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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TFG-CD46

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TFG-CD46
FusionPDB ID: 90357
FusionGDB2.0 ID: 90357
HgeneTgene
Gene symbol

TFG

CD46

Gene ID

10342

4179

Gene nametrafficking from ER to golgi regulatorCD46 molecule
SynonymsHMSNP|SPG57|TF6|TRKT3AHUS2|MCP|MIC10|TLX|TRA2.10
Cytomap

3q12.2

1q32.2

Type of geneprotein-codingprotein-coding
Descriptionprotein TFGTRK-fusedTRK-fused gene proteinTRKT3 oncogenemembrane cofactor proteinCD46 antigen, complement regulatory proteinCD46 molecule, complement regulatory proteinantigen identified by monoclonal antibody TRA-2-10complement membrane cofactor proteinmeasles virus receptormembrane cofactor protein (CD
Modification date2020031320200313
UniProtAcc

Q92734

P15529

Ensembl transtripts involved in fusion geneENST idsENST00000240851, ENST00000418917, 
ENST00000476228, ENST00000490574, 
ENST00000481203, 		ENST00000469535, 
ENST00000322918, ENST00000357714, 
ENST00000358170, ENST00000360212, 
ENST00000361067, ENST00000367041, 
ENST00000367047, ENST00000480003, 
ENST00000322875, ENST00000354848, 
ENST00000367042, ENST00000441839, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 14 X 7=127416 X 13 X 7=1456
# samples 1917
** MAII scorelog2(19/1274*10)=-2.74529395392535
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1456*10)=-3.098403704061
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TFG [Title/Abstract] AND CD46 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TFG(100447702)-CD46(207941124), # samples:1
Anticipated loss of major functional domain due to fusion event.TFG-CD46 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-CD46 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-CD46 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-CD46 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD46

GO:0008593

regulation of Notch signaling pathway

23086448

TgeneCD46

GO:0010629

negative regulation of gene expression

23086448

TgeneCD46

GO:0032613

interleukin-10 production

23086448

TgeneCD46

GO:0032733

positive regulation of interleukin-10 production

12540904

TgeneCD46

GO:0035581

sequestering of extracellular ligand from receptor

23086448

TgeneCD46

GO:0042102

positive regulation of T cell proliferation

12540904

TgeneCD46

GO:0043382

positive regulation of memory T cell differentiation

12540904

TgeneCD46

GO:0045591

positive regulation of regulatory T cell differentiation

12540904

TgeneCD46

GO:0071636

positive regulation of transforming growth factor beta production

12540904


check buttonFusion gene breakpoints across TFG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD46 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2787-01ATFGchr3

100447702

+CD46chr1

207941124

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418917TFGchr3100447702+ENST00000367042CD46chr1207941124+2843529102806234
ENST00000418917TFGchr3100447702+ENST00000354848CD46chr1207941124+2750529102827241
ENST00000418917TFGchr3100447702+ENST00000441839CD46chr1207941124+2686529102767221
ENST00000418917TFGchr3100447702+ENST00000322875CD46chr1207941124+2750529102827241
ENST00000490574TFGchr3100447702+ENST00000367042CD46chr1207941124+282651285789234
ENST00000490574TFGchr3100447702+ENST00000354848CD46chr1207941124+273351285810241
ENST00000490574TFGchr3100447702+ENST00000441839CD46chr1207941124+266951285750221
ENST00000490574TFGchr3100447702+ENST00000322875CD46chr1207941124+273351285810241
ENST00000240851TFGchr3100447702+ENST00000367042CD46chr1207941124+30697553281032234
ENST00000240851TFGchr3100447702+ENST00000354848CD46chr1207941124+29767553281053241
ENST00000240851TFGchr3100447702+ENST00000441839CD46chr1207941124+2912755328993221
ENST00000240851TFGchr3100447702+ENST00000322875CD46chr1207941124+29767553281053241
ENST00000476228TFGchr3100447702+ENST00000367042CD46chr1207941124+2888574147851234
ENST00000476228TFGchr3100447702+ENST00000354848CD46chr1207941124+2795574147872241
ENST00000476228TFGchr3100447702+ENST00000441839CD46chr1207941124+2731574147812221
ENST00000476228TFGchr3100447702+ENST00000322875CD46chr1207941124+2795574147872241

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418917ENST00000367042TFGchr3100447702+CD46chr1207941124+0.0004547630.99954516
ENST00000418917ENST00000354848TFGchr3100447702+CD46chr1207941124+0.0006219740.99937797
ENST00000418917ENST00000441839TFGchr3100447702+CD46chr1207941124+0.0008415170.9991585
ENST00000418917ENST00000322875TFGchr3100447702+CD46chr1207941124+0.0006219740.99937797
ENST00000490574ENST00000367042TFGchr3100447702+CD46chr1207941124+0.0005205310.9994795
ENST00000490574ENST00000354848TFGchr3100447702+CD46chr1207941124+0.0005899240.99941003
ENST00000490574ENST00000441839TFGchr3100447702+CD46chr1207941124+0.0009152380.9990847
ENST00000490574ENST00000322875TFGchr3100447702+CD46chr1207941124+0.0005899240.99941003
ENST00000240851ENST00000367042TFGchr3100447702+CD46chr1207941124+0.0005353210.9994647
ENST00000240851ENST00000354848TFGchr3100447702+CD46chr1207941124+0.0006061850.9993938
ENST00000240851ENST00000441839TFGchr3100447702+CD46chr1207941124+0.0005980750.9994019
ENST00000240851ENST00000322875TFGchr3100447702+CD46chr1207941124+0.0006061850.9993938
ENST00000476228ENST00000367042TFGchr3100447702+CD46chr1207941124+0.000529460.99947053
ENST00000476228ENST00000354848TFGchr3100447702+CD46chr1207941124+0.0006227690.9993773
ENST00000476228ENST00000441839TFGchr3100447702+CD46chr1207941124+0.0008122480.99918777
ENST00000476228ENST00000322875TFGchr3100447702+CD46chr1207941124+0.0006227690.9993773

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90357_90357_1_TFG-CD46_TFG_chr3_100447702_ENST00000240851_CD46_chr1_207941124_ENST00000322875_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_2_TFG-CD46_TFG_chr3_100447702_ENST00000240851_CD46_chr1_207941124_ENST00000354848_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_3_TFG-CD46_TFG_chr3_100447702_ENST00000240851_CD46_chr1_207941124_ENST00000367042_length(amino acids)=234AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_4_TFG-CD46_TFG_chr3_100447702_ENST00000240851_CD46_chr1_207941124_ENST00000441839_length(amino acids)=221AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_5_TFG-CD46_TFG_chr3_100447702_ENST00000418917_CD46_chr1_207941124_ENST00000322875_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_6_TFG-CD46_TFG_chr3_100447702_ENST00000418917_CD46_chr1_207941124_ENST00000354848_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_7_TFG-CD46_TFG_chr3_100447702_ENST00000418917_CD46_chr1_207941124_ENST00000367042_length(amino acids)=234AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_8_TFG-CD46_TFG_chr3_100447702_ENST00000418917_CD46_chr1_207941124_ENST00000441839_length(amino acids)=221AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_9_TFG-CD46_TFG_chr3_100447702_ENST00000476228_CD46_chr1_207941124_ENST00000322875_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_10_TFG-CD46_TFG_chr3_100447702_ENST00000476228_CD46_chr1_207941124_ENST00000354848_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_11_TFG-CD46_TFG_chr3_100447702_ENST00000476228_CD46_chr1_207941124_ENST00000367042_length(amino acids)=234AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_12_TFG-CD46_TFG_chr3_100447702_ENST00000476228_CD46_chr1_207941124_ENST00000441839_length(amino acids)=221AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_13_TFG-CD46_TFG_chr3_100447702_ENST00000490574_CD46_chr1_207941124_ENST00000322875_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_14_TFG-CD46_TFG_chr3_100447702_ENST00000490574_CD46_chr1_207941124_ENST00000354848_length(amino acids)=241AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_15_TFG-CD46_TFG_chr3_100447702_ENST00000490574_CD46_chr1_207941124_ENST00000367042_length(amino acids)=234AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

>90357_90357_16_TFG-CD46_TFG_chr3_100447702_ENST00000490574_CD46_chr1_207941124_ENST00000441839_length(amino acids)=221AA_BP=142
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100447702/chr1:207941124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFG

Q92734

CD46

P15529

FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.; FUNCTION: (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; FUNCTION: (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {ECO:0000269|PubMed:12915534, ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, ECO:0000269|PubMed:16254377}.; FUNCTION: (Microbial infection) Acts as a receptor for cultured Measles virus. {ECO:0000269|PubMed:10972291}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {ECO:0000269|PubMed:12663806, ECO:0000269|PubMed:12724329}.; FUNCTION: (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFGchr3:100447702chr1:207941124ENST00000240851+4897_124138.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr1:207941124ENST00000418917+4897_124138.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr1:207941124ENST00000476228+4897_124138.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr1:207941124ENST00000490574+4897_124138.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100447702chr1:207941124ENST00000240851+4810_91138.33333333333334401.0DomainPB1
HgeneTFGchr3:100447702chr1:207941124ENST00000418917+4810_91138.33333333333334397.0DomainPB1
HgeneTFGchr3:100447702chr1:207941124ENST00000476228+4810_91138.33333333333334397.0DomainPB1
HgeneTFGchr3:100447702chr1:207941124ENST00000490574+4810_91138.33333333333334401.0DomainPB1
TgeneCD46chr3:100447702chr1:207941124ENST00000322875613302_326300.3333333333333400.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000322918010302_3260350.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000354848512302_326285.3333333333333385.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000357714011302_3260370.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000358170614302_326300.3333333333333973.6666666666666Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000360212010302_3260356.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000361067612302_326300.3333333333333386.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000367041012302_3260943.6666666666666Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000367042513302_326285.3333333333333958.6666666666666Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000367047512302_326237.33333333333334337.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000441839511302_326285.3333333333333365.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000480003511302_326285.3333333333333371.0Compositional biasNote=Ser/Thr-rich
TgeneCD46chr3:100447702chr1:207941124ENST00000322918010160_2250350.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000322918010226_2850350.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000032291801035_960350.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000032291801097_1590350.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000357714011160_2250370.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000357714011226_2850370.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000035771401135_960370.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000035771401197_1590370.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000360212010160_2250356.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000360212010226_2850356.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000036021201035_960356.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000036021201097_1590356.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000367041012160_2250943.6666666666666DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000367041012226_2850943.6666666666666DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000036704101235_960943.6666666666666DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000036704101297_1590943.6666666666666DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000322875613367_392300.3333333333333400.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST0000032291801035_3430350.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST00000322918010367_3920350.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000354848512367_392285.3333333333333385.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST0000035771401135_3430370.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST00000357714011367_3920370.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000358170614367_392300.3333333333333973.6666666666666Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST0000036021201035_3430356.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST00000360212010367_3920356.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000361067612367_392300.3333333333333386.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST0000036704101235_3430943.6666666666666Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST00000367041012367_3920943.6666666666666Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000367042513367_392285.3333333333333958.6666666666666Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000367047512367_392237.33333333333334337.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000441839511367_392285.3333333333333365.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000480003511367_392285.3333333333333371.0Topological domainCytoplasmic
TgeneCD46chr3:100447702chr1:207941124ENST00000322875613344_366300.3333333333333400.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000322918010344_3660350.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000354848512344_366285.3333333333333385.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000357714011344_3660370.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000358170614344_366300.3333333333333973.6666666666666TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000360212010344_3660356.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000361067612344_366300.3333333333333386.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000367041012344_3660943.6666666666666TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000367042513344_366285.3333333333333958.6666666666666TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000367047512344_366237.33333333333334337.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000441839511344_366285.3333333333333365.0TransmembraneHelical
TgeneCD46chr3:100447702chr1:207941124ENST00000480003511344_366285.3333333333333371.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD46chr3:100447702chr1:207941124ENST00000322875613160_225300.3333333333333400.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000322875613226_285300.3333333333333400.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000032287561335_96300.3333333333333400.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000032287561397_159300.3333333333333400.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000354848512160_225285.3333333333333385.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000354848512226_285285.3333333333333385.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000035484851235_96285.3333333333333385.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000035484851297_159285.3333333333333385.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000358170614160_225300.3333333333333973.6666666666666DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000358170614226_285300.3333333333333973.6666666666666DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000035817061435_96300.3333333333333973.6666666666666DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000035817061497_159300.3333333333333973.6666666666666DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000361067612160_225300.3333333333333386.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000361067612226_285300.3333333333333386.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000036106761235_96300.3333333333333386.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000036106761297_159300.3333333333333386.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000367042513160_225285.3333333333333958.6666666666666DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000367042513226_285285.3333333333333958.6666666666666DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000036704251335_96285.3333333333333958.6666666666666DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000036704251397_159285.3333333333333958.6666666666666DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000367047512160_225237.33333333333334337.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000367047512226_285237.33333333333334337.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000036704751235_96237.33333333333334337.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000036704751297_159237.33333333333334337.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000441839511160_225285.3333333333333365.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000441839511226_285285.3333333333333365.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000044183951135_96285.3333333333333365.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000044183951197_159285.3333333333333365.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST00000480003511160_225285.3333333333333371.0DomainSushi 3
TgeneCD46chr3:100447702chr1:207941124ENST00000480003511226_285285.3333333333333371.0DomainSushi 4
TgeneCD46chr3:100447702chr1:207941124ENST0000048000351135_96285.3333333333333371.0DomainSushi 1
TgeneCD46chr3:100447702chr1:207941124ENST0000048000351197_159285.3333333333333371.0DomainSushi 2
TgeneCD46chr3:100447702chr1:207941124ENST0000032287561335_343300.3333333333333400.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000035484851235_343285.3333333333333385.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000035817061435_343300.3333333333333973.6666666666666Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000036106761235_343300.3333333333333386.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000036704251335_343285.3333333333333958.6666666666666Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000036704751235_343237.33333333333334337.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000044183951135_343285.3333333333333365.0Topological domainExtracellular
TgeneCD46chr3:100447702chr1:207941124ENST0000048000351135_343285.3333333333333371.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TFGPLSCR1, C14orf1, GPRASP1, GBP2, ARL15, CRMP1, KIAA1377, TFG, Mapk13, GRB2, RAD21, TSG101, PPP1CA, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, TRAF3, CFTR, TRIM25, STAT5B, MYOT, PIN1, PALM2-AKAP2, BABAM1, BRE, EHBP1L1, ASB18, HSPA5, TRIM68, ANXA11, CSTF2, EWSR1, HNRNPF, MAGED1, SEC24A, RBPMS, ARHGEF16, SPG21, VPS37C, CEP55, BOLL, MAPK1IP1L, RIPPLY2, PEF1, CUL7, SEC13, IGHG1, SEC31A, SPINK5, PKP1, EIF1AX, VSIG8, S100A3, LRRC15, S100A7, FBXO11, HNRNPCL1, DSG4, SELENBP1, DUSP14, HEPHL1, HIST1H2AG, UNK, FEN1, NTRK1, IFI16, TMEM17, ANXA1, ATP6V1B2, ATP6V0A1, CLTA, FLOT2, RPL10A, CHMP1A, RARS, RPL4, ITSN1, TOP2A, NCOA4, SNX3, AURKB, CLINT1, IST1, URB1, PDCD6IP, RCL1, ATP5H, MTUS2, NIPBL, C3orf17, ABI3BP, FBXL6, CHMP2A, CHMP4A, PHF20, CHMP5, SCLY, CHMP3, DPM3, DGCR8, NAT10, CHMP1B, ERGIC1, BICC1, KLHL13, TOP1MT, CHMP4B, MITD1, PLBD2, UMAD1, MCM2, CRYAB, RCAN2, BRCA1, YLR108C, GTS1, PDCD6, KIAA1715, UBE2M, EFTUD2, AAR2, PIH1D1, TNIP2, HGS, PPT1, AGO2, AGR2, BET1, KIAA1429, PHB, BMH1, BMH2, ATXN3, ITFG1, BIRC3, LASP1, FAM168A, RNF4, EYA2, PLA2G10, NID2, UBE2I, SF3A2, MED25, CRX, POU2AF1, PFDN5, SMUG1, CPSF3L, ZMYM5, KHDC1, UBAP2, TBX19, SF3B4, FOXH1, DVL3, PPP1R32, OXER1, WBSCR27, MSS51, LENG8, TEX37, NADSYN1, DAZAP2, WWOX, C19orf54, PLEKHG4, ZNF34, INCA1, KRTAP26-1, BPIFA1, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, STH, ARIH2, PLEKHA4, ORF6, PRRC2B, R3HDM2, TNRC6C, KIF14, PRNP, ORF3a, TBK1, CRTC1, LGALS9, BARD1, MBD4, OGT, nsp2, NR4A1, EBAG9, UBQLN2, FURIN, IFITM1, ORF7a, FBXO32, TOLLIP, nsp14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TFGall structure
CD46


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TFG-CD46


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TFG-CD46


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFGC3714897SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC1858338Neuropathy, hereditary motor and sensory, Okinawa type4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC0238463Papillary thyroid carcinoma2ORPHANET
HgeneTFGC0442874Neuropathy1GENOMICS_ENGLAND
HgeneTFGC1275278Extraskeletal Myxoid Chondrosarcoma1GENOMICS_ENGLAND;ORPHANET
HgeneTFGC3714756Intellectual Disability1GENOMICS_ENGLAND