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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:THOC3-NUP214

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: THOC3-NUP214
FusionPDB ID: 90668
FusionGDB2.0 ID: 90668
HgeneTgene
Gene symbol

THOC3

NUP214

Gene ID

84321

8021

Gene nameTHO complex 3nucleoporin 214
SynonymsTHO3|hTREX45CAIN|CAN|IIAE9
Cytomap

5q35.2

9q34.13

Type of geneprotein-codingprotein-coding
DescriptionTHO complex subunit 3TEX1 homolognuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2020031320200322
UniProtAcc.

P35658

Ensembl transtripts involved in fusion geneENST idsENST00000265097, ENST00000510300, 
ENST00000513482, ENST00000514861, 
ENST00000465486, ENST00000359428, 
ENST00000411637, ENST00000451030, 
ENST00000483497, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 1=1619 X 26 X 11=5434
# samples 429
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/5434*10)=-4.22788976020704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: THOC3 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)THOC3(175386534)-NUP214(134067589), # samples:1
Anticipated loss of major functional domain due to fusion event.THOC3-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THOC3-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THOC3-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
THOC3-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHOC3

GO:0006406

mRNA export from nucleus

17190602

HgeneTHOC3

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across THOC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP214 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AN81164THOC3chr5

175386534

-NUP214chr9

134067589

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265097THOC3chr5175386534-ENST00000359428NUP214chr9134067589-5471158915644287907
ENST00000265097THOC3chr5175386534-ENST00000411637NUP214chr9134067589-5464158915644287907
ENST00000265097THOC3chr5175386534-ENST00000451030NUP214chr9134067589-4502158915644287907
ENST00000265097THOC3chr5175386534-ENST00000483497NUP214chr9134067589-4504158915644287907

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265097ENST00000359428THOC3chr5175386534-NUP214chr9134067589-0.0193198980.9806801
ENST00000265097ENST00000411637THOC3chr5175386534-NUP214chr9134067589-0.0191585660.9808414
ENST00000265097ENST00000451030THOC3chr5175386534-NUP214chr9134067589-0.0231179020.97688216
ENST00000265097ENST00000483497THOC3chr5175386534-NUP214chr9134067589-0.02305370.9769463

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90668_90668_1_THOC3-NUP214_THOC3_chr5_175386534_ENST00000265097_NUP214_chr9_134067589_ENST00000359428_length(amino acids)=907AA_BP=9
MTFVIMELRTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

>90668_90668_2_THOC3-NUP214_THOC3_chr5_175386534_ENST00000265097_NUP214_chr9_134067589_ENST00000411637_length(amino acids)=907AA_BP=9
MTFVIMELRTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

>90668_90668_3_THOC3-NUP214_THOC3_chr5_175386534_ENST00000265097_NUP214_chr9_134067589_ENST00000451030_length(amino acids)=907AA_BP=9
MTFVIMELRTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

>90668_90668_4_THOC3-NUP214_THOC3_chr5_175386534_ENST00000265097_NUP214_chr9_134067589_ENST00000483497_length(amino acids)=907AA_BP=9
MTFVIMELRTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP
PSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPT
KTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPS
APPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVL
AQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAA
AFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQ
TTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFG
QGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPF
SSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPA
FGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:175386534/chr9:134067589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NUP214

P35658

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-66139_178499.3333333333333352.0RepeatNote=WD 3
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-66180_221499.3333333333333352.0RepeatNote=WD 4
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-66222_261499.3333333333333352.0RepeatNote=WD 5
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-66264_303499.3333333333333352.0RepeatNote=WD 6
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-6653_94499.3333333333333352.0RepeatNote=WD 1
HgeneTHOC3chr5:175386534chr9:134067589ENST00000265097-6697_137499.3333333333333352.0RepeatNote=WD 2
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361213_20901191.33333333333332091.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361213_20901181.33333333333332081.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361213_20901192.33333333333332092.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361409_20841191.33333333333332091.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361427_20851191.33333333333332091.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361409_20841181.33333333333332081.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361427_20851181.33333333333332081.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361409_20841192.33333333333332092.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361427_20851192.33333333333332092.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361225_12261191.33333333333332091.0Repeat3
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361411_14121191.33333333333332091.0Repeat4
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361427_14281191.33333333333332091.0Repeat5
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361441_14421191.33333333333332091.0Repeat6
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361473_14741191.33333333333332091.0Repeat7
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361635_16361191.33333333333332091.0Repeat8
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361674_16751191.33333333333332091.0Repeat9
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361686_16871191.33333333333332091.0Repeat10
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361713_17141191.33333333333332091.0Repeat11
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361721_17221191.33333333333332091.0Repeat12
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361726_17271191.33333333333332091.0Repeat13
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361732_17331191.33333333333332091.0Repeat14
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361756_17571191.33333333333332091.0Repeat15
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361772_17731191.33333333333332091.0Repeat16
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361786_17871191.33333333333332091.0Repeat17
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361798_17991191.33333333333332091.0Repeat18
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361806_18071191.33333333333332091.0Repeat19
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361812_18131191.33333333333332091.0Repeat20
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361819_18201191.33333333333332091.0Repeat21
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361842_18431191.33333333333332091.0Repeat22
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361851_18521191.33333333333332091.0Repeat23
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361862_18631191.33333333333332091.0Repeat24
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361874_18751191.33333333333332091.0Repeat25
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361910_19111191.33333333333332091.0Repeat26
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361922_19231191.33333333333332091.0Repeat27
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361930_19311191.33333333333332091.0Repeat28
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361938_19391191.33333333333332091.0Repeat29
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361959_19601191.33333333333332091.0Repeat30
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361970_19711191.33333333333332091.0Repeat31
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361976_19771191.33333333333332091.0Repeat32
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361982_19831191.33333333333332091.0Repeat33
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361988_19891191.33333333333332091.0Repeat34
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825361994_19951191.33333333333332091.0Repeat35
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362012_20131191.33333333333332091.0Repeat36
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362024_20251191.33333333333332091.0Repeat37
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362026_20271191.33333333333332091.0Repeat38
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362035_20361191.33333333333332091.0Repeat39
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362046_20471191.33333333333332091.0Repeat40
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362056_20571191.33333333333332091.0Repeat41
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362066_20671191.33333333333332091.0Repeat42
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362075_20761191.33333333333332091.0Repeat43
TgeneNUP214chr5:175386534chr9:134067589ENST0000035942825362085_20861191.33333333333332091.0Repeat44
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361225_12261181.33333333333332081.0Repeat3
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361411_14121181.33333333333332081.0Repeat4
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361427_14281181.33333333333332081.0Repeat5
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361441_14421181.33333333333332081.0Repeat6
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361473_14741181.33333333333332081.0Repeat7
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361635_16361181.33333333333332081.0Repeat8
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361674_16751181.33333333333332081.0Repeat9
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361686_16871181.33333333333332081.0Repeat10
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361713_17141181.33333333333332081.0Repeat11
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361721_17221181.33333333333332081.0Repeat12
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361726_17271181.33333333333332081.0Repeat13
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361732_17331181.33333333333332081.0Repeat14
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361756_17571181.33333333333332081.0Repeat15
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361772_17731181.33333333333332081.0Repeat16
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361786_17871181.33333333333332081.0Repeat17
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361798_17991181.33333333333332081.0Repeat18
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361806_18071181.33333333333332081.0Repeat19
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361812_18131181.33333333333332081.0Repeat20
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361819_18201181.33333333333332081.0Repeat21
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361842_18431181.33333333333332081.0Repeat22
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361851_18521181.33333333333332081.0Repeat23
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361862_18631181.33333333333332081.0Repeat24
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361874_18751181.33333333333332081.0Repeat25
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361910_19111181.33333333333332081.0Repeat26
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361922_19231181.33333333333332081.0Repeat27
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361930_19311181.33333333333332081.0Repeat28
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361938_19391181.33333333333332081.0Repeat29
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361959_19601181.33333333333332081.0Repeat30
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361970_19711181.33333333333332081.0Repeat31
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361976_19771181.33333333333332081.0Repeat32
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361982_19831181.33333333333332081.0Repeat33
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361988_19891181.33333333333332081.0Repeat34
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725361994_19951181.33333333333332081.0Repeat35
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362012_20131181.33333333333332081.0Repeat36
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362024_20251181.33333333333332081.0Repeat37
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362026_20271181.33333333333332081.0Repeat38
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362035_20361181.33333333333332081.0Repeat39
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362046_20471181.33333333333332081.0Repeat40
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362056_20571181.33333333333332081.0Repeat41
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362066_20671181.33333333333332081.0Repeat42
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362075_20761181.33333333333332081.0Repeat43
TgeneNUP214chr5:175386534chr9:134067589ENST0000041163725362085_20861181.33333333333332081.0Repeat44
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361225_12261192.33333333333332092.0Repeat3
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361411_14121192.33333333333332092.0Repeat4
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361427_14281192.33333333333332092.0Repeat5
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361441_14421192.33333333333332092.0Repeat6
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361473_14741192.33333333333332092.0Repeat7
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361635_16361192.33333333333332092.0Repeat8
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361674_16751192.33333333333332092.0Repeat9
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361686_16871192.33333333333332092.0Repeat10
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361713_17141192.33333333333332092.0Repeat11
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361721_17221192.33333333333332092.0Repeat12
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361726_17271192.33333333333332092.0Repeat13
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361732_17331192.33333333333332092.0Repeat14
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361756_17571192.33333333333332092.0Repeat15
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361772_17731192.33333333333332092.0Repeat16
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361786_17871192.33333333333332092.0Repeat17
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361798_17991192.33333333333332092.0Repeat18
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361806_18071192.33333333333332092.0Repeat19
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361812_18131192.33333333333332092.0Repeat20
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361819_18201192.33333333333332092.0Repeat21
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361842_18431192.33333333333332092.0Repeat22
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361851_18521192.33333333333332092.0Repeat23
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361862_18631192.33333333333332092.0Repeat24
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361874_18751192.33333333333332092.0Repeat25
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361910_19111192.33333333333332092.0Repeat26
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361922_19231192.33333333333332092.0Repeat27
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361930_19311192.33333333333332092.0Repeat28
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361938_19391192.33333333333332092.0Repeat29
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361959_19601192.33333333333332092.0Repeat30
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361970_19711192.33333333333332092.0Repeat31
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361976_19771192.33333333333332092.0Repeat32
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361982_19831192.33333333333332092.0Repeat33
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361988_19891192.33333333333332092.0Repeat34
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025361994_19951192.33333333333332092.0Repeat35
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362012_20131192.33333333333332092.0Repeat36
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362024_20251192.33333333333332092.0Repeat37
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362026_20271192.33333333333332092.0Repeat38
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362035_20361192.33333333333332092.0Repeat39
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362046_20471192.33333333333332092.0Repeat40
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362056_20571192.33333333333332092.0Repeat41
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362066_20671192.33333333333332092.0Repeat42
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362075_20761192.33333333333332092.0Repeat43
TgeneNUP214chr5:175386534chr9:134067589ENST0000045103025362085_20861192.33333333333332092.0Repeat44

