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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TAOK1-NCOR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TAOK1-NCOR1
FusionPDB ID: 89021
FusionGDB2.0 ID: 89021
HgeneTgene
Gene symbol

TAOK1

NCOR1

Gene ID

57551

9611

Gene nameTAO kinase 1nuclear receptor corepressor 1
SynonymsKFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR
Cytomap

17q11.2

17p12-p11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kinnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1
Modification date2020031520200313
UniProtAcc.

O75376

Ensembl transtripts involved in fusion geneENST idsENST00000261716, ENST00000536202, 
ENST00000395848, ENST00000395857, 
ENST00000583226, ENST00000268712, 
ENST00000395851, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score42 X 23 X 20=1932014 X 14 X 6=1176
# samples 5214
** MAII scorelog2(52/19320*10)=-5.21543966069468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1176*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TAOK1 [Title/Abstract] AND NCOR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TAOK1(27838010)-NCOR1(15984041), # samples:3
Anticipated loss of major functional domain due to fusion event.TAOK1-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAOK1-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAOK1-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TAOK1-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK1

GO:0016310

phosphorylation

12639963

HgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

HgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310

TgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check buttonFusion gene breakpoints across TAOK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCOR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA31-01ATAOK1chr17

27838010

-NCOR1chr17

15984041

-
ChimerDB4CHOLTCGA-W5-AA31-01ATAOK1chr17

27838010

+NCOR1chr17

15984041

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261716TAOK1chr1727838010+ENST00000268712NCOR1chr1715984041-9508222350763681953
ENST00000261716TAOK1chr1727838010+ENST00000395851NCOR1chr1715984041-6904222350760111834
ENST00000536202TAOK1chr1727838010+ENST00000268712NCOR1chr1715984041-9177189217660371953
ENST00000536202TAOK1chr1727838010+ENST00000395851NCOR1chr1715984041-6573189217656801834

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261716ENST00000268712TAOK1chr1727838010+NCOR1chr1715984041-0.0003557130.9996443
ENST00000261716ENST00000395851TAOK1chr1727838010+NCOR1chr1715984041-0.0016519330.9983481
ENST00000536202ENST00000268712TAOK1chr1727838010+NCOR1chr1715984041-0.0002553290.9997447
ENST00000536202ENST00000395851TAOK1chr1727838010+NCOR1chr1715984041-0.0013021510.9986979

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89021_89021_1_TAOK1-NCOR1_TAOK1_chr17_27838010_ENST00000261716_NCOR1_chr17_15984041_ENST00000268712_length(amino acids)=1953AA_BP=572
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNS
QPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASK
GHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIM
QGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTP
IKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYD
DTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTH
LDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTN
MPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGR
PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVS
KTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTI
TAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHY
RPQQESPSPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQA
QSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTK
LENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMS
QPMGVVPGTANTSVVTSGETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSS

--------------------------------------------------------------

>89021_89021_2_TAOK1-NCOR1_TAOK1_chr17_27838010_ENST00000261716_NCOR1_chr17_15984041_ENST00000395851_length(amino acids)=1834AA_BP=572
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNS
QPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASK
GHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIM
QGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTP
IKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYD
DTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTH
LDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTN
MPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGR
PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVS
KTKEISSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQLPPSSQAEGMGQVPRTH
RLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKS
PERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDM
AAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP
HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPS

--------------------------------------------------------------

>89021_89021_3_TAOK1-NCOR1_TAOK1_chr17_27838010_ENST00000536202_NCOR1_chr17_15984041_ENST00000268712_length(amino acids)=1953AA_BP=572
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNS
QPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASK
GHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIM
QGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTP
IKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYD
DTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTH
LDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTN
MPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGR
PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVS
KTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTI
TAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHY
RPQQESPSPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQA
QSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTK
LENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMS
QPMGVVPGTANTSVVTSGETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSS

--------------------------------------------------------------

>89021_89021_4_TAOK1-NCOR1_TAOK1_chr17_27838010_ENST00000536202_NCOR1_chr17_15984041_ENST00000395851_length(amino acids)=1834AA_BP=572
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNS
QPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASK
GHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIM
QGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTP
IKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYD
DTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTH
LDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTN
MPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGR
PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVS
KTKEISSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQLPPSSQAEGMGQVPRTH
RLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKS
PERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDM
AAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP
HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:27838010/chr17:15984041)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCOR1

O75376

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+1520330_334568.01002.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+1520347_379568.01002.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+1518330_334568.0854.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+1518347_379568.0854.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+152028_281568.01002.0DomainProtein kinase
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+151828_281568.0854.0DomainProtein kinase
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+152034_42568.01002.0Nucleotide bindingATP
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+151834_42568.0854.0Nucleotide bindingATP
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019174_2160915.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019299_3280915.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019501_5570915.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222461707_17121059.02441.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222461952_19631059.02441.0Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480191032_10350915.0Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480191707_17120915.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480191952_19630915.0Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039584801958_640915.0Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019593_6030915.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019607_6170915.0Compositional biasNote=Pro-rich
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121451707_17121075.02338.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121451952_19631075.02338.0Compositional biasNote=Poly-Ser
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019435_4860915.0DomainSANT 1
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395848019623_6740915.0DomainSANT 2
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222461933_19371059.02441.0MotifNote=CORNR box 1
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222462055_20591059.02441.0MotifNote=CORNR box 2
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222462263_22671059.02441.0MotifNote=CORNR box 3
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480191933_19370915.0MotifNote=CORNR box 1
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480192055_20590915.0MotifNote=CORNR box 2
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480192263_22670915.0MotifNote=CORNR box 3
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121451933_19371075.02338.0MotifNote=CORNR box 1
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121452055_20591075.02338.0MotifNote=CORNR box 2
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121452263_22671075.02338.0MotifNote=CORNR box 3
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222462032_21151059.02441.0RegionID1
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222462212_22731059.02441.0RegionID2
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480192032_21150915.0RegionID1
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958480192212_22730915.0RegionID2
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121452032_21151075.02338.0RegionID1
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121452212_22731075.02338.0RegionID2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+1520458_651568.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27838010chr17:15984041ENST00000261716+1520754_877568.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+1518458_651568.0854.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27838010chr17:15984041ENST00000536202+1518754_877568.0854.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246174_2161059.02441.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246299_3281059.02441.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246501_5571059.02441.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145174_2161075.02338.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145299_3281075.02338.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145501_5571075.02338.0Coiled coilOntology_term=ECO:0000255
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222461032_10351059.02441.0Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:27838010chr17:15984041ENST00000268712224658_641059.02441.0Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246593_6031059.02441.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246607_6171059.02441.0Compositional biasNote=Pro-rich
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121451032_10351075.02338.0Compositional biasNote=Poly-Pro
TgeneNCOR1chr17:27838010chr17:15984041ENST00000395851214558_641075.02338.0Compositional biasNote=Poly-Gln
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145593_6031075.02338.0Compositional biasNote=Poly-Ala
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145607_6171075.02338.0Compositional biasNote=Pro-rich
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246435_4861059.02441.0DomainSANT 1
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246623_6741059.02441.0DomainSANT 2
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145435_4861075.02338.0DomainSANT 1
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145623_6741075.02338.0DomainSANT 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TAOK1
NCOR1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246988_18161059.02441.0ETO
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145988_18161075.02338.0ETO
TgeneNCOR1chr17:27838010chr17:15984041ENST000002687122246254_3121059.02441.0SIN3A/B
TgeneNCOR1chr17:27838010chr17:15984041ENST000003958512145254_3121075.02338.0SIN3A/B
TgeneNCOR1chr17:27838010chr17:15984041ENST0000026871222461_3731059.02441.0ZBTB33 and HEXIM1
TgeneNCOR1chr17:27838010chr17:15984041ENST0000039585121451_3731075.02338.0ZBTB33 and HEXIM1


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Related Drugs to TAOK1-NCOR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TAOK1-NCOR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource