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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TFE3-ASPSCR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TFE3-ASPSCR1
FusionPDB ID: 90313
FusionGDB2.0 ID: 90313
HgeneTgene
Gene symbol

TFE3

ASPSCR1

Gene ID

7030

79058

Gene nametranscription factor binding to IGHM enhancer 3ASPSCR1 tether for SLC2A4, UBX domain containing
SynonymsRCCP2|RCCX1|TFEA|bHLHe33ASPCR1|ASPL|ASPS|RCC17|TUG|UBXD9|UBXN9
Cytomap

Xp11.23

17q25.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3tether containing UBX domain for GLUT4ASPSCR1, UBX domain containing tether for SLC2A4UBX domain protein 9UBX domain-containing protein 9alveolar soft part sarcoma chromosomal region candidate gene 1 proteinalveolar soft part sarcoma chromosome regio
Modification date2020032720200313
UniProtAcc

P19532

Q9BZE9

Ensembl transtripts involved in fusion geneENST idsENST00000315869, ENST00000487451, 
ENST00000580534, ENST00000581647, 
ENST00000582404, ENST00000306729, 
ENST00000306739, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 12 X 6=64816 X 16 X 12=3072
# samples 1219
** MAII scorelog2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/3072*10)=-4.01510689239021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TFE3 [Title/Abstract] AND ASPSCR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ASPSCR1(79954722)-TFE3(48895640), # samples:2
Anticipated loss of major functional domain due to fusion event.ASPSCR1-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASPSCR1-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFE3-ASPSCR1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-ASPSCR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFE3-ASPSCR1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TFE3-ASPSCR1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-ASPSCR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TFE3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASPSCR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..TFE3chrX

48895534

-ASPSCR1chr17

79966912

+
ChimerKB3..TFE3chrX

48895721

-ASPSCR1chr17

79935425

+
ChimerKB3..TFE3chrX

48895721

-ASPSCR1chr17

79966912

+
ChimerKB3..TFE3chrX

48896631

-ASPSCR1chr17

79937059

+
ChimerKB4..TFE3chrX

48895721

-ASPSCR1chr17

79935425

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315869TFE3chrX48895534-ENST00000306729ASPSCR1chr1779966912+223811452602155631
ENST00000315869TFE3chrX48895534-ENST00000306739ASPSCR1chr1779966912+195811452601873537
ENST00000315869TFE3chrX48895534-ENST00000580534ASPSCR1chr1779966912+203111452601948562
ENST00000315869TFE3chrX48895721-ENST00000306729ASPSCR1chr1779966912+213310402602050596
ENST00000315869TFE3chrX48895721-ENST00000306739ASPSCR1chr1779966912+185310402601768502
ENST00000315869TFE3chrX48895721-ENST00000580534ASPSCR1chr1779966912+192610402601843527
ENST00000315869TFE3chrX48896631-ENST00000306729ASPSCR1chr1779937059+27187942602635791
ENST00000315869TFE3chrX48896631-ENST00000306739ASPSCR1chr1779937059+24387942602353697

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90313_90313_1_TFE3-ASPSCR1_TFE3_chrX_48895534_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000306729_length(amino acids)=631AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIIS
LESSYNDEMLSYLPGGTTGLQLPSTPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAF
REAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGDRVAPFTLGPS
LKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRGRASPSTGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHL
GAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPASK

--------------------------------------------------------------

>90313_90313_2_TFE3-ASPSCR1_TFE3_chrX_48895534_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000306739_length(amino acids)=537AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIIS
LESSYNDEMLSYLPGGTTGLQLPSTPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAF
REAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEE

--------------------------------------------------------------

>90313_90313_3_TFE3-ASPSCR1_TFE3_chrX_48895534_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000580534_length(amino acids)=562AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIIS
LESSYNDEMLSYLPGGTTGLQLPSTPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAF
REAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLCLSSFGRMDGRGPRCFLTRRCLLSSVITPPKTV
LDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGT

--------------------------------------------------------------

>90313_90313_4_TFE3-ASPSCR1_TFE3_chrX_48895721_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000306729_length(amino acids)=596AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEPVDREPVDRE
PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE
TVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGDRVAPFTLGPSLKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRG
RASPSTGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRA

--------------------------------------------------------------

>90313_90313_5_TFE3-ASPSCR1_TFE3_chrX_48895721_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000306739_length(amino acids)=502AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEPVDREPVDRE
PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE
TVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSP

--------------------------------------------------------------

>90313_90313_6_TFE3-ASPSCR1_TFE3_chrX_48895721_ENST00000315869_ASPSCR1_chr17_79966912_ENST00000580534_length(amino acids)=527AA_BP=136
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEPVDREPVDRE
PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE
TVGDLRDFVRSHLGNPELSFYLCLSSFGRMDGRGPRCFLTRRCLLSSVITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGL

--------------------------------------------------------------

>90313_90313_7_TFE3-ASPSCR1_TFE3_chrX_48896631_ENST00000315869_ASPSCR1_chr17_79937059_ENST00000306729_length(amino acids)=791AA_BP=85
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVL
EDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRE
CLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPE
DADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQE
QERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVL
FPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGDRVAPFTLGPSLKRCLGPEQRTRLPVVGDGG
DVDSGRLLFWGPSRGRASPSTGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHLGAEEPAGVYLEPGLLEHAIS

--------------------------------------------------------------

>90313_90313_8_TFE3-ASPSCR1_TFE3_chrX_48896631_ENST00000315869_ASPSCR1_chr17_79937059_ENST00000306739_length(amino acids)=697AA_BP=85
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPA
TLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVL
EDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRE
CLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPE
DADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQE
QERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVL
FPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:79954722/chr17:48895640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFE3

P19532

ASPSCR1

Q9BZE9

FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}.FUNCTION: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (305) >>>305.pdbFusion protein BP residue: 136
CIF file (305) >>>305.cif		TFE3chrX48895721-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDD
VRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRY
VLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQ
ANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSP
SPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPAS
502
3D view using mol* of 305 (AA BP:136)
PDB file (354) >>>354.pdbFusion protein BP residue: 136
CIF file (354) >>>354.cif		TFE3chrX48895721-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDD
VRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRY
VLQGFFRPSETVGDLRDFVRSHLGNPELSFYLCLSSFGRMDGRGPRCFLT
RRCLLSSVITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGL
LEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPE
527
3D view using mol* of 354 (AA BP:136)
PDB file (369) >>>369.pdbFusion protein BP residue: 136
CIF file (369) >>>369.cif		TFE3chrX48895534-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTPVDRE
PVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRL
EEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDL
RDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEE
PAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPA
537
3D view using mol* of 369 (AA BP:136)
PDB file (412) >>>412.pdbFusion protein BP residue: 136
CIF file (412) >>>412.cif		TFE3chrX48895534-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTPVDRE
PVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRL
EEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDL
RDFVRSHLGNPELSFYLCLSSFGRMDGRGPRCFLTRRCLLSSVITPPKTV
LDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVA
RYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGK
562
3D view using mol* of 412 (AA BP:136)
PDB file (464) >>>464.pdbFusion protein BP residue: 136
CIF file (464) >>>464.cif		TFE3chrX48895721-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDD
VRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRY
VLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQ
PQLGDRVAPFTLGPSLKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRG
RASPSTGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPA
ALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAP
596
3D view using mol* of 464 (AA BP:136)
PDB file (502) >>>502.pdbFusion protein BP residue: 136
CIF file (502) >>>502.cif		TFE3chrX48895534-ASPSCR1chr1779966912+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVK
QYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMAL
LTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTPVDRE
PVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRL
EEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDL
RDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGDRVAPFTLGPS
LKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRGRASPSTGQPPCHPVC
RPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHLGAEEPAGVYL
EPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGAL
631
3D view using mol* of 502 (AA BP:136)
PDB file (566) >>>566.pdbFusion protein BP residue: 85
CIF file (566) >>>566.cif		TFE3chrX48896631-ASPSCR1chr1779937059+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVLEDTCRRQDFNPCEYDLKFQR
SVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQD
SFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTL
QSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGE
LSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPP
GPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQE
QERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRL
AQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGF
FRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFP
AALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPA
697
3D view using mol* of 566 (AA BP:85)
PDB file (645) >>>645.pdbFusion protein BP residue: 85
CIF file (645) >>>645.cif		TFE3chrX48896631-ASPSCR1chr1779937059+
MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIV
ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGG
SRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASP
AISVVGVSAGGHTLSRPPPAQVPREVLKVLEDTCRRQDFNPCEYDLKFQR
SVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQD
SFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTL
QSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGE
LSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPP
GPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQE
QERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRL
AQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGF
FRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGD
RVAPFTLGPSLKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRGRASPS
TGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHL
GAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPK
791
3D view using mol* of 645 (AA BP:85)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TFE3_pLDDT.png
all structure
all structure
ASPSCR1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TFE3_ASPSCR1_305_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_305_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_305_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_354_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_354_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_354_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_369_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_369_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_369_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_412_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_412_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_412_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_464_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_464_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_464_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_502_pLDDT.png (AA BP:136)
all structure
TFE3_ASPSCR1_502_pLDDT_and_active_sites.png (AA BP:136)
all structure
TFE3_ASPSCR1_502_violinplot.png (AA BP:136)
all structure
TFE3_ASPSCR1_566_pLDDT.png (AA BP:85)
all structure
TFE3_ASPSCR1_566_pLDDT_and_active_sites.png (AA BP:85)
all structure
TFE3_ASPSCR1_566_violinplot.png (AA BP:85)
all structure
TFE3_ASPSCR1_645_pLDDT.png (AA BP:85)
all structure
TFE3_ASPSCR1_645_pLDDT_and_active_sites.png (AA BP:85)
all structure
TFE3_ASPSCR1_645_violinplot.png (AA BP:85)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
TFE3_ASPSCR1_305.png
all structure
TFE3_ASPSCR1_354.png
all structure
TFE3_ASPSCR1_369.png
all structure
TFE3_ASPSCR1_412.png
all structure
TFE3_ASPSCR1_464.png
all structure
TFE3_ASPSCR1_502.png
all structure
TFE3_ASPSCR1_645.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
3050.542160.47754.1940.8140.6020.7120.1880.7990.2351.321Chain A: 384,385,403,407,408,410
3540.83670.866137.20.6940.550.7250.6040.7170.8421.404Chain A: 185,186,188,191,192,194,195,196,198,199,3
12,315,316,318,319,320
3690.91645571.04171963.3320.75950.38960.33380.25580.4050.63161.1004Chain A: 32,33,34,35,36,37,38,39,40,41,42,43,44,45
,46,109,110,112,113,114,116,117,118,120,121,122,12
4,125,126,127,128,129,130,131,132,133,134,135,136,
193,195,196,197,198,199,200,201,202,203,204,207,20
8,209,242,243,244,245,246,247,248,249,250,251,253,
255,256,257,258,260,261,264,267,268,270,271,272,27
4,275,278,279,280,281,282,283,284,285,286,287,288,
289,290,291,292,293,294,295,296,297,298,299,300,30
1,302,303,304,305,306,307,308,309,311,312,313,314,
315,316,317,318,319,320,321,322,323,324,326,327,32
8,329,330,331,332,334,335,336,338,339,340,342,343,
344,345,346,347,348,349,350,351,352,353,354,355,35
6,357,358,360,361,362,363,364,365,366,367,368,369,
370,371,372,373,374,376,378,380,381,382,383,384,38
5,386,388,389,390,392,393,394,395,396,397,398,399,
401,402,403,405,406,407,408,409,410,411,412,413,41
4,415,416,417,418,419,420,421,422,423,424,425,426,
427,428,429,430,431,432,434,435,436,437,438,439,44
0,441,442,443,445,446,447,448,449,450,451,452,453,
454,455,456,457,460,461,463,464,465,466,467,468,47
1,473,474,475,476,477,478,479,480,481,482,483,484,
485,486,488
4121.0542781.12756.6580.5810.6820.8891.0750.7051.5251.218Chain A: 36,37,38,39,40,41,42,43,44,45,47,49,309,3
11,312,314,315,316,318,364,367,368,370,371,372,373
,374,376,377,378,380,384,386,419,420,421,422,465,4
66,467,468,491,492,493,496,497,499,500,503,504,506
,507
4641.00271641.0543570.7520.65760.64090.84310.84540.8291.01991.4839Chain A: 276,277,279,280,281,283,285,286,335,336,3
37,338,339,343,345,351,440,442,443,444,445,446,447
,449,499,500,502,526,527,530,533,534,537,540,541
5021.0381371.064406.1120.5020.7360.9120.4840.9740.4970.451Chain A: 309,311,378,386,419,420,421,422,424,437,4
42,443,444,445,446,447,448,449,450,451,531,532,533
,535,536,537,539,561,565
5661.0071591.05786.1560.6840.6630.8180.6660.8810.7560.833Chain A: 20,21,22,23,24,25,26,27,28,152,153,154,15
5,170,171,172,173,174,175,178,179,182,183,186,187,
208,209,210,213,214,215,216,218,222,286,287,298,30
2,303
6451.0152351.059821.4850.5460.6720.9130.8780.8721.0071.117Chain A: 469,471,472,474,475,476,478,479,480,481,5
31,532,533,538,540,544,546,632,633,634,635,636,637
,638,639,640,641,642,644,694,695,697,720,721,722,7
25,728,729,732,733,735,736

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
305ZINC000034676245DB00260Cycloserine-4.95839-5.20539
305ZINC000006382803DB00352Tioguanine-4.86027-5.01067
305ZINC000000004321DB00909Zonisamide-4.78674-4.78814
305ZINC000000002028DB11085Resorcinol-4.70668-4.71028
305ZINC000000896755DB00524Metolazone-4.64557-4.64757
305ZINC000001481833DB01273Varenicline-4.53928-4.53948
305ZINC000012360535DB01275Hydralazine-3.98484-4.50804
305ZINC000008034121DB00847Cysteamine-4.46259-4.48499
305ZINC000003812933DB01043Memantine-4.46314-4.46314
305ZINC000000001735DB00350Minoxidil-4.38268-4.38268
305ZINC000001547851DB11868Etiracetam-4.36329-4.36329
305ZINC000003831430DB00478Rimantadine-4.35981-4.35981
305ZINC000000388081DB05381Histamine-3.84923-4.30423
305ZINC000005133329DB03255Phenol-4.30337-4.30397
305ZINC000100007011DB00302Tranexamic acid-4.30169-4.30169
305ZINC000019168887DB00190Carbidopa-4.29334-4.29334
305ZINC000100003200DB01043Memantine-4.29153-4.29153
305ZINC000003802690DB00442Entecavir-4.27561-4.27561
305ZINC000100003201DB01043Memantine-4.25694-4.25694
305ZINC000242648948DB13595Almasilate-4.25621-4.25621

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000034676245DB00260CycloserineSmall moleculeN[C@@H]1CONC1=OApproved
ZINC000006382803DB00352TioguanineSmall moleculeNC1=NC(=S)C2=C(N1)N=CN2Approved
ZINC000000004321DB00909ZonisamideSmall moleculeNS(=O)(=O)CC1=NOC2=CC=CC=C12Approved|Investigational
ZINC000000002028DB11085ResorcinolSmall moleculeOC1=CC(O)=CC=C1Approved
ZINC000000896755DB00524MetolazoneSmall moleculeCC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=OApproved
ZINC000001481833DB01273VareniclineSmall moleculeC1C2CNCC1C1=C2C=C2N=CC=NC2=C1Approved|Investigational
ZINC000012360535DB01275HydralazineSmall moleculeNNC1=NN=CC2=CC=CC=C12Approved
ZINC000008034121DB00847CysteamineSmall moleculeNCCSApproved|Investigational
ZINC000003812933DB01043MemantineSmall moleculeCC12CC3CC(C)(C1)CC(N)(C3)C2Approved|Investigational
ZINC000000001735DB00350MinoxidilSmall moleculeNC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1Approved|Investigational
ZINC000000388081DB05381HistamineSmall moleculeNCCC1=CNC=N1Approved|Investigational
ZINC000005133329DB03255PhenolSmall moleculeOC1=CC=CC=C1Approved|Experimental
ZINC000019168887DB00190CarbidopaSmall moleculeC[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=OApproved
ZINC000003802690DB00442EntecavirSmall moleculeNC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](CO)C1=CApproved|Investigational
ZINC000242648948DB13595AlmasilateSmall moleculeO.[Mg++].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-]Approved|Experimental

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000034676245102.0934.945262.74482.71180.03400374.74635.29.761245.72700
ZINC000034676245102.0934.751261.73782.916178.82200371.29335.29.725245.88500
ZINC000006382803167.1882.913334.0990174.67282.56276.865508.157458.609368.38600
ZINC000006382803167.18810.353334.2370175.32682.48776.423508.122458.464368.2800
ZINC000006382803167.1883.972333.7640164.06191.94377.76507.0323.848.378369.61600
ZINC000000004321212.2236.978398.51740.32185.554172.6440642.453269.667365.95900
ZINC000000002028110.1122.168289.8370109.426180.410424.05821.59.033384.5700
ZINC000000896755365.83412.136575.582140.004175.36206.80553.4121022.28538.59.282376.01400
ZINC000001481833211.2660.553433.511186.67672.196174.6390721.44913.59.365384.39500
ZINC000012360535160.1787.214358.4310140.633217.7980560.687348.65262.14700
ZINC000012360535160.1787.112358.1260139.921218.2050560.377348.54262.29200
ZINC00000803412177.1442.492249.274104.51164.872079.891342.7552.81.59.348375.11700
ZINC00000803412177.1442.221250.566104.00264.508082.056344.5342.81.59.186375.29600
ZINC00000803412177.1442.332247.427103.85564.014079.558339.7792.81.59.243375.19600
ZINC000003812933179.3051.192396.742347.49549.24700681.839219.398389.19700
ZINC000000001735209.255.141437.436217.593169.97449.8690711.86443.57.733376.87300
ZINC000001547851170.2113.554386.861254.133132.72800627.87225.59.606259.07500
ZINC000003831430179.3051.188400.518356.27744.24100681.143219.262391.72800
ZINC000000388081111.1464.788315.23192.229118.535104.4680466.77632.59.295265.25300
ZINC000000388081111.1465.535313.53290.818116.688106.0260465.559339.188264.91700
ZINC000000388081111.1464.794316.56991.628116.549108.3930470.46832.59.292265.82300
ZINC00000513332994.1131.53277.38054.599222.780401.01610.759.194310000
ZINC000100007011157.2121.799375.783216.456159.32700603.499339.574242.47101
ZINC000019168887226.2323.09431.11796.823239.53394.7610720.488548.9241011
ZINC000100003200179.3051.192396.742347.49549.24700681.839219.398389.19700
ZINC000003802690277.2826.742504.225143.129289.37471.7210851.66258.98.512242.61301
ZINC000100003201179.3051.192396.742347.49549.24700681.839219.398389.19700
ZINC00024264894896.1155.453236.38311.116225.26700318.87243.410.763249.90800


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000034676245N[C@@H]1CON=C1O0.0253140150.650044735
ZINC000006382803Nc1nc2nc[nH]c2c(=S)[nH]10.100054570.571375233
ZINC000000004321NS(=O)(=O)Cc1noc2ccccc120.2545692540.46155884
ZINC000000002028Oc1cccc(O)c10.5033244850.69843582
ZINC000000896755Cc1ccccc1N1C(=O)c2cc(S(N)(=O)=O)c(Cl)cc2N[C@@H]1C0.1286227910.34655414
ZINC000001481833c1cnc2cc3c(cc2n1)[C@H]1CNC[C@@H]3C10.0417058020.478476814
ZINC000012360535NNc1nncc2ccccc120.2881403140.47282688
ZINC000008034121NCCS0.1028506960.651927925
ZINC000003812933C[C@@]12CC3CC(N)(C1)C[C@](C)(C3)C20.0117577210.563647343
ZINC000000001735Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]0.1297409460.395964399
ZINC000001547851CC[C@@H](C(N)=O)N1CCCC1=O0.1573358610.410047131
ZINC000003831430C[C@@H](N)C12CC3CC(CC(C3)C1)C20.0365491280.449954027
ZINC000000388081NCCc1cnc[nH]10.2129447840.352067312
ZINC000005133329Oc1ccccc10.8381474170.698650374
ZINC000100007011NC[C@@H]1CC[C@@H](C(=O)O)CC10.343577740.472488357
ZINC000019168887C[C@@](Cc1ccc(O)c(O)c1)(NN)C(=O)O0.1368359620.241973462
ZINC000100003200C[C@@]12CC3CC(N)(C1)C[C@@](C)(C3)C20.0159855520.563647343
ZINC000003802690C=C1[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@H](O)[C@H]1CO0.0456937720.309972869
ZINC000100003201C[C@]12CC3CC(N)(C1)C[C@](C)(C3)C20.0159855520.563647343
ZINC000242648948O[Si](O)(O)O0.0812332580.744708505


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ASPSCR1UBC, VCP, ALPP, NPLOC4, UFD1L, VCPIP1, PHAX, NEDD4, HHV8GK18_gp81, UBXN6, APP, VCPKMT, DCAF11, KRT31, TCF4, TACC3, ADAMTSL4, KRTAP10-8, NOTCH2NL, EZH2, GAPDH, GLUL, UBXN2B, HPD, MAT1A, NSF, AGL, BANF1, DERA, YTHDF1, YTHDF2, NTRK1, UBXN2A, UBXN7, NSFL1C, UBXN10, FAF1, KCTD3, FAM136A, SHKBP1, HAO2, ASNA1, HK1, HACL1, SERPINB2, GLTP, FADS1, HNRNPL, CUL1, USP25, CLK2, KRTAP1-1, INCA1, PINK1, PPIB, DDX58, GOPC, PREX1, EFTUD2, XAF1, NDOR1, URGCP, FTL, SEPHS1, MAN2C1, PIPSL, SLC12A9,
TFE3AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TFE3all structure
ASPSCR1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TFE3-ASPSCR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TFE3-ASPSCR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TFE3ASPSCR1Alveolar Soft Part SarcomaMyCancerGenome
TFE3ASPSCR1Renal Cell CarcinomaMyCancerGenome
TFE3ASPSCR1Translocation-Associated Renal Cell CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFE3C4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneTFE3C0206657Alveolar Soft Part Sarcoma1ORPHANET
HgeneTFE3C0206732Epithelioid hemangioendothelioma1ORPHANET
TgeneASPSCR1C4518356MiT family translocation renal cell carcinoma3ORPHANET
TgeneASPSCR1C0206657Alveolar Soft Part Sarcoma1CTD_human;ORPHANET