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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TFB2M-SMYD3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TFB2M-SMYD3
FusionPDB ID: 90264
FusionGDB2.0 ID: 90264
HgeneTgene
Gene symbol

TFB2M

SMYD3

Gene ID

64216

64754

Gene nametranscription factor B2, mitochondrialSET and MYND domain containing 3
SynonymsHkp1|mtTFB2KMT3E|ZMYND1|ZNFN3A1|bA74P14.1
Cytomap

1q44

1q44

Type of geneprotein-codingprotein-coding
Descriptiondimethyladenosine transferase 2, mitochondrialHCV NS5A-transactivated protein 5S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2h-mtTFBh-mtTFB2hTFB2Mhepatitis C virus NS5A-transactivated protein 5mitochondrial 12S rRNA dimethylase histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000544618, ENST00000366514, 
ENST00000388985, ENST00000490107, 
ENST00000541742, ENST00000366517, 
ENST00000403792, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 6 X 5=6029 X 14 X 17=6902
# samples 1147
** MAII scorelog2(11/60*10)=0.874469117916141
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(47/6902*10)=-3.87628181187052
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TFB2M [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TFB2M(246727648)-SMYD3(246093239), # samples:3
SMYD3(246518332)-TFB2M(246720836), # samples:1
SMYD3(246670356)-TFB2M(246711909), # samples:1
Anticipated loss of major functional domain due to fusion event.SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SMYD3-TFB2M seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMYD3-TFB2M seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TFB2M-SMYD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFB2M

GO:0006390

mitochondrial transcription

12068295

HgeneTFB2M

GO:0006391

transcription initiation from mitochondrial promoter

20410300|29149603

HgeneTFB2M

GO:0045893

positive regulation of transcription, DNA-templated

20410300


check buttonFusion gene breakpoints across TFB2M (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMYD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0D2-01ATFB2Mchr1

246719875

-SMYD3chr1

246498776

-
ChimerDB4HNSCTCGA-CR-6474-01ATFB2Mchr1

246727648

-SMYD3chr1

246498776

-
ChimerDB4HNSCTCGA-CR-6474TFB2Mchr1

246727647

-SMYD3chr1

246498776

-
ChimerDB4HNSCTCGA-CR-6474TFB2Mchr1

246727648

-SMYD3chr1

246498776

-
ChimerDB4HNSCTCGA-CR-7367-01ATFB2Mchr1

246711847

-SMYD3chr1

246093239

-
ChimerDB4HNSCTCGA-CR-7367TFB2Mchr1

246711846

-SMYD3chr1

246093239

-
ChimerDB4HNSCTCGA-CR-7367TFB2Mchr1

246711847

-SMYD3chr1

246093239

-
ChimerDB4STADTCGA-BR-8077-01ATFB2Mchr1

246727648

-SMYD3chr1

246093239

-
ChimerDB4STADTCGA-BR-8077TFB2Mchr1

246727647

-SMYD3chr1

246093239

-
ChimerDB4STADTCGA-VQ-A8DZTFB2Mchr1

246719874

-SMYD3chr1

246093239

-
ChimerDB4STADTCGA-VQ-A91N-01ATFB2Mchr1

246727648

-SMYD3chr1

246093239

-
ChimerDB4STADTCGA-VQ-A91NTFB2Mchr1

246727647

-SMYD3chr1

246093239

-
ChimerDB4UCECTCGA-H5-A2HR-01ATFB2Mchr1

246719875

-SMYD3chr1

246027188

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366514TFB2Mchr1246719875-ENST00000541742SMYD3chr1246498776-21738911711949592
ENST00000366514TFB2Mchr1246719875-ENST00000490107SMYD3chr1246498776-21718911711949592
ENST00000366514TFB2Mchr1246719875-ENST00000388985SMYD3chr1246498776-19508911711949592
ENST00000366514TFB2Mchr1246727648-ENST00000541742SMYD3chr1246498776-18705881711646491
ENST00000366514TFB2Mchr1246727648-ENST00000490107SMYD3chr1246498776-18685881711646491
ENST00000366514TFB2Mchr1246727648-ENST00000388985SMYD3chr1246498776-16475881711646491
ENST00000544618TFB2Mchr1246727648-ENST00000541742SMYD3chr1246498776-18075251081583491
ENST00000544618TFB2Mchr1246727648-ENST00000490107SMYD3chr1246498776-18055251081583491
ENST00000544618TFB2Mchr1246727648-ENST00000388985SMYD3chr1246498776-15845251081583491
ENST00000366514TFB2Mchr1246711847-ENST00000541742SMYD3chr1246093239-202310441711799542
ENST00000366514TFB2Mchr1246711847-ENST00000490107SMYD3chr1246093239-202110441711799542
ENST00000366514TFB2Mchr1246711847-ENST00000388985SMYD3chr1246093239-180010441711799542
ENST00000366514TFB2Mchr1246727648-ENST00000541742SMYD3chr1246093239-15675881711343390
ENST00000366514TFB2Mchr1246727648-ENST00000490107SMYD3chr1246093239-15655881711343390
ENST00000366514TFB2Mchr1246727648-ENST00000388985SMYD3chr1246093239-13445881711343390
ENST00000544618TFB2Mchr1246727648-ENST00000541742SMYD3chr1246093239-15045251081280390
ENST00000544618TFB2Mchr1246727648-ENST00000490107SMYD3chr1246093239-15025251081280390
ENST00000544618TFB2Mchr1246727648-ENST00000388985SMYD3chr1246093239-12815251081280390
ENST00000366514TFB2Mchr1246719875-ENST00000541742SMYD3chr1246027188-15888911711364397
ENST00000366514TFB2Mchr1246719875-ENST00000490107SMYD3chr1246027188-15868911711364397
ENST00000366514TFB2Mchr1246719875-ENST00000388985SMYD3chr1246027188-13658911711364397
ENST00000366514TFB2Mchr1246727647-ENST00000541742SMYD3chr1246498776-18705881711646491
ENST00000366514TFB2Mchr1246727647-ENST00000490107SMYD3chr1246498776-18685881711646491
ENST00000366514TFB2Mchr1246727647-ENST00000388985SMYD3chr1246498776-16475881711646491
ENST00000544618TFB2Mchr1246727647-ENST00000541742SMYD3chr1246498776-18075251081583491
ENST00000544618TFB2Mchr1246727647-ENST00000490107SMYD3chr1246498776-18055251081583491
ENST00000544618TFB2Mchr1246727647-ENST00000388985SMYD3chr1246498776-15845251081583491
ENST00000366514TFB2Mchr1246711846-ENST00000541742SMYD3chr1246093239-202310441711799542
ENST00000366514TFB2Mchr1246711846-ENST00000490107SMYD3chr1246093239-202110441711799542
ENST00000366514TFB2Mchr1246711846-ENST00000388985SMYD3chr1246093239-180010441711799542
ENST00000366514TFB2Mchr1246727647-ENST00000541742SMYD3chr1246093239-15675881711343390
ENST00000366514TFB2Mchr1246727647-ENST00000490107SMYD3chr1246093239-15655881711343390
ENST00000366514TFB2Mchr1246727647-ENST00000388985SMYD3chr1246093239-13445881711343390
ENST00000544618TFB2Mchr1246727647-ENST00000541742SMYD3chr1246093239-15045251081280390
ENST00000544618TFB2Mchr1246727647-ENST00000490107SMYD3chr1246093239-15025251081280390
ENST00000544618TFB2Mchr1246727647-ENST00000388985SMYD3chr1246093239-12815251081280390
ENST00000366514TFB2Mchr1246719874-ENST00000541742SMYD3chr1246093239-18708911711646491
ENST00000366514TFB2Mchr1246719874-ENST00000490107SMYD3chr1246093239-18688911711646491
ENST00000366514TFB2Mchr1246719874-ENST00000388985SMYD3chr1246093239-16478911711646491

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366514ENST00000541742TFB2Mchr1246719875-SMYD3chr1246498776-0.0011012770.99889874
ENST00000366514ENST00000490107TFB2Mchr1246719875-SMYD3chr1246498776-0.0011168570.9988832
ENST00000366514ENST00000388985TFB2Mchr1246719875-SMYD3chr1246498776-0.0014529990.998547
ENST00000366514ENST00000541742TFB2Mchr1246727648-SMYD3chr1246498776-0.0015326940.99846727
ENST00000366514ENST00000490107TFB2Mchr1246727648-SMYD3chr1246498776-0.0015573650.9984426
ENST00000366514ENST00000388985TFB2Mchr1246727648-SMYD3chr1246498776-0.0021985730.99780136
ENST00000544618ENST00000541742TFB2Mchr1246727648-SMYD3chr1246498776-0.0012038310.9987961
ENST00000544618ENST00000490107TFB2Mchr1246727648-SMYD3chr1246498776-0.0012255910.99877435
ENST00000544618ENST00000388985TFB2Mchr1246727648-SMYD3chr1246498776-0.0016886510.9983114
ENST00000366514ENST00000541742TFB2Mchr1246711847-SMYD3chr1246093239-0.0009917150.99900836
ENST00000366514ENST00000490107TFB2Mchr1246711847-SMYD3chr1246093239-0.001001910.9989981
ENST00000366514ENST00000388985TFB2Mchr1246711847-SMYD3chr1246093239-0.0013096480.9986903
ENST00000366514ENST00000541742TFB2Mchr1246727648-SMYD3chr1246093239-0.0023129160.9976871
ENST00000366514ENST00000490107TFB2Mchr1246727648-SMYD3chr1246093239-0.0023596750.9976404
ENST00000366514ENST00000388985TFB2Mchr1246727648-SMYD3chr1246093239-0.0032327280.9967673
ENST00000544618ENST00000541742TFB2Mchr1246727648-SMYD3chr1246093239-0.0018225550.9981774
ENST00000544618ENST00000490107TFB2Mchr1246727648-SMYD3chr1246093239-0.0018558630.99814415
ENST00000544618ENST00000388985TFB2Mchr1246727648-SMYD3chr1246093239-0.0024355740.99756444
ENST00000366514ENST00000541742TFB2Mchr1246719875-SMYD3chr1246027188-0.0009586710.99904126
ENST00000366514ENST00000490107TFB2Mchr1246719875-SMYD3chr1246027188-0.0009712630.9990288
ENST00000366514ENST00000388985TFB2Mchr1246719875-SMYD3chr1246027188-0.0014576010.9985424
ENST00000366514ENST00000541742TFB2Mchr1246727647-SMYD3chr1246498776-0.0015326940.99846727
ENST00000366514ENST00000490107TFB2Mchr1246727647-SMYD3chr1246498776-0.0015573650.9984426
ENST00000366514ENST00000388985TFB2Mchr1246727647-SMYD3chr1246498776-0.0021985730.99780136
ENST00000544618ENST00000541742TFB2Mchr1246727647-SMYD3chr1246498776-0.0012038310.9987961
ENST00000544618ENST00000490107TFB2Mchr1246727647-SMYD3chr1246498776-0.0012255910.99877435
ENST00000544618ENST00000388985TFB2Mchr1246727647-SMYD3chr1246498776-0.0016886510.9983114
ENST00000366514ENST00000541742TFB2Mchr1246711846-SMYD3chr1246093239-0.0009917150.99900836
ENST00000366514ENST00000490107TFB2Mchr1246711846-SMYD3chr1246093239-0.001001910.9989981
ENST00000366514ENST00000388985TFB2Mchr1246711846-SMYD3chr1246093239-0.0013096480.9986903
ENST00000366514ENST00000541742TFB2Mchr1246727647-SMYD3chr1246093239-0.0023129160.9976871
ENST00000366514ENST00000490107TFB2Mchr1246727647-SMYD3chr1246093239-0.0023596750.9976404
ENST00000366514ENST00000388985TFB2Mchr1246727647-SMYD3chr1246093239-0.0032327280.9967673
ENST00000544618ENST00000541742TFB2Mchr1246727647-SMYD3chr1246093239-0.0018225550.9981774
ENST00000544618ENST00000490107TFB2Mchr1246727647-SMYD3chr1246093239-0.0018558630.99814415
ENST00000544618ENST00000388985TFB2Mchr1246727647-SMYD3chr1246093239-0.0024355740.99756444
ENST00000366514ENST00000541742TFB2Mchr1246719874-SMYD3chr1246093239-0.0007814280.9992186
ENST00000366514ENST00000490107TFB2Mchr1246719874-SMYD3chr1246093239-0.0007929390.9992071
ENST00000366514ENST00000388985TFB2Mchr1246719874-SMYD3chr1246093239-0.0010768470.9989231

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90264_90264_1_TFB2M-SMYD3_TFB2M_chr1_246711846_ENST00000366514_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_2_TFB2M-SMYD3_TFB2M_chr1_246711846_ENST00000366514_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_3_TFB2M-SMYD3_TFB2M_chr1_246711846_ENST00000366514_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_4_TFB2M-SMYD3_TFB2M_chr1_246711847_ENST00000366514_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_5_TFB2M-SMYD3_TFB2M_chr1_246711847_ENST00000366514_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_6_TFB2M-SMYD3_TFB2M_chr1_246711847_ENST00000366514_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=542AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHM
EPWSSFDIYTRKGPLENPKRRVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTS
EERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMD
ACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIR

--------------------------------------------------------------

>90264_90264_7_TFB2M-SMYD3_TFB2M_chr1_246719874_ENST00000366514_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_8_TFB2M-SMYD3_TFB2M_chr1_246719874_ENST00000366514_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_9_TFB2M-SMYD3_TFB2M_chr1_246719874_ENST00000366514_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_10_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246027188_ENST00000388985_length(amino acids)=397AA_BP=239
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQDADMLTGDEQVWKEVQESLKKIEELKAHWK
WEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMK

--------------------------------------------------------------

>90264_90264_11_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246027188_ENST00000490107_length(amino acids)=397AA_BP=239
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQDADMLTGDEQVWKEVQESLKKIEELKAHWK
WEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMK

--------------------------------------------------------------

>90264_90264_12_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246027188_ENST00000541742_length(amino acids)=397AA_BP=239
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQDADMLTGDEQVWKEVQESLKKIEELKAHWK
WEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMK

--------------------------------------------------------------

>90264_90264_13_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246498776_ENST00000388985_length(amino acids)=592AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKKAWPDHKRECKCLKSCKPRYPPDSVRLLG
RVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVG
LYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEV
QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKV

--------------------------------------------------------------

>90264_90264_14_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246498776_ENST00000490107_length(amino acids)=592AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKKAWPDHKRECKCLKSCKPRYPPDSVRLLG
RVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVG
LYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEV
QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKV

--------------------------------------------------------------

>90264_90264_15_TFB2M-SMYD3_TFB2M_chr1_246719875_ENST00000366514_SMYD3_chr1_246498776_ENST00000541742_length(amino acids)=592AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKN
LGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKKAWPDHKRECKCLKSCKPRYPPDSVRLLG
RVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVG
LYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEV
QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKV

--------------------------------------------------------------

>90264_90264_16_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_17_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_18_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_19_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246498776_ENST00000388985_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_20_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246498776_ENST00000490107_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_21_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000366514_SMYD3_chr1_246498776_ENST00000541742_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_22_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_23_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_24_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_25_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246498776_ENST00000388985_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_26_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246498776_ENST00000490107_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_27_TFB2M-SMYD3_TFB2M_chr1_246727647_ENST00000544618_SMYD3_chr1_246498776_ENST00000541742_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_28_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_29_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_30_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_31_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246498776_ENST00000388985_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_32_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246498776_ENST00000490107_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_33_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000366514_SMYD3_chr1_246498776_ENST00000541742_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_34_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246093239_ENST00000388985_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_35_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246093239_ENST00000490107_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_36_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246093239_ENST00000541742_length(amino acids)=390AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD

--------------------------------------------------------------

>90264_90264_37_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246498776_ENST00000388985_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_38_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246498776_ENST00000490107_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

>90264_90264_39_TFB2M-SMYD3_TFB2M_chr1_246727648_ENST00000544618_SMYD3_chr1_246498776_ENST00000541742_length(amino acids)=491AA_BP=1
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP
SESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHS
CDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELK
AHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246727648/chr1:246093239)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMYD3chr1:246711846chr1:246093239ENST00000388985412205_206177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711846chr1:246093239ENST00000490107412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711846chr1:246093239ENST00000541742412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST00000388985412205_206177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST00000490107412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST00000541742412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST00000388985412205_206177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST00000490107412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST00000541742412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST00000388985112205_20676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST0000049010711214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST00000490107112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST0000054174211214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST00000541742112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST00000388985412205_206177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST00000490107412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST00000541742412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST00000388985112205_20676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST0000049010711214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST00000490107112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST0000054174211214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST00000541742112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST00000388985412205_206177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST00000490107412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST00000541742412205_206118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST00000388985112205_20676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST0000049010711214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST00000490107112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST0000054174211214_1617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST00000541742112205_20617.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST0000049010711249_8717.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719875chr1:246498776ENST0000054174211249_8717.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246498776ENST0000049010711249_8717.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246498776ENST0000054174211249_8717.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246498776ENST0000049010711249_8717.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246498776ENST0000054174211249_8717.0370.0Zinc fingerMYND-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFB2Mchr1:246711846chr1:246093239ENST00000366514-68330_331286.0397.0RegionDNA binding
HgeneTFB2Mchr1:246711847chr1:246093239ENST00000366514-68330_331286.0397.0RegionDNA binding
HgeneTFB2Mchr1:246719874chr1:246093239ENST00000366514-48330_331235.0397.0RegionDNA binding
HgeneTFB2Mchr1:246719875chr1:246027188ENST00000366514-48330_331235.0397.0RegionDNA binding
HgeneTFB2Mchr1:246719875chr1:246498776ENST00000366514-48330_331235.0397.0RegionDNA binding
HgeneTFB2Mchr1:246727647chr1:246093239ENST00000366514-28330_331134.0397.0RegionDNA binding
HgeneTFB2Mchr1:246727647chr1:246498776ENST00000366514-28330_331134.0397.0RegionDNA binding
HgeneTFB2Mchr1:246727648chr1:246093239ENST00000366514-28330_331134.0397.0RegionDNA binding
HgeneTFB2Mchr1:246727648chr1:246498776ENST00000366514-28330_331134.0397.0RegionDNA binding
TgeneSMYD3chr1:246711846chr1:246093239ENST000003889854124_240177.0429.0DomainSET
TgeneSMYD3chr1:246711846chr1:246093239ENST000004901074124_240118.0370.0DomainSET
TgeneSMYD3chr1:246711846chr1:246093239ENST000005417424124_240118.0370.0DomainSET
TgeneSMYD3chr1:246711847chr1:246093239ENST000003889854124_240177.0429.0DomainSET
TgeneSMYD3chr1:246711847chr1:246093239ENST000004901074124_240118.0370.0DomainSET
TgeneSMYD3chr1:246711847chr1:246093239ENST000005417424124_240118.0370.0DomainSET
TgeneSMYD3chr1:246719874chr1:246093239ENST000003889854124_240177.0429.0DomainSET
TgeneSMYD3chr1:246719874chr1:246093239ENST000004901074124_240118.0370.0DomainSET
TgeneSMYD3chr1:246719874chr1:246093239ENST000005417424124_240118.0370.0DomainSET
TgeneSMYD3chr1:246719875chr1:246027188ENST000003889857124_240271.0429.0DomainSET
TgeneSMYD3chr1:246719875chr1:246027188ENST000004901077124_240212.0370.0DomainSET
TgeneSMYD3chr1:246719875chr1:246027188ENST000005417427124_240212.0370.0DomainSET
TgeneSMYD3chr1:246719875chr1:246498776ENST000003889851124_24076.0429.0DomainSET
TgeneSMYD3chr1:246719875chr1:246498776ENST000004901071124_24017.0370.0DomainSET
TgeneSMYD3chr1:246719875chr1:246498776ENST000005417421124_24017.0370.0DomainSET
TgeneSMYD3chr1:246727647chr1:246093239ENST000003889854124_240177.0429.0DomainSET
TgeneSMYD3chr1:246727647chr1:246093239ENST000004901074124_240118.0370.0DomainSET
TgeneSMYD3chr1:246727647chr1:246093239ENST000005417424124_240118.0370.0DomainSET
TgeneSMYD3chr1:246727647chr1:246498776ENST000003889851124_24076.0429.0DomainSET
TgeneSMYD3chr1:246727647chr1:246498776ENST000004901071124_24017.0370.0DomainSET
TgeneSMYD3chr1:246727647chr1:246498776ENST000005417421124_24017.0370.0DomainSET
TgeneSMYD3chr1:246727648chr1:246093239ENST000003889854124_240177.0429.0DomainSET
TgeneSMYD3chr1:246727648chr1:246093239ENST000004901074124_240118.0370.0DomainSET
TgeneSMYD3chr1:246727648chr1:246093239ENST000005417424124_240118.0370.0DomainSET
TgeneSMYD3chr1:246727648chr1:246498776ENST000003889851124_24076.0429.0DomainSET
TgeneSMYD3chr1:246727648chr1:246498776ENST000004901071124_24017.0370.0DomainSET
TgeneSMYD3chr1:246727648chr1:246498776ENST000005417421124_24017.0370.0DomainSET
TgeneSMYD3chr1:246711846chr1:246093239ENST0000038898541214_16177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711846chr1:246093239ENST0000049010741214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711846chr1:246093239ENST0000054174241214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST0000038898541214_16177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST0000049010741214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711847chr1:246093239ENST0000054174241214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST0000038898541214_16177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST0000049010741214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719874chr1:246093239ENST0000054174241214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST0000038898571214_16271.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST00000388985712205_206271.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST0000049010771214_16212.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST00000490107712205_206212.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST0000054174271214_16212.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246027188ENST00000541742712205_206212.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246719875chr1:246498776ENST0000038898511214_1676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST0000038898541214_16177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST0000049010741214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246093239ENST0000054174241214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727647chr1:246498776ENST0000038898511214_1676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST0000038898541214_16177.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST0000049010741214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246093239ENST0000054174241214_16118.0370.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246727648chr1:246498776ENST0000038898511214_1676.0429.0RegionS-adenosyl-L-methionine binding
TgeneSMYD3chr1:246711846chr1:246093239ENST0000038898541249_87177.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246711846chr1:246093239ENST0000049010741249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246711846chr1:246093239ENST0000054174241249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246711847chr1:246093239ENST0000038898541249_87177.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246711847chr1:246093239ENST0000049010741249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246711847chr1:246093239ENST0000054174241249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719874chr1:246093239ENST0000038898541249_87177.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719874chr1:246093239ENST0000049010741249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719874chr1:246093239ENST0000054174241249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719875chr1:246027188ENST0000038898571249_87271.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719875chr1:246027188ENST0000049010771249_87212.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719875chr1:246027188ENST0000054174271249_87212.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246719875chr1:246498776ENST0000038898511249_8776.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246093239ENST0000038898541249_87177.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246093239ENST0000049010741249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246093239ENST0000054174241249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727647chr1:246498776ENST0000038898511249_8776.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246093239ENST0000038898541249_87177.0429.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246093239ENST0000049010741249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246093239ENST0000054174241249_87118.0370.0Zinc fingerMYND-type
TgeneSMYD3chr1:246727648chr1:246498776ENST0000038898511249_8776.0429.0Zinc fingerMYND-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>782_TFB2M_246727647_SMYD3_246093239_ranked_0.pdbTFB2M246719874246727647ENST00000388985SMYD3chr1246093239-
MRDKDMWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLA
QIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLEVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAM
CQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFD
390


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TFB2M_pLDDT.png
all structure
all structure
SMYD3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TFB2M
SMYD3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TFB2M-SMYD3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TFB2M-SMYD3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource