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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TLK2-THRA

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TLK2-THRA
FusionPDB ID: 91169
FusionGDB2.0 ID: 91169
HgeneTgene
Gene symbol

TLK2

THRA

Gene ID

11011

7067

Gene nametousled like kinase 2thyroid hormone receptor alpha
SynonymsHsHPK|MRD57|PKU-ALPHAAR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1
Cytomap

17q23.2

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 2thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000326270, ENST00000343388, 
ENST00000346027, ENST00000542523, 
ENST00000582809, ENST00000577616, 
ENST00000264637, ENST00000394121, 
ENST00000450525, ENST00000546243, 
ENST00000584985, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 11 X 9=178210 X 11 X 6=660
# samples 2412
** MAII scorelog2(24/1782*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TLK2 [Title/Abstract] AND THRA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TLK2(60613698)-THRA(38240088), # samples:2
Anticipated loss of major functional domain due to fusion event.TLK2-THRA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-THRA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-THRA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-THRA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK2

GO:0006468

protein phosphorylation

12660173

HgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

HgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

HgeneTLK2

GO:0035556

intracellular signal transduction

12660173

HgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173

TgeneTHRA

GO:0006357

regulation of transcription by RNA polymerase II

18052923

TgeneTHRA

GO:0006366

transcription by RNA polymerase II

8710870|9653119

TgeneTHRA

GO:0009755

hormone-mediated signaling pathway

18052923

TgeneTHRA

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8524305

TgeneTHRA

GO:0045892

negative regulation of transcription, DNA-templated

8710870

TgeneTHRA

GO:2000143

negative regulation of DNA-templated transcription, initiation

8524305


check buttonFusion gene breakpoints across TLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THRA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A43P-01ATLK2chr17

60613698

+THRAchr17

38240088

+
ChimerDB4BLCATCGA-FD-A43PTLK2chr17

60613698

+THRAchr17

38240087

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000582809TLK2chr1760613698+ENST00000394121THRAchr1738240088+22697873702037555
ENST00000582809TLK2chr1760613698+ENST00000264637THRAchr1738240088+25237873702037555
ENST00000582809TLK2chr1760613698+ENST00000584985THRAchr1738240088+24067873701920516
ENST00000582809TLK2chr1760613698+ENST00000450525THRAchr1738240088+49697873701797475
ENST00000582809TLK2chr1760613698+ENST00000546243THRAchr1738240088+20727873701797475
ENST00000326270TLK2chr1760613698+ENST00000394121THRAchr1738240088+22817991212049642
ENST00000326270TLK2chr1760613698+ENST00000264637THRAchr1738240088+25357991212049642
ENST00000326270TLK2chr1760613698+ENST00000584985THRAchr1738240088+24187991211932603
ENST00000326270TLK2chr1760613698+ENST00000450525THRAchr1738240088+49817991211809562
ENST00000326270TLK2chr1760613698+ENST00000546243THRAchr1738240088+20847991211809562
ENST00000346027TLK2chr1760613698+ENST00000394121THRAchr1738240088+22848021212052643
ENST00000346027TLK2chr1760613698+ENST00000264637THRAchr1738240088+25388021212052643
ENST00000346027TLK2chr1760613698+ENST00000584985THRAchr1738240088+24218021211935604
ENST00000346027TLK2chr1760613698+ENST00000450525THRAchr1738240088+49848021211812563
ENST00000346027TLK2chr1760613698+ENST00000546243THRAchr1738240088+20878021211812563
ENST00000343388TLK2chr1760613698+ENST00000394121THRAchr1738240088+2063581501831593
ENST00000343388TLK2chr1760613698+ENST00000264637THRAchr1738240088+2317581501831593
ENST00000343388TLK2chr1760613698+ENST00000584985THRAchr1738240088+2200581501714554
ENST00000343388TLK2chr1760613698+ENST00000450525THRAchr1738240088+4763581501591513
ENST00000343388TLK2chr1760613698+ENST00000546243THRAchr1738240088+1866581501591513
ENST00000542523TLK2chr1760613698+ENST00000394121THRAchr1738240088+1942460251710561
ENST00000542523TLK2chr1760613698+ENST00000264637THRAchr1738240088+2196460251710561
ENST00000542523TLK2chr1760613698+ENST00000584985THRAchr1738240088+2079460251593522
ENST00000542523TLK2chr1760613698+ENST00000450525THRAchr1738240088+4642460251470481
ENST00000542523TLK2chr1760613698+ENST00000546243THRAchr1738240088+1745460251470481
ENST00000582809TLK2chr1760613698+ENST00000394121THRAchr1738240087+22697873702037555
ENST00000582809TLK2chr1760613698+ENST00000264637THRAchr1738240087+25237873702037555
ENST00000582809TLK2chr1760613698+ENST00000584985THRAchr1738240087+24067873701920516
ENST00000582809TLK2chr1760613698+ENST00000450525THRAchr1738240087+49697873701797475
ENST00000582809TLK2chr1760613698+ENST00000546243THRAchr1738240087+20727873701797475
ENST00000326270TLK2chr1760613698+ENST00000394121THRAchr1738240087+22817991212049642
ENST00000326270TLK2chr1760613698+ENST00000264637THRAchr1738240087+25357991212049642
ENST00000326270TLK2chr1760613698+ENST00000584985THRAchr1738240087+24187991211932603
ENST00000326270TLK2chr1760613698+ENST00000450525THRAchr1738240087+49817991211809562
ENST00000326270TLK2chr1760613698+ENST00000546243THRAchr1738240087+20847991211809562
ENST00000346027TLK2chr1760613698+ENST00000394121THRAchr1738240087+22848021212052643
ENST00000346027TLK2chr1760613698+ENST00000264637THRAchr1738240087+25388021212052643
ENST00000346027TLK2chr1760613698+ENST00000584985THRAchr1738240087+24218021211935604
ENST00000346027TLK2chr1760613698+ENST00000450525THRAchr1738240087+49848021211812563
ENST00000346027TLK2chr1760613698+ENST00000546243THRAchr1738240087+20878021211812563
ENST00000343388TLK2chr1760613698+ENST00000394121THRAchr1738240087+2063581501831593
ENST00000343388TLK2chr1760613698+ENST00000264637THRAchr1738240087+2317581501831593
ENST00000343388TLK2chr1760613698+ENST00000584985THRAchr1738240087+2200581501714554
ENST00000343388TLK2chr1760613698+ENST00000450525THRAchr1738240087+4763581501591513
ENST00000343388TLK2chr1760613698+ENST00000546243THRAchr1738240087+1866581501591513
ENST00000542523TLK2chr1760613698+ENST00000394121THRAchr1738240087+1942460251710561
ENST00000542523TLK2chr1760613698+ENST00000264637THRAchr1738240087+2196460251710561
ENST00000542523TLK2chr1760613698+ENST00000584985THRAchr1738240087+2079460251593522
ENST00000542523TLK2chr1760613698+ENST00000450525THRAchr1738240087+4642460251470481
ENST00000542523TLK2chr1760613698+ENST00000546243THRAchr1738240087+1745460251470481

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582809ENST00000394121TLK2chr1760613698+THRAchr1738240088+0.0166509280.9833491
ENST00000582809ENST00000264637TLK2chr1760613698+THRAchr1738240088+0.0128396120.98716044
ENST00000582809ENST00000584985TLK2chr1760613698+THRAchr1738240088+0.0103003390.98969966
ENST00000582809ENST00000450525TLK2chr1760613698+THRAchr1738240088+0.0021851810.9978148
ENST00000582809ENST00000546243TLK2chr1760613698+THRAchr1738240088+0.0056504430.99434954
ENST00000326270ENST00000394121TLK2chr1760613698+THRAchr1738240088+0.0165586580.98344135
ENST00000326270ENST00000264637TLK2chr1760613698+THRAchr1738240088+0.0112096660.9887903
ENST00000326270ENST00000584985TLK2chr1760613698+THRAchr1738240088+0.0102337490.9897662
ENST00000326270ENST00000450525TLK2chr1760613698+THRAchr1738240088+0.0015432780.9984567
ENST00000326270ENST00000546243TLK2chr1760613698+THRAchr1738240088+0.0065538190.9934462
ENST00000346027ENST00000394121TLK2chr1760613698+THRAchr1738240088+0.0168201660.9831798
ENST00000346027ENST00000264637TLK2chr1760613698+THRAchr1738240088+0.0116079170.98839206
ENST00000346027ENST00000584985TLK2chr1760613698+THRAchr1738240088+0.0105046680.98949534
ENST00000346027ENST00000450525TLK2chr1760613698+THRAchr1738240088+0.0015627950.9984372
ENST00000346027ENST00000546243TLK2chr1760613698+THRAchr1738240088+0.0067721370.9932279
ENST00000343388ENST00000394121TLK2chr1760613698+THRAchr1738240088+0.0153117890.9846882
ENST00000343388ENST00000264637TLK2chr1760613698+THRAchr1738240088+0.0109494370.9890506
ENST00000343388ENST00000584985TLK2chr1760613698+THRAchr1738240088+0.0086909060.99130905
ENST00000343388ENST00000450525TLK2chr1760613698+THRAchr1738240088+0.0016696520.9983304
ENST00000343388ENST00000546243TLK2chr1760613698+THRAchr1738240088+0.0061072390.9938928
ENST00000542523ENST00000394121TLK2chr1760613698+THRAchr1738240088+0.0161907840.98380923
ENST00000542523ENST00000264637TLK2chr1760613698+THRAchr1738240088+0.0112246240.9887754
ENST00000542523ENST00000584985TLK2chr1760613698+THRAchr1738240088+0.0087596980.9912403
ENST00000542523ENST00000450525TLK