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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TBL1XR1-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TBL1XR1-RET
FusionPDB ID: 89554
FusionGDB2.0 ID: 89554
HgeneTgene
Gene symbol

TBL1XR1

RET

Gene ID

79718

5979

Gene nameTBL1X receptor 1ret proto-oncogene
SynonymsC21|DC42|IRA1|MRD41|TBLR1CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

3q26.32

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1transducin beta like 1 X-linked receptor 1proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc.

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000457928, ENST00000430069, 
ENST00000340058, ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score51 X 31 X 15=2371532 X 31 X 11=10912
# samples 6648
** MAII scorelog2(66/23715*10)=-5.16719003372107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TBL1XR1 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TBL1XR1(176765088)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TBL1XR1-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBL1XR1

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

HgeneTBL1XR1

GO:0045893

positive regulation of transcription, DNA-templated

18193033

HgeneTBL1XR1

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across TBL1XR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A40R-01ATBL1XR1chr3

176765088

-RETchr10

43612032

+
ChimerDB4THCATCGA-ET-A40RTBL1XR1chr3

176765087

-RETchr10

43612031

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000430069TBL1XR1chr3176765088-ENST00000355710RETchr1043612032+441511242602332690
ENST00000430069TBL1XR1chr3176765088-ENST00000340058RETchr1043612032+295711242602206648
ENST00000430069TBL1XR1chr3176765087-ENST00000355710RETchr1043612031+441511242602332690
ENST00000430069TBL1XR1chr3176765087-ENST00000340058RETchr1043612031+295711242602206648

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000430069ENST00000355710TBL1XR1chr3176765088-RETchr1043612032+0.0027515570.9972485
ENST00000430069ENST00000340058TBL1XR1chr3176765088-RETchr1043612032+0.0077415030.9922585
ENST00000430069ENST00000355710TBL1XR1chr3176765087-RETchr1043612031+0.0027515570.9972485
ENST00000430069ENST00000340058TBL1XR1chr3176765087-RETchr1043612031+0.0077415030.9922585

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89554_89554_1_TBL1XR1-RET_TBL1XR1_chr3_176765087_ENST00000430069_RET_chr10_43612031_ENST00000340058_length(amino acids)=648AA_BP=288
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPD
VVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF
ALKWNKKGNFILSAGVDKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH
PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL
KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPS

--------------------------------------------------------------

>89554_89554_2_TBL1XR1-RET_TBL1XR1_chr3_176765087_ENST00000430069_RET_chr10_43612031_ENST00000355710_length(amino acids)=690AA_BP=288
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPD
VVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF
ALKWNKKGNFILSAGVDKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH
PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL
KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPS

--------------------------------------------------------------

>89554_89554_3_TBL1XR1-RET_TBL1XR1_chr3_176765088_ENST00000430069_RET_chr10_43612032_ENST00000340058_length(amino acids)=648AA_BP=288
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPD
VVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF
ALKWNKKGNFILSAGVDKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH
PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL
KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPS

--------------------------------------------------------------

>89554_89554_4_TBL1XR1-RET_TBL1XR1_chr3_176765088_ENST00000430069_RET_chr10_43612032_ENST00000355710_length(amino acids)=690AA_BP=288
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPD
VVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF
ALKWNKKGNFILSAGVDKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH
PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL
KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:176765088/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RET

RTL1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916108_118288.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916108_118288.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916108_118288.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916108_118288.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-91641_86288.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-9164_36288.0515.0DomainLisH
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-91641_86288.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-9164_36288.0515.0DomainLisH
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-91641_86288.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-9164_36288.0515.0DomainLisH
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-91641_86288.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-9164_36288.0515.0DomainLisH
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916167_206288.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916223_262288.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916167_206288.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916223_262288.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916167_206288.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916223_262288.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916167_206288.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916223_262288.0515.0RepeatNote=WD 2
TgeneRETchr3:176765087chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr3:176765087chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr3:176765088chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr3:176765088chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr3:176765087chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr3:176765087chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr3:176765088chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr3:176765088chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr3:176765087chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr3:176765087chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr3:176765088chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr3:176765088chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916264_303288.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916306_344288.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916347_386288.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916389_437288.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916440_479288.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000430069-916481_513288.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916264_303288.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916306_344288.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916347_386288.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916389_437288.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916440_479288.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176765087chr10:43612031ENST00000457928-916481_513288.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916264_303288.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916306_344288.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916347_386288.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916389_437288.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916440_479288.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000430069-916481_513288.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916264_303288.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916306_344288.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916347_386288.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916389_437288.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916440_479288.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176765088chr10:43612032ENST00000457928-916481_513288.0515.0RepeatNote=WD 8
TgeneRETchr3:176765087chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr3:176765087chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr3:176765088chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr3:176765088chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr3:176765087chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr3:176765087chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr3:176765087chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr3:176765087chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr3:176765088chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr3:176765088chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr3:176765088chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr3:176765088chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr3:176765087chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr3:176765087chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr3:176765088chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr3:176765088chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TBL1XR1
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TBL1XR1-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TBL1XR1-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human