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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:THUMPD2-VSNL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: THUMPD2-VSNL1
FusionPDB ID: 90807
FusionGDB2.0 ID: 90807
HgeneTgene
Gene symbol

THUMPD2

VSNL1

Gene ID

80745

7447

Gene nameTHUMP domain containing 2visinin like 1
SynonymsC2orf8HLP3|HPCAL3|HUVISL1|VILIP|VILIP-1
Cytomap

2p22.1|2p22-p21

2p24.2

Type of geneprotein-codingprotein-coding
DescriptionTHUMP domain-containing protein 2SAM-dependent methyltransferaseepididymis secretory sperm binding proteinvisinin-like protein 1VLP-1hippocalcin-like protein 3
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000260619, ENST00000454352, 
ENST00000505747, ENST00000403537, 
ENST00000483921, ENST00000295156, 
ENST00000404666, ENST00000406397, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=807 X 8 X 6=336
# samples 69
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: THUMPD2 [Title/Abstract] AND VSNL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)THUMPD2(40006254)-VSNL1(17830677), # samples:3
Anticipated loss of major functional domain due to fusion event.THUMPD2-VSNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THUMPD2-VSNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THUMPD2-VSNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
THUMPD2-VSNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across THUMPD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VSNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-A4DG-01ATHUMPD2chr2

40006254

-VSNL1chr2

17830677

+
ChimerDB4LUADTCGA-55-A4DGTHUMPD2chr2

40006253

-VSNL1chr2

17830676

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000505747THUMPD2chr240006254-ENST00000404666VSNL1chr217830677+125215428567179
ENST00000505747THUMPD2chr240006254-ENST00000295156VSNL1chr217830677+161315428567179
ENST00000505747THUMPD2chr240006254-ENST00000406397VSNL1chr217830677+219215428567179
ENST00000260619THUMPD2chr240006254-ENST00000404666VSNL1chr217830677+1134360449149
ENST00000260619THUMPD2chr240006254-ENST00000295156VSNL1chr217830677+1495360449149
ENST00000260619THUMPD2chr240006254-ENST00000406397VSNL1chr217830677+2074360449149
ENST00000454352THUMPD2chr240006254-ENST00000404666VSNL1chr217830677+1137393452149
ENST00000454352THUMPD2chr240006254-ENST00000295156VSNL1chr217830677+1498393452149
ENST00000454352THUMPD2chr240006254-ENST00000406397VSNL1chr217830677+2077393452149
ENST00000505747THUMPD2chr240006253-ENST00000404666VSNL1chr217830676+125215428567179
ENST00000505747THUMPD2chr240006253-ENST00000295156VSNL1chr217830676+161315428567179
ENST00000505747THUMPD2chr240006253-ENST00000406397VSNL1chr217830676+219215428567179
ENST00000260619THUMPD2chr240006253-ENST00000404666VSNL1chr217830676+1134360449149
ENST00000260619THUMPD2chr240006253-ENST00000295156VSNL1chr217830676+1495360449149
ENST00000260619THUMPD2chr240006253-ENST00000406397VSNL1chr217830676+2074360449149
ENST00000454352THUMPD2chr240006253-ENST00000404666VSNL1chr217830676+1137393452149
ENST00000454352THUMPD2chr240006253-ENST00000295156VSNL1chr217830676+1498393452149
ENST00000454352THUMPD2chr240006253-ENST00000406397VSNL1chr217830676+2077393452149

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000505747ENST00000404666THUMPD2chr240006254-VSNL1chr217830677+0.0018054380.9981945
ENST00000505747ENST00000295156THUMPD2chr240006254-VSNL1chr217830677+0.0012924810.99870753
ENST00000505747ENST00000406397THUMPD2chr240006254-VSNL1chr217830677+0.0009110730.9990889
ENST00000260619ENST00000404666THUMPD2chr240006254-VSNL1chr217830677+0.0018430870.99815696
ENST00000260619ENST00000295156THUMPD2chr240006254-VSNL1chr217830677+0.0014075420.99859244
ENST00000260619ENST00000406397THUMPD2chr240006254-VSNL1chr217830677+0.0014448490.9985551
ENST00000454352ENST00000404666THUMPD2chr240006254-VSNL1chr217830677+0.0019313140.99806875
ENST00000454352ENST00000295156THUMPD2chr240006254-VSNL1chr217830677+0.0014751160.99852496
ENST00000454352ENST00000406397THUMPD2chr240006254-VSNL1chr217830677+0.0018135550.9981864
ENST00000505747ENST00000404666THUMPD2chr240006253-VSNL1chr217830676+0.0018054380.9981945
ENST00000505747ENST00000295156THUMPD2chr240006253-VSNL1chr217830676+0.0012924810.99870753
ENST00000505747ENST00000406397THUMPD2chr240006253-VSNL1chr217830676+0.0009110730.9990889
ENST00000260619ENST00000404666THUMPD2chr240006253-VSNL1chr217830676+0.0018430870.99815696
ENST00000260619ENST00000295156THUMPD2chr240006253-VSNL1chr217830676+0.0014075420.99859244
ENST00000260619ENST00000406397THUMPD2chr240006253-VSNL1chr217830676+0.0014448490.9985551
ENST00000454352ENST00000404666THUMPD2chr240006253-VSNL1chr217830676+0.0019313140.99806875
ENST00000454352ENST00000295156THUMPD2chr240006253-VSNL1chr217830676+0.0014751160.99852496
ENST00000454352ENST00000406397THUMPD2chr240006253-VSNL1chr217830676+0.0018135550.9981864

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90807_90807_1_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000260619_VSNL1_chr2_17830676_ENST00000295156_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_2_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000260619_VSNL1_chr2_17830676_ENST00000404666_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_3_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000260619_VSNL1_chr2_17830676_ENST00000406397_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_4_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000454352_VSNL1_chr2_17830676_ENST00000295156_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_5_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000454352_VSNL1_chr2_17830676_ENST00000404666_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_6_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000454352_VSNL1_chr2_17830676_ENST00000406397_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_7_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000505747_VSNL1_chr2_17830676_ENST00000295156_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

>90807_90807_8_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000505747_VSNL1_chr2_17830676_ENST00000404666_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

>90807_90807_9_THUMPD2-VSNL1_THUMPD2_chr2_40006253_ENST00000505747_VSNL1_chr2_17830676_ENST00000406397_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

>90807_90807_10_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000260619_VSNL1_chr2_17830677_ENST00000295156_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_11_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000260619_VSNL1_chr2_17830677_ENST00000404666_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_12_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000260619_VSNL1_chr2_17830677_ENST00000406397_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_13_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000454352_VSNL1_chr2_17830677_ENST00000295156_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_14_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000454352_VSNL1_chr2_17830677_ENST00000404666_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_15_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000454352_VSNL1_chr2_17830677_ENST00000406397_length(amino acids)=149AA_BP=11
MREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMV

--------------------------------------------------------------

>90807_90807_16_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000505747_VSNL1_chr2_17830677_ENST00000295156_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

>90807_90807_17_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000505747_VSNL1_chr2_17830677_ENST00000404666_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

>90807_90807_18_THUMPD2-VSNL1_THUMPD2_chr2_40006254_ENST00000505747_VSNL1_chr2_17830677_ENST00000406397_length(amino acids)=179AA_BP=41
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:40006254/chr2:17830677)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVSNL1chr2:40006253chr2:17830676ENST0000029515614109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006253chr2:17830676ENST0000029515614159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006253chr2:17830676ENST000002951561473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040466614109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040466614159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006253chr2:17830676ENST000004046661473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040639714109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040639714159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006253chr2:17830676ENST000004063971473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006254chr2:17830677ENST0000029515614109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006254chr2:17830677ENST0000029515614159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006254chr2:17830677ENST000002951561473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040466614109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040466614159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006254chr2:17830677ENST000004046661473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040639714109_12054.0192.0Calcium binding2
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040639714159_17054.0192.0Calcium binding3
TgeneVSNL1chr2:40006254chr2:17830677ENST000004063971473_8454.0192.0Calcium binding1
TgeneVSNL1chr2:40006253chr2:17830676ENST0000029515614146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006253chr2:17830676ENST000002951561460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006253chr2:17830676ENST000002951561496_13154.0192.0DomainEF-hand 3
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040466614146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006253chr2:17830676ENST000004046661460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006253chr2:17830676ENST000004046661496_13154.0192.0DomainEF-hand 3
TgeneVSNL1chr2:40006253chr2:17830676ENST0000040639714146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006253chr2:17830676ENST000004063971460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006253chr2:17830676ENST000004063971496_13154.0192.0DomainEF-hand 3
TgeneVSNL1chr2:40006254chr2:17830677ENST0000029515614146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006254chr2:17830677ENST000002951561460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006254chr2:17830677ENST000002951561496_13154.0192.0DomainEF-hand 3
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040466614146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006254chr2:17830677ENST000004046661460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006254chr2:17830677ENST000004046661496_13154.0192.0DomainEF-hand 3
TgeneVSNL1chr2:40006254chr2:17830677ENST0000040639714146_18154.0192.0DomainEF-hand 4
TgeneVSNL1chr2:40006254chr2:17830677ENST000004063971460_9554.0192.0DomainEF-hand 2
TgeneVSNL1chr2:40006254chr2:17830677ENST000004063971496_13154.0192.0DomainEF-hand 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHUMPD2chr2:40006253chr2:17830676ENST00000260619-110161_26612.0474.0DomainTHUMP
HgeneTHUMPD2chr2:40006253chr2:17830676ENST00000505747-110161_26642.0504.0DomainTHUMP
HgeneTHUMPD2chr2:40006254chr2:17830677ENST00000260619-110161_26612.0474.0DomainTHUMP
HgeneTHUMPD2chr2:40006254chr2:17830677ENST00000505747-110161_26642.0504.0DomainTHUMP
TgeneVSNL1chr2:40006253chr2:17830676ENST000002951561423_5854.0192.0DomainEF-hand 1
TgeneVSNL1chr2:40006253chr2:17830676ENST000004046661423_5854.0192.0DomainEF-hand 1
TgeneVSNL1chr2:40006253chr2:17830676ENST000004063971423_5854.0192.0DomainEF-hand 1
TgeneVSNL1chr2:40006254chr2:17830677ENST000002951561423_5854.0192.0DomainEF-hand 1
TgeneVSNL1chr2:40006254chr2:17830677ENST000004046661423_5854.0192.0DomainEF-hand 1
TgeneVSNL1chr2:40006254chr2:17830677ENST000004063971423_5854.0192.0DomainEF-hand 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
THUMPD2
VSNL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to THUMPD2-VSNL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to THUMPD2-VSNL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource