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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TBL1XR1-TP73

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TBL1XR1-TP73
FusionPDB ID: 89567
FusionGDB2.0 ID: 89567
HgeneTgene
Gene symbol

TBL1XR1

TP73

Gene ID

79718

7161

Gene nameTBL1X receptor 1tumor protein p73
SynonymsC21|DC42|IRA1|MRD41|TBLR1P73
Cytomap

3q26.32

1p36.32

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1transducin beta like 1 X-linked receptor 1tumor protein p73p53-like transcription factorp53-related protein
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000430069, ENST00000457928, 
ENST00000378290, ENST00000346387, 
ENST00000354437, ENST00000357733, 
ENST00000378280, ENST00000378285, 
ENST00000378288, ENST00000378295, 
ENST00000603362, ENST00000604074, 
ENST00000604479, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score51 X 31 X 15=237151 X 2 X 1=2
# samples 662
** MAII scorelog2(66/23715*10)=-5.16719003372107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: TBL1XR1 [Title/Abstract] AND TP73 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TBL1XR1(176771561)-TP73(3624113), # samples:3
Anticipated loss of major functional domain due to fusion event.TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
TBL1XR1-TP73 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBL1XR1

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

HgeneTBL1XR1

GO:0045893

positive regulation of transcription, DNA-templated

18193033

HgeneTBL1XR1

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033

TgeneTP73

GO:0006974

cellular response to DNA damage stimulus

18174154

TgeneTP73

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

18174154|19490146

TgeneTP73

GO:0045893

positive regulation of transcription, DNA-templated

15678106|16343436

TgeneTP73

GO:0045944

positive regulation of transcription by RNA polymerase II

16343436|18174154|18421303|19490146|24652652

TgeneTP73

GO:0071158

positive regulation of cell cycle arrest

18421303


check buttonFusion gene breakpoints across TBL1XR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TP73 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-FA-A4XK-01ATBL1XR1chr3

176771561

-TP73chr1

3624113

+
ChimerDB4DLBCTCGA-FA-A4XKTBL1XR1chr3

176771560

-TP73chr1

3624112

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000430069TBL1XR1chr3176771561-ENST00000378295TP73chr13624113+53114642602188642
ENST00000430069TBL1XR1chr3176771561-ENST00000604074TP73chr13624113+49294642601489409
ENST00000430069TBL1XR1chr3176771561-ENST00000354437TP73chr13624113+23084642601777505
ENST00000430069TBL1XR1chr3176771561-ENST00000346387TP73chr13624113+27254642601900546
ENST00000430069TBL1XR1chr3176771561-ENST00000357733TP73chr13624113+27704642601945561
ENST00000430069TBL1XR1chr3176771561-ENST00000603362TP73chr13624113+19464642601945562
ENST00000430069TBL1XR1chr3176771561-ENST00000604479TP73chr13624113+19014642601900547
ENST00000430069TBL1XR1chr3176771561-ENST00000378285TP73chr13624113+23084642601777505
ENST00000430069TBL1XR1chr3176771561-ENST00000378280TP73chr13624113+22534642601705481
ENST00000430069TBL1XR1chr3176771561-ENST00000378288TP73chr13624113+53114642602188642
ENST00000430069TBL1XR1chr3176771560-ENST00000378295TP73chr13624112+53114642602188642
ENST00000430069TBL1XR1chr3176771560-ENST00000604074TP73chr13624112+49294642601489409
ENST00000430069TBL1XR1chr3176771560-ENST00000354437TP73chr13624112+23084642601777505
ENST00000430069TBL1XR1chr3176771560-ENST00000346387TP73chr13624112+27254642601900546
ENST00000430069TBL1XR1chr3176771560-ENST00000357733TP73chr13624112+27704642601945561
ENST00000430069TBL1XR1chr3176771560-ENST00000603362TP73chr13624112+19464642601945562
ENST00000430069TBL1XR1chr3176771560-ENST00000604479TP73chr13624112+19014642601900547
ENST00000430069TBL1XR1chr3176771560-ENST00000378285TP73chr13624112+23084642601777505
ENST00000430069TBL1XR1chr3176771560-ENST00000378280TP73chr13624112+22534642601705481
ENST00000430069TBL1XR1chr3176771560-ENST00000378288TP73chr13624112+53114642602188642

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000430069ENST00000378295TBL1XR1chr3176771561-TP73chr13624113+0.0143244230.98567563
ENST00000430069ENST00000604074TBL1XR1chr3176771561-TP73chr13624113+0.0150702350.98492974
ENST00000430069ENST00000354437TBL1XR1chr3176771561-TP73chr13624113+0.0095714070.99042857
ENST00000430069ENST00000346387TBL1XR1chr3176771561-TP73chr13624113+0.017497880.9825021
ENST00000430069ENST00000357733TBL1XR1chr3176771561-TP73chr13624113+0.0193545130.9806455
ENST00000430069ENST00000603362TBL1XR1chr3176771561-TP73chr13624113+0.0065271850.99347275
ENST00000430069ENST00000604479TBL1XR1chr3176771561-TP73chr13624113+0.0098835090.99011654
ENST00000430069ENST00000378285TBL1XR1chr3176771561-TP73chr13624113+0.0095714070.99042857
ENST00000430069ENST00000378280TBL1XR1chr3176771561-TP73chr13624113+0.0121375620.98786247
ENST00000430069ENST00000378288TBL1XR1chr3176771561-TP73chr13624113+0.0143244230.98567563
ENST00000430069ENST00000378295TBL1XR1chr3176771560-TP73chr13624112+0.0143244230.98567563
ENST00000430069ENST00000604074TBL1XR1chr3176771560-TP73chr13624112+0.0150702350.98492974
ENST00000430069ENST00000354437TBL1XR1chr3176771560-TP73chr13624112+0.0095714070.99042857
ENST00000430069ENST00000346387TBL1XR1chr3176771560-TP73chr13624112+0.017497880.9825021
ENST00000430069ENST00000357733TBL1XR1chr3176771560-TP73chr13624112+0.0193545130.9806455
ENST00000430069ENST00000603362TBL1XR1chr3176771560-TP73chr13624112+0.0065271850.99347275
ENST00000430069ENST00000604479TBL1XR1chr3176771560-TP73chr13624112+0.0098835090.99011654
ENST00000430069ENST00000378285TBL1XR1chr3176771560-TP73chr13624112+0.0095714070.99042857
ENST00000430069ENST00000378280TBL1XR1chr3176771560-TP73chr13624112+0.0121375620.98786247
ENST00000430069ENST00000378288TBL1XR1chr3176771560-TP73chr13624112+0.0143244230.98567563

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89567_89567_1_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000346387_length(amino acids)=546AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEF

--------------------------------------------------------------

>89567_89567_2_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000354437_length(amino acids)=505AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN

--------------------------------------------------------------

>89567_89567_3_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000357733_length(amino acids)=561AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR
QDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFD

--------------------------------------------------------------

>89567_89567_4_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000378280_length(amino acids)=481AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR

--------------------------------------------------------------

>89567_89567_5_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000378285_length(amino acids)=505AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN

--------------------------------------------------------------

>89567_89567_6_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000378288_length(amino acids)=642AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN
LGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIP
EQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQ

--------------------------------------------------------------

>89567_89567_7_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000378295_length(amino acids)=642AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN
LGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIP
EQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQ

--------------------------------------------------------------

>89567_89567_8_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000603362_length(amino acids)=562AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR
QDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFD

--------------------------------------------------------------

>89567_89567_9_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000604074_length(amino acids)=409AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT

--------------------------------------------------------------

>89567_89567_10_TBL1XR1-TP73_TBL1XR1_chr3_176771560_ENST00000430069_TP73_chr1_3624112_ENST00000604479_length(amino acids)=547AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEF

--------------------------------------------------------------

>89567_89567_11_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000346387_length(amino acids)=546AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEF

--------------------------------------------------------------

>89567_89567_12_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000354437_length(amino acids)=505AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN

--------------------------------------------------------------

>89567_89567_13_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000357733_length(amino acids)=561AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR
QDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFD

--------------------------------------------------------------

>89567_89567_14_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000378280_length(amino acids)=481AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR

--------------------------------------------------------------

>89567_89567_15_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000378285_length(amino acids)=505AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN

--------------------------------------------------------------

>89567_89567_16_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000378288_length(amino acids)=642AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN
LGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIP
EQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQ

--------------------------------------------------------------

>89567_89567_17_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000378295_length(amino acids)=642AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPN
LGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIP
EQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQ

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>89567_89567_18_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000603362_length(amino acids)=562AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPR
QDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFD

--------------------------------------------------------------

>89567_89567_19_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000604074_length(amino acids)=409AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT

--------------------------------------------------------------

>89567_89567_20_TBL1XR1-TP73_TBL1XR1_chr3_176771561_ENST00000430069_TP73_chr1_3624113_ENST00000604479_length(amino acids)=547AA_BP=68
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEAQFNLLSSTMDQMSSRAASASP
YTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTA
IRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVG
GMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDT
YYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEF

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:176771561/chr1:3624113)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-4164_3668.0515.0DomainLisH
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-4164_3668.0515.0DomainLisH
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-4164_3668.0515.0DomainLisH
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-4164_3668.0515.0DomainLisH
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212168_17162.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212391_39462.0541.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212483_48662.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213168_17162.0500.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213391_39462.0500.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213483_48662.0500.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011168_17113.0518.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011391_39413.0518.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011483_48613.0518.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011168_17113.0451.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011391_39413.0451.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011483_48613.0451.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012168_17113.0588.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012391_39413.0588.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012483_48613.0588.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012168_1710566.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST000003782900121_550566.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012391_3940566.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012483_4860566.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214168_17162.0637.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214391_39462.0637.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214483_48662.0637.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211168_17162.0404.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211391_39462.0404.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211483_48662.0404.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111168_17162.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111391_39462.0541.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111483_48662.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212168_17162.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212391_39462.0541.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212483_48662.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213168_17162.0500.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213391_39462.0500.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213483_48662.0500.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011168_17113.0518.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011391_39413.0518.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011483_48613.0518.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011168_17113.0451.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011391_39413.0451.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011483_48613.0451.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012168_17113.0588.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012391_39413.0588.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012483_48613.0588.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012168_1710566.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST000003782900121_550566.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012391_3940566.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012483_4860566.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214168_17162.0637.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214391_39462.0637.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214483_48662.0637.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211168_17162.0404.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211391_39462.0404.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211483_48662.0404.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111168_17162.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111391_39462.0541.0Compositional biasNote=Poly-Gln
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111483_48662.0541.0Compositional biasNote=Poly-Pro
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212485_55162.0541.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213485_55162.0500.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011485_55113.0518.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011485_55113.0451.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012485_55113.0588.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012485_5510566.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214485_55162.0637.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211485_55162.0404.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111485_55162.0541.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212485_55162.0541.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213485_55162.0500.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011485_55113.0518.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011485_55113.0451.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012485_55113.0588.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012485_5510566.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214485_55162.0637.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211485_55162.0404.0DomainNote=SAM
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111485_55162.0541.0DomainNote=SAM
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212483_48762.0541.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213483_48762.0500.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011483_48713.0518.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011483_48713.0451.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012483_48713.0588.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012483_4870566.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214483_48762.0637.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211483_48762.0404.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111483_48762.0541.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212483_48762.0541.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213483_48762.0500.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011483_48713.0518.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011483_48713.0451.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012483_48713.0588.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012483_4870566.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214483_48762.0637.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211483_48762.0404.0MotifNote=PPxY motif
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111483_48762.0541.0MotifNote=PPxY motif
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212131_31062.0541.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000346387212345_38662.0541.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213131_31062.0500.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000354437213345_38662.0500.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011131_31013.0518.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000378280011345_38613.0518.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011131_31013.0451.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000378285011345_38613.0451.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012131_31013.0588.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000378288012345_38613.0588.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012131_3100566.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST000003782900121_460566.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST00000378290012345_3860566.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214131_31062.0637.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000378295214345_38662.0637.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211131_31062.0404.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000604074211345_38662.0404.0RegionOligomerization
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111131_31062.0541.0RegionDNA-binding
TgeneTP73chr3:176771560chr1:3624112ENST00000604479111345_38662.0541.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212131_31062.0541.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000346387212345_38662.0541.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213131_31062.0500.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000354437213345_38662.0500.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011131_31013.0518.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000378280011345_38613.0518.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011131_31013.0451.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000378285011345_38613.0451.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012131_31013.0588.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000378288012345_38613.0588.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012131_3100566.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST000003782900121_460566.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST00000378290012345_3860566.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214131_31062.0637.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000378295214345_38662.0637.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211131_31062.0404.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000604074211345_38662.0404.0RegionOligomerization
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111131_31062.0541.0RegionDNA-binding
TgeneTP73chr3:176771561chr1:3624113ENST00000604479111345_38662.0541.0RegionOligomerization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416108_11868.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416108_11868.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416108_11868.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416108_11868.0515.0Compositional biasNote=Poly-Ala
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-41641_8668.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-41641_8668.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-41641_8668.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-41641_8668.0515.0DomainNote=F-box-like
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416167_20668.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416223_26268.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416264_30368.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416306_34468.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416347_38668.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416389_43768.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416440_47968.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000430069-416481_51368.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416167_20668.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416223_26268.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416264_30368.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416306_34468.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416347_38668.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416389_43768.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416440_47968.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176771560chr1:3624112ENST00000457928-416481_51368.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416167_20668.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416223_26268.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416264_30368.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416306_34468.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416347_38668.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416389_43768.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416440_47968.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000430069-416481_51368.0515.0RepeatNote=WD 8
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416167_20668.0515.0RepeatNote=WD 1
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416223_26268.0515.0RepeatNote=WD 2
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416264_30368.0515.0RepeatNote=WD 3
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416306_34468.0515.0RepeatNote=WD 4
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416347_38668.0515.0RepeatNote=WD 5
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416389_43768.0515.0RepeatNote=WD 6
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416440_47968.0515.0RepeatNote=WD 7
HgeneTBL1XR1chr3:176771561chr1:3624113ENST00000457928-416481_51368.0515.0RepeatNote=WD 8
TgeneTP73chr3:176771560chr1:3624112ENST000003463872121_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003544372131_5562.0500.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003782800111_5513.0518.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003782850111_5513.0451.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003782880121_5513.0588.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003782952141_5562.0637.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000006040742111_5562.0404.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000006044791111_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003463872121_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003544372131_5562.0500.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003782800111_5513.0518.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003782850111_5513.0451.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003782880121_5513.0588.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000003782952141_5562.0637.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000006040742111_5562.0404.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771561chr1:3624113ENST000006044791111_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTP73chr3:176771560chr1:3624112ENST000003463872121_4662.0541.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000003544372131_4662.0500.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000003782800111_4613.0518.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000003782850111_4613.0451.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000003782880121_4613.0588.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000003782952141_4662.0637.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000006040742111_4662.0404.0RegionTransactivation
TgeneTP73chr3:176771560chr1:3624112ENST000006044791111_4662.0541.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003463872121_4662.0541.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003544372131_4662.0500.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003782800111_4613.0518.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003782850111_4613.0451.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003782880121_4613.0588.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000003782952141_4662.0637.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000006040742111_4662.0404.0RegionTransactivation
TgeneTP73chr3:176771561chr1:3624113ENST000006044791111_4662.0541.0RegionTransactivation


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TBL1XR1
TP73


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TBL1XR1-TP73


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TBL1XR1-TP73


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource