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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TFG-NTRK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TFG-NTRK1
FusionPDB ID: 90362
FusionGDB2.0 ID: 90362
HgeneTgene
Gene symbol

TFG

NTRK1

Gene ID

10342

4914

Gene nametrafficking from ER to golgi regulatorneurotrophic receptor tyrosine kinase 1
SynonymsHMSNP|SPG57|TF6|TRKT3MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA
Cytomap

3q12.2

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein TFGTRK-fusedTRK-fused gene proteinTRKT3 oncogenehigh affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
Modification date2020031320200313
UniProtAcc

Q92734

P04629

Ensembl transtripts involved in fusion geneENST idsENST00000240851, ENST00000418917, 
ENST00000476228, ENST00000481203, 
ENST00000490574, 		ENST00000358660, 
ENST00000368196, ENST00000392302, 
ENST00000524377, ENST00000531606, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 14 X 7=127425 X 24 X 13=7800
# samples 1933
** MAII scorelog2(19/1274*10)=-2.74529395392535
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/7800*10)=-4.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TFG [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TFG(100455560)-NTRK1(156844363), # samples:3
Anticipated loss of major functional domain due to fusion event.TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFG-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFG-NTRK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TFG-NTRK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TFG-NTRK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTRK1

GO:0006468

protein phosphorylation

15488758

TgeneNTRK1

GO:0008285

negative regulation of cell proliferation

15488758

TgeneNTRK1

GO:0010976

positive regulation of neuron projection development

15488758

TgeneNTRK1

GO:0018108

peptidyl-tyrosine phosphorylation

2927393

TgeneNTRK1

GO:0043547

positive regulation of GTPase activity

15488758

TgeneNTRK1

GO:0046579

positive regulation of Ras protein signal transduction

15488758

TgeneNTRK1

GO:0046777

protein autophosphorylation

15488758

TgeneNTRK1

GO:0048011

neurotrophin TRK receptor signaling pathway

15488758

TgeneNTRK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15488758

TgeneNTRK1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15488758

TgeneNTRK1

GO:1904646

cellular response to amyloid-beta

11927634


check buttonFusion gene breakpoints across TFG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-EM-A3AO-01ATFGchr3

100455548

+NTRK1chr1

156844363

+
ChimerDB4THCATCGA-EM-A3AO-01ATFGchr3

100455560

-NTRK1chr1

156844363

+
ChimerDB4THCATCGA-EM-A3AO-01ATFGchr3

100455560

+NTRK1chr1

156844363

+
ChimerDB4THCATCGA-EM-A3AOTFGchr3

100455560

+NTRK1chr1

156844362

+
ChimerKB3..TFGchr3

100451516

+NTRK1chr1

156844174

+
ChimerKB3..TFGchr3

100451516

+NTRK1chr1

156844362

+
ChimerKB3..TFGchr3

100467811

+NTRK1chr1

156843424

+
ChiTaRS5.0N/AX85960TFGchr3

100451516

+NTRK1chr1

156844360

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418917TFGchr3100451516+ENST00000392302NTRK1chr1156844362+20426941021889595
ENST00000418917TFGchr3100451516+ENST00000368196NTRK1chr1156844362+20986941021889595
ENST00000418917TFGchr3100451516+ENST00000524377NTRK1chr1156844362+18906941021889595
ENST00000418917TFGchr3100451516+ENST00000358660NTRK1chr1156844362+19686941021898598
ENST00000490574TFGchr3100451516+ENST00000392302NTRK1chr1156844362+2025677851872595
ENST00000490574TFGchr3100451516+ENST00000368196NTRK1chr1156844362+2081677851872595
ENST00000490574TFGchr3100451516+ENST00000524377NTRK1chr1156844362+1873677851872596
ENST00000490574TFGchr3100451516+ENST00000358660NTRK1chr1156844362+1951677851881598
ENST00000240851TFGchr3100451516+ENST00000392302NTRK1chr1156844362+22689203282115595
ENST00000240851TFGchr3100451516+ENST00000368196NTRK1chr1156844362+23249203282115595
ENST00000240851TFGchr3100451516+ENST00000524377NTRK1chr1156844362+21169203282115596
ENST00000240851TFGchr3100451516+ENST00000358660NTRK1chr1156844362+21949203282124598
ENST00000476228TFGchr3100451516+ENST00000392302NTRK1chr1156844362+20877391471934595
ENST00000476228TFGchr3100451516+ENST00000368196NTRK1chr1156844362+21437391471934595
ENST00000476228TFGchr3100451516+ENST00000524377NTRK1chr1156844362+19357391471934595
ENST00000476228TFGchr3100451516+ENST00000358660NTRK1chr1156844362+20137391471943598
ENST00000476228TFGchr3100467811+ENST00000392302NTRK1chr1156843424+3458178317703305511
ENST00000476228TFGchr3100467811+ENST00000368196NTRK1chr1156843424+3514178317703305511
ENST00000476228TFGchr3100467811+ENST00000524377NTRK1chr1156843424+3324178317703323517
ENST00000476228TFGchr3100467811+ENST00000358660NTRK1chr1156843424+3384178317703314514
ENST00000481203TFGchr3100467811+ENST00000392302NTRK1chr1156843424+4946327132884793501
ENST00000481203TFGchr3100467811+ENST00000368196NTRK1chr1156843424+5002327132884793501
ENST00000481203TFGchr3100467811+ENST00000524377NTRK1chr1156843424+4812327132884811507
ENST00000481203TFGchr3100467811+ENST00000358660NTRK1chr1156843424+4872327132884802504
ENST00000490574TFGchr3100455560+ENST00000392302NTRK1chr1156844363+2166818852013642
ENST00000490574TFGchr3100455560+ENST00000368196NTRK1chr1156844363+2222818852013642
ENST00000490574TFGchr3100455560+ENST00000524377NTRK1chr1156844363+2014818852013643
ENST00000490574TFGchr3100455560+ENST00000358660NTRK1chr1156844363+2092818852022645
ENST00000240851TFGchr3100455560+ENST00000392302NTRK1chr1156844363+240910613282256642
ENST00000240851TFGchr3100455560+ENST00000368196NTRK1chr1156844363+246510613282256642
ENST00000240851TFGchr3100455560+ENST00000524377NTRK1chr1156844363+225710613282256643
ENST00000240851TFGchr3100455560+ENST00000358660NTRK1chr1156844363+233510613282265645
ENST00000490574TFGchr3100455560+ENST00000392302NTRK1chr1156844362+2166818852013642
ENST00000490574TFGchr3100455560+ENST00000368196NTRK1chr1156844362+2222818852013642
ENST00000490574TFGchr3100455560+ENST00000524377NTRK1chr1156844362+2014818852013643
ENST00000490574TFGchr3100455560+ENST00000358660NTRK1chr1156844362+2092818852022645
ENST00000240851TFGchr3100455560+ENST00000392302NTRK1chr1156844362+240910613282256642
ENST00000240851TFGchr3100455560+ENST00000368196NTRK1chr1156844362+246510613282256642
ENST00000240851TFGchr3100455560+ENST00000524377NTRK1chr1156844362+225710613282256643
ENST00000240851TFGchr3100455560+ENST00000358660NTRK1chr1156844362+233510613282265645
ENST00000418917TFGchr3100455548+ENST00000392302NTRK1chr1156844363+21718231022018638
ENST00000418917TFGchr3100455548+ENST00000368196NTRK1chr1156844363+22278231022018638
ENST00000418917TFGchr3100455548+ENST00000524377NTRK1chr1156844363+20198231022018638
ENST00000418917TFGchr3100455548+ENST00000358660NTRK1chr1156844363+20978231022027641
ENST00000490574TFGchr3100455548+ENST00000392302NTRK1chr1156844363+2037689851884599
ENST00000490574TFGchr3100455548+ENST00000368196NTRK1chr1156844363+2093689851884599
ENST00000490574TFGchr3100455548+ENST00000524377NTRK1chr1156844363+1885689851884600
ENST00000490574TFGchr3100455548+ENST00000358660NTRK1chr1156844363+1963689851893602
ENST00000240851TFGchr3100455548+ENST00000392302NTRK1chr1156844363+22809323282127599
ENST00000240851TFGchr3100455548+ENST00000368196NTRK1chr1156844363+23369323282127599
ENST00000240851TFGchr3100455548+ENST00000524377NTRK1chr1156844363+21289323282127600
ENST00000240851TFGchr3100455548+ENST00000358660NTRK1chr1156844363+22069323282136602
ENST00000476228TFGchr3100455548+ENST00000392302NTRK1chr1156844363+22168681472063638
ENST00000476228TFGchr3100455548+ENST00000368196NTRK1chr1156844363+22728681472063638
ENST00000476228TFGchr3100455548+ENST00000524377NTRK1chr1156844363+20648681472063638
ENST00000476228TFGchr3100455548+ENST00000358660NTRK1chr1156844363+21428681472072641
ENST00000418917TFGchr3100451516+ENST00000392302NTRK1chr1156844360+20426941021889595
ENST00000418917TFGchr3100451516+ENST00000368196NTRK1chr1156844360+20986941021889595
ENST00000418917TFGchr3100451516+ENST00000524377NTRK1chr1156844360+18906941021889595
ENST00000418917TFGchr3100451516+ENST00000358660NTRK1chr1156844360+19686941021898598
ENST00000490574TFGchr3100451516+ENST00000392302NTRK1chr1156844360+2025677851872595
ENST00000490574TFGchr3100451516+ENST00000368196NTRK1chr1156844360+2081677851872595
ENST00000490574TFGchr3100451516+ENST00000524377NTRK1chr1156844360+1873677851872596
ENST00000490574TFGchr3100451516+ENST00000358660NTRK1chr1156844360+1951677851881598
ENST00000240851TFGchr3100451516+ENST00000392302NTRK1chr1156844360+22689203282115595
ENST00000240851TFGchr3100451516+ENST00000368196NTRK1chr1156844360+23249203282115595
ENST00000240851TFGchr3100451516+ENST00000524377NTRK1chr1156844360+21169203282115596
ENST00000240851TFGchr3100451516+ENST00000358660NTRK1chr1156844360+21949203282124598
ENST00000476228TFGchr3100451516+ENST00000392302NTRK1chr1156844360+20877391471934595
ENST00000476228TFGchr3100451516+ENST00000368196NTRK1chr1156844360+21437391471934595
ENST00000476228TFGchr3100451516+ENST00000524377NTRK1chr1156844360+19357391471934595
ENST00000476228TFGchr3100451516+ENST00000358660NTRK1chr1156844360+20137391471943598

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490574ENST00000392302TFGchr3100455560+NTRK1chr1156844363+0.007986510.9920135
ENST00000490574ENST00000368196TFGchr3100455560+NTRK1chr1156844363+0.0076598120.9923402
ENST00000490574ENST00000524377TFGchr3100455560+NTRK1chr1156844363+0.0086805840.99131936
ENST00000490574ENST00000358660TFGchr3100455560+NTRK1chr1156844363+0.0086240530.991376
ENST00000240851ENST00000392302TFGchr3100455560+NTRK1chr1156844363+0.0056215020.9943785
ENST00000240851ENST00000368196TFGchr3100455560+NTRK1chr1156844363+0.005347150.99465287
ENST00000240851ENST00000524377TFGchr3100455560+NTRK1chr1156844363+0.00606050.9939395
ENST00000240851ENST00000358660TFGchr3100455560+NTRK1chr1156844363+0.0060972790.9939028
ENST00000490574ENST00000392302TFGchr3100455560+NTRK1chr1156844362+0.007986510.9920135
ENST00000490574ENST00000368196TFGchr3100455560+NTRK1chr1156844362+0.0076598120.9923402
ENST00000490574ENST00000524377TFGchr3100455560+NTRK1chr1156844362+0.0086805840.99131936
ENST00000490574ENST00000358660TFGchr3100455560+NTRK1chr1156844362+0.0086240530.991376
ENST00000240851ENST00000392302TFGchr3100455560+NTRK1chr1156844362+0.0056215020.9943785
ENST00000240851ENST00000368196TFGchr3100455560+NTRK1chr1156844362+0.005347150.99465287
ENST00000240851ENST00000524377TFGchr3100455560+NTRK1chr1156844362+0.00606050.9939395
ENST00000240851ENST00000358660TFGchr3100455560+NTRK1chr1156844362+0.0060972790.9939028
ENST00000418917ENST00000392302TFGchr3100455548+NTRK1chr1156844363+0.009126180.9908738
ENST00000418917ENST00000368196TFGchr3100455548+NTRK1chr1156844363+0.0086597390.9913402
ENST00000418917ENST00000524377TFGchr3100455548+NTRK1chr1156844363+0.0098010210.99019897
ENST00000418917ENST00000358660TFGchr3100455548+NTRK1chr1156844363+0.0090431280.99095684
ENST00000490574ENST00000392302TFGchr3100455548+NTRK1chr1156844363+0.0050418680.9949581
ENST00000490574ENST00000368196TFGchr3100455548+NTRK1chr1156844363+0.0047447670.99525523
ENST00000490574ENST00000524377TFGchr3100455548+NTRK1chr1156844363+0.0055187470.9944812
ENST00000490574ENST00000358660TFGchr3100455548+NTRK1chr1156844363+0.0056849340.9943151
ENST00000240851ENST00000392302TFGchr3100455548+NTRK1chr1156844363+0.0035818240.9964181
ENST00000240851ENST00000368196TFGchr3100455548+NTRK1chr1156844363+0.0033665920.99663347
ENST00000240851ENST00000524377TFGchr3100455548+NTRK1chr1156844363+0.0038843970.99611557
ENST00000240851ENST00000358660TFGchr3100455548+NTRK1chr1156844363+0.0040714170.9959286
ENST00000476228ENST00000392302TFGchr3100455548+NTRK1chr1156844363+0.0086002680.99139977
ENST00000476228ENST00000368196TFGchr3100455548+NTRK1chr1156844363+0.0081244090.9918755
ENST00000476228ENST00000524377TFGchr3100455548+NTRK1chr1156844363+0.0092079210.99079216
ENST00000476228ENST00000358660TFGchr3100455548+NTRK1chr1156844363+0.0084612430.9915387
ENST00000418917ENST00000392302TFGchr3100451516+NTRK1chr1156844360+0.0056486060.9943514
ENST00000418917ENST00000368196TFGchr3100451516+NTRK1chr1156844360+0.0053231740.9946768
ENST00000418917ENST00000524377TFGchr3100451516+NTRK1chr1156844360+0.0062431840.9937568
ENST00000418917ENST00000358660TFGchr3100451516+NTRK1chr1156844360+0.005839180.99416083
ENST00000490574ENST00000392302TFGchr3100451516+NTRK1chr1156844360+0.0056555280.9943445
ENST00000490574ENST00000368196TFGchr3100451516+NTRK1chr1156844360+0.0053327950.9946672
ENST00000490574ENST00000524377TFGchr3100451516+NTRK1chr1156844360+0.0062698760.9937302
ENST00000490574ENST00000358660TFGchr3100451516+NTRK1chr1156844360+0.0058614280.9941386
ENST00000240851ENST00000392302TFGchr3100451516+NTRK1chr1156844360+0.0040797680.9959202
ENST00000240851ENST00000368196TFGchr3100451516+NTRK1chr1156844360+0.0038216110.9961784
ENST00000240851ENST00000524377TFGchr3100451516+NTRK1chr1156844360+0.0044105910.9955894
ENST00000240851ENST00000358660TFGchr3100451516+NTRK1chr1156844360+0.0041837720.9958163
ENST00000476228ENST00000392302TFGchr3100451516+NTRK1chr1156844360+0.0055993160.9944007
ENST00000476228ENST00000368196TFGchr3100451516+NTRK1chr1156844360+0.0052224310.99477756
ENST00000476228ENST00000524377TFGchr3100451516+NTRK1chr1156844360+0.0062396650.9937603
ENST00000476228ENST00000358660TFGchr3100451516+NTRK1chr1156844360+0.0057896890.99421036

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90362_90362_1_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844360_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_2_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844360_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_3_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844360_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_4_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844360_ENST00000524377_length(amino acids)=596AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_5_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_6_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_7_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_8_TFG-NTRK1_TFG_chr3_100451516_ENST00000240851_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=596AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_9_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844360_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_10_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844360_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_11_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844360_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_12_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844360_ENST00000524377_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_13_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_14_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_15_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_16_TFG-NTRK1_TFG_chr3_100451516_ENST00000418917_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_17_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844360_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_18_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844360_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_19_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844360_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_20_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844360_ENST00000524377_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_21_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_22_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_23_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_24_TFG-NTRK1_TFG_chr3_100451516_ENST00000476228_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_25_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844360_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_26_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844360_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_27_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844360_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_28_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844360_ENST00000524377_length(amino acids)=596AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_29_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=598AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ
REAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID

--------------------------------------------------------------

>90362_90362_30_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_31_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=595AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_32_TFG-NTRK1_TFG_chr3_100451516_ENST00000490574_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=596AA_BP=197
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTL
GGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA
ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT

--------------------------------------------------------------

>90362_90362_33_TFG-NTRK1_TFG_chr3_100455548_ENST00000240851_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=602AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR
QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL
HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNT

--------------------------------------------------------------

>90362_90362_34_TFG-NTRK1_TFG_chr3_100455548_ENST00000240851_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=599AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_35_TFG-NTRK1_TFG_chr3_100455548_ENST00000240851_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=599AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_36_TFG-NTRK1_TFG_chr3_100455548_ENST00000240851_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=600AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_37_TFG-NTRK1_TFG_chr3_100455548_ENST00000418917_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=641AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWE
LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHG
PDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMP
PESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALA

--------------------------------------------------------------

>90362_90362_38_TFG-NTRK1_TFG_chr3_100455548_ENST00000418917_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_39_TFG-NTRK1_TFG_chr3_100455548_ENST00000418917_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_40_TFG-NTRK1_TFG_chr3_100455548_ENST00000418917_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_41_TFG-NTRK1_TFG_chr3_100455548_ENST00000476228_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=641AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWE
LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHG
PDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMP
PESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALA

--------------------------------------------------------------

>90362_90362_42_TFG-NTRK1_TFG_chr3_100455548_ENST00000476228_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_43_TFG-NTRK1_TFG_chr3_100455548_ENST00000476228_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_44_TFG-NTRK1_TFG_chr3_100455548_ENST00000476228_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=638AA_BP=240
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQADTNSTSGDPVEKKDETPFGVSVAVGLAVFA
CLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGE
GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP

--------------------------------------------------------------

>90362_90362_45_TFG-NTRK1_TFG_chr3_100455548_ENST00000490574_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=602AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR
QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL
HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNT

--------------------------------------------------------------

>90362_90362_46_TFG-NTRK1_TFG_chr3_100455548_ENST00000490574_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=599AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_47_TFG-NTRK1_TFG_chr3_100455548_ENST00000490574_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=599AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_48_TFG-NTRK1_TFG_chr3_100455548_ENST00000490574_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=600AA_BP=201
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGQIEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLH
FMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDF
QREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV
HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI

--------------------------------------------------------------

>90362_90362_49_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=645AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIV
LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI
RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL

--------------------------------------------------------------

>90362_90362_50_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_51_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_52_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=643AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_53_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=645AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIV
LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI
RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL

--------------------------------------------------------------

>90362_90362_54_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_55_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_56_TFG-NTRK1_TFG_chr3_100455560_ENST00000240851_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=643AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_57_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=645AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIV
LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI
RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL

--------------------------------------------------------------

>90362_90362_58_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_59_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_60_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=643AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_61_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844363_ENST00000358660_length(amino acids)=645AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIV
LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI
RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL

--------------------------------------------------------------

>90362_90362_62_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844363_ENST00000368196_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_63_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844363_ENST00000392302_length(amino acids)=642AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_64_TFG-NTRK1_TFG_chr3_100455560_ENST00000490574_NTRK1_chr1_156844363_ENST00000524377_length(amino acids)=643AA_BP=244
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKL
TLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDE
INKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEDTNSTSGDPVEKKDETPFGVSVAVGL
AVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH
GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM
PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL

--------------------------------------------------------------

>90362_90362_65_TFG-NTRK1_TFG_chr3_100467811_ENST00000476228_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=514AA_BP=5
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQ
ASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMS
LHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES
ARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLA
GLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLS

--------------------------------------------------------------

>90362_90362_66_TFG-NTRK1_TFG_chr3_100467811_ENST00000476228_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=511AA_BP=5
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQ
ASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMS
LHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ
DFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLH
FVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE

--------------------------------------------------------------

>90362_90362_67_TFG-NTRK1_TFG_chr3_100467811_ENST00000476228_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=511AA_BP=5
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQ
ASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMS
LHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ
DFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLH
FVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE

--------------------------------------------------------------

>90362_90362_68_TFG-NTRK1_TFG_chr3_100467811_ENST00000476228_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=517AA_BP=5
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQ
ASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPE
DGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA
SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMV
YLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWY

--------------------------------------------------------------

>90362_90362_69_TFG-NTRK1_TFG_chr3_100467811_ENST00000481203_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=504AA_BP=
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>90362_90362_70_TFG-NTRK1_TFG_chr3_100467811_ENST00000481203_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=501AA_BP=
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>90362_90362_71_TFG-NTRK1_TFG_chr3_100467811_ENST00000481203_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=501AA_BP=
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>90362_90362_72_TFG-NTRK1_TFG_chr3_100467811_ENST00000481203_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=507AA_BP=
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100455560/chr1:156844363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TFG

Q92734

NTRK1

P04629

FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFGchr3:100451516chr1:156844360ENST00000240851+5897_124193.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr1:156844360ENST00000418917+5897_124193.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr1:156844360ENST00000476228+5897_124193.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr1:156844360ENST00000490574+5897_124193.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455548chr1:156844363ENST00000418917+6897_124236.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455548chr1:156844363ENST00000476228+6897_124236.33333333333334397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844362ENST00000240851+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844362ENST00000490574+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844363ENST00000240851+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844363ENST00000490574+6897_124240.33333333333334401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100451516chr1:156844360ENST00000240851+5810_91193.33333333333334401.0DomainPB1
HgeneTFGchr3:100451516chr1:156844360ENST00000418917+5810_91193.33333333333334397.0DomainPB1
HgeneTFGchr3:100451516chr1:156844360ENST00000476228+5810_91193.33333333333334397.0DomainPB1
HgeneTFGchr3:100451516chr1:156844360ENST00000490574+5810_91193.33333333333334401.0DomainPB1
HgeneTFGchr3:100455548chr1:156844363ENST00000418917+6810_91236.33333333333334397.0DomainPB1
HgeneTFGchr3:100455548chr1:156844363ENST00000476228+6810_91236.33333333333334397.0DomainPB1
HgeneTFGchr3:100455560chr1:156844362ENST00000240851+6810_91240.33333333333334401.0DomainPB1
HgeneTFGchr3:100455560chr1:156844362ENST00000490574+6810_91240.33333333333334401.0DomainPB1
HgeneTFGchr3:100455560chr1:156844363ENST00000240851+6810_91240.33333333333334401.0DomainPB1
HgeneTFGchr3:100455560chr1:156844363ENST00000490574+6810_91240.33333333333334401.0DomainPB1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716510_781392.3333333333333791.0DomainProtein kinase
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817510_781362.3333333333333761.0DomainProtein kinase
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817510_781398.3333333333333797.0DomainProtein kinase
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716510_781392.3333333333333791.0DomainProtein kinase
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817510_781362.3333333333333761.0DomainProtein kinase
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817510_781398.3333333333333797.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716510_781392.3333333333333791.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817510_781362.3333333333333761.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817510_781398.3333333333333797.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716510_781392.3333333333333791.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817510_781362.3333333333333761.0DomainProtein kinase
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817510_781398.3333333333333797.0DomainProtein kinase
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716537_541392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716607_611392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817537_541362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817607_611362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817537_541398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817607_611398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716537_541392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716607_611392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817537_541362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817607_611362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817537_541398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817607_611398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716537_541392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716607_611392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817537_541362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817607_611362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817537_541398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817607_611398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716537_541392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716607_611392.3333333333333791.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817537_541362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817607_611362.3333333333333761.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817537_541398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817607_611398.3333333333333797.0MotifDXXLL
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716516_524392.3333333333333791.0Nucleotide bindingATP
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817516_524362.3333333333333761.0Nucleotide bindingATP
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817516_524398.3333333333333797.0Nucleotide bindingATP
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716516_524392.3333333333333791.0Nucleotide bindingATP
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817516_524362.3333333333333761.0Nucleotide bindingATP
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817516_524398.3333333333333797.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716516_524392.3333333333333791.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817516_524362.3333333333333761.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817516_524398.3333333333333797.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716516_524392.3333333333333791.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817516_524362.3333333333333761.0Nucleotide bindingATP
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817516_524398.3333333333333797.0Nucleotide bindingATP
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716440_796392.3333333333333791.0Topological domainCytoplasmic
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817440_796362.3333333333333761.0Topological domainCytoplasmic
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817440_796398.3333333333333797.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716440_796392.3333333333333791.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817440_796362.3333333333333761.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817440_796398.3333333333333797.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716440_796392.3333333333333791.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817440_796362.3333333333333761.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817440_796398.3333333333333797.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716440_796392.3333333333333791.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817440_796362.3333333333333761.0Topological domainCytoplasmic
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817440_796398.3333333333333797.0Topological domainCytoplasmic
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716424_439392.3333333333333791.0TransmembraneHelical
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817424_439362.3333333333333761.0TransmembraneHelical
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817424_439398.3333333333333797.0TransmembraneHelical
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716424_439392.3333333333333791.0TransmembraneHelical
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817424_439362.3333333333333761.0TransmembraneHelical
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817424_439398.3333333333333797.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716424_439392.3333333333333791.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817424_439362.3333333333333761.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817424_439398.3333333333333797.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716424_439392.3333333333333791.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817424_439362.3333333333333761.0TransmembraneHelical
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817424_439398.3333333333333797.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFGchr3:100455548chr1:156844363ENST00000240851+1897_1240401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455548chr1:156844363ENST00000490574+1897_1240401.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844362ENST00000418917+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844362ENST00000476228+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844363ENST00000418917+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455560chr1:156844363ENST00000476228+1897_1240397.0Coiled coilOntology_term=ECO:0000255
HgeneTFGchr3:100455548chr1:156844363ENST00000240851+1810_910401.0DomainPB1
HgeneTFGchr3:100455548chr1:156844363ENST00000490574+1810_910401.0DomainPB1
HgeneTFGchr3:100455560chr1:156844362ENST00000418917+1810_910397.0DomainPB1
HgeneTFGchr3:100455560chr1:156844362ENST00000476228+1810_910397.0DomainPB1
HgeneTFGchr3:100455560chr1:156844363ENST00000418917+1810_910397.0DomainPB1
HgeneTFGchr3:100455560chr1:156844363ENST00000476228+1810_910397.0DomainPB1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716148_193392.3333333333333791.0DomainNote=LRRCT
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716194_283392.3333333333333791.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716299_365392.3333333333333791.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817148_193362.3333333333333761.0DomainNote=LRRCT
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817194_283362.3333333333333761.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817299_365362.3333333333333761.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817148_193398.3333333333333797.0DomainNote=LRRCT
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817194_283398.3333333333333797.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817299_365398.3333333333333797.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716148_193392.3333333333333791.0DomainNote=LRRCT
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716194_283392.3333333333333791.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716299_365392.3333333333333791.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817148_193362.3333333333333761.0DomainNote=LRRCT
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817194_283362.3333333333333761.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817299_365362.3333333333333761.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817148_193398.3333333333333797.0DomainNote=LRRCT
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817194_283398.3333333333333797.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817299_365398.3333333333333797.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716148_193392.3333333333333791.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716194_283392.3333333333333791.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716299_365392.3333333333333791.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817148_193362.3333333333333761.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817194_283362.3333333333333761.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817299_365362.3333333333333761.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817148_193398.3333333333333797.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817194_283398.3333333333333797.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817299_365398.3333333333333797.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716148_193392.3333333333333791.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716194_283392.3333333333333791.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716299_365392.3333333333333791.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817148_193362.3333333333333761.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817194_283362.3333333333333761.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817299_365362.3333333333333761.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817148_193398.3333333333333797.0DomainNote=LRRCT
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817194_283398.3333333333333797.0DomainIg-like C2-type 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817299_365398.3333333333333797.0DomainIg-like C2-type 2
TgeneNTRK1chr3:100451516chr1:156844360ENST00000368196716116_137392.3333333333333791.0RepeatNote=LRR 2
TgeneNTRK1chr3:100451516chr1:156844360ENST0000036819671690_113392.3333333333333791.0RepeatNote=LRR 1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000392302817116_137362.3333333333333761.0RepeatNote=LRR 2
TgeneNTRK1chr3:100451516chr1:156844360ENST0000039230281790_113362.3333333333333761.0RepeatNote=LRR 1
TgeneNTRK1chr3:100451516chr1:156844360ENST00000524377817116_137398.3333333333333797.0RepeatNote=LRR 2
TgeneNTRK1chr3:100451516chr1:156844360ENST0000052437781790_113398.3333333333333797.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000368196716116_137392.3333333333333791.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455548chr1:156844363ENST0000036819671690_113392.3333333333333791.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000392302817116_137362.3333333333333761.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455548chr1:156844363ENST0000039230281790_113362.3333333333333761.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455548chr1:156844363ENST00000524377817116_137398.3333333333333797.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455548chr1:156844363ENST0000052437781790_113398.3333333333333797.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000368196716116_137392.3333333333333791.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844362ENST0000036819671690_113392.3333333333333791.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000392302817116_137362.3333333333333761.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844362ENST0000039230281790_113362.3333333333333761.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844362ENST00000524377817116_137398.3333333333333797.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844362ENST0000052437781790_113398.3333333333333797.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000368196716116_137392.3333333333333791.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844363ENST0000036819671690_113392.3333333333333791.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000392302817116_137362.3333333333333761.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844363ENST0000039230281790_113362.3333333333333761.0RepeatNote=LRR 1
TgeneNTRK1chr3:100455560chr1:156844363ENST00000524377817116_137398.3333333333333797.0RepeatNote=LRR 2
TgeneNTRK1chr3:100455560chr1:156844363ENST0000052437781790_113398.3333333333333797.0RepeatNote=LRR 1
TgeneNTRK1chr3:100451516chr1:156844360ENST0000036819671633_423392.3333333333333791.0Topological domainExtracellular
TgeneNTRK1chr3:100451516chr1:156844360ENST0000039230281733_423362.3333333333333761.0Topological domainExtracellular
TgeneNTRK1chr3:100451516chr1:156844360ENST0000052437781733_423398.3333333333333797.0Topological domainExtracellular
TgeneNTRK1chr3:100455548chr1:156844363ENST0000036819671633_423392.3333333333333791.0Topological domainExtracellular
TgeneNTRK1chr3:100455548chr1:156844363ENST0000039230281733_423362.3333333333333761.0Topological domainExtracellular
TgeneNTRK1chr3:100455548chr1:156844363ENST0000052437781733_423398.3333333333333797.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844362ENST0000036819671633_423392.3333333333333791.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844362ENST0000039230281733_423362.3333333333333761.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844362ENST0000052437781733_423398.3333333333333797.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844363ENST0000036819671633_423392.3333333333333791.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844363ENST0000039230281733_423362.3333333333333761.0Topological domainExtracellular
TgeneNTRK1chr3:100455560chr1:156844363ENST0000052437781733_423398.3333333333333797.0Topological domainExtracellular


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (302) >>>302.pdbFusion protein BP residue:
CIF file (302) >>>302.cif		TFGchr3100467811+NTRK1chr1156843424+
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANE
TVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPED
PIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRR
NKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQ
YFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKA
LKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG
DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLH
FVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMP
PESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE
LERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL
501
3D view using mol* of 302 (AA BP:)
PDB file (311) >>>311.pdbFusion protein BP residue:
CIF file (311) >>>311.cif		TFGchr3100467811+NTRK1chr1156843424+
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANE
TVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPED
PIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRR
NKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQ
YFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA
VKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYM
RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLA
GLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ
GRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYL
504
3D view using mol* of 311 (AA BP:)
PDB file (318) >>>318.pdbFusion protein BP residue:
CIF file (318) >>>318.cif		TFGchr3100467811+NTRK1chr1156843424+
MHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANE
TVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPED
PIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVL
NKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGH
IIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKM
LVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVF
EYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMV
YLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML
PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC
ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPP
507
3D view using mol* of 318 (AA BP:)
PDB file (320) >>>320.pdbFusion protein BP residue: 5
CIF file (320) >>>320.cif		TFGchr3100467811+NTRK1chr1156843424+
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIF
TEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTL
LLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSG
LQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE
QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPL
LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVA
AGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGG
RTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE
AIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALA
511
3D view using mol* of 320 (AA BP:5)
PDB file (328) >>>328.pdbFusion protein BP residue: 5
CIF file (328) >>>328.cif		TFGchr3100467811+NTRK1chr1156843424+
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIF
TEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTL
LLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSG
LQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNL
LPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEG
RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS
QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR
VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLS
NTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ
514
3D view using mol* of 328 (AA BP:5)
PDB file (334) >>>334.pdbFusion protein BP residue: 5
CIF file (334) >>>334.cif		TFGchr3100467811+NTRK1chr1156843424+
MIESIPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIF
TEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC
LFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPT
EGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAEC
HNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVC
TEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA
VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD
YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWY
QLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA
517
3D view using mol* of 334 (AA BP:5)
PDB file (463) >>>463.pdbFusion protein BP residue: 197
CIF file (463) >>>463.cif		TFGchr3100451516+NTRK1chr1156844362+
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRG
KLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRP
LESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREE
KSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSDTN
STSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGIN
RPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDAC
VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASE
SARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILY
RKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA
595
3D view using mol* of 463 (AA BP:197)
PDB file (468) >>>468.pdbFusion protein BP residue: 197
CIF file (468) >>>468.cif		TFGchr3100451516+NTRK1chr1156844362+
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRG
KLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRP
LESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREE
KSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSDTN
STSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGIN
RPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDAC
VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASE
SARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL
RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILY
RKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA
596
3D view using mol* of 468 (AA BP:197)
PDB file (471) >>>471.pdbFusion protein BP residue: 197
CIF file (471) >>>471.cif		TFGchr3100451516+NTRK1chr1156844362+
MESTMNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRG
KLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRP
LESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREE
KSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSDTN
STSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGIN
RPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDAS
PSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE
ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLN
RFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH
RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES
ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELER
598
3D view using mol* of 471 (AA BP:197)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
NTRK1_pLDDT.png
all structure
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check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TFG_NTRK1_302_pLDDT.png (AA BP:)
all structure
TFG_NTRK1_302_pLDDT_and_active_sites.png (AA BP:)
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TFG_NTRK1_302_violinplot.png (AA BP:)
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TFG_NTRK1_311_pLDDT.png (AA BP:)
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TFG_NTRK1_311_pLDDT_and_active_sites.png (AA BP:)
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TFG_NTRK1_311_violinplot.png (AA BP:)
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TFG_NTRK1_318_pLDDT.png (AA BP:)
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TFG_NTRK1_318_pLDDT_and_active_sites.png (AA BP:)
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TFG_NTRK1_318_violinplot.png (AA BP:)
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TFG_NTRK1_320_pLDDT.png (AA BP:5)
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TFG_NTRK1_320_pLDDT_and_active_sites.png (AA BP:5)
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TFG_NTRK1_320_violinplot.png (AA BP:5)
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TFG_NTRK1_328_pLDDT.png (AA BP:5)
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TFG_NTRK1_328_pLDDT_and_active_sites.png (AA BP:5)
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TFG_NTRK1_328_violinplot.png (AA BP:5)
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TFG_NTRK1_334_pLDDT.png (AA BP:5)
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TFG_NTRK1_334_pLDDT_and_active_sites.png (AA BP:5)
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TFG_NTRK1_334_violinplot.png (AA BP:5)
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TFG_NTRK1_463_pLDDT.png (AA BP:197)
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TFG_NTRK1_463_pLDDT_and_active_sites.png (AA BP:197)
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TFG_NTRK1_463_violinplot.png (AA BP:197)
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TFG_NTRK1_468_pLDDT.png (AA BP:197)
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TFG_NTRK1_468_pLDDT_and_active_sites.png (AA BP:197)
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TFG_NTRK1_468_violinplot.png (AA BP:197)
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TFG_NTRK1_471_pLDDT.png (AA BP:197)
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TFG_NTRK1_471_pLDDT_and_active_sites.png (AA BP:197)
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TFG_NTRK1_471_violinplot.png (AA BP:197)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
TFG_NTRK1_302.png
all structure
TFG_NTRK1_311.png
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TFG_NTRK1_318.png
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TFG_NTRK1_320.png
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TFG_NTRK1_328.png
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TFG_NTRK1_334.png
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TFG_NTRK1_463.png
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TFG_NTRK1_468.png
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TFG_NTRK1_471.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
3021.0354641.0761468.040.5560.7050.9030.880.8820.9980.969Chain A: 166,167,168,169,170,171,172,173,174,175,1
76,177,178,192,193,194,195,197,198,199,200,202,203
,204,205,224,225,226,249,251,252,257,258,261,262,2
64,265,267,268,269,272,277,278,280,294,346,351,352
,353,354,355,371,372,373,374,375,377,378,379,381,3
82,385,386,388,389,391,392,393,394,395,396,399,404
,405,406,407,408,409,439,442
3111.0114211.0381132.2430.5750.6960.9090.5820.980.5940.865Chain A: 9,28,29,36,37,38,39,60,61,62,63,64,65,66,
67,91,92,97,98,99,224,225,226,232,250,299,300,301,
302,303,304,307,308,310,311,312,313,314,315,316,31
7,318,320,321,322,325,362,363,365,377,379,380,383,
384,419,426,429,430,431,433,434,436,437,438,439,45
1,452,453,454,455,456,457,458,459,465,469,472,473,
474,475,499,500,501,502,503
3181.0384101.037985.0960.5350.7560.9680.7111.0940.650.85Chain A: 4,5,6,7,8,171,172,173,174,175,176,177,178
,179,180,181,182,183,184,198,199,201,203,204,205,2
06,207,208,209,229,230,231,232,255,257,258,268,270
,271,273,274,275,277,278,283,284,285,286,298,300,3
52,357,359,360,361,366,377,378,379,380,381,384,385
,394,395,397,398,399,400,401,405,413,415
3201.0582341.074629.4050.4810.7811.020.8711.0270.8480.828Chain A: 177,178,180,181,182,183,184,185,186,202,2
03,205,235,236,259,261,262,263,268,271,272,275,302
,363,364,365,383,384,385,388,395,401,402,403,404,4
05,417,418,419
3281.0384901.0571318.1490.5430.7470.9780.6411.0170.630.779Chain A: 15,16,17,18,19,20,21,52,54,66,68,70,71,72
,99,100,101,232,233,234,235,236,237,240,242,260,26
2,291,307,309,310,311,312,313,314,317,318,320,321,
322,323,324,325,326,327,328,329,330,331,332,335,34
0,341,342,345,372,373,375,389,390,391,392,393,394,
436,439,440,441,443,444,446,447,448,463,464,465,46
7,468,469,509,510,511
3340.99815101.01651409.730.61650.69520.88510.5041.04490.48240.7989Chain A: 12,13,14,15,16,17,18,19,20,52,53,54,55,56
,57,58,60,62,63,64,65,66,68,69,70,71,72,95,96,97,9
8,99,100,227,228,229,231,232,233,235,236,237,238,2
39,243,244,245,246,247,261,263,266,267,268,269,270
,275,301,302,303,304,305,306,307,311,312,313,314,3
15,316,317,319,320,321,323,324,325,326,328,329,330
,331,333,334,335,336,338,373,374,375,376,378,390,3
92,393,395,396,397,399,400,414,440,444,445,446,447
,448,450
4631.03931951.0696731.2760.65490.72840.86490.76590.9430.81221.003Chain A: 289,290,291,292,295,296,319,320,343,345,3
46,347,352,355,356,358,359,362,363,366,371,372,373
,374,386,388,440,444,445,446,447,448,449,454,465,4
66,467,468,469,472,479,487,488,489,501,502,503
4681.03032501.04607.7960.54710.74330.95820.84231.06150.79350.8434Chain A: 262,263,264,265,266,267,268,269,295,296,2
97,299,300,301,303,320,343,345,353,354,355,356,357
,358,359,360,361,362,377,379,384,386,445,447,448,4
49,454,467,468,469,471,472,479,486,487,488,489,501
,503
4711.1012471.149555.660.4410.7781.0681.3280.7911.6781.037Chain A: 260,261,262,263,264,265,266,267,268,269,2
70,271,272,273,289,321,322,323,324,354,355,357,358
,361,450,451,452,457,470,471,472,473,474,475,476,4
78,479,482,484,488,489,490,491,492,504,506

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NTRK1ABL1, NGF, MATK, PLCG1, GRB2, CAV1, NTF3, SQSTM1, SH2B1, SHC1, SH2B2, ARHGAP32, FRS2, NTRK1, RAP1A, SHC3, GIPC1, RGS19, PTPN1, TRAF6, NEDD4, CBL, HSP90AA1, HSPA4, CDC37, NEDD4L, MYC, SGSM3, SORBS1, TNK2, SNX17, SNX27, GAREML, SOS2, PIK3CA, GAREM, PIK3C2B, ARHGEF40, PIK3R1, PIK3R2, SOS1, PIK3CB, PML, UBC, AMFR, CBLB, GAB1, EPN1, PIK3C2A, ANKRD13A, DOCK4, TRIO, LGR5, WRNIP1, RABEP1, PDGFRA, KANK2, RABGEF1, VAV2, TBC1D15, PTPN11, GAK, IRS2, PCDHGC3, EPS15, LRRN3, HUWE1, ACVR1B, MIB1, OFD1, PIBF1, ZNF497, TXN, CAT, FABP3, JUP, DSG1, TGM1, CFL1, LCN1, HIST2H4A, DSP, PFN1, LGALS3BP, HIST1H2BL, LTF, S100A9, IGLL5, TGM3, DSC1, LYZ, DCD, LEKR1, ENO2, PPIA, BTN1A1, XRCC5, XRCC6, HLA-A, GSTP1, ABCB7, PA2G4, PRDX1, HDGF, HSPA4L, TBC1D10B, HP1BP3, KIF26B, SYT4, RHOBTB3, NOTCH3, GAB2, ATAD3A, RBM15B, KCNH2, USP15, PDCD11, RBFOX2, RBM14, RNF31, ADNP, ZC3HAV1, MAP7D1, USP4, JAK1, PTPRS, PDGFRB, HIST1H1C, USP11, PPFIBP1, INTS6, VGF, ARHGEF11, SMPD4, SYNPO2, HNRNPM, SLC27A4, DDX41, EGFR, H1FX, ASAP1, HIST1H1B, RRBP1, EPHA2, KIDINS220, CPT1A, UNC5B, IGF1R, DDR2, AUP1, XPR1, RP9, MARK2, REPS1, EMD, SMARCA4, DDX21, DAB2IP, C7, MSTO1, CDC27, ZNF629, ASAP2, NCAPH2, SRBD1, ATAD3B, TCF12, PLEKHA6, INPPL1, PRPF4B, DPM1, SMARCA1, FIP1L1, DLGAP5, PLEKHH3, TRA2A, ACIN1, DDX10, TAX1BP1, SMARCA5, RABEP2, DDX5, MYO1C, SRSF10, DNAJA2, RET, TRA2B, MYEF2, PNPLA6, SLC12A2, TAF6L, RSL1D1, ARAP3, DDX18, ABL2, KHDRBS1, CERK, SRSF7, SPTLC2, PBXIP1, DNAJA1, IQGAP3, DDX31, ZC3H11A, PLRG1, CNP, FMR1, HIP1R, KIAA1429, CDC5L, ARAP1, ZNF316, SMARCC2, EML5, VANGL2, SLC25A1, UNC5C, SLC16A1, RFC1, ZKSCAN1, CHD1, PTK7, SMARCD2, AP3B1, YTHDC2, AKAP8L, RPL15, CTNND1, PHLDB1, ZNF574, DDX27, TOM1, RASA1, MORC2, MTCH2, IMMT, SMARCC1, ROR2, CAPN2, DNAJC11, SYT11, AP2A1, LBR, MEPCE, NCAPD3, CEP97, QKI, LRRC41, LPCAT2, EPS15L1, LAS1L, TMEM131, CWF19L2, NCAPG2, MAP4K5, CCP110, ARHGEF2, ITGAV, ZC3H18, CWC22, VIM, FAM171A1, TMEM132A, SRSF9, SOGA1, NKRF, RBL1, FMNL3, TOP1, PIGT, RBM15, GBAS, EDC3, WDR5, NOP2, GNL2, SLC25A11, RRP1B, FAM115A, INTS5, SLC25A5, AAK1, HERC5, CCNT1, FERMT2, CDC42BPA, MRPL28, UBAP2, WWP2, SEC24B, HNRNPU, GPD2, FXR2, DHX15, SLC25A22, SSR1, PLXNB2, PROX1, TEX10, USP19, FTSJ3, TMEM59, GTF3C2, PGAM5, CPSF1, KLHL22, TMX3, SIN3A, NOP58, PTCD3, RPRD2, DHX9, PICALM, FARP1, SLC25A6, ERLIN2, SMARCD1, RHOT1, ALDH1B1, SGPL1, USP9X, HNRNPF, KIAA1211, MAPK7, DDX17, GSE1, DVL3, MRPL44, DNAJB6, GTPBP4, HNRNPA0, PLXNA4, SFXN3, NAT10, DDX28, SNW1, MYO6, MRPL24, PRRT4, FAM98A, PURA, DHX29, C1QBP, TRIP4, TBK1, RBM28, ZNF609, POLRMT, PCDHB3, XRN1, HSD17B11, DKC1, DHX30, CDK13, SENP3, LPHN2, GPATCH4, NDUFA9, RASA4, MCCC1, DDX24, RPL14, RPS8, ATG2B, MYO1B, PTPN12, CEBPZ, ILVBL, RALY, KIF14, ZC3H7A, MOV10, MAP4K4, DHX57, RBMX, FXR1, MRPS35, SART1, MARK3, DECR1, CCDC88A, ANKLE2, PRPF31, LARP7, RPL10, PACS1, RPL13, FAM120A, SLC25A13, ADAR, CDK1, HNRNPR, CSNK1E, DLG1, LEMD3, NOL9, IFT122, NCLN, STK11IP, GATAD2B, CHERP, LARP4, MAP3K1, HNRNPUL2, PPIL2, ESYT2, MYH10, RPL8, UQCRC2, NDUFA10, HAX1, HELLS, MED14, RBM42, CHCHD3, RPL7, ABCD3, TUBGCP6, MRPS9, SNRNP200, IGF2BP3, LRCH3, MRPL3, RSBN1L, SAFB, TUBG1, ALDH16A1, ARHGEF12, EPB41L5, AP2A2, SRSF6, HLTF, PTPLAD1, TMPO, AGO2, POP1, RPS9, HDAC6, ILF3, VWA8, ABCB1, SCRIB, GTF3C5, YBX1, RBM4, PTPN9, PRPF8, BRD3, TRIM24, CLASP2, MADD, TCF4, MAP4K3, TSC2, DDX23, RPL7A, RRP12, PRKD2, TRMT1L, EDC4, CSTF3, RPS2, NDUFS2, RPL13A, PTPRR, ATP7A, EXD2, IK, HIP1, MATR3, IGSF3, PTPRF, SPATA5L1, EFTUD2, RPS3A, TUBGCP5, TTN, GIT1, PATL1, NUP160, PDE4B, SUN2, PTPN23, RPS6, DCP1A, CDC73, MEX3A, EIF2AK2, RPL3, PPP1R10, SRP72, ELAVL3, NOM1, RPL18, CEP170, THRAP3, MED17, MRPS7, DDX20, PDPR, SH3PXD2A, DBN1, DAP3, OAS3, STT3B, COPE, MED12, AP3D1, CAPRIN1, PHB2, U2SURP, BSG, TECR, FARSA, HSD17B12, RPL4, HNRNPUL1, PPFIA1, MRPS22, TBL3, GNL3, MTA2, CPSF2, ATP2B1, AP3B2, PPIP5K2, DDX56, ASCC3, FMNL2, SMCHD1, MYBBP1A, SRPK2, RHOT2, SRP68, PUM1, SLC25A3, SRPK1, RPL19, BEND3, SEC61A1, LSG1, NOC3L, TNKS1BP1, GTF3C3, TUBGCP3, PRPF40A, TRMT10C, URGCP, XRN2, MSH3, XRCC1, GEMIN4, DIS3L2, BCLAF1, SBF2, DHTKD1, ATXN2, ARID4B, TOR1AIP1, RPL29, NAA16, PRPF6, KIFAP3, TMEM33, WASF2, NACAD, LIG3, POLE, CKAP4, TCEB3, MTA1, GNA13, DHX38, PHF6, ELAVL4, DDX3X, CTR9, PRPF19, CAMSAP2, PRMT3, SH3PXD2B, SCAF8, MAGED1, ILF2, TONSL, PPP1R12A, SRSF5, KIAA0020, PTBP1, CAD, ACSL3, CHD1L, STAU1, MRPL38, DVL2, GNAI3, RPL10A, RPL6, MRPS5, CDK11B, MRPS34, PES1, ATP5C1, STXBP3, HNRNPLL, CHTF18, VPS39, SART3, COPA, PRPF3, UBE2O, ABCF2, HNRNPH3, EARS2, DHX40, ARHGEF7, EMC1, CASK, PTK2, SORT1, OGT, ATP12A, LMNB1, SLC4A7, PFKP, VDAC2, RBM25, ATL3, DHX36, TFIP11, EXOSC10, GTF3C1, SRSF1, PPP6C, TRAPPC9, RAD21, DNAJC13, ACOT1, ZC3H4, SRRM1, NDUFS3, DYRK1A, INTS1, SF3B2, EHHADH, MYO9B, ASCC2, WDR11, RPN1, EHD4, WDR91, SMARCAL1, NBAS, PI4KA, PAF1, EIF2B4, NUP107, EMC2, SYNE1, KLHL13, TBL1XR1, DNAJC10, SEC16A, METTL13, C7orf50, CDC42BPB, CLCN5, PGM3, DOCK7, ALYREF, POLR3A, TOP3A, WDR48, WDR81, DOCK1, CSNK2A2, CYC1, TLE3, THOC2, EIF2S3, MYO5A, SNX9, TARDBP, NAP1L4, CRKL, YTHDF2, PYGB, PABPC1, LTV1, PSMD4, KTN1, UBTF, WDR6, FUBP3, UBXN7, PHB, PDXP, CNOT3, TBL2, LLGL1, PLOD1, AHSA1, AAAS, ERGIC1, LARP4B, CYFIP1, DNM1, TARS2, ACSL1, ATXN1L, WDR59, SUCLA2, MLH1, CSNK2B, SYNCRIP, WDR36, FAM91A1, MTDH, UBE3C, CAPN1, BRIX1, DNAJB11, EDEM3, PLOD3, CLASP1, DPYSL3, MED16, NONO, EPM2AIP1, NT5DC2, ADRBK2, RPTOR, TELO2, MRPL37, PRKACB, ELMO1, TRAPPC8, ANAPC1, NIPSNAP1, EWSR1, PIK3R4, POLD1, IQGAP1, PRRC2A, COG1, ANKRD44, TFRC, DIEXF, FHOD1, SERPINH1, SPATA5, MED1, ABCF3, ZSWIM8, LMNA, HAT1, PABPC4, SMC4, HADH, RNGTT, TUBGCP2, ZNF598, SKIV2L2, GNB2L1, LARP1, DIP2B, BCR, IDH3B, LSM14A, FBL, NDUFS1, APPL2, USP39, SMC2, HCFC1, LANCL1, POLR2B, UPF2, CCBL2, MRPL15, MAGED2, AGK, GNPAT, AIMP1, GTF3C4, KDM1A, SCAMP3, RDH11, SRGAP2, CRNKL1, RFC5, PFKL, SPTBN1, PHOX2A, VDAC3, HNRNPA1, WDR26, DNM2, HAUS5, LCMT2, MCM7, CLINT1, UGDH, ACO1, TRIM46, PHKB, USP10, PCF11, YTHDF3, AARS2, FIGNL1, SFPQ, ATP5A1, NUP133, CPSF3, ANKRD28, PNN, C9orf64, ABCF1, ATL1, NAP1L1, HSPA9, MCCC2, FKBP5, CNOT1, TAF6, NEMF, UHRF1, SDHA, PELP1, HADHB, OAT, NEK9, AP3M1, PRKCA, LPCAT1, MRPL39, AFG3L2, WASF1, HNRNPL, RALGAPB, HK1, GBA, PLD3, CPSF7, HADHA, PDE12, DCX, LIMA1, HNRNPA2B1, POLR2A, MYH9, ZNF207, DDX55, ELP3, EIF2B5, MICAL1, TTI1, NES, HSDL1, GPSM1, PPM1F, C4orf27, SRRM2, OSBPL9, STAT3, IRF2BPL, KLC2, P3H1, STAT5B, UQCRC1, PCK2, CCAR2, TBC1D5, SACM1L, QARS, XPO4, CHD4, KIF2A, TACC3, NCL, BTAF1, RARS2, NCKAP1, EIF3D, RPS3, YME1L1, EIF4A3, HAUS6, HNRNPDL, MON2, G3BP2, WDHD1, CSNK1A1, SDAD1, RPS25, LSM14B, AP1M1, CCDC47, HNRNPK, DNMT1, NUP85, CUL5, TANC1, STAT1, COG5, STOML2, CDC45, OSBPL11, CIC, ABCD2, ARFGEF1, TROVE2, GBF1, SRPRB, UBE3A, GTPBP1, SCCPDH, RPS4X, PRPF4, ACTL6A, CCAR1, KIAA1033, TRAPPC12, HNRNPA3, FASTKD5, LYN, VPS18, PGRMC2, NUP214, AIFM1, TSG101, PPP6R3, OCRL, GANAB, IARS, SARS2, ATP2A2, EXOC1, NCAPH, TTC27, GNE, SRC, MIOS, ZCCHC8, GOLGA2, CARM1, ABCC1, PRMT5, LEO1, LMNB2, USP8, DARS, GYS1, APEH, ZYG11B, AKAP1, ELAVL1, MCM5, LRWD1, PSMC1, MOGS, TRIM28, EXOC6, LUC7L3, ANKFY1, NSUN2, HDAC2, G3BP1, QRICH1, INTS3, UBR1, XAB2, DYNC1LI1, TUFM, GAA, EXOC8, DHX8, LIMCH1, CLTC, SRPR, RNH1, ABI2, AQR, PREP, PPM1E, COG2, SEPT9, IDH2, MFN2, EXOC4, VPS33B, INTS4, GNB1, MSH6, HNRNPC, ERLIN1, EPRS, LRRC49, RPAP1, MCM3, PSMC4, PSMD3, GNL1, TRIP13, CUX1, PFAS, MAP1S, LRCH1, MRPL19, ABCD1, EIF3F, PDS5B, SMC3, KIF4A, FANCD2, IRF2BP1, SMC1A, RNF20, CLPX, NOC2L, DLAT, CTBP1, APPL1, NAA35, VPS45, PUM2, RELA, NUP210, RANBP9, DNAJC9, WRN, PRKAA1, AIMP2, VPS8, MAD1L1, MRE11A, ATP13A1, ATG7, CEP131, TRIM33, SLC25A10, HERC4, LRRFIP1, POLR1C, IPO9, GEMIN5, METAP2, SMG8, WASL, PPP1CB, SCFD1, RANBP3, RB1, CLTA, RNF40, SNRNP70, NCSTN, MGEA5, NARS, EIF4E, INPP4A, TFB2M, SEL1L, ARGLU1, PPP4R1, ANKRD17, TTK, RAD50, KIF2C, GOLGA3, TRAPPC11, GIGYF2, MSI2, CYFIP2, CDK5, HBS1L, IFT81, UFL1, PFKM, SMARCAD1, WDR35, PRIM2, NAMPT, PSMD2, MSH2, SOGA3, HEATR6, SFXN1, ARCN1, OGDH, FDPS, PSMC5, INSR, IRF2BP2, DDOST, ATXN2L, CSNK2A1, EIF2S2, MAP4, LTN1, COPB1, BRAT1, SMC6, SNRPN, RIC8A, SKIV2L, EIF4A1, KIF15, CLPTM1L, KPNA1, VPS16, VPS26B, RNPEP, RBM39, PMS1, FAM129B, RFC3, NUP155, RBM26, KIF21A, GAPVD1, C2CD5, WAPAL, RPS13, ARHGEF1, ACTR1A, KLC4, ISLR2, DCK, LRRC8A, STT3A, BOP1, RPN2, AFTPH, ORC3, FOXK1, CD2BP2, PDHA1, PPP6R1, PANK4, KIAA0196, WDR77, CHUK, DDX1, COLGALT1, VAPA, PPME1, CAMSAP1, RABL6, RTCB, SRRT, PIK3C3, NUMA1, STXBP1, OTUB1, UBAP2L, EXOC5, LRRC59, EXOC3, RQCD1, FLII, COPG2, USP5, XPOT, TIMM44, ATP1A1, SBF1, ARPC1B, PLK1, OSBPL8, BAG6, PPP6R2, FAM98B, VPS52, FADS2, EIF4G2, EIF4G3, HSPA8, POLR1B, PSMC6, SFSWAP, VPS33A, MCM10, AVL9, RINT1, PPIB, FBXL18, MFAP1, KIF13B, ATP2C1, ERCC2, CTTNBP2NL, WDR82, VARS, KPNA6, MIA3, HEATR1, SEC23B, AASDHPPT, POLR3B, ALDH18A1, PIKFYVE, MPP6, MRI1, CAPN7, RAB3GAP2, NCAPD2, UGGT1, IKBKAP, KDM3B, CLNS1A, FEN1, ECH1, AP2B1, HNRNPH1, RARS, AGPS, FANCI, PYCR2, EHD1, BUB3, KIF5B, SYMPK, PC, ACAA2, NDC80, PRRC2C, MTHFD1L, FASN, RANBP6, VPS11, NUP93, STRN, SCYL1, DDX19A, GTF2I, SEC23A, CTNNB1, STAM, VPRBP, VCL, PDHB, SEC24D, ERCC4, GRN, ACADM, HSPA6, ERCC6L, RPL5, ARHGAP17, DDX6, MAPK8IP3, TJP1, RIOK1, ERP29, PARG, NUP205, PALLD, COG4, TPP2, EPB41, VAC14, FUS, ZW10, KIF11, GET4, MCM6, EIF2S1, CSDE1, DHX16, GFM1, RABGAP1, TTC28, XPO1, EXOC2, DCTN1, ACBD3, RFC4, PARP1, COPG1, GPRIN1, EIF3C, CUL1, C14orf166, RTL1, STRIP1, MRPS2, PPP2R5D, EIF4G1, EXOSC4, MCM4, SEC63, WDR1, CUL4B, CRMP1, NSF, RNMT, BLVRA, UBE4A, PCBP1, MLLT4, RNF214, ARVCF, CKAP5, NUP188, SMCR8, CTNNA1, SYT1, PCM1, KNTC1, GFPT1, THYN1, SARM1, LPIN1, TIA1, NUP54, PKN1, SUMO4, DICER1, KIF3A, IPO8, CLIC4, PSMD14, GLG1, ABCE1, SMEK1, NCAPG, PPP5C, RTF1, IARS2, PDS5A, PHGDH, RPS6KA3, LONP1, ROCK1, CDK6, LARS, KPNA3, HNRNPAB, MCM2, PPP2R2A, HSP90AB2P, VCPIP1, PCBP2, RPA1, SEC24A, HECTD3, RCC2, DIS3, SMS, KHSRP, CLGN, GNAS, FOCAD, SEC23IP, ACOT7, HK2, CCDC6, MFN1, WDR7, CNN3, KIAA1524, RAB3GAP1, OXCT1, SBNO1, PRPSAP2, ACTR3, CTPS2, TMEM43, FAM21A, LRRC47, VAPB, SCYL2, STRN4, NAE1, SREK1, TFG, SF3A1, CDK2, GPKOW, GPHN, PDCD4, U2AF2, UNC45A, VPS35, NAA15, ASNS, TOP2B, ACO2, AGAP3, ROCK2, NUDT21, NPEPPS, ADD1, AP1G1, CPSF6, DNAJC2, RPS5, CTPS1, IDH1, SEC24C, KIF3B, ACTR2, CPD, EEF1D, SAMHD1, ETFB, DNM1L, LRPPRC, MCMBP, RBM12, OPA1, FARSB, UPF1, PCMT1, USO1, COG3, CLPTM1, TLK2, PRUNE, ASPSCR1, MARS, PYCR1, TCERG1, MED23, PITPNB, ARPC2, UBE4B, DBR1, ETFA, BICD1, KLC1, WDR70, PXDN, DPYSL4, USP7, CLUH, TBRG4, OGFR, SV2A, PDCD6IP, PDLIM5, PSMC2, TRAP1, DRG1, SMEK2, TCP1, TNPO2, CALD1, ARIH2, POR, FKBP3, DCTN2, NPM1, USP48, IPO13, NUP88, NNT, TAOK1, PPWD1, PSPC1, PABPN1, POLA1, MTR, BCCIP, RUVBL2, C16orf62, SORD, PPP2CA, STRN3, RUVBL1, PPP1CA, CACTIN, RPAP3, VPS51, TUBB3, PRKDC, HSPA5, CCDC132, MRPS27, RBBP4, CAPZA1, SLC4A1AP, THUMPD3, FAF1, CDK4, GSTO1, NCBP1, CAPZB, SNRPA, TXLNG, NELFE, MUT, DYNC1LI2, CTTN, DYNC1I2, TIMELESS, CBS, TTLL12, ESYT1, LAMB1, KARS, PPIL4, LRRC40, TXLNA, RAD23B, TBCE, ACAD9, THADA, GCN1L1, SLK, PNKP, ACLY, ATP6V0A1, VTA1, TXNDC5, OXSR1, ACACA, TNPO3, CCDC93, TIPRL, RAN, HOOK3, PSME4, YWHAQ, PPM1G, PSMC3, SCARB2, EXOC7, DFNA5, TRMT6, CPNE3, SLC3A2, G6PD, EIF2B1, SF3B1, EXOC6B, HGS, DYNC1H1, DNAJC7, CANX, TSR1, TTC37, DARS2, ZPR1, SERBP1, HSP90AB1, TBCB, UCHL5, IMPDH2, PUF60, RANGAP1, PDXDC1, YWHAH, LARS2, ZC3H15, GMPS, YWHAG, SUPV3L1, SPAG9, IMPDH1, HSD17B10, GTF2F1, EXOSC9, CUL3, ARHGAP35, TUBB4B, EIF5B, KIF5C, PDIA6, LDHA, ATL2, SNX1, SF3B3, SRM, MAP2, DIAPH1, DBH, NHLRC2, ELP2, GRPEL1, TWF1, WBP11, ERP44, SERPINB6, VCP, HSPH1, CMTR1, KIF1A, USP47, EML4, PRMT1, ATP6V1B2, GPS1, CAND1, CLPB, PCNA, RPLP0, CORO7, TUBB, ANXA2, API5, SUPT16H, RUFY1, KIAA1279, PDIA3, ACTA1, SF3A3, DCTN4, CUL2, WARS, PGM2, NELFB, XPO5, UGP2, HSP90B1, GSR, SHMT2, IPO11, EIF3E, RDX, DNAJB1, KIAA1598, AARS, EFTUD1, HEATR5B, ENAH, TNPO1, LIG1, NRD1, DLD, STRA6, PAFAH1B1, NT5C2, SSRP1, NTRK3, HDGFRP2, EIF3G, CSE1L, ACAT1, TBCD, NAA10, MTHFD1, RALA, EIF3A, PRPS1, ISOC1, IPO7, HNRNPD, GAPDH, U2AF1, SUPT5H, PSMD8, RPS6KA1, NUF2, GDAP1, VPS26A, TUBB2B, CDH2, TMOD1, CBR1, HDLBP, CS, HSPD1, LMAN1, EIF3B, DDB1, PSMD1, DPYSL2, STRAP, RTN4, FLNA, AHCY, HSD17B4, GOLIM4, SPTAN1, IPO4, PKM, EIF3I, SF1, BZW2, XPO7, ACADVL, STAG2, DPP9, RECQL, GDI1, GARS, MMS19, EIF2A, IPO5, TCOF1, RAB5C, SAP30BP, VDAC1, TUBA1A, SEPT2, DBNL, PLAA, TOMM70A, NOMO1, ISYNA1, CTNNA2, EEF1B2, PAK4, NELFCD, GSPT1, KPNB1, MAP1A, COPS4, YWHAZ, KPNA2, EIF4B, PLS3, COPS3, HSPBP1, AP1B1, NASP, DDX39A, LUC7L2, APMAP, SEC31A, SRSF2, TXNRD1, ATP1A3, RRM2, COG7, FSD1, PRDX4, DCPS, NCAM1, NUDCD1, NAA25, RPL9, NPLOC4, YWHAB, ATP1B1, LSS, DNAAF5, METTL16, COPS6, XPNPEP1, ELAC2, PUS7, CCT3, SFN, AGL, PAPOLA, SRSF11, ALDH2, PSME2, CKMT1B, LDHB, PSMA7, RAB11A, PPP2R1A, GNAO1, LUC7L, COPS5, IMPA1, RRM1, PPID, DPP3, KIAA0368, SLC1A5, YARS, NUP50, TPM4, ITGB1, SARS, SEZ6L2, GTF2F2, GART, ALDOC, PSMD11, EIF6, DFFA, RAP1GDS1, NELFA, CARS, CCT4, P4HB, FSCN1, PSMD13, PSMA5, CCT5, PAPSS1, OSBP, SAE1, ATP6V1A, LMAN2, YWHAE, SRP54, IDE, SNX2, RPSA, BZW1, SND1, UBQLN1, MAPK1, CALR, MARCKSL1, SUGT1, TBC1D4, GLRX3, LETM1, HMGB1, EIF3H, SLC9A3R1, DDX42, LAP3, PRKCSH, EEF2, PSMD6, BCAP31, ANXA11, ACTN1, CCT6A, PSMA4, ANXA5, CCT7, EIF3L, FUBP1, SSB, PGM1, MAPRE1, UBA2, AMPD2, PPAT, CLIC1, CCT2, ECHS1, LTA4H, USP14, CCT8, ANK2, PDIA4, TPR, NRCAM, MAT2A, HTATSF1, THOP1, RANBP1, RSRC2, NMT1, AK2, EEF1G, TPM3, PSMA3, EIF4H, GLUD1, CAP1, TKT, ATP5B, TXNL1, STIP1, HMGB2, GGH, HSPB1, CALU, RPL17, PSMA1, RSRC1, ST13, PRDX6, EIF3J, PNPT1, APEX1, TARS, MARCKS, PSMA6, EEF1A1, COPB2, NUDT5, HSPA1A, ERO1L, ME2, RPH3A, ESD, EIF5, ADSL, RUFY3, DPYSL5, ANXA6, NUDC, NANS, GOT2, GLDC, PSAT1, SET, PAK2, UBA6, UCHL1, L1CAM, PGLS, MAP1B, CCDC124, EIF3M, VAT1, PAFAH1B3, ALDOA, IRGQ, UBQLN2, NACA, OLA1, ACTN4, ARHGDIA, PSMD7, CACYBP, PSMA2, CPNE1, MDH2, PGAM1, DDX46, ACAT2, ALCAM, HARS, CKB, FKBP4, ASNA1, GPI, INA, HYOU1, CHGA, MDH1, EZR, ANP32A, UBA1, ARG1, ANP32B, PAICS, ATIC, TPI1, PPA1, TALDO1, PGK1, DDX39B, TLN1, AKR1B1, ENO1, NGFR, TPTE, GGA1, GGA2, GGA3, USP36, NDFIP1, SOCS2, CDK12, EPHB4, NDUFA4L2, AKT1, SLC5A5, DOT1L, AKT2, SHC4, TRAF4, PTPN6, ERBB2, EGR1, HIPK2, POU4F2,
