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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TCF4-PMAIP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TCF4-PMAIP1
FusionPDB ID: 89790
FusionGDB2.0 ID: 89790
HgeneTgene
Gene symbol

TCF4

PMAIP1

Gene ID

6934

5366

Gene nametranscription factor 7 like 2phorbol-12-myristate-13-acetate-induced protein 1
SynonymsTCF-4|TCF4APR|NOXA
Cytomap

10q25.2-q25.3

18q21.32

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)phorbol-12-myristate-13-acetate-induced protein 1PMA-induced protein 1adult T cell leukemia-derived PMA-responsiveimmediate-early-response protein APRprotein Noxa
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000563760, ENST00000354452, 
ENST00000356073, ENST00000537578, 
ENST00000537856, ENST00000540999, 
ENST00000561992, ENST00000564999, 
ENST00000566279, ENST00000568673, 
ENST00000568740, ENST00000398339, 
ENST00000457482, ENST00000543082, 
ENST00000544241, ENST00000561831, 
ENST00000564228, ENST00000564403, 
ENST00000565018, ENST00000566286, 
ENST00000567880, ENST00000570177, 
ENST00000570287, 		ENST00000269518, 
ENST00000316660, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 13 X 4=6761 X 1 X 1=1
# samples 131
** MAII scorelog2(13/676*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: TCF4 [Title/Abstract] AND PMAIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TCF4(52928696)-PMAIP1(57569878), # samples:1
Anticipated loss of major functional domain due to fusion event.TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TCF4-PMAIP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF4

GO:0000122

negative regulation of transcription by RNA polymerase II

12799378

HgeneTCF4

GO:0006357

regulation of transcription by RNA polymerase II

9727977

HgeneTCF4

GO:0032092

positive regulation of protein binding

12799378

HgeneTCF4

GO:0032350

regulation of hormone metabolic process

15525634

HgeneTCF4

GO:0042593

glucose homeostasis

15525634

HgeneTCF4

GO:0043433

negative regulation of DNA-binding transcription factor activity

12799378

HgeneTCF4

GO:0045444

fat cell differentiation

10937998

HgeneTCF4

GO:0045892

negative regulation of transcription, DNA-templated

12799378|15525634

HgeneTCF4

GO:0045944

positive regulation of transcription by RNA polymerase II

9065401|19168596

HgeneTCF4

GO:0048625

myoblast fate commitment

10937998

TgenePMAIP1

GO:0010498

proteasomal protein catabolic process

15901672

TgenePMAIP1

GO:0010907

positive regulation of glucose metabolic process

21145489

TgenePMAIP1

GO:0043065

positive regulation of apoptotic process

21145489

TgenePMAIP1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

14699081

TgenePMAIP1

GO:0043331

response to dsRNA

15705586

TgenePMAIP1

GO:0046902

regulation of mitochondrial membrane permeability

14500711

TgenePMAIP1

GO:0051607

defense response to virus

15705586

TgenePMAIP1

GO:0072593

reactive oxygen species metabolic process

14699081

TgenePMAIP1

GO:0090200

positive regulation of release of cytochrome c from mitochondria

14500711|14699081|15705586

TgenePMAIP1

GO:0097193

intrinsic apoptotic signaling pathway

14500711

TgenePMAIP1

GO:1902043

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

15705586

TgenePMAIP1

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

21454712


check buttonFusion gene breakpoints across TCF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PMAIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-ZQ-A9CRTCF4chr18

52928696

-PMAIP1chr18

57569878

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457482TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+272610665561116186
ENST00000457482TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+195710665561116186
ENST00000543082TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+269610361721086304
ENST00000543082TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+192710361721086304
ENST00000544241TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+271810582061108300
ENST00000544241TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+194910582061108300
ENST00000561831TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+2312652142702186
ENST00000561831TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+1543652142702186
ENST00000565018TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+289412342261284352
ENST00000565018TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+212512342261284352
ENST00000570287TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+2418758248808186
ENST00000570287TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+1649758248808186
ENST00000564228TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+24377770827275
ENST00000564228TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+16687770827275
ENST00000567880TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+24708100860286
ENST00000567880TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+17018100860286
ENST00000566286TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+264498401034344
ENST00000566286TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+187598401034344
ENST00000564403TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+319515355091585358
ENST00000564403TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+242615355091585358
ENST00000398339TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+30131353571403448
ENST00000398339TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+22441353571403448
ENST00000570177TCF4chr1852928696-ENST00000316660PMAIP1chr1857569878+246780778857259
ENST00000570177TCF4chr1852928696-ENST00000269518PMAIP1chr1857569878+169880778857259

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457482ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0064071690.9935928
ENST00000457482ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.008350580.9916494
ENST00000543082ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0020137670.9979862
ENST00000543082ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0039399690.99605995
ENST00000544241ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0040596860.9959403
ENST00000544241ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0094573950.9905426
ENST00000561831ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0096417580.9903583
ENST00000561831ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0059371810.99406284
ENST00000565018ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.000511140.99948883
ENST00000565018ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0015314330.9984686
ENST00000570287ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0036565830.99634343
ENST00000570287ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0032305590.9967694
ENST00000564228ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0034088110.9965912
ENST00000564228ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0055332470.99446684
ENST00000567880ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0016493270.99835074
ENST00000567880ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0044852980.9955147
ENST00000566286ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0005871030.9994129
ENST00000566286ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0017368820.9982632
ENST00000564403ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0005362650.99946374
ENST00000564403ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0013144240.99868554
ENST00000398339ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0011488210.9988512
ENST00000398339ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0039200730.99608
ENST00000570177ENST00000316660TCF4chr1852928696-PMAIP1chr1857569878+0.0038175870.9961824
ENST00000570177ENST00000269518TCF4chr1852928696-PMAIP1chr1857569878+0.0039586130.9960414

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89790_89790_1_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000398339_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=448AA_BP=80
MFSKRLEKIAQVPLLFPFIFIILTNYSKMEGAVESQPSFFKTSQDIVTCTWVENCYSSFSRRPLEQMFCKHQSKNIISWTGMVAHTCNPS
TLGGQGLCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYD
HMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEV
QTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLH

--------------------------------------------------------------

>89790_89790_2_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000398339_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=448AA_BP=80
MFSKRLEKIAQVPLLFPFIFIILTNYSKMEGAVESQPSFFKTSQDIVTCTWVENCYSSFSRRPLEQMFCKHQSKNIISWTGMVAHTCNPS
TLGGQGLCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYD
HMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEV
QTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLH

--------------------------------------------------------------

>89790_89790_3_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000457482_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=186AA_BP=170
MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

>89790_89790_4_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000457482_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=186AA_BP=170
MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

>89790_89790_5_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000543082_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=304AA_BP=288
MEEDSRDVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMD
MGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHH
SSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGS

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>89790_89790_6_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000543082_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=304AA_BP=288
MEEDSRDVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMD
MGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHH
SSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGS

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>89790_89790_7_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000544241_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=300AA_BP=284
MFVRESGGHWNDSFWKCGAVWLRIGMKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNP
GTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDP
WSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAG

--------------------------------------------------------------

>89790_89790_8_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000544241_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=300AA_BP=284
MFVRESGGHWNDSFWKCGAVWLRIGMKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNP
GTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDP
WSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAG

--------------------------------------------------------------

>89790_89790_9_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000561831_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=186AA_BP=170
MKFKQCRCSDTGLCCLDHEGKAEVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

>89790_89790_10_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000561831_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=186AA_BP=170
MKFKQCRCSDTGLCCLDHEGKAEVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

>89790_89790_11_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000564228_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=275AA_BP=259
MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPL
HSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQS
SSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNSG

--------------------------------------------------------------

>89790_89790_12_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000564228_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=275AA_BP=259
MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLRKTERGSYSSYGRESNLQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPL
HSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQS
SSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNSG

--------------------------------------------------------------

>89790_89790_13_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000564403_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=358AA_BP=342
MCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRD
LGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVR
KVPPGLPSSLVLSPQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLH

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>89790_89790_14_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000564403_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=358AA_BP=342
MCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRD
LGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVR
KVPPGLPSSLVLSPQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLH

--------------------------------------------------------------

>89790_89790_15_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000565018_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=352AA_BP=336
MCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRD
LGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVR
KVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLS

--------------------------------------------------------------

>89790_89790_16_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000565018_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=352AA_BP=336
MCDFAKMHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRD
LGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVR
KVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLS

--------------------------------------------------------------

>89790_89790_17_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000566286_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=344AA_BP=328
MQRAKTELFRLQIVTDDLRKNEMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLS
PPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPS
SVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSAD

--------------------------------------------------------------

>89790_89790_18_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000566286_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=344AA_BP=328
MQRAKTELFRLQIVTDDLRKNEMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLS
PPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPS
SVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSAD

--------------------------------------------------------------

>89790_89790_19_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000567880_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=286AA_BP=270
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN
LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG
MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS

--------------------------------------------------------------

>89790_89790_20_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000567880_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=286AA_BP=270
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDN
LSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG
MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALAS

--------------------------------------------------------------

>89790_89790_21_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000570177_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=259AA_BP=243
MVKSSCRSAVHGSLFGKNSAGKKFTAIPAQRKHLWNQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVP
PGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPS

--------------------------------------------------------------

>89790_89790_22_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000570177_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=259AA_BP=243
MVKSSCRSAVHGSLFGKNSAGKKFTAIPAQRKHLWNQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVP
PGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPS

--------------------------------------------------------------

>89790_89790_23_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000570287_PMAIP1_chr18_57569878_ENST00000269518_length(amino acids)=186AA_BP=170
MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

>89790_89790_24_TCF4-PMAIP1_TCF4_chr18_52928696_ENST00000570287_PMAIP1_chr18_57569878_ENST00000316660_length(amino acids)=186AA_BP=170
MYCAYTIPGMGGNSLMYYYNGKAVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQ
SSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASSWKSSVLLNS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:52928696/chr18:57569878)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-1220228_231330.02391.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-1220228_231330.02386.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-1119228_231306.0591.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-1119228_231306.0682.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-1018228_231288.0702.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-816228_231259.0560.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-816228_231259.0631.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-1220228_231330.0700.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-1220228_231330.0662.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-1018228_231270.0619.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-1119228_231328.0705.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-917228_231270.0646.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-1119228_231306.0757.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-122018_26330.02391.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-122018_26330.02386.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-51318_26170.0429.3333333333333MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-111918_26306.0591.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-71518_26200.0566.3333333333334MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-111918_26306.0682.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-101818_26288.0702.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-81618_26259.0560.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-51318_26170.0500.3333333333333MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-81618_26200.0514.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-81618_26259.0631.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-122018_26330.0700.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-122018_26330.0662.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-101818_26270.0619.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-111918_26328.0705.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-91718_26270.0646.6666666666666MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-111918_26306.0757.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-71518_26200.0495.3333333333333MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-51318_26170.0454.0MotifNote=9aaTAD
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-12201_83330.02391.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-12201_83330.02386.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-5131_83170.0429.3333333333333RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-11191_83306.0591.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-7151_83200.0566.3333333333334RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-11191_83306.0682.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-10181_83288.0702.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-8161_83259.0560.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-5131_83170.0500.3333333333333RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-8161_83200.0514.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-8161_83259.0631.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-12201_83330.0700.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-12201_83330.0662.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-10181_83270.0619.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-11191_83328.0705.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-9171_83270.0646.6666666666666RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-11191_83306.0757.0RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-7151_83200.0495.3333333333333RegionEssential for MYOD1 inhibition
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-5131_83170.0454.0RegionEssential for MYOD1 inhibition
TgenePMAIP1chr18:52928696chr18:57569878ENST000003166600229_3719.33333333333333255.0MotifNote=BH3
TgenePMAIP1chr18:52928696chr18:57569878ENST000003166600241_5019.33333333333333255.0RegionNote=Required for mitochondrial location

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-513228_231170.0429.3333333333333Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-715228_231200.0566.3333333333334Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-513228_231170.0500.3333333333333Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-816228_231200.0514.6666666666666Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-715228_231200.0495.3333333333333Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-513228_231170.0454.0Compositional biasNote=Poly-Ser
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-1220564_617330.02391.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-1220564_617330.02386.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-513564_617170.0429.3333333333333DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-1119564_617306.0591.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-715564_617200.0566.3333333333334DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-1119564_617306.0682.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-1018564_617288.0702.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-816564_617259.0560.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-513564_617170.0500.3333333333333DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-816564_617200.0514.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-816564_617259.0631.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-1220564_617330.0700.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-1220564_617330.0662.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-1018564_617270.0619.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-1119564_617328.0705.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-917564_617270.0646.6666666666666DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-1119564_617306.0757.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-715564_617200.0495.3333333333333DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-513564_617170.0454.0DomainbHLH
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-1220379_400330.02391.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000354452-1220619_642330.02391.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-1220379_400330.02386.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000356073-1220619_642330.02386.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-513379_400170.0429.3333333333333RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000457482-513619_642170.0429.3333333333333RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-1119379_400306.0591.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000537578-1119619_642306.0591.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-715379_400200.0566.3333333333334RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000537856-715619_642200.0566.3333333333334RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-1119379_400306.0682.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000540999-1119619_642306.0682.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-1018379_400288.0702.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000543082-1018619_642288.0702.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-816379_400259.0560.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000544241-816619_642259.0560.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-513379_400170.0500.3333333333333RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000561831-513619_642170.0500.3333333333333RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-816379_400200.0514.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000561992-816619_642200.0514.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-816379_400259.0631.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000564228-816619_642259.0631.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-1220379_400330.0700.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000564999-1220619_642330.0700.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-1220379_400330.0662.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000565018-1220619_642330.0662.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-1018379_400270.0619.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000566279-1018619_642270.0619.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-1119379_400328.0705.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000566286-1119619_642328.0705.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-917379_400270.0646.6666666666666RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000567880-917619_642270.0646.6666666666666RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-1119379_400306.0757.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000568673-1119619_642306.0757.0RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-715379_400200.0495.3333333333333RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000570177-715619_642200.0495.3333333333333RegionNote=Class A specific domain
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-513379_400170.0454.0RegionNote=Leucine-zipper
HgeneTCF4chr18:52928696chr18:57569878ENST00000570287-513619_642170.0454.0RegionNote=Class A specific domain


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TCF4
PMAIP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TCF4-PMAIP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TCF4-PMAIP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF4C1970431PITT-HOPKINS SYNDROME14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTCF4C0005586Bipolar Disorder5PSYGENET
HgeneTCF4C0036341Schizophrenia4PSYGENET
HgeneTCF4C0016781Fuchs Endothelial Dystrophy1ORPHANET
HgeneTCF4C0018799Heart Diseases1CTD_human
HgeneTCF4C0022333Jacksonian Seizure1CTD_human
HgeneTCF4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTCF4C0023903Liver neoplasms1CTD_human
HgeneTCF4C0025958Microcephaly1CTD_human
HgeneTCF4C0033975Psychotic Disorders1PSYGENET
HgeneTCF4C0036572Seizures1CTD_human
HgeneTCF4C0149958Complex partial seizures1CTD_human
HgeneTCF4C0234533Generalized seizures1CTD_human
HgeneTCF4C0234535Clonic Seizures1CTD_human
HgeneTCF4C0270824Visual seizure1CTD_human
HgeneTCF4C0270844Tonic Seizures1CTD_human
HgeneTCF4C0270846Epileptic drop attack1CTD_human
HgeneTCF4C0345904Malignant neoplasm of liver1CTD_human
HgeneTCF4C0349204Nonorganic psychosis1PSYGENET
HgeneTCF4C0376634Craniofacial Abnormalities1CTD_human
HgeneTCF4C0422850Seizures, Somatosensory1CTD_human
HgeneTCF4C0422852Seizures, Auditory1CTD_human
HgeneTCF4C0422853Olfactory seizure1CTD_human
HgeneTCF4C0422854Gustatory seizure1CTD_human
HgeneTCF4C0422855Vertiginous seizure1CTD_human
HgeneTCF4C0494475Tonic - clonic seizures1CTD_human
HgeneTCF4C0566602Primary sclerosing cholangitis1ORPHANET
HgeneTCF4C0751056Non-epileptic convulsion1CTD_human
HgeneTCF4C0751110Single Seizure1CTD_human
HgeneTCF4C0751123Atonic Absence Seizures1CTD_human
HgeneTCF4C0751494Convulsive Seizures1CTD_human
HgeneTCF4C0751495Seizures, Focal1CTD_human
HgeneTCF4C0751496Seizures, Sensory1CTD_human
HgeneTCF4C1456784Paranoia1PSYGENET
HgeneTCF4C1535926Neurodevelopmental Disorders1CTD_human
HgeneTCF4C1956147Microlissencephaly1CTD_human
HgeneTCF4C2750451CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 31CTD_human;GENOMICS_ENGLAND
HgeneTCF4C2931456Prostate cancer, familial1CTD_human
HgeneTCF4C3495874Nonepileptic Seizures1CTD_human
HgeneTCF4C3853041Severe Congenital Microcephaly1CTD_human
HgeneTCF4C4048158Convulsions1CTD_human
HgeneTCF4C4316903Absence Seizures1CTD_human
HgeneTCF4C4317109Epileptic Seizures1CTD_human
HgeneTCF4C4317123Myoclonic Seizures1CTD_human
HgeneTCF4C4505436Generalized Absence Seizures1CTD_human
HgeneTCF4C4721453Peripheral Nervous System Diseases1CTD_human
HgeneTCF4C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human