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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BAZ1B-ZP3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BAZ1B-ZP3
FusionPDB ID: 9034
FusionGDB2.0 ID: 9034
HgeneTgene
Gene symbol

BAZ1B

ZP3

Gene ID

9031

7784

Gene namebromodomain adjacent to zinc finger domain 1Bzona pellucida glycoprotein 3
SynonymsWBSCR10|WBSCR9|WSTFOOMD3|ZP3A|ZP3B|ZPC|Zp-3
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase BAZ1BhWALp2transcription factor WSTFwilliams syndrome transcription factorwilliams-Beuren syndrome chromosomal region 10 proteinwilliams-Beuren syndrome chromosomal region 9 proteinzona pellucida sperm-binding protein 3ZP3A/ZP3Bsperm receptorzona pellucida glycoprotein 3Bzona pellucida glycoprotein ZP3zona pellucida protein C
Modification date2020031320200313
UniProtAcc

Q9UIG0

.
Ensembl transtripts involved in fusion geneENST idsENST00000339594, ENST00000404251, 
ENST00000467555, ENST00000336517, 
ENST00000394857, ENST00000416245, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 17 X 6=14289 X 10 X 9=810
# samples 2014
** MAII scorelog2(20/1428*10)=-2.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/810*10)=-2.53249508082702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BAZ1B [Title/Abstract] AND ZP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BAZ1B(72873866)-ZP3(76069567), # samples:2
Anticipated loss of major functional domain due to fusion event.BAZ1B-ZP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-ZP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-ZP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-ZP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAZ1B

GO:0006974

cellular response to DNA damage stimulus

19092802

HgeneBAZ1B

GO:0016572

histone phosphorylation

19092802

TgeneZP3

GO:0002922

positive regulation of humoral immune response

19004505

TgeneZP3

GO:0007339

binding of sperm to zona pellucida

19246320|19700799

TgeneZP3

GO:2000344

positive regulation of acrosome reaction

11751269|18667750|20394732

TgeneZP3

GO:2000360

negative regulation of binding of sperm to zona pellucida

18667750

TgeneZP3

GO:2000368

positive regulation of acrosomal vesicle exocytosis

19246320


check buttonFusion gene breakpoints across BAZ1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8265-01ABAZ1Bchr7

72873866

-ZP3chr7

76069567

+
ChimerDB4PRADTCGA-HC-8265BAZ1Bchr7

72873865

-ZP3chr7

76069566

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339594BAZ1Bchr772873866-ENST00000336517ZP3chr776069567+4230377116842141348
ENST00000339594BAZ1Bchr772873866-ENST00000394857ZP3chr776069567+4230377116842141348
ENST00000339594BAZ1Bchr772873866-ENST00000416245ZP3chr776069567+4221377116842141348
ENST00000404251BAZ1Bchr772873866-ENST00000336517ZP3chr776069567+4236377717442201348
ENST00000404251BAZ1Bchr772873866-ENST00000394857ZP3chr776069567+4236377717442201348
ENST00000404251BAZ1Bchr772873866-ENST00000416245ZP3chr776069567+4227377717442201348
ENST00000339594BAZ1Bchr772873865-ENST00000336517ZP3chr776069566+4230377116842141348
ENST00000339594BAZ1Bchr772873865-ENST00000394857ZP3chr776069566+4230377116842141348
ENST00000339594BAZ1Bchr772873865-ENST00000416245ZP3chr776069566+4221377116842141348
ENST00000404251BAZ1Bchr772873865-ENST00000336517ZP3chr776069566+4236377717442201348
ENST00000404251BAZ1Bchr772873865-ENST00000394857ZP3chr776069566+4236377717442201348
ENST00000404251BAZ1Bchr772873865-ENST00000416245ZP3chr776069566+4227377717442201348

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339594ENST00000336517BAZ1Bchr772873866-ZP3chr776069567+0.0012336650.9987663
ENST00000339594ENST00000394857BAZ1Bchr772873866-ZP3chr776069567+0.0012336650.9987663
ENST00000339594ENST00000416245BAZ1Bchr772873866-ZP3chr776069567+0.001230810.9987691
ENST00000404251ENST00000336517BAZ1Bchr772873866-ZP3chr776069567+0.0012252710.9987747
ENST00000404251ENST00000394857BAZ1Bchr772873866-ZP3chr776069567+0.0012252710.9987747
ENST00000404251ENST00000416245BAZ1Bchr772873866-ZP3chr776069567+0.0012223860.99877757
ENST00000339594ENST00000336517BAZ1Bchr772873865-ZP3chr776069566+0.0012336650.9987663
ENST00000339594ENST00000394857BAZ1Bchr772873865-ZP3chr776069566+0.0012336650.9987663
ENST00000339594ENST00000416245BAZ1Bchr772873865-ZP3chr776069566+0.001230810.9987691
ENST00000404251ENST00000336517BAZ1Bchr772873865-ZP3chr776069566+0.0012252710.9987747
ENST00000404251ENST00000394857BAZ1Bchr772873865-ZP3chr776069566+0.0012252710.9987747
ENST00000404251ENST00000416245BAZ1Bchr772873865-ZP3chr776069566+0.0012223860.99877757

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9034_9034_1_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000339594_ZP3_chr7_76069566_ENST00000336517_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_2_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000339594_ZP3_chr7_76069566_ENST00000394857_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_3_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000339594_ZP3_chr7_76069566_ENST00000416245_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_4_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000404251_ZP3_chr7_76069566_ENST00000336517_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_5_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000404251_ZP3_chr7_76069566_ENST00000394857_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_6_BAZ1B-ZP3_BAZ1B_chr7_72873865_ENST00000404251_ZP3_chr7_76069566_ENST00000416245_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_7_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000339594_ZP3_chr7_76069567_ENST00000336517_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_8_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000339594_ZP3_chr7_76069567_ENST00000394857_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_9_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000339594_ZP3_chr7_76069567_ENST00000416245_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_10_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000404251_ZP3_chr7_76069567_ENST00000336517_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_11_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000404251_ZP3_chr7_76069567_ENST00000394857_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

--------------------------------------------------------------

>9034_9034_12_BAZ1B-ZP3_BAZ1B_chr7_72873866_ENST00000404251_ZP3_chr7_76069567_ENST00000416245_length(amino acids)=1348AA_BP=1201
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE
VGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWA
PPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNP
STKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKK
PGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYK
ENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLER
LEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLL
QDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALC
HRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVK
SRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSI
DYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK
RYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFM
APKQKRRKLQSEDSAKTEEVDEEKKMVEEAKIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQ

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:72873866/chr7:76069567)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ1B

Q9UIG0

.
FUNCTION: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320533_5861144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320768_8141144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320850_8931144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319533_5861144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319768_8141144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319850_8931144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320533_5861144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320768_8141144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320850_8931144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319533_5861144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319768_8141144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319850_8931144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320306_5781144.01852.6666666666667Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319306_5781144.01484.0Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320306_5781144.01852.6666666666667Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319306_5781144.01484.0Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-132020_1261144.01852.6666666666667DomainWAC
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320604_6681144.01852.6666666666667DomainDDT
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-131920_1261144.01484.0DomainWAC
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319604_6681144.01484.0DomainDDT
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-132020_1261144.01852.6666666666667DomainWAC
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320604_6681144.01852.6666666666667DomainDDT
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-131920_1261144.01484.0DomainWAC
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319604_6681144.01484.0DomainDDT
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-1320207_2131144.01852.6666666666667MotifNote=C motif
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-1319207_2131144.01484.0MotifNote=C motif
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-1320207_2131144.01852.6666666666667MotifNote=C motif
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-1319207_2131144.01484.0MotifNote=C motif
TgeneZP3chr7:72873865chr7:76069566ENST0000033651759409_424226.0374.0Topological domainCytoplasmic
TgeneZP3chr7:72873865chr7:76069566ENST0000039485748409_424277.0425.0Topological domainCytoplasmic
TgeneZP3chr7:72873866chr7:76069567ENST0000033651759409_424226.0374.0Topological domainCytoplasmic
TgeneZP3chr7:72873866chr7:76069567ENST0000039485748409_424277.0425.0Topological domainCytoplasmic
TgeneZP3chr7:72873865chr7:76069566ENST0000033651759388_408226.0374.0TransmembraneHelical
TgeneZP3chr7:72873865chr7:76069566ENST0000039485748388_408277.0425.0TransmembraneHelical
TgeneZP3chr7:72873866chr7:76069567ENST0000033651759388_408226.0374.0TransmembraneHelical
TgeneZP3chr7:72873866chr7:76069567ENST0000039485748388_408277.0425.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-13201245_12831144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-13191245_12831144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-13201245_12831144.01852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-13191245_12831144.01484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-13201261_12731144.01852.6666666666667Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-13191261_12731144.01484.0Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-13201261_12731144.01852.6666666666667Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-13191261_12731144.01484.0Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-13201356_14261144.01852.6666666666667DomainBromo
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-13191356_14261144.01484.0DomainBromo
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-13201356_14261144.01852.6666666666667DomainBromo
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-13191356_14261144.01484.0DomainBromo
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000339594-13201184_12341144.01852.6666666666667Zinc fingerPHD-type
HgeneBAZ1Bchr7:72873865chr7:76069566ENST00000404251-13191184_12341144.01484.0Zinc fingerPHD-type
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000339594-13201184_12341144.01852.6666666666667Zinc fingerPHD-type
HgeneBAZ1Bchr7:72873866chr7:76069567ENST00000404251-13191184_12341144.01484.0Zinc fingerPHD-type
TgeneZP3chr7:72873865chr7:76069566ENST000003365175945_307226.0374.0DomainZP
TgeneZP3chr7:72873865chr7:76069566ENST000003948574845_307277.0425.0DomainZP
TgeneZP3chr7:72873866chr7:76069567ENST000003365175945_307226.0374.0DomainZP
TgeneZP3chr7:72873866chr7:76069567ENST000003948574845_307277.0425.0DomainZP
TgeneZP3chr7:72873865chr7:76069566ENST000003365175923_387226.0374.0Topological domainExtracellular
TgeneZP3chr7:72873865chr7:76069566ENST000003948574823_387277.0425.0Topological domainExtracellular
TgeneZP3chr7:72873866chr7:76069567ENST000003365175923_387226.0374.0Topological domainExtracellular
TgeneZP3chr7:72873866chr7:76069567ENST000003948574823_387277.0425.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BAZ1B
ZP3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BAZ1B-ZP3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BAZ1B-ZP3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource