UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level3
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Potentially Interacting Small Molecules through Virtual Screening

leaf

Biochemical Features of Small Molecules with ADME

leaf

Drug Toxicity Information

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:TFG-ALK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TFG-ALK
FusionPDB ID: 90355
FusionGDB2.0 ID: 90355
HgeneTgene
Gene symbol

TFG

ALK

Gene ID

10342

238

Gene nametrafficking from ER to golgi regulatorALK receptor tyrosine kinase
SynonymsHMSNP|SPG57|TF6|TRKT3CD246|NBLST3
Cytomap

3q12.2

2p23.2-p23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein TFGTRK-fusedTRK-fused gene proteinTRKT3 oncogeneALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
Modification date2020031320200329
UniProtAcc

Q92734

Q96BT7

Ensembl transtripts involved in fusion geneENST idsENST00000240851, ENST00000418917, 
ENST00000476228, ENST00000490574, 
ENST00000481203, 		ENST00000389048, 
ENST00000431873, ENST00000498037, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 14 X 7=127456 X 74 X 20=82880
# samples 1957
** MAII scorelog2(19/1274*10)=-2.74529395392535
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(57/82880*10)=-7.18391827352181
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TFG [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TFG(100447702)-ALK(29446395), # samples:1
TFG(100451516)-ALK(29446397), # samples:1
TFG(100448131)-ALK(29448078), # samples:1
TFG(100455560)-ALK(29446396), # samples:1
Anticipated loss of major functional domain due to fusion event.TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFG-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFG-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TFG-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TFG-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALK

GO:0016310

phosphorylation

9174053

TgeneALK

GO:0046777

protein autophosphorylation

9174053


check buttonFusion gene breakpoints across TFG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..TFGchr3

100447702

+ALKchr2

29415640

-
ChimerKB3..TFGchr3

100447702

+ALKchr2

29446394

-
ChimerKB3..TFGchr3

100448131

+ALKchr2

29446395

-
ChimerKB3..TFGchr3

100451516

+ALKchr2

29415640

-
ChimerKB3..TFGchr3

100451516

+ALKchr2

29446394

-
ChimerKB3..TFGchr3

100455560

+ALKchr2

29416090

-
ChiTaRS5.0N/AAF125093TFGchr3

100447702

+ALKchr2

29446395

-
ChiTaRS5.0N/AAF143407TFGchr3

100451516

+ALKchr2

29446397

-
ChiTaRS5.0N/AAF390891TFGchr3

100448131

+ALKchr2

29448078

-
ChiTaRS5.0N/AAF390893TFGchr3

100455560

+ALKchr2

29446396

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418917TFGchr3100447702+ENST00000389048ALKchr229446394-26705291022219705
ENST00000490574TFGchr3100447702+ENST00000389048ALKchr229446394-2653512852202705
ENST00000240851TFGchr3100447702+ENST00000389048ALKchr229446394-28967553282445705
ENST00000476228TFGchr3100447702+ENST00000389048ALKchr229446394-27155741472264705
ENST00000418917TFGchr3100451516+ENST00000389048ALKchr229446394-28356941022384760
ENST00000490574TFGchr3100451516+ENST00000389048ALKchr229446394-2818677852367760
ENST00000240851TFGchr3100451516+ENST00000389048ALKchr229446394-30619203282610760
ENST00000476228TFGchr3100451516+ENST00000389048ALKchr229446394-28807391472429760
ENST00000418917TFGchr3100447702+ENST00000389048ALKchr229446395-26705291022219705
ENST00000490574TFGchr3100447702+ENST00000389048ALKchr229446395-2653512852202705
ENST00000240851TFGchr3100447702+ENST00000389048ALKchr229446395-28967553282445705
ENST00000476228TFGchr3100447702+ENST00000389048ALKchr229446395-27155741472264705
ENST00000418917TFGchr3100451516+ENST00000389048ALKchr229446397-28356941022384760
ENST00000490574TFGchr3100451516+ENST00000389048ALKchr229446397-2818677852367760
ENST00000240851TFGchr3100451516+ENST00000389048ALKchr229446397-30619203282610760
ENST00000476228TFGchr3100451516+ENST00000389048ALKchr229446397-28807391472429760
ENST00000490574TFGchr3100455560+ENST00000389048ALKchr229446396-2959818852508807
ENST00000240851TFGchr3100455560+ENST00000389048ALKchr229446396-320210613282751807

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418917ENST00000389048TFGchr3100447702+ALKchr229446395-0.0023529720.997647
ENST00000490574ENST00000389048TFGchr3100447702+ALKchr229446395-0.002344230.99765575
ENST00000240851ENST00000389048TFGchr3100447702+ALKchr229446395-0.0019055150.9980945
ENST00000476228ENST00000389048TFGchr3100447702+ALKchr229446395-0.0024835120.9975165
ENST00000418917ENST00000389048TFGchr3100451516+ALKchr229446397-0.0015779820.998422
ENST00000490574ENST00000389048TFGchr3100451516+ALKchr229446397-0.0015657060.99843425
ENST00000240851ENST00000389048TFGchr3100451516+ALKchr229446397-0.0012905690.99870944
ENST00000476228ENST00000389048TFGchr3100451516+ALKchr229446397-0.0016360150.99836403
ENST00000490574ENST00000389048TFGchr3100455560+ALKchr229446396-0.0023390760.9976609
ENST00000240851ENST00000389048TFGchr3100455560+ALKchr229446396-0.0019194580.9980805

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90355_90355_1_TFG-ALK_TFG_chr3_100447702_ENST00000240851_ALK_chr2_29446394_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_2_TFG-ALK_TFG_chr3_100447702_ENST00000240851_ALK_chr2_29446395_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_3_TFG-ALK_TFG_chr3_100447702_ENST00000418917_ALK_chr2_29446394_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_4_TFG-ALK_TFG_chr3_100447702_ENST00000418917_ALK_chr2_29446395_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_5_TFG-ALK_TFG_chr3_100447702_ENST00000476228_ALK_chr2_29446394_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_6_TFG-ALK_TFG_chr3_100447702_ENST00000476228_ALK_chr2_29446395_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_7_TFG-ALK_TFG_chr3_100447702_ENST00000490574_ALK_chr2_29446394_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_8_TFG-ALK_TFG_chr3_100447702_ENST00000490574_ALK_chr2_29446395_ENST00000389048_length(amino acids)=705AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN
YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR
DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKK
PTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNV

--------------------------------------------------------------

>90355_90355_9_TFG-ALK_TFG_chr3_100451516_ENST00000240851_ALK_chr2_29446394_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_10_TFG-ALK_TFG_chr3_100451516_ENST00000240851_ALK_chr2_29446397_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_11_TFG-ALK_TFG_chr3_100451516_ENST00000418917_ALK_chr2_29446394_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_12_TFG-ALK_TFG_chr3_100451516_ENST00000418917_ALK_chr2_29446397_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_13_TFG-ALK_TFG_chr3_100451516_ENST00000476228_ALK_chr2_29446394_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_14_TFG-ALK_TFG_chr3_100451516_ENST00000476228_ALK_chr2_29446397_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_15_TFG-ALK_TFG_chr3_100451516_ENST00000490574_ALK_chr2_29446394_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_16_TFG-ALK_TFG_chr3_100451516_ENST00000490574_ALK_chr2_29446397_ENST00000389048_length(amino acids)=760AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEV
YEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS
LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
YGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELH
KVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCG

--------------------------------------------------------------

>90355_90355_17_TFG-ALK_TFG_chr3_100455560_ENST00000240851_ALK_chr2_29446396_ENST00000389048_length(amino acids)=807AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEVYRRKHQELQAMQMELQSPEYKLSKL
RTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK
FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG
RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN
CPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPP
LPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNL

--------------------------------------------------------------

>90355_90355_18_TFG-ALK_TFG_chr3_100455560_ENST00000490574_ALK_chr2_29446396_ENST00000389048_length(amino acids)=807AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEVYRRKHQELQAMQMELQSPEYKLSKL
RTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK
FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG
RVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN
CPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPP
LPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100447702/chr2:29446395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFG

Q92734

ALK

Q96BT7

FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFGchr3:100447702chr2:29446395ENST00000240851+4897_124138.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr2:29446395ENST00000418917+4897_124138.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr2:29446395ENST00000476228+4897_124138.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr2:29446395ENST00000490574+4897_124138.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr2:29446397ENST00000240851+5897_124193.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr2:29446397ENST00000418917+5897_124193.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr2:29446397ENST00000476228+5897_124193.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr2:29446397ENST00000490574+5897_124193.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr2:29446396ENST00000240851+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr2:29446396ENST00000490574+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr2:29446395ENST00000240851+4810_91138.33333333333334401.0DomainPB1
HgeneTFGchr3:100447702chr2:29446395ENST00000418917+4810_91138.33333333333334397.0DomainPB1
HgeneTFGchr3:100447702chr2:29446395ENST00000476228+4810_91138.33333333333334397.0DomainPB1
HgeneTFGchr3:100447702chr2:29446395ENST00000490574+4810_91138.33333333333334401.0DomainPB1
HgeneTFGchr3:100451516chr2:29446397ENST00000240851+5810_91193.33333333333334401.0DomainPB1
HgeneTFGchr3:100451516chr2:29446397ENST00000418917+5810_91193.33333333333334397.0DomainPB1
HgeneTFGchr3:100451516chr2:29446397ENST00000476228+5810_91193.33333333333334397.0DomainPB1
HgeneTFGchr3:100451516chr2:29446397ENST00000490574+5810_91193.33333333333334401.0DomainPB1
HgeneTFGchr3:100455560chr2:29446396ENST00000240851+6810_91240.33333333333334401.0DomainPB1
HgeneTFGchr3:100455560chr2:29446396ENST00000490574+6810_91240.33333333333334401.0DomainPB1
TgeneALKchr3:100447702chr2:29446395ENST0000038904818291116_13921057.33333333333331621.0DomainProtein kinase
TgeneALKchr3:100451516chr2:29446397ENST0000038904818291116_13921057.33333333333331621.0DomainProtein kinase
TgeneALKchr3:100455560chr2:29446396ENST0000038904818291116_13921057.33333333333331621.0DomainProtein kinase
TgeneALKchr3:100447702chr2:29446395ENST0000038904818291197_11991057.33333333333331621.0RegionNote=Inhibitor binding
TgeneALKchr3:100451516chr2:29446397ENST0000038904818291197_11991057.33333333333331621.0RegionNote=Inhibitor binding
TgeneALKchr3:100455560chr2:29446396ENST0000038904818291197_11991057.33333333333331621.0RegionNote=Inhibitor binding
TgeneALKchr3:100447702chr2:29446395ENST0000038904818291060_16201057.33333333333331621.0Topological domainCytoplasmic
TgeneALKchr3:100451516chr2:29446397ENST0000038904818291060_16201057.33333333333331621.0Topological domainCytoplasmic
TgeneALKchr3:100455560chr2:29446396ENST0000038904818291060_16201057.33333333333331621.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFGchr3:100455560chr2:29446396ENST00000418917+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr2:29446396ENST00000476228+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr2:29446396ENST00000418917+1810_910397.0DomainPB1
HgeneTFGchr3:100455560chr2:29446396ENST00000476228+1810_910397.0DomainPB1
TgeneALKchr3:100447702chr2:29446395ENST000003890481829816_9401057.33333333333331621.0Compositional biasNote=Gly-rich
TgeneALKchr3:100451516chr2:29446397ENST000003890481829816_9401057.33333333333331621.0Compositional biasNote=Gly-rich
TgeneALKchr3:100455560chr2:29446396ENST000003890481829816_9401057.33333333333331621.0Compositional biasNote=Gly-rich
TgeneALKchr3:100447702chr2:29446395ENST000003890481829264_4271057.33333333333331621.0DomainMAM 1
TgeneALKchr3:100447702chr2:29446395ENST000003890481829437_4731057.33333333333331621.0DomainNote=LDL-receptor class A
TgeneALKchr3:100447702chr2:29446395ENST000003890481829478_6361057.33333333333331621.0DomainMAM 2
TgeneALKchr3:100451516chr2:29446397ENST000003890481829264_4271057.33333333333331621.0DomainMAM 1
TgeneALKchr3:100451516chr2:29446397ENST000003890481829437_4731057.33333333333331621.0DomainNote=LDL-receptor class A
TgeneALKchr3:100451516chr2:29446397ENST000003890481829478_6361057.33333333333331621.0DomainMAM 2
TgeneALKchr3:100455560chr2:29446396ENST000003890481829264_4271057.33333333333331621.0DomainMAM 1
TgeneALKchr3:100455560chr2:29446396ENST000003890481829437_4731057.33333333333331621.0DomainNote=LDL-receptor class A
TgeneALKchr3:100455560chr2:29446396ENST000003890481829478_6361057.33333333333331621.0DomainMAM 2
TgeneALKchr3:100447702chr2:29446395ENST00000389048182919_10381057.33333333333331621.0Topological domainExtracellular
TgeneALKchr3:100451516chr2:29446397ENST00000389048182919_10381057.33333333333331621.0Topological domainExtracellular
TgeneALKchr3:100455560chr2:29446396ENST00000389048182919_10381057.33333333333331621.0Topological domainExtracellular
TgeneALKchr3:100447702chr2:29446395ENST0000038904818291039_10591057.33333333333331621.0TransmembraneHelical
TgeneALKchr3:100451516chr2:29446397ENST0000038904818291039_10591057.33333333333331621.0TransmembraneHelical
TgeneALKchr3:100455560chr2:29446396ENST0000038904818291039_10591057.33333333333331621.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (577) >>>577.pdbFusion protein BP residue: 142
CIF file (577) >>>577.cif		TFGchr3100447702+ALKchr229446394-
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRG
KLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRP
LESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVYRRKHQE
LQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKN
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFL
MEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP
SQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRV
AKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSF
GVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC
WQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRP
KDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRV
PRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKP
TKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTAN
MKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSM
705
3D view using mol* of 577 (AA BP:142)
PDB file (621) >>>621.pdbFusion protein BP residue: 197
CIF file (621) >>>621.cif		TFGchr3100451516+ALKchr229446394-
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRG
KLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRP
LESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREE
KSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSVYR
RKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKE
VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD
ELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRE
TRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP
GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKT
DTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYR
IMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEK
VPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAE
ISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSW
FTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS
SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK
760
3D view using mol* of 621 (AA BP:197)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
ALK_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TFG_ALK_577_pLDDT.png (AA BP:142)
all structure
TFG_ALK_577_pLDDT_and_active_sites.png (AA BP:142)
all structure
TFG_ALK_577_violinplot.png (AA BP:142)
all structure
TFG_ALK_621_pLDDT.png (AA BP:197)
all structure
TFG_ALK_621_pLDDT_and_active_sites.png (AA BP:197)
all structure
TFG_ALK_621_violinplot.png (AA BP:197)
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
TFG_ALK_621.png
all structure

Top

Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
5770.765570.741163.9540.70.6130.8220.2591.0320.2510.745Chain A: 401,402,405,406,408,409,411,413,463,492,4
93,494,495,496,497,498
6211.0235941.0431464.610.540.7240.9280.6371.0160.6270.819Chain A: 33,34,35,36,61,62,68,69,70,71,73,74,75,76
,77,78,79,80,82,83,260,261,262,263,264,265,266,267
,269,270,271,272,288,290,299,300,303,307,320,336,3
37,338,339,340,341,342,343,345,346,347,349,350,352
,353,387,389,393,394,396,400,409,410,411,412,413,4
14,415,416,419,425,428,429,430,431,432,433,434,435
,460,464,465,466,467,468,470,471,472,473,474,475,4
76,479,481,487,488,489,491,492,538,539,540,541,639
,640,641,643,645,646,647,648,649,650,651,652

Top

Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

Top

check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

Top

Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


Top

Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TFGPLSCR1, C14orf1, GPRASP1, GBP2, ARL15, CRMP1, KIAA1377, TFG, Mapk13, GRB2, RAD21, TSG101, PPP1CA, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, TRAF3, CFTR, TRIM25, STAT5B, MYOT, PIN1, PALM2-AKAP2, BABAM1, BRE, EHBP1L1, ASB18, HSPA5, TRIM68, ANXA11, CSTF2, EWSR1, HNRNPF, MAGED1, SEC24A, RBPMS, ARHGEF16, SPG21, VPS37C, CEP55, BOLL, MAPK1IP1L, RIPPLY2, PEF1, CUL7, SEC13, IGHG1, SEC31A, SPINK5, PKP1, EIF1AX, VSIG8, S100A3, LRRC15, S100A7, FBXO11, HNRNPCL1, DSG4, SELENBP1, DUSP14, HEPHL1, HIST1H2AG, UNK, FEN1, NTRK1, IFI16, TMEM17, ANXA1, ATP6V1B2, ATP6V0A1, CLTA, FLOT2, RPL10A, CHMP1A, RARS, RPL4, ITSN1, TOP2A, NCOA4, SNX3, AURKB, CLINT1, IST1, URB1, PDCD6IP, RCL1, ATP5H, MTUS2, NIPBL, C3orf17, ABI3BP, FBXL6, CHMP2A, CHMP4A, PHF20, CHMP5, SCLY, CHMP3, DPM3, DGCR8, NAT10, CHMP1B, ERGIC1, BICC1, KLHL13, TOP1MT, CHMP4B, MITD1, PLBD2, UMAD1, MCM2, CRYAB, RCAN2, BRCA1, YLR108C, GTS1, PDCD6, KIAA1715, UBE2M, EFTUD2, AAR2, PIH1D1, TNIP2, HGS, PPT1, AGO2, AGR2, BET1, KIAA1429, PHB, BMH1, BMH2, ATXN3, ITFG1, BIRC3, LASP1, FAM168A, RNF4, EYA2, PLA2G10, NID2, UBE2I, SF3A2, MED25, CRX, POU2AF1, PFDN5, SMUG1, CPSF3L, ZMYM5, KHDC1, UBAP2, TBX19, SF3B4, FOXH1, DVL3, PPP1R32, OXER1, WBSCR27, MSS51, LENG8, TEX37, NADSYN1, DAZAP2, WWOX, C19orf54, PLEKHG4, ZNF34, INCA1, KRTAP26-1, BPIFA1, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, STH, ARIH2, PLEKHA4, ORF6, PRRC2B, R3HDM2, TNRC6C, KIF14, PRNP, ORF3a, TBK1, CRTC1, LGALS9, BARD1, MBD4, OGT, nsp2, NR4A1, EBAG9, UBQLN2, FURIN, IFITM1, ORF7a, FBXO32, TOLLIP, nsp14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TFGall structure
ALKall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to TFG-ALK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to TFG-ALK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TFGALKLung AdenocarcinomaMyCancerGenome
TFGALKAcute Myeloid LeukemiaMyCancerGenome
TFGALKCancer Of Unknown PrimaryMyCancerGenome
TFGALKDiffuse Large B-Cell LymphomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFGC3714897SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC1858338Neuropathy, hereditary motor and sensory, Okinawa type4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC0238463Papillary thyroid carcinoma2ORPHANET
HgeneTFGC0442874Neuropathy1GENOMICS_ENGLAND
HgeneTFGC1275278Extraskeletal Myxoid Chondrosarcoma1GENOMICS_ENGLAND;ORPHANET
HgeneTFGC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneALKC0007131Non-Small Cell Lung Carcinoma28CGI;CTD_human
TgeneALKC0027819Neuroblastoma13CGI;CTD_human;ORPHANET
TgeneALKC0152013Adenocarcinoma of lung (disorder)8CGI;CTD_human
TgeneALKC2751681NEUROBLASTOMA, SUSCEPTIBILITY TO, 38CLINGEN;UNIPROT
TgeneALKC0206180Ki-1+ Anaplastic Large Cell Lymphoma6CGI;CTD_human
TgeneALKC0334121Inflammatory Myofibroblastic Tumor4CGI;CTD_human;ORPHANET
TgeneALKC0018199Granuloma, Plasma Cell3CTD_human
TgeneALKC0007621Neoplastic Cell Transformation2CTD_human
TgeneALKC0027627Neoplasm Metastasis2CTD_human
TgeneALKC0238463Papillary thyroid carcinoma2ORPHANET
TgeneALKC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneALKC0006118Brain Neoplasms1CGI;CTD_human
TgeneALKC0006142Malignant neoplasm of breast1CTD_human
TgeneALKC0007134Renal Cell Carcinoma1CTD_human
TgeneALKC0011570Mental Depression1PSYGENET
TgeneALKC0011581Depressive disorder1PSYGENET
TgeneALKC0027643Neoplasm Recurrence, Local1CTD_human
TgeneALKC0036341Schizophrenia1PSYGENET
TgeneALKC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneALKC0085269Plasma Cell Granuloma, Pulmonary1CTD_human
TgeneALKC0153633Malignant neoplasm of brain1CGI;CTD_human
TgeneALKC0278601Inflammatory Breast Carcinoma1CTD_human
TgeneALKC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneALKC0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneALKC0678222Breast Carcinoma1CTD_human
TgeneALKC0750974Brain Tumor, Primary1CTD_human
TgeneALKC0750977Recurrent Brain Neoplasm1CTD_human
TgeneALKC0750979Primary malignant neoplasm of brain1CTD_human
TgeneALKC1257931Mammary Neoplasms, Human1CTD_human
TgeneALKC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneALKC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneALKC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneALKC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneALKC1332079Anaplastic Large Cell Lymphoma, ALK-Positive1ORPHANET
TgeneALKC1458155Mammary Neoplasms1CTD_human
TgeneALKC1527390Neoplasms, Intracranial1CTD_human
TgeneALKC2931189Neural crest tumor1ORPHANET
TgeneALKC3899155hereditary neuroblastoma1GENOMICS_ENGLAND
TgeneALKC4704874Mammary Carcinoma, Human1CTD_human