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536680_12091191.33333333333332091.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536680_12091181.33333333333332081.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536680_12091192.33333333333332092.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536236_14181191.33333333333332091.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:175386534chr9:134067589ENST00000359428253641_4041191.33333333333332091.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536450_5861191.33333333333332091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536481_20761191.33333333333332091.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536740_7681191.33333333333332091.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536861_8821191.33333333333332091.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536236_14181181.33333333333332081.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:175386534chr9:134067589ENST00000411637253641_4041181.33333333333332081.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536450_5861181.33333333333332081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536481_20761181.33333333333332081.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536740_7681181.33333333333332081.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536861_8821181.33333333333332081.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536236_14181192.33333333333332092.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr5:175386534chr9:134067589ENST00000451030253641_4041192.33333333333332092.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536450_5861192.33333333333332092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536481_20761192.33333333333332092.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536740_7681192.33333333333332092.0RegionNote=Leucine-zipper 1
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536861_8821192.33333333333332092.0RegionNote=Leucine-zipper 2
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536151_1931191.33333333333332091.0RepeatNote=Blade 3
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536194_2391191.33333333333332091.0RepeatNote=Blade 4
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536240_3031191.33333333333332091.0RepeatNote=Blade 5
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536304_3591191.33333333333332091.0RepeatNote=Blade 6
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536360_4041191.33333333333332091.0RepeatNote=Blade 7
TgeneNUP214chr5:175386534chr9:134067589ENST00000359428253641_931191.33333333333332091.0RepeatNote=Blade 1
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536484_4851191.33333333333332091.0Repeat1
TgeneNUP214chr5:175386534chr9:134067589ENST000003594282536548_5491191.33333333333332091.0Repeat2
TgeneNUP214chr5:175386534chr9:134067589ENST00000359428253694_1501191.33333333333332091.0RepeatNote=Blade 2
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536151_1931181.33333333333332081.0RepeatNote=Blade 3
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536194_2391181.33333333333332081.0RepeatNote=Blade 4
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536240_3031181.33333333333332081.0RepeatNote=Blade 5
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536304_3591181.33333333333332081.0RepeatNote=Blade 6
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536360_4041181.33333333333332081.0RepeatNote=Blade 7
TgeneNUP214chr5:175386534chr9:134067589ENST00000411637253641_931181.33333333333332081.0RepeatNote=Blade 1
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536484_4851181.33333333333332081.0Repeat1
TgeneNUP214chr5:175386534chr9:134067589ENST000004116372536548_5491181.33333333333332081.0Repeat2
TgeneNUP214chr5:175386534chr9:134067589ENST00000411637253694_1501181.33333333333332081.0RepeatNote=Blade 2
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536151_1931192.33333333333332092.0RepeatNote=Blade 3
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536194_2391192.33333333333332092.0RepeatNote=Blade 4
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536240_3031192.33333333333332092.0RepeatNote=Blade 5
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536304_3591192.33333333333332092.0RepeatNote=Blade 6
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536360_4041192.33333333333332092.0RepeatNote=Blade 7
TgeneNUP214chr5:175386534chr9:134067589ENST00000451030253641_931192.33333333333332092.0RepeatNote=Blade 1
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536484_4851192.33333333333332092.0Repeat1
TgeneNUP214chr5:175386534chr9:134067589ENST000004510302536548_5491192.33333333333332092.0Repeat2
TgeneNUP214chr5:175386534chr9:134067589ENST00000451030253694_1501192.33333333333332092.0RepeatNote=Blade 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
THOC3
NUP214all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to THOC3-NUP214


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to THOC3-NUP214


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
TgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
TgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET