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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TET1-CCAR1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TET1-CCAR1
	FusionPDB ID: 90156
	FusionGDB2.0 ID: 90156
		Hgene	Tgene
	Gene symbol	TET1	CCAR1
	Gene ID	80312	55749
	Gene name	tet methylcytosine dioxygenase 1	cell division cycle and apoptosis regulator 1
	Synonyms	CXXC6\|LCX\|bA119F7.1	-
	Cytomap	10q21.3	10q21.3
	Type of gene	protein-coding	protein-coding
	Description	methylcytosine dioxygenase TET1CXXC finger 6CXXC zinc finger 6CXXC-type zinc finger protein 6TET1 splice variant VP_DE4TET1 splice variant VP_DE456leukemia-associated protein with a CXXC domainten-eleven translocation 1 gene proteinten-eleven tran	cell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domain
	Modification date	20200313	20200313
	UniProtAcc	Q8NFU7	Q8IX12
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000373644,	ENST00000483264, ENST00000265872, ENST00000535016, ENST00000543719,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 14 X 7=980	5 X 6 X 3=90
	# samples	14	6
	** MAII score	log2(14/980*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TET1 [Title/Abstract] AND CCAR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CCAR1(70520949)-TET1(70432652), # samples:2 CCAR1(70517134)-TET1(70432652), # samples:2 TET1(70446464)-CCAR1(70549467), # samples:1
Anticipated loss of major functional domain due to fusion event.	TET1-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TET1-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TET1-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TET1-CCAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CCAR1-TET1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CCAR1-TET1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CCAR1-TET1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CCAR1-TET1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. CCAR1-TET1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CCAR1-TET1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CCAR1	GO:0043065	positive regulation of apoptotic process	12816952

Fusion gene breakpoints across TET1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCAR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0130-01A	TET1	chr10	70446464	+	CCAR1	chr10	70549467	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000373644

TET1

chr10

70446464

ENST00000535016

CCAR1

chr10

70549467

6165

5613

176

5878

1900

ENST00000373644

TET1

chr10

70446464

ENST00000265872

CCAR1

chr10

70549467

6990

5613

176

5878

1900

ENST00000373644

TET1

chr10

70446464

ENST00000543719

CCAR1

chr10

70549467

5879

5613

176

5878

1901

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373644	ENST00000535016	TET1	chr10	70446464	+	CCAR1	chr10	70549467	+	0.000253077	0.99974686
ENST00000373644	ENST00000265872	TET1	chr10	70446464	+	CCAR1	chr10	70549467	+	0.000200823	0.9997992
ENST00000373644	ENST00000543719	TET1	chr10	70446464	+	CCAR1	chr10	70549467	+	0.000308784	0.99969125

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90156_90156_1_TET1-CCAR1_TET1_chr10_70446464_ENST00000373644_CCAR1_chr10_70549467_ENST00000265872_length(amino acids)=1900AA_BP=1
MRPFIFSYSVAMSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGA
ARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDI
ETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPK
VTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAF
EATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNP
IATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLG
IAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQIC
KKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEK
WTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTAN
HKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLE
QVVAIEALTQLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSN
SHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDAT
HTQIEEDVATQLTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRR
KKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPE
SAEEKVKVEPLDSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPG
ISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVI
QKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLI
MVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHE
KNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVI
PQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTT
TNNSKPSSLPTLDEDEKTILNLENSNKSLSGELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNVKNEDKD

--------------------------------------------------------------

>90156_90156_2_TET1-CCAR1_TET1_chr10_70446464_ENST00000373644_CCAR1_chr10_70549467_ENST00000535016_length(amino acids)=1900AA_BP=1
MRPFIFSYSVAMSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGA
ARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDI
ETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPK
VTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAF
EATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNP
IATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLG
IAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQIC
KKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEK
WTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTAN
HKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLE
QVVAIEALTQLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSN
SHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDAT
HTQIEEDVATQLTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRR
KKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPE
SAEEKVKVEPLDSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPG
ISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVI
QKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLI
MVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHE
KNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVI
PQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTT
TNNSKPSSLPTLDEDEKTILNLENSNKSLSGELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNVKNEDKD

--------------------------------------------------------------

>90156_90156_3_TET1-CCAR1_TET1_chr10_70446464_ENST00000373644_CCAR1_chr10_70549467_ENST00000543719_length(amino acids)=1901AA_BP=1
MRPFIFSYSVAMSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGA
ARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDI
ETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPK
VTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAF
EATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNP
IATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLG
IAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQIC
KKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEK
WTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTAN
HKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLE
QVVAIEALTQLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSN
SHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDAT
HTQIEEDVATQLTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRR
KKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPE
SAEEKVKVEPLDSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPG
ISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVI
QKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLI
MVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHE
KNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVI
PQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTT
TNNSKPSSLPTLDEDEKTILNLENSNKSLSGELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNVKNEDKD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70520949/chr10:70432652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TET1 Q8NFU7	CCAR1 Q8IX12
FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation (PubMed:19372391, PubMed:21496894). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC) (PubMed:21778364). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes and diseases, including stem cell maintenance, T and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Plays an essential role in the protection and maintenance of transcriptional and developmental programs together with QSER1 to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). {ECO:0000269\|PubMed:12124344, ECO:0000269\|PubMed:19372391, ECO:0000269\|PubMed:19372393, ECO:0000269\|PubMed:21496894, ECO:0000269\|PubMed:21778364, ECO:0000269\|PubMed:25284789, ECO:0000269\|PubMed:29276034, ECO:0000269\|PubMed:31278917, ECO:0000269\|PubMed:33833093}.	FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250\|UniProtKB:Q8CH18, ECO:0000269\|PubMed:12816952, ECO:0000269\|PubMed:23887938, ECO:0000269\|PubMed:24245781}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TET1

chr10:70446464

chr10:70549467

ENST00000373644

528_674

1801.3333333333333

2137.0

Region

Note=Sufficient for binding to genomic CpG islands

Hgene

TET1

chr10:70446464

chr10:70549467

ENST00000373644

584_625

1801.3333333333333

2137.0

Zinc finger

CXXC-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TET1

chr10:70446464

chr10:70549467

ENST00000373644

2043_2045

1801.3333333333333

2137.0

Region

2-oxoglutarate binding

Hgene

TET1

chr10:70446464

chr10:70549467

ENST00000373644

2049_2051

1801.3333333333333

2137.0

Region

Substrate binding

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

1033_1114

1062.3333333333333

1151.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

594_618

1062.3333333333333

1151.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

1033_1114

1047.3333333333333

1136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

594_618

1047.3333333333333

1136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

1033_1114

1047.3333333333333

1136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

594_618

1047.3333333333333

1136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

293_361

1062.3333333333333

1151.0

Compositional bias

Note=Arg-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

673_889

1062.3333333333333

1151.0

Compositional bias

Note=Glu-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

73_79

1062.3333333333333

1151.0

Compositional bias

Note=Poly-Ala

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

293_361

1047.3333333333333

1136.0

Compositional bias

Note=Arg-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

673_889

1047.3333333333333

1136.0

Compositional bias

Note=Glu-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

73_79

1047.3333333333333

1136.0

Compositional bias

Note=Poly-Ala

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

293_361

1047.3333333333333

1136.0

Compositional bias

Note=Arg-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

673_889

1047.3333333333333

1136.0

Compositional bias

Note=Glu-rich

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

73_79

1047.3333333333333

1136.0

Compositional bias

Note=Poly-Ala

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000265872

636_670

1062.3333333333333

1151.0

Domain

SAP

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000535016

636_670

1047.3333333333333

1136.0

Domain

SAP

Tgene

CCAR1

chr10:70446464

chr10:70549467

ENST00000543719

636_670

1047.3333333333333

1136.0

Domain

SAP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
TET1	MBD3, VPRBP, DDB1, OGT, ZFP36L2, EPAS1, HIF1A, HNRNPD, SMG7, RELN, GAD1, BDNF, GOLGA2, POLR1E, S100P,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TET1
CCAR1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000265872		22	25	1_249	1062.3333333333333	1151.0	AR
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000535016		21	24	1_249	1047.3333333333333	1136.0	AR
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000543719		21	24	1_249	1047.3333333333333	1136.0	AR
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000265872		22	25	643_1150	1062.3333333333333	1151.0	GATA1
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000535016		21	24	643_1150	1047.3333333333333	1136.0	GATA1
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000543719		21	24	643_1150	1047.3333333333333	1136.0	GATA1
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000265872		22	25	203_660	1062.3333333333333	1151.0	GATA2
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000535016		21	24	203_660	1047.3333333333333	1136.0	GATA2
Tgene	CCAR1	chr10:70446464	chr10:70549467	ENST00000543719		21	24	203_660	1047.3333333333333	1136.0	GATA2

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Related Drugs to TET1-CCAR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TET1-CCAR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TET1	C0033975	Psychotic Disorders	1	PSYGENET
Hgene	TET1	C0036341	Schizophrenia	1	PSYGENET
Hgene	TET1	C0349204	Nonorganic psychosis	1	PSYGENET
Hgene	TET1	C1510586	Autism Spectrum Disorders	1	CTD_human