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Fusion Protein:TCF12-DSCAM |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: TCF12-DSCAM | FusionPDB ID: 89700 | FusionGDB2.0 ID: 89700 | Hgene | Tgene | Gene symbol | TCF12 | DSCAM | Gene ID | 6938 | 1826 |
| Gene name | transcription factor 12 | DS cell adhesion molecule | |
| Synonyms | CRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64 | CHD2|CHD2-42|CHD2-52 | |
| Cytomap | 15q21.3 | 21q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4 | Down syndrome cell adhesion molecule | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q8TD84 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000267811, ENST00000333725, ENST00000438423, ENST00000452095, ENST00000557843, ENST00000343827, ENST00000537840, ENST00000543579, ENST00000559703, ENST00000559710, ENST00000560764, | ENST00000400454, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 29 X 19 X 12=6612 | 13 X 11 X 6=858 |
| # samples | 32 | 15 | |
| ** MAII score | log2(32/6612*10)=-4.36894291440495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: TCF12 [Title/Abstract] AND DSCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TCF12(57384089)-DSCAM(41741172), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | TCF12-DSCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-DSCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-DSCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-DSCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF12 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11802795 |
| Tgene | DSCAM | GO:0042327 | positive regulation of phosphorylation | 19196994 |
| Tgene | DSCAM | GO:0048842 | positive regulation of axon extension involved in axon guidance | 18585357 |
| Fusion gene breakpoints across TCF12 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DSCAM (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-M7-A725-01A | TCF12 | chr15 | 57384089 | - | DSCAM | chr21 | 41741172 | - |
| ChimerDB4 | PRAD | TCGA-M7-A725-01A | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000438423 | TCF12 | chr15 | 57384089 | + | ENST00000400454 | DSCAM | chr21 | 41741172 | - | 8187 | 621 | 260 | 6151 | 1963 |
| ENST00000267811 | TCF12 | chr15 | 57384089 | + | ENST00000400454 | DSCAM | chr21 | 41741172 | - | 8195 | 629 | 304 | 6159 | 1951 |
| ENST00000452095 | TCF12 | chr15 | 57384089 | + | ENST00000400454 | DSCAM | chr21 | 41741172 | - | 8173 | 607 | 294 | 6137 | 1947 |
| ENST00000333725 | TCF12 | chr15 | 57384089 | + | ENST00000400454 | DSCAM | chr21 | 41741172 | - | 8126 | 560 | 235 | 6090 | 1951 |
| ENST00000557843 | TCF12 | chr15 | 57384089 | + | ENST00000400454 | DSCAM | chr21 | 41741172 | - | 7978 | 412 | 51 | 5942 | 1963 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000438423 | ENST00000400454 | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - | 0.001200241 | 0.9987998 |
| ENST00000267811 | ENST00000400454 | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - | 0.001228525 | 0.9987715 |
| ENST00000452095 | ENST00000400454 | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - | 0.001203474 | 0.99879646 |
| ENST00000333725 | ENST00000400454 | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - | 0.001157367 | 0.9988426 |
| ENST00000557843 | ENST00000400454 | TCF12 | chr15 | 57384089 | + | DSCAM | chr21 | 41741172 | - | 0.000951251 | 0.99904877 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >89700_89700_1_TCF12-DSCAM_TCF12_chr15_57384089_ENST00000267811_DSCAM_chr21_41741172_ENST00000400454_length(amino acids)=1951AA_BP=108 MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR LGAHEGLSPTPFMNSNLMGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQR VELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQV SLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPA EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMK NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQP FEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSY GEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY AKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL DNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK NITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYP TVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG YILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWND GGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNE GLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDR STVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLP TPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSS TPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAA -------------------------------------------------------------- >89700_89700_2_TCF12-DSCAM_TCF12_chr15_57384089_ENST00000333725_DSCAM_chr21_41741172_ENST00000400454_length(amino acids)=1951AA_BP=108 MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR LGAHEGLSPTPFMNSNLMGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQR VELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQV SLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPA EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMK NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQP FEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSY GEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMY AKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL DNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK NITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYP TVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG YILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWND GGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNE GLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDR STVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLP TPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSS TPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAA -------------------------------------------------------------- >89700_89700_3_TCF12-DSCAM_TCF12_chr15_57384089_ENST00000438423_DSCAM_chr21_41741172_ENST00000400454_length(amino acids)=1963AA_BP=120 MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILD GFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATIS PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKI ISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI NVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSV HVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVE HQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED SGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGII RKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKA VGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT TRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKS VVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLI EERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTI SAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTA GTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKR -------------------------------------------------------------- >89700_89700_4_TCF12-DSCAM_TCF12_chr15_57384089_ENST00000452095_DSCAM_chr21_41741172_ENST00000400454_length(amino acids)=1947AA_BP=104 MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAH EGLSPTPFMNSNLMGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELP CKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSC SVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVS LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITA IAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK IPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR GIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR IGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN KFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT TQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVIS EFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNG TPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQ YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCP ITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKM LVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVL LTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRA AGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSE SGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSAS -------------------------------------------------------------- >89700_89700_5_TCF12-DSCAM_TCF12_chr15_57384089_ENST00000557843_DSCAM_chr21_41741172_ENST00000400454_length(amino acids)=1963AA_BP=120 MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILD GFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATIS PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKI ISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI NVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSV HVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVE HQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED SGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGII RKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKA VGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT TRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKS VVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLI EERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTI SAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTA GTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:57384089/chr21:41741172) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DSCAM |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:E1C8P7, ECO:0000250|UniProtKB:Q4VA61, ECO:0000269|PubMed:11453658}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000267811 | + | 5 | 20 | 19_27 | 108.33333333333333 | 1821.3333333333333 | Motif | Note=9aaTAD |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000333725 | + | 5 | 21 | 19_27 | 108.33333333333333 | 1420.0 | Motif | Note=9aaTAD |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000438423 | + | 5 | 21 | 19_27 | 108.33333333333333 | 1398.3333333333333 | Motif | Note=9aaTAD |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000557843 | + | 5 | 20 | 19_27 | 108.33333333333333 | 1301.0 | Motif | Note=9aaTAD |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1091_1187 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 3 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1191_1285 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 4 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1285_1377 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 10 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1379_1473 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 5 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1474_1575 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 6 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 225_305 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 313_401 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 407_500 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 504_592 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 596_685 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 7 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 690_783 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 8 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 787_883 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 9 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 885_982 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 1 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 987_1086 | 169.33333333333334 | 2013.0 | Domain | Fibronectin type-III 2 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1617_2012 | 169.33333333333334 | 2013.0 | Region | Required for netrin-mediated axon repulsion of neuronal growth cones | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 1596_1616 | 169.33333333333334 | 2013.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000267811 | + | 5 | 20 | 577_630 | 108.33333333333333 | 1821.3333333333333 | Domain | bHLH |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000333725 | + | 5 | 21 | 577_630 | 108.33333333333333 | 1420.0 | Domain | bHLH |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000343827 | + | 1 | 13 | 577_630 | 0 | 1254.6666666666667 | Domain | bHLH |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000438423 | + | 5 | 21 | 577_630 | 108.33333333333333 | 1398.3333333333333 | Domain | bHLH |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000557843 | + | 5 | 20 | 577_630 | 108.33333333333333 | 1301.0 | Domain | bHLH |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000343827 | + | 1 | 13 | 19_27 | 0 | 1254.6666666666667 | Motif | Note=9aaTAD |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000267811 | + | 5 | 20 | 119_140 | 108.33333333333333 | 1821.3333333333333 | Region | Note=Leucine-zipper |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000267811 | + | 5 | 20 | 632_655 | 108.33333333333333 | 1821.3333333333333 | Region | Note=Class A specific domain |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000333725 | + | 5 | 21 | 119_140 | 108.33333333333333 | 1420.0 | Region | Note=Leucine-zipper |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000333725 | + | 5 | 21 | 632_655 | 108.33333333333333 | 1420.0 | Region | Note=Class A specific domain |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000343827 | + | 1 | 13 | 119_140 | 0 | 1254.6666666666667 | Region | Note=Leucine-zipper |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000343827 | + | 1 | 13 | 632_655 | 0 | 1254.6666666666667 | Region | Note=Class A specific domain |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000438423 | + | 5 | 21 | 119_140 | 108.33333333333333 | 1398.3333333333333 | Region | Note=Leucine-zipper |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000438423 | + | 5 | 21 | 632_655 | 108.33333333333333 | 1398.3333333333333 | Region | Note=Class A specific domain |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000557843 | + | 5 | 20 | 119_140 | 108.33333333333333 | 1301.0 | Region | Note=Leucine-zipper |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000557843 | + | 5 | 20 | 632_655 | 108.33333333333333 | 1301.0 | Region | Note=Class A specific domain |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 125_216 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 39_129 | 169.33333333333334 | 2013.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | DSCAM | chr15:57384089 | chr21:41741172 | ENST00000400454 | 2 | 33 | 18_1595 | 169.33333333333334 | 2013.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| TCF12 | |
| DSCAM |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000267811 | + | 5 | 20 | 182_196 | 108.33333333333333 | 1821.3333333333333 | RUNX1T1 |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000333725 | + | 5 | 21 | 182_196 | 108.33333333333333 | 1420.0 | RUNX1T1 |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000343827 | + | 1 | 13 | 182_196 | 0 | 1254.6666666666667 | RUNX1T1 |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000438423 | + | 5 | 21 | 182_196 | 108.33333333333333 | 1398.3333333333333 | RUNX1T1 |
| Hgene | TCF12 | chr15:57384089 | chr21:41741172 | ENST00000557843 | + | 5 | 20 | 182_196 | 108.33333333333333 | 1301.0 | RUNX1T1 |
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Related Drugs to TCF12-DSCAM |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TCF12-DSCAM |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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