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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TIA1-ACTR2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TIA1-ACTR2
	FusionPDB ID: 90813
	FusionGDB2.0 ID: 90813
		Hgene	Tgene
	Gene symbol	TIA1	ACTR2
	Gene ID	7072	10097
	Gene name	TIA1 cytotoxic granule associated RNA binding protein	actin related protein 2
	Synonyms	TIA-1\|WDM	ARP2
	Cytomap	2p13.3	2p14
	Type of gene	protein-coding	protein-coding
	Description	nucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1)	actin-related protein 2ARP2 actin related protein 2 homologactin-like protein 2
	Modification date	20200313	20200327
	UniProtAcc	.	P61160
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000282574, ENST00000415783, ENST00000416149, ENST00000433529, ENST00000445587, ENST00000482876,	ENST00000377982, ENST00000476840, ENST00000542850, ENST00000260641,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 9 X 8=792	6 X 6 X 3=108
	# samples	13	6
	** MAII score	log2(13/792*10)=-2.60698880705116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TIA1 [Title/Abstract] AND ACTR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TIA1(70463211)-ACTR2(65478161), # samples:3
Anticipated loss of major functional domain due to fusion event.	TIA1-ACTR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TIA1-ACTR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TIA1	GO:0048024	regulation of mRNA splicing, via spliceosome	11106748
Tgene	ACTR2	GO:0034314	Arp2/3 complex-mediated actin nucleation	11741539\|17220302\|29925947
Tgene	ACTR2	GO:0045944	positive regulation of transcription by RNA polymerase II	17220302
Tgene	ACTR2	GO:1905168	positive regulation of double-strand break repair via homologous recombination	29925947
Tgene	ACTR2	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	29925947

Fusion gene breakpoints across TIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A7AP-01A	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+
ChimerDB4	PRAD	TCGA-KK-A7AP	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+
ChimerDB4	PRAD	TCGA-KK-A7AP	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000433529	TIA1	chr2	70463211	-	ENST00000260641	ACTR2	chr2	65478161	+	3663	334	100	1143	347
ENST00000415783	TIA1	chr2	70463211	-	ENST00000260641	ACTR2	chr2	65478161	+	3682	353	119	1162	347
ENST00000282574	TIA1	chr2	70463211	-	ENST00000260641	ACTR2	chr2	65478161	+	3602	273	39	1082	347
ENST00000445587	TIA1	chr2	70463211	-	ENST00000260641	ACTR2	chr2	65478161	+	3632	303	69	1112	347
ENST00000416149	TIA1	chr2	70463211	-	ENST00000260641	ACTR2	chr2	65478161	+	3476	147	24	956	310
ENST00000433529	TIA1	chr2	70463210	-	ENST00000260641	ACTR2	chr2	65478160	+	3663	334	100	1143	347
ENST00000415783	TIA1	chr2	70463210	-	ENST00000260641	ACTR2	chr2	65478160	+	3682	353	119	1162	347
ENST00000282574	TIA1	chr2	70463210	-	ENST00000260641	ACTR2	chr2	65478160	+	3602	273	39	1082	347
ENST00000445587	TIA1	chr2	70463210	-	ENST00000260641	ACTR2	chr2	65478160	+	3632	303	69	1112	347
ENST00000416149	TIA1	chr2	70463210	-	ENST00000260641	ACTR2	chr2	65478160	+	3476	147	24	956	310

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000433529	ENST00000260641	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+	0.00022717	0.99977285
ENST00000415783	ENST00000260641	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+	0.000232903	0.9997671
ENST00000282574	ENST00000260641	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+	0.000229237	0.9997708
ENST00000445587	ENST00000260641	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+	0.000224925	0.9997751
ENST00000416149	ENST00000260641	TIA1	chr2	70463211	-	ACTR2	chr2	65478161	+	0.00021971	0.99978036
ENST00000433529	ENST00000260641	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+	0.00022717	0.99977285
ENST00000415783	ENST00000260641	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+	0.000232903	0.9997671
ENST00000282574	ENST00000260641	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+	0.000229237	0.9997708
ENST00000445587	ENST00000260641	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+	0.000224925	0.9997751
ENST00000416149	ENST00000260641	TIA1	chr2	70463210	-	ACTR2	chr2	65478160	+	0.00021971	0.99978036

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90813_90813_1_TIA1-ACTR2_TIA1_chr2_70463210_ENST00000282574_ACTR2_chr2_65478160_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_2_TIA1-ACTR2_TIA1_chr2_70463210_ENST00000415783_ACTR2_chr2_65478160_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_3_TIA1-ACTR2_TIA1_chr2_70463210_ENST00000416149_ACTR2_chr2_65478160_ENST00000260641_length(amino acids)=310AA_BP=41
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFS
LPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEA
LFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMV

--------------------------------------------------------------

>90813_90813_4_TIA1-ACTR2_TIA1_chr2_70463210_ENST00000433529_ACTR2_chr2_65478160_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_5_TIA1-ACTR2_TIA1_chr2_70463210_ENST00000445587_ACTR2_chr2_65478160_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_6_TIA1-ACTR2_TIA1_chr2_70463211_ENST00000282574_ACTR2_chr2_65478161_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_7_TIA1-ACTR2_TIA1_chr2_70463211_ENST00000415783_ACTR2_chr2_65478161_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_8_TIA1-ACTR2_TIA1_chr2_70463211_ENST00000416149_ACTR2_chr2_65478161_ENST00000260641_length(amino acids)=310AA_BP=41
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFS
LPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEA
LFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMV

--------------------------------------------------------------

>90813_90813_9_TIA1-ACTR2_TIA1_chr2_70463211_ENST00000433529_ACTR2_chr2_65478161_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

>90813_90813_10_TIA1-ACTR2_TIA1_chr2_70463211_ENST00000445587_ACTR2_chr2_65478161_ENST00000260641_length(amino acids)=347AA_BP=78
MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY
VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI
EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70463211/chr2:65478161)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTR2 P61160
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269\|PubMed:17220302, ECO:0000269\|PubMed:29058690, ECO:0000269\|PubMed:29925947, ECO:0000269\|PubMed:9000076}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000260641

160_162

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000260641

214_218

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000260641

305_310

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000377982

160_162

130.0

400.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000377982

214_218

130.0

400.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463210

chr2:65478160

ENST00000377982

305_310

130.0

400.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000260641

160_162

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000260641

214_218

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000260641

305_310

125.0

395.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000377982

160_162

130.0

400.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000377982

214_218

130.0

400.0

Nucleotide binding

ATP

Tgene

ACTR2

chr2:70463211

chr2:65478161

ENST00000377982

305_310

130.0

400.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000415783

106_184

41.0

376.0

Domain

RRM 2

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000415783

214_286

41.0

376.0

Domain

RRM 3

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000415783

7_83

41.0

376.0

Domain

RRM 1

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000433529

106_184

41.0

387.0

Domain

RRM 2

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000433529

214_286

41.0

387.0

Domain

RRM 3

Hgene

TIA1

chr2:70463210

chr2:65478160

ENST00000433529

7_83

41.0

387.0

Domain

RRM 1

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000415783

106_184

41.0

376.0

Domain

RRM 2

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000415783

214_286

41.0

376.0

Domain

RRM 3

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000415783

7_83

41.0

376.0

Domain

RRM 1

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000433529

106_184

41.0

387.0

Domain

RRM 2

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000433529

214_286

41.0

387.0

Domain

RRM 3

Hgene

TIA1

chr2:70463211

chr2:65478161

ENST00000433529

7_83

41.0

387.0

Domain

RRM 1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>668_TIA1_70463211_ACTR2_65478161_ranked_0.pdb	TIA1	70463210	70463211	ENST00000260641	ACTR2	chr2	65478161	+	MVSRETPLSCSHNRLNDLGGSEGQGAGPGGAAATAAAMEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVMFETYQFSGVY VAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNI EQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRL	347

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TIA1_pLDDT.png

ACTR2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TIA1
ACTR2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TIA1-ACTR2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TIA1-ACTR2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source