TFGPLSCR1, C14orf1, GPRASP1, GBP2, ARL15, CRMP1, KIAA1377, TFG, Mapk13, GRB2, RAD21, TSG101, PPP1CA, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, TRAF3, CFTR, TRIM25, STAT5B, MYOT, PIN1, PALM2-AKAP2, BABAM1, BRE, EHBP1L1, ASB18, HSPA5, TRIM68, ANXA11, CSTF2, EWSR1, HNRNPF, MAGED1, SEC24A, RBPMS, ARHGEF16, SPG21, VPS37C, CEP55, BOLL, MAPK1IP1L, RIPPLY2, PEF1, CUL7, SEC13, IGHG1, SEC31A, SPINK5, PKP1, EIF1AX, VSIG8, S100A3, LRRC15, S100A7, FBXO11, HNRNPCL1, DSG4, SELENBP1, DUSP14, HEPHL1, HIST1H2AG, UNK, FEN1, NTRK1, IFI16, TMEM17, ANXA1, ATP6V1B2, ATP6V0A1, CLTA, FLOT2, RPL10A, CHMP1A, RARS, RPL4, ITSN1, TOP2A, NCOA4, SNX3, AURKB, CLINT1, IST1, URB1, PDCD6IP, RCL1, ATP5H, MTUS2, NIPBL, C3orf17, ABI3BP, FBXL6, CHMP2A, CHMP4A, PHF20, CHMP5, SCLY, CHMP3, DPM3, DGCR8, NAT10, CHMP1B, ERGIC1, BICC1, KLHL13, TOP1MT, CHMP4B, MITD1, PLBD2, UMAD1, MCM2, CRYAB, RCAN2, BRCA1, YLR108C, GTS1, PDCD6, KIAA1715, UBE2M, EFTUD2, AAR2, PIH1D1, TNIP2, HGS, PPT1, AGO2, AGR2, BET1, KIAA1429, PHB, BMH1, BMH2, ATXN3, ITFG1, BIRC3, LASP1, FAM168A, RNF4, EYA2, PLA2G10, NID2, UBE2I, SF3A2, MED25, CRX, POU2AF1, PFDN5, SMUG1, CPSF3L, ZMYM5, KHDC1, UBAP2, TBX19, SF3B4, FOXH1, DVL3, PPP1R32, OXER1, WBSCR27, MSS51, LENG8, TEX37, NADSYN1, DAZAP2, WWOX, C19orf54, PLEKHG4, ZNF34, INCA1, KRTAP26-1, BPIFA1, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, STH, ARIH2, PLEKHA4, ORF6, PRRC2B, R3HDM2, TNRC6C, KIF14, PRNP, ORF3a, TBK1, CRTC1, LGALS9, BARD1, MBD4, OGT, nsp2, NR4A1, EBAG9, UBQLN2, FURIN, IFITM1, ORF7a, FBXO32, TOLLIP, nsp14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TFGall structure
NTRK1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TFG-NTRK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TFG-NTRK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TFGNTRK1SarcomaMyCancerGenome
TFGNTRK1NosMyCancerGenome
TFGNTRK1Breast Invasive Ductal CarcinomaMyCancerGenome
TFGNTRK1Gastric AdenocarcinomaMyCancerGenome
TFGNTRK1Lung AdenocarcinomaMyCancerGenome
TFGNTRK1Pancreatic Acinar Cell CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFGC3714897SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC1858338Neuropathy, hereditary motor and sensory, Okinawa type4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFGC0238463Papillary thyroid carcinoma2ORPHANET
HgeneTFGC0442874Neuropathy1GENOMICS_ENGLAND
HgeneTFGC1275278Extraskeletal Myxoid Chondrosarcoma1GENOMICS_ENGLAND;ORPHANET
HgeneTFGC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneNTRK1C0020074HSAN Type IV17CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK1C0238463Papillary thyroid carcinoma3ORPHANET
TgeneNTRK1C0002768Congenital Pain Insensitivity1ORPHANET
TgeneNTRK1C0005586Bipolar Disorder1CTD_human
TgeneNTRK1C0005587Depression, Bipolar1CTD_human
TgeneNTRK1C0017638Glioma1CTD_human
TgeneNTRK1C0020075Hereditary Sensory Autonomic Neuropathy, Type 51CTD_human;ORPHANET
TgeneNTRK1C0024713Manic Disorder1CTD_human
TgeneNTRK1C0027796Neuralgia1CTD_human
TgeneNTRK1C0027819Neuroblastoma1CTD_human
TgeneNTRK1C0033958Psychosis, Brief Reactive1CTD_human
TgeneNTRK1C0033975Psychotic Disorders1CTD_human
TgeneNTRK1C0036337Schizoaffective Disorder1CTD_human
TgeneNTRK1C0036341Schizophrenia1CTD_human
TgeneNTRK1C0036358Schizophreniform Disorders1CTD_human
TgeneNTRK1C0038870Neuralgia, Supraorbital1CTD_human
TgeneNTRK1C0042656Neuralgia, Vidian1CTD_human
TgeneNTRK1C0234247Neuralgia, Atypical1CTD_human
TgeneNTRK1C0234249Neuralgia, Stump1CTD_human
TgeneNTRK1C0259783mixed gliomas1CTD_human
TgeneNTRK1C0273115Lung Injury1CTD_human
TgeneNTRK1C0338831Manic1CTD_human
TgeneNTRK1C0423711Neuralgia, Perineal1CTD_human
TgeneNTRK1C0423712Neuralgia, Iliohypogastric Nerve1CTD_human
TgeneNTRK1C0555198Malignant Glioma1CTD_human
TgeneNTRK1C0598589Inherited neuropathies1GENOMICS_ENGLAND
TgeneNTRK1C0751371Neuralgia, Ilioinguinal1CTD_human
TgeneNTRK1C0751372Nerve Pain1CTD_human
TgeneNTRK1C0751373Paroxysmal Nerve Pain1CTD_human
TgeneNTRK1C0752347Lewy Body Disease1CTD_human
TgeneNTRK1C1833921Familial medullary thyroid carcinoma1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNTRK1C2350344Chronic Lung Injury1CTD_human