| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:TC2N-TRIP11 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: TC2N-TRIP11 | FusionPDB ID: 89632 | FusionGDB2.0 ID: 89632 | Hgene | Tgene | Gene symbol | TC2N | TRIP11 | Gene ID | 123036 | 9321 |
| Gene name | tandem C2 domains, nuclear | thyroid hormone receptor interactor 11 | |
| Synonyms | C14orf47|C2CD1|MTAC2D1|Tac2-N | ACG1A|CEV14|GMAP-210|GMAP210|ODCD|TRIP-11|TRIP230 | |
| Cytomap | 14q32.12 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tandem C2 domains nuclear proteinC2 calcium-dependent domain containing 1membrane targeting (tandem) C2 domain containing 1tandem C2 protein in nucleus | thyroid receptor-interacting protein 11Golgi-microtubule-associated protein of 210 kDaTR-interacting protein 11clonal evolution-related gene on chromosome 14 proteingolgi-associated microtubule-binding protein 210 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | . | Q15643 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000340892, ENST00000360594, ENST00000435962, ENST00000556018, ENST00000555302, | ENST00000555105, ENST00000267622, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 11 X 7=462 | 2 X 4 X 4=32 |
| # samples | 15 | 6 | |
| ** MAII score | log2(15/462*10)=-1.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: TC2N [Title/Abstract] AND TRIP11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TC2N(92302715)-TRIP11(92460256), # samples:2 TC2N(92280047)-TRIP11(92442533), # samples:2 TC2N(92278656)-TRIP11(92474196), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | TC2N-TRIP11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TC2N-TRIP11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TC2N-TRIP11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TC2N-TRIP11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TC2N-TRIP11 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TC2N-TRIP11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across TC2N (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across TRIP11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A0EE-01A | TC2N | chr14 | 92302527 | - | TRIP11 | chr14 | 92460256 | - |
| ChimerDB4 | BRCA | TCGA-BH-A0EE-01A | TC2N | chr14 | 92302715 | - | TRIP11 | chr14 | 92460256 | - |
| ChimerDB4 | BRCA | TCGA-BH-A0EE | TC2N | chr14 | 92302526 | - | TRIP11 | chr14 | 92460256 | - |
| ChimerDB4 | BRCA | TCGA-BH-A0EE | TC2N | chr14 | 92302714 | - | TRIP11 | chr14 | 92460256 | - |
| ChimerDB4 | LIHC | TCGA-BC-A216-01A | TC2N | chr14 | 92280047 | - | TRIP11 | chr14 | 92442533 | - |
| ChimerDB4 | LUAD | TCGA-55-6987-01A | TC2N | chr14 | 92246920 | - | TRIP11 | chr14 | 92442533 | - |
| ChimerDB4 | STAD | TCGA-BR-8289-01A | TC2N | chr14 | 92278656 | - | TRIP11 | chr14 | 92474196 | - |
| ChimerDB4 | STAD | TCGA-BR-8289 | TC2N | chr14 | 92278655 | - | TRIP11 | chr14 | 92474196 | - |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000340892 | TC2N | chr14 | 92278655 | - | ENST00000267622 | TRIP11 | chr14 | 92474196 | - | 8923 | 615 | 477 | 5240 | 1587 |
| ENST00000435962 | TC2N | chr14 | 92280047 | - | ENST00000267622 | TRIP11 | chr14 | 92442533 | - | 4753 | 391 | 315 | 1070 | 251 |
| ENST00000360594 | TC2N | chr14 | 92280047 | - | ENST00000267622 | TRIP11 | chr14 | 92442533 | - | 4562 | 200 | 124 | 879 | 251 |
| ENST00000556018 | TC2N | chr14 | 92280047 | - | ENST00000267622 | TRIP11 | chr14 | 92442533 | - | 4641 | 279 | 203 | 958 | 251 |
| ENST00000340892 | TC2N | chr14 | 92278656 | - | ENST00000267622 | TRIP11 | chr14 | 92474196 | - | 8923 | 615 | 477 | 5240 | 1587 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000340892 | ENST00000267622 | TC2N | chr14 | 92278655 | - | TRIP11 | chr14 | 92474196 | - | 0.000317325 | 0.99968266 |
| ENST00000435962 | ENST00000267622 | TC2N | chr14 | 92280047 | - | TRIP11 | chr14 | 92442533 | - | 0.001769763 | 0.9982303 |
| ENST00000360594 | ENST00000267622 | TC2N | chr14 | 92280047 | - | TRIP11 | chr14 | 92442533 | - | 0.001604315 | 0.9983956 |
| ENST00000556018 | ENST00000267622 | TC2N | chr14 | 92280047 | - | TRIP11 | chr14 | 92442533 | - | 0.001652481 | 0.9983475 |
| ENST00000340892 | ENST00000267622 | TC2N | chr14 | 92278656 | - | TRIP11 | chr14 | 92474196 | - | 0.000317325 | 0.99968266 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >89632_89632_1_TC2N-TRIP11_TC2N_chr14_92278655_ENST00000340892_TRIP11_chr14_92474196_ENST00000267622_length(amino acids)=1587AA_BP=46 MAVLRIICFPNYHLMAKKYHLWCPSLSYLTFNPGHKKLLHIWKNLKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELE QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS LQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV KGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN QFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ HSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSE LERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTA LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQR DETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV KEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWM TGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPF -------------------------------------------------------------- >89632_89632_2_TC2N-TRIP11_TC2N_chr14_92278656_ENST00000340892_TRIP11_chr14_92474196_ENST00000267622_length(amino acids)=1587AA_BP=46 MAVLRIICFPNYHLMAKKYHLWCPSLSYLTFNPGHKKLLHIWKNLKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELE QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS LQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV KGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN QFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ HSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSE LERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY RGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTA LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQR DETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV KEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWM TGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPF -------------------------------------------------------------- >89632_89632_3_TC2N-TRIP11_TC2N_chr14_92280047_ENST00000360594_TRIP11_chr14_92442533_ENST00000267622_length(amino acids)=251AA_BP=26 MNVMATEFIKSCCGGCFYGETEKHNYELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEME QLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDT -------------------------------------------------------------- >89632_89632_4_TC2N-TRIP11_TC2N_chr14_92280047_ENST00000435962_TRIP11_chr14_92442533_ENST00000267622_length(amino acids)=251AA_BP=26 MNVMATEFIKSCCGGCFYGETEKHNYELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEME QLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDT -------------------------------------------------------------- >89632_89632_5_TC2N-TRIP11_TC2N_chr14_92280047_ENST00000556018_TRIP11_chr14_92442533_ENST00000267622_length(amino acids)=251AA_BP=26 MNVMATEFIKSCCGGCFYGETEKHNYELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEME QLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDT -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:92302715/chr14:92460256) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | TRIP11 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TRIP11 | chr14:92278655 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1774_1823 | 438.0 | 1980.0 | Domain | GRIP | |
| Tgene | TRIP11 | chr14:92278656 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1774_1823 | 438.0 | 1980.0 | Domain | GRIP | |
| Tgene | TRIP11 | chr14:92280047 | chr14:92442533 | ENST00000267622 | 15 | 21 | 1774_1823 | 1753.3333333333333 | 1980.0 | Domain | GRIP | |
| Tgene | TRIP11 | chr14:92278655 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1017_1195 | 438.0 | 1980.0 | Region | Involved in RAB2A binding | |
| Tgene | TRIP11 | chr14:92278655 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1325_1599 | 438.0 | 1980.0 | Region | Involved in RAB2A binding | |
| Tgene | TRIP11 | chr14:92278656 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1017_1195 | 438.0 | 1980.0 | Region | Involved in RAB2A binding | |
| Tgene | TRIP11 | chr14:92278656 | chr14:92474196 | ENST00000267622 | 8 | 21 | 1325_1599 | 438.0 | 1980.0 | Region | Involved in RAB2A binding |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 223_342 | 100.33333333333333 | 427.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 344_471 | 100.33333333333333 | 427.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 223_342 | 100.33333333333333 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 344_471 | 100.33333333333333 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 223_342 | 100.33333333333333 | 427.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 344_471 | 100.33333333333333 | 427.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000340892 | - | 2 | 12 | 223_342 | 22.333333333333332 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000340892 | - | 2 | 12 | 344_471 | 22.333333333333332 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000360594 | - | 2 | 12 | 223_342 | 22.333333333333332 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000360594 | - | 2 | 12 | 344_471 | 22.333333333333332 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000435962 | - | 2 | 12 | 223_342 | 22.333333333333332 | 491.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000435962 | - | 2 | 12 | 344_471 | 22.333333333333332 | 491.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000556018 | - | 2 | 11 | 223_342 | 22.333333333333332 | 427.0 | Domain | C2 1 |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000556018 | - | 2 | 11 | 344_471 | 22.333333333333332 | 427.0 | Domain | C2 2 |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278655 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 447_449 | 100.33333333333333 | 427.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000340892 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000360594 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000435962 | - | 3 | 12 | 447_449 | 100.33333333333333 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92278656 | chr14:92474196 | ENST00000556018 | - | 3 | 11 | 447_449 | 100.33333333333333 | 427.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000340892 | - | 2 | 12 | 447_449 | 22.333333333333332 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000360594 | - | 2 | 12 | 447_449 | 22.333333333333332 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000435962 | - | 2 | 12 | 447_449 | 22.333333333333332 | 491.0 | Motif | Nuclear localization signal |
| Hgene | TC2N | chr14:92280047 | chr14:92442533 | ENST00000556018 | - | 2 | 11 | 447_449 | 22.333333333333332 | 427.0 | Motif | Nuclear localization signal |
| Tgene | TRIP11 | chr14:92278655 | chr14:92474196 | ENST00000267622 | 8 | 21 | 52_1773 | 438.0 | 1980.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TRIP11 | chr14:92278656 | chr14:92474196 | ENST00000267622 | 8 | 21 | 52_1773 | 438.0 | 1980.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TRIP11 | chr14:92280047 | chr14:92442533 | ENST00000267622 | 15 | 21 | 52_1773 | 1753.3333333333333 | 1980.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | TRIP11 | chr14:92280047 | chr14:92442533 | ENST00000267622 | 15 | 21 | 1017_1195 | 1753.3333333333333 | 1980.0 | Region | Involved in RAB2A binding | |
| Tgene | TRIP11 | chr14:92280047 | chr14:92442533 | ENST00000267622 | 15 | 21 | 1325_1599 | 1753.3333333333333 | 1980.0 | Region | Involved in RAB2A binding |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| TRIP11 | Thrb, RB1, THRA, COPS2, ATXN1L, PSMC5, YWHAE, USO1, NCOA1, TMEM17, MYH6, Dctn1, Sidt2, Haus1, Tuba3a, CDH1, EXOC3, BFSP2, ASB7, CHPF, MED4, BACH1, ATG16L1, HOOK1, ARNT, BET1, LAMP1, RAB9A, GOLGA2, TGOLN2, KIAA1429, NRAS, CSK, CA9, RHBDD1, IFT20, RALY, LEKR1, OR6X1, HNRNPCL2, SPTAN1, E, M, nsp13, nsp4, nsp6, ORF3a, ORF6, ORF7a, ORF7b, S, MYBPC2, MKRN2, TNRC6A, TNRC6B, KIF20A, SLC25A46, Rnf183, NR3C1, AP2B1, B3GAT1, CAV1, CXADR, EBAG9, ELOVL5, EMD, ERGIC1, ERGIC2, GJA1, GJD3, GORASP1, HSD3B7, KRT8, LAMP2, LAMP3, LAMTOR1, LATS1, LCK, METTL7A, MLLT4, NUP155, OCLN, PCNT, PFN1, PXMP2, PXN, RAB11A, RAB2A, RAB3B, RAB4A, RAB5A, RAB5C, SASS6, SEPT10, STIL, STX4, STX6, STX7, ZFPL1, NAA40, VPS33A, KXD1, C15orf59, DUSP16, YWHAB, BDH2, DISC1, YWHAG, YWHAH, BRK1, CCT8L2, PIGH, ZRANB1, NRP1, FURIN, IFITM1, ANPEP, DPP4, BSG, IFITM3, TMPRSS11B, CLEC4D, ACE2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| TC2N | |
| TRIP11 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to TC2N-TRIP11 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to TC2N-TRIP11 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TRIP11 | C0018036 | Hypertension, Goldblatt | 1 | ORPHANET |
| Tgene | TRIP11 | C0265273 | Achondrogenesis type 1A | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | TRIP11 | C2745953 | Spondylometaphyseal dysplasia with dentinogenesis imperfecta | 1 | ORPHANET;UNIPROT |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies