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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TFEB-SUPT3H

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TFEB-SUPT3H
	FusionPDB ID: 90333
	FusionGDB2.0 ID: 90333
		Hgene	Tgene
	Gene symbol	TFEB	SUPT3H
	Gene ID	7942	8464
	Gene name	transcription factor EB	SPT3 homolog, SAGA and STAGA complex component
	Synonyms	ALPHATFEB\|BHLHE35\|TCFEB	SPT3\|SPT3L
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor EBT-cell transcription factor EBclass E basic helix-loop-helix protein 35	transcription initiation protein SPT3 homologSPT3-like proteinsuppressor of Ty 3 homolog
	Modification date	20200329	20200313
	UniProtAcc	P19484	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000230323, ENST00000358871, ENST00000373033, ENST00000394283, ENST00000403298, ENST00000420312,	ENST00000459689, ENST00000306867, ENST00000371458, ENST00000371459, ENST00000371460, ENST00000371461,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 11 X 8=1056	19 X 9 X 9=1539
	# samples	14	22
	** MAII score	log2(14/1056*10)=-2.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/1539*10)=-2.80641780280355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TFEB [Title/Abstract] AND SUPT3H [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TFEB(41657469)-SUPT3H(44797594), # samples:2
Anticipated loss of major functional domain due to fusion event.	TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TFEB-SUPT3H seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TFEB-SUPT3H seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. TFEB-SUPT3H seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TFEB	GO:0010468	regulation of gene expression	27278822
Hgene	TFEB	GO:0045893	positive regulation of transcription, DNA-templated	27278822\|29146937
Hgene	TFEB	GO:0045944	positive regulation of transcription by RNA polymerase II	19556463
Tgene	SUPT3H	GO:0016578	histone deubiquitination	18206972
Tgene	SUPT3H	GO:0043966	histone H3 acetylation	11564863

Fusion gene breakpoints across TFEB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SUPT3H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A92D-01A	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-
ChimerDB4	STAD	TCGA-VQ-A92D	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000230323	TFEB	chr6	41657469	-	ENST00000371460	SUPT3H	chr6	44797594	-	1977	851	1167	1775	202
ENST00000230323	TFEB	chr6	41657469	-	ENST00000371459	SUPT3H	chr6	44797594	-	1864	851	1167	1775	202
ENST00000230323	TFEB	chr6	41657469	-	ENST00000371461	SUPT3H	chr6	44797594	-	893	851	302	892	197
ENST00000230323	TFEB	chr6	41657469	-	ENST00000371458	SUPT3H	chr6	44797594	-	942	851	302	892	196
ENST00000358871	TFEB	chr6	41657469	-	ENST00000371460	SUPT3H	chr6	44797594	-	1811	685	82	726	214
ENST00000358871	TFEB	chr6	41657469	-	ENST00000371459	SUPT3H	chr6	44797594	-	1698	685	82	726	214
ENST00000358871	TFEB	chr6	41657469	-	ENST00000371461	SUPT3H	chr6	44797594	-	727	685	82	726	215
ENST00000358871	TFEB	chr6	41657469	-	ENST00000371458	SUPT3H	chr6	44797594	-	776	685	82	726	214
ENST00000420312	TFEB	chr6	41657469	-	ENST00000371460	SUPT3H	chr6	44797594	-	1722	596	912	1520	202
ENST00000420312	TFEB	chr6	41657469	-	ENST00000371459	SUPT3H	chr6	44797594	-	1609	596	912	1520	202
ENST00000420312	TFEB	chr6	41657469	-	ENST00000371461	SUPT3H	chr6	44797594	-	638	596	393	1	131
ENST00000420312	TFEB	chr6	41657469	-	ENST00000371458	SUPT3H	chr6	44797594	-	687	596	302	637	111
ENST00000403298	TFEB	chr6	41657469	-	ENST00000371460	SUPT3H	chr6	44797594	-	1811	685	82	726	214
ENST00000403298	TFEB	chr6	41657469	-	ENST00000371459	SUPT3H	chr6	44797594	-	1698	685	82	726	214
ENST00000403298	TFEB	chr6	41657469	-	ENST00000371461	SUPT3H	chr6	44797594	-	727	685	82	726	215
ENST00000403298	TFEB	chr6	41657469	-	ENST00000371458	SUPT3H	chr6	44797594	-	776	685	82	726	214
ENST00000394283	TFEB	chr6	41657469	-	ENST00000306867	SUPT3H	chr6	44797594	-	1818	1776	1227	1817	196
ENST00000230323	TFEB	chr6	41657468	-	ENST00000371460	SUPT3H	chr6	44797594	-	1977	851	1167	1775	202
ENST00000230323	TFEB	chr6	41657468	-	ENST00000371459	SUPT3H	chr6	44797594	-	1864	851	1167	1775	202
ENST00000230323	TFEB	chr6	41657468	-	ENST00000371461	SUPT3H	chr6	44797594	-	893	851	302	892	197
ENST00000230323	TFEB	chr6	41657468	-	ENST00000371458	SUPT3H	chr6	44797594	-	942	851	302	892	196
ENST00000358871	TFEB	chr6	41657468	-	ENST00000371460	SUPT3H	chr6	44797594	-	1811	685	82	726	214
ENST00000358871	TFEB	chr6	41657468	-	ENST00000371459	SUPT3H	chr6	44797594	-	1698	685	82	726	214
ENST00000358871	TFEB	chr6	41657468	-	ENST00000371461	SUPT3H	chr6	44797594	-	727	685	82	726	215
ENST00000358871	TFEB	chr6	41657468	-	ENST00000371458	SUPT3H	chr6	44797594	-	776	685	82	726	214
ENST00000420312	TFEB	chr6	41657468	-	ENST00000371460	SUPT3H	chr6	44797594	-	1722	596	912	1520	202
ENST00000420312	TFEB	chr6	41657468	-	ENST00000371459	SUPT3H	chr6	44797594	-	1609	596	912	1520	202
ENST00000420312	TFEB	chr6	41657468	-	ENST00000371461	SUPT3H	chr6	44797594	-	638	596	393	1	131
ENST00000420312	TFEB	chr6	41657468	-	ENST00000371458	SUPT3H	chr6	44797594	-	687	596	302	637	111
ENST00000403298	TFEB	chr6	41657468	-	ENST00000371460	SUPT3H	chr6	44797594	-	1811	685	82	726	214
ENST00000403298	TFEB	chr6	41657468	-	ENST00000371459	SUPT3H	chr6	44797594	-	1698	685	82	726	214
ENST00000403298	TFEB	chr6	41657468	-	ENST00000371461	SUPT3H	chr6	44797594	-	727	685	82	726	215
ENST00000403298	TFEB	chr6	41657468	-	ENST00000371458	SUPT3H	chr6	44797594	-	776	685	82	726	214
ENST00000394283	TFEB	chr6	41657468	-	ENST00000306867	SUPT3H	chr6	44797594	-	1818	1776	1227	1817	196

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000230323	ENST00000371460	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001249979	0.99875
ENST00000230323	ENST00000371459	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001087015	0.99891305
ENST00000230323	ENST00000371461	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.00094694	0.99905306
ENST00000230323	ENST00000371458	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001194915	0.99880505
ENST00000358871	ENST00000371460	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001889283	0.9981108
ENST00000358871	ENST00000371459	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001865919	0.9981341
ENST00000358871	ENST00000371461	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.000319768	0.9996803
ENST00000358871	ENST00000371458	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.000453671	0.99954635
ENST00000420312	ENST00000371460	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.067438744	0.9325613
ENST00000420312	ENST00000371459	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.056868408	0.9431316
ENST00000420312	ENST00000371461	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.004646984	0.995353
ENST00000420312	ENST00000371458	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.005571259	0.99442875
ENST00000403298	ENST00000371460	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001889283	0.9981108
ENST00000403298	ENST00000371459	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.001865919	0.9981341
ENST00000403298	ENST00000371461	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.000319768	0.9996803
ENST00000403298	ENST00000371458	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.000453671	0.99954635
ENST00000394283	ENST00000306867	TFEB	chr6	41657469	-	SUPT3H	chr6	44797594	-	0.00718113	0.9928189
ENST00000230323	ENST00000371460	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001249979	0.99875
ENST00000230323	ENST00000371459	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001087015	0.99891305
ENST00000230323	ENST00000371461	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.00094694	0.99905306
ENST00000230323	ENST00000371458	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001194915	0.99880505
ENST00000358871	ENST00000371460	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001889283	0.9981108
ENST00000358871	ENST00000371459	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001865919	0.9981341
ENST00000358871	ENST00000371461	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.000319768	0.9996803
ENST00000358871	ENST00000371458	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.000453671	0.99954635
ENST00000420312	ENST00000371460	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.067438744	0.9325613
ENST00000420312	ENST00000371459	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.056868408	0.9431316
ENST00000420312	ENST00000371461	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.004646984	0.995353
ENST00000420312	ENST00000371458	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.005571259	0.99442875
ENST00000403298	ENST00000371460	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001889283	0.9981108
ENST00000403298	ENST00000371459	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.001865919	0.9981341
ENST00000403298	ENST00000371461	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.000319768	0.9996803
ENST00000403298	ENST00000371458	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.000453671	0.99954635
ENST00000394283	ENST00000306867	TFEB	chr6	41657468	-	SUPT3H	chr6	44797594	-	0.00718113	0.9928189

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90333_90333_1_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=196AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_2_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_3_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_4_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=197AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_5_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_6_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_7_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_8_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=215AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_9_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000394283_SUPT3H_chr6_44797594_ENST00000306867_length(amino acids)=196AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_10_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_11_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_12_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_13_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=215AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_14_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=111AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKLDDVIDNIMRLDDVLGYIN

--------------------------------------------------------------

>90333_90333_15_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_16_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_17_TFEB-SUPT3H_TFEB_chr6_41657468_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=131AA_BP=
MTACCCMRSRCSSCCACSRMSCMRNPMRDAMVAAGAGSHVPGTAAPLVLTTACEVGVFSSPSSQMRIHTVHAYMFTASSDPLSGIAGPSR

--------------------------------------------------------------

>90333_90333_18_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=196AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_19_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_20_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_21_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000230323_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=197AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_22_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_23_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_24_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_25_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000358871_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=215AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_26_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000394283_SUPT3H_chr6_44797594_ENST00000306867_length(amino acids)=196AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQ
KVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM

--------------------------------------------------------------

>90333_90333_27_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_28_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_29_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=214AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_30_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000403298_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=215AA_BP=
MSSNMTASSGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKV
QSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVID

--------------------------------------------------------------

>90333_90333_31_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371458_length(amino acids)=111AA_BP=
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKLDDVIDNIMRLDDVLGYIN

--------------------------------------------------------------

>90333_90333_32_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371459_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_33_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371460_length(amino acids)=202AA_BP=
MSRFTALSSHTLKAVVAPVQRFVCILFDIFYNPGLEQGNKIKRTVSFRLPLHHQLYFPTFVDMCFSDSYPFYKLTVIKDLTDLINHLFPP
PFPFTPLIVCVIFNACFPTSCHLPFMCVFPHTEPLPPSSFPSFSCSSNPQIHHSCTCHTHLEAKYSESVEGEQSDFLLPPFKALPHLDWK

--------------------------------------------------------------

>90333_90333_34_TFEB-SUPT3H_TFEB_chr6_41657469_ENST00000420312_SUPT3H_chr6_44797594_ENST00000371461_length(amino acids)=131AA_BP=
MTACCCMRSRCSSCCACSRMSCMRNPMRDAMVAAGAGSHVPGTAAPLVLTTACEVGVFSSPSSQMRIHTVHAYMFTASSDPLSGIAGPSR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:41657469/chr6:44797594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TFEB P19484	.
FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:30120233, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus or S.enterica, acting downstream of protein kinase D (PKD), probably by regulating cytokine and chemokine expression (By similarity). {ECO:0000250\|UniProtKB:Q9R210, ECO:0000269\|PubMed:1748288, ECO:0000269\|PubMed:19556463, ECO:0000269\|PubMed:2115126, ECO:0000269\|PubMed:21617040, ECO:0000269\|PubMed:22343943, ECO:0000269\|PubMed:22576015, ECO:0000269\|PubMed:22692423, ECO:0000269\|PubMed:23434374, ECO:0000269\|PubMed:27278822, ECO:0000269\|PubMed:29146937, ECO:0000269\|PubMed:30120233, ECO:0000269\|PubMed:31672913}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

10_44

98.0

392.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

35_44

98.0

392.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

10_44

183.0

477.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

35_44

183.0

477.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

10_44

98.0

392.0

Compositional bias

Note=Gln-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

35_44

98.0

392.0

Compositional bias

Note=Poly-Gln

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

136_153

183.0

477.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

156_165

183.0

477.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

156_165

183.0

477.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

156_165

183.0

477.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

156_165

183.0

477.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

156_165

183.0

477.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

156_165

183.0

477.0

Region

Strong transcription activation domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

366_414

98.0

392.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

366_414

183.0

477.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

366_414

98.0

392.0

Compositional bias

Note=Pro-rich

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

235_288

98.0

392.0

Domain

bHLH

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

235_288

183.0

477.0

Domain

bHLH

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

235_288

98.0

392.0

Domain

bHLH

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

136_153

98.0

392.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

136_153

98.0

392.0

Motif

Nuclear export signal

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000230323

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000373033

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000403298

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

156_165

98.0

392.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657468

chr6:44797594

ENST00000420312

298_319

98.0

392.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000230323

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000373033

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000403298

298_319

183.0

477.0

Region

Note=Leucine-zipper

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

156_165

98.0

392.0

Region

Strong transcription activation domain

Hgene

TFEB

chr6:41657469

chr6:44797594

ENST00000420312

298_319

98.0

392.0

Region

Note=Leucine-zipper

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TFEB
SUPT3H

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TFEB-SUPT3H

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TFEB-SUPT3H

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TFEB	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET