.3333333333333

1991.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

1325_1358

312.3333333333333

1991.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

846_878

312.3333333333333

1991.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

884_913

312.3333333333333

1991.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

917_946

312.3333333333333

1991.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

950_979

312.3333333333333

1991.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345233

chr19:6465555

ENST00000424789

990_1019

312.3333333333333

1991.0

Repeat

Note=ANK 5

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1033_1062

312.3333333333333

2001.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1066_1095

312.3333333333333

2001.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1099_1128

312.3333333333333

2001.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1132_1161

312.3333333333333

2001.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1165_1194

312.3333333333333

2001.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1198_1227

312.3333333333333

2001.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1244_1277

312.3333333333333

2001.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1291_1324

312.3333333333333

2001.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

1325_1358

312.3333333333333

2001.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

846_878

312.3333333333333

2001.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

884_913

312.3333333333333

2001.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

917_946

312.3333333333333

2001.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

950_979

312.3333333333333

2001.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000389520

990_1019

312.3333333333333

2001.0

Repeat

Note=ANK 5

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1033_1062

312.3333333333333

1991.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1066_1095

312.3333333333333

1991.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1099_1128

312.3333333333333

1991.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1132_1161

312.3333333333333

1991.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1165_1194

312.3333333333333

1991.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1198_1227

312.3333333333333

1991.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1244_1277

312.3333333333333

1991.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1291_1324

312.3333333333333

1991.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

1325_1358

312.3333333333333

1991.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

846_878

312.3333333333333

1991.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

884_913

312.3333333333333

1991.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

917_946

312.3333333333333

1991.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

950_979

312.3333333333333

1991.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345234

chr19:6465555

ENST00000424789

990_1019

312.3333333333333

1991.0

Repeat

Note=ANK 5

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1033_1062

312.3333333333333

2001.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1066_1095

312.3333333333333

2001.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1099_1128

312.3333333333333

2001.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1132_1161

312.3333333333333

2001.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1165_1194

312.3333333333333

2001.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1198_1227

312.3333333333333

2001.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1244_1277

312.3333333333333

2001.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1291_1324

312.3333333333333

2001.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

1325_1358

312.3333333333333

2001.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

846_878

312.3333333333333

2001.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

884_913

312.3333333333333

2001.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

917_946

312.3333333333333

2001.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

950_979

312.3333333333333

2001.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000389520

990_1019

312.3333333333333

2001.0

Repeat

Note=ANK 5

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1033_1062

312.3333333333333

1991.0

Repeat

Note=ANK 6

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1066_1095

312.3333333333333

1991.0

Repeat

Note=ANK 7

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1099_1128

312.3333333333333

1991.0

Repeat

Note=ANK 8

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1132_1161

312.3333333333333

1991.0

Repeat

Note=ANK 9

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1165_1194

312.3333333333333

1991.0

Repeat

Note=ANK 10

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1198_1227

312.3333333333333

1991.0

Repeat

Note=ANK 11

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1244_1277

312.3333333333333

1991.0

Repeat

Note=TPR 1

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1291_1324

312.3333333333333

1991.0

Repeat

Note=TPR 2

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

1325_1358

312.3333333333333

1991.0

Repeat

Note=TPR 3

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

846_878

312.3333333333333

1991.0

Repeat

Note=ANK 1

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

884_913

312.3333333333333

1991.0

Repeat

Note=ANK 2

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

917_946

312.3333333333333

1991.0

Repeat

Note=ANK 3

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

950_979

312.3333333333333

1991.0

Repeat

Note=ANK 4

Hgene

TANC2

chr17:61345234

chr19:6465556

ENST00000424789

990_1019

312.3333333333333

1991.0

Repeat

Note=ANK 5

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>830_TANC2_61345234_CRB3_6465556_ranked_0.pdb	TANC2	61345233	61345234	ENST00000308243	CRB3	chr19	6465556	+	MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTL MTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSG IIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVA ATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVG	408

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TANC2_pLDDT.png

CRB3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TANC2
CRB3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TANC2-CRB3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TANC2-CRB3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source