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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TLE4-HDAC5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TLE4-HDAC5
FusionPDB ID: 91129
FusionGDB2.0 ID: 91129
HgeneTgene
Gene symbol

TLE4

HDAC5

Gene ID

7091

10014

Gene nameTLE family member 4, transcriptional corepressorhistone deacetylase 5
SynonymsBCE-1|BCE1|E(spI)|E(spl)|ESG|ESG4|GRG4|Grg-4HD5|NY-CO-9
Cytomap

9q21.31

17q21.31

Type of geneprotein-codingprotein-coding
Descriptiontransducin-like enhancer protein 4B lymphocyte gene 1enhancer of split groucho 4groucho-related protein 4transducin like enhancer of split 4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)transducin-like enhancer of split 4, homolog histone deacetylase 5antigen NY-CO-9
Modification date2020031320200313
UniProtAcc.

Q9UQL6

Ensembl transtripts involved in fusion geneENST idsENST00000376534, ENST00000265284, 
ENST00000376520, ENST00000376537, 
ENST00000376552, ENST00000376544, 
ENST00000455913, 		ENST00000225983, 
ENST00000336057, ENST00000393622, 
ENST00000586802, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 2=8413 X 11 X 8=1144
# samples 714
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TLE4 [Title/Abstract] AND HDAC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TLE4(82320857)-HDAC5(42165064), # samples:1
Anticipated loss of major functional domain due to fusion event.TLE4-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLE4-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLE4-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TLE4-HDAC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC5

GO:0000122

negative regulation of transcription by RNA polymerase II

16236793

TgeneHDAC5

GO:0016575

histone deacetylation

10869435


check buttonFusion gene breakpoints across TLE4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HDAC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0749-01ATLE4chr9

82320857

+HDAC5chr17

42165064

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376552TLE4chr982320857+ENST00000225983HDAC5chr1742165064-5201180110183570850
ENST00000376552TLE4chr982320857+ENST00000393622HDAC5chr1742165064-5194180110183570850
ENST00000376552TLE4chr982320857+ENST00000336057HDAC5chr1742165064-4938180110183315765
ENST00000376552TLE4chr982320857+ENST00000586802HDAC5chr1742165064-3653180110183570850
ENST00000376520TLE4chr982320857+ENST00000225983HDAC5chr1742165064-501116118283380850
ENST00000376520TLE4chr982320857+ENST00000393622HDAC5chr1742165064-500416118283380850
ENST00000376520TLE4chr982320857+ENST00000336057HDAC5chr1742165064-474816118283125765
ENST00000376520TLE4chr982320857+ENST00000586802HDAC5chr1742165064-346316118283380850
ENST00000376537TLE4chr982320857+ENST00000225983HDAC5chr1742165064-43599591762728850
ENST00000376537TLE4chr982320857+ENST00000393622HDAC5chr1742165064-43529591762728850
ENST00000376537TLE4chr982320857+ENST00000336057HDAC5chr1742165064-40969591762473765
ENST00000376537TLE4chr982320857+ENST00000586802HDAC5chr1742165064-28119591762728850
ENST00000265284TLE4chr982320857+ENST00000225983HDAC5chr1742165064-4154754462523825
ENST00000265284TLE4chr982320857+ENST00000393622HDAC5chr1742165064-4147754462523825
ENST00000265284TLE4chr982320857+ENST00000336057HDAC5chr1742165064-3891754462268740
ENST00000265284TLE4chr982320857+ENST00000586802HDAC5chr1742165064-2606754462523825

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376552ENST00000225983TLE4chr982320857+HDAC5chr1742165064-0.0013761870.99862385
ENST00000376552ENST00000393622TLE4chr982320857+HDAC5chr1742165064-0.0014027370.9985972
ENST00000376552ENST00000336057TLE4chr982320857+HDAC5chr1742165064-0.0017625420.9982375
ENST00000376552ENST00000586802TLE4chr982320857+HDAC5chr1742165064-0.0031400230.99686
ENST00000376520ENST00000225983TLE4chr982320857+HDAC5chr1742165064-0.0013286630.9986714
ENST00000376520ENST00000393622TLE4chr982320857+HDAC5chr1742165064-0.0013541550.99864584
ENST00000376520ENST00000336057TLE4chr982320857+HDAC5chr1742165064-0.0017047280.99829525
ENST00000376520ENST00000586802TLE4chr982320857+HDAC5chr1742165064-0.003131470.99686855
ENST00000376537ENST00000225983TLE4chr982320857+HDAC5chr1742165064-0.0022633380.9977367
ENST00000376537ENST00000393622TLE4chr982320857+HDAC5chr1742165064-0.0023125820.99768746
ENST00000376537ENST00000336057TLE4chr982320857+HDAC5chr1742165064-0.0028501330.9971499
ENST00000376537ENST00000586802TLE4chr982320857+HDAC5chr1742165064-0.0078951330.9921049
ENST00000265284ENST00000225983TLE4chr982320857+HDAC5chr1742165064-0.0014982930.9985018
ENST00000265284ENST00000393622TLE4chr982320857+HDAC5chr1742165064-0.0015427020.9984573
ENST00000265284ENST00000336057TLE4chr982320857+HDAC5chr1742165064-0.0013428130.9986572
ENST00000265284ENST00000586802TLE4chr982320857+HDAC5chr1742165064-0.0054853770.9945147

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91129_91129_1_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000265284_HDAC5_chr17_42165064_ENST00000225983_length(amino acids)=825AA_BP=236
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSS
SVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELPRQPTTHPEETEEELTEQQEVLLGEG
ALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALG
RTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY
HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEES
TAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG
VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEA
CVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH

--------------------------------------------------------------

>91129_91129_2_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000265284_HDAC5_chr17_42165064_ENST00000336057_length(amino acids)=740AA_BP=236
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSS
SVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELPRQPTTHPEETEEELTEQQEVLLGEG
ALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALG
RTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGH
HAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNV
AWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAIC
DASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAA

--------------------------------------------------------------

>91129_91129_3_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000265284_HDAC5_chr17_42165064_ENST00000393622_length(amino acids)=825AA_BP=236
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSS
SVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELPRQPTTHPEETEEELTEQQEVLLGEG
ALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALG
RTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY
HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEES
TAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG
VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEA
CVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH

--------------------------------------------------------------

>91129_91129_4_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000265284_HDAC5_chr17_42165064_ENST00000586802_length(amino acids)=825AA_BP=236
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSS
SVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELPRQPTTHPEETEEELTEQQEVLLGEG
ALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALG
RTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY
HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEES
TAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG
VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEA
CVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH

--------------------------------------------------------------

>91129_91129_5_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376520_HDAC5_chr17_42165064_ENST00000225983_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRERDKLNHKSLSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_6_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376520_HDAC5_chr17_42165064_ENST00000336057_length(amino acids)=765AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRERDKLNHKSLSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC
LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDN
GNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT
RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQA

--------------------------------------------------------------

>91129_91129_7_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376520_HDAC5_chr17_42165064_ENST00000393622_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRERDKLNHKSLSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_8_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376520_HDAC5_chr17_42165064_ENST00000586802_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRERDKLNHKSLSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_9_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376537_HDAC5_chr17_42165064_ENST00000225983_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_10_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376537_HDAC5_chr17_42165064_ENST00000336057_length(amino acids)=765AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC
LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDN
GNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT
RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQA

--------------------------------------------------------------

>91129_91129_11_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376537_HDAC5_chr17_42165064_ENST00000393622_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_12_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376537_HDAC5_chr17_42165064_ENST00000586802_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_13_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376552_HDAC5_chr17_42165064_ENST00000225983_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_14_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376552_HDAC5_chr17_42165064_ENST00000336057_length(amino acids)=765AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC
LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDN
GNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT
RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQA

--------------------------------------------------------------

>91129_91129_15_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376552_HDAC5_chr17_42165064_ENST00000393622_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

>91129_91129_16_TLE4-HDAC5_TLE4_chr9_82320857_ENST00000376552_HDAC5_chr17_42165064_ENST00000586802_length(amino acids)=850AA_BP=261
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKR
LNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQS
HLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEILTKTGELP
RQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSD
AQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG
LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELA
FKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP
GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMT
LAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:82320857/chr17:42165064)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HDAC5

Q9UQL6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021137_204261.0806.0RegionGP domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+10211_136261.0806.0RegionQ domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020137_204261.0774.0RegionGP domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+10201_136261.0774.0RegionQ domain
TgeneHDAC5chr9:82320857chr17:42165064ENST0000022598311271099_1104534.01124.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr9:82320857chr17:42165064ENST000002259831127596_599534.01124.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr9:82320857chr17:42165064ENST0000033605711251099_1104533.01038.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr9:82320857chr17:42165064ENST000003360571125596_599533.01038.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr9:82320857chr17:42165064ENST0000039362211271099_1104533.01123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr9:82320857chr17:42165064ENST000003936221127596_599533.01123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr9:82320857chr17:42165064ENST0000058680211271099_1104533.01123.0Compositional biasNote=Poly-Ala
TgeneHDAC5chr9:82320857chr17:42165064ENST000005868021127596_599533.01123.0Compositional biasNote=Poly-Glu
TgeneHDAC5chr9:82320857chr17:42165064ENST0000022598311271081_1122534.01124.0MotifNote=Nuclear export signal
TgeneHDAC5chr9:82320857chr17:42165064ENST0000033605711251081_1122533.01038.0MotifNote=Nuclear export signal
TgeneHDAC5chr9:82320857chr17:42165064ENST0000039362211271081_1122533.01123.0MotifNote=Nuclear export signal
TgeneHDAC5chr9:82320857chr17:42165064ENST0000058680211271081_1122533.01123.0MotifNote=Nuclear export signal
TgeneHDAC5chr9:82320857chr17:42165064ENST000002259831127684_1028534.01124.0RegionNote=Histone deacetylase
TgeneHDAC5chr9:82320857chr17:42165064ENST000003360571125684_1028533.01038.0RegionNote=Histone deacetylase
TgeneHDAC5chr9:82320857chr17:42165064ENST000003936221127684_1028533.01123.0RegionNote=Histone deacetylase
TgeneHDAC5chr9:82320857chr17:42165064ENST000005868021127684_1028533.01123.0RegionNote=Histone deacetylase

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021205_274261.0806.0RegionCcN domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021275_452261.0806.0RegionSP domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020205_274261.0774.0RegionCcN domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020275_452261.0774.0RegionSP domain
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021485_523261.0806.0RepeatNote=WD 1
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021531_570261.0806.0RepeatNote=WD 2
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021575_614261.0806.0RepeatNote=WD 3
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021617_656261.0806.0RepeatNote=WD 4
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021658_697261.0806.0RepeatNote=WD 5
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021699_738261.0806.0RepeatNote=WD 6
HgeneTLE4chr9:82320857chr17:42165064ENST00000376537+1021740_773261.0806.0RepeatNote=WD 7
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020485_523261.0774.0RepeatNote=WD 1
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020531_570261.0774.0RepeatNote=WD 2
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020575_614261.0774.0RepeatNote=WD 3
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020617_656261.0774.0RepeatNote=WD 4
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020658_697261.0774.0RepeatNote=WD 5
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020699_738261.0774.0RepeatNote=WD 6
HgeneTLE4chr9:82320857chr17:42165064ENST00000376552+1020740_773261.0774.0RepeatNote=WD 7
TgeneHDAC5chr9:82320857chr17:42165064ENST00000225983112747_52534.01124.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr9:82320857chr17:42165064ENST00000225983112785_92534.01124.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr9:82320857chr17:42165064ENST00000336057112547_52533.01038.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr9:82320857chr17:42165064ENST00000336057112585_92533.01038.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr9:82320857chr17:42165064ENST00000393622112747_52533.01123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr9:82320857chr17:42165064ENST00000393622112785_92533.01123.0Compositional biasNote=Poly-Gln
TgeneHDAC5chr9:82320857chr17:42165064ENST00000586802112747_52533.01123.0Compositional biasNote=Poly-Gly
TgeneHDAC5chr9:82320857chr17:42165064ENST00000586802112785_92533.01123.0Compositional biasNote=Poly-Gln


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TLE4
HDAC5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TLE4-HDAC5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TLE4-HDAC5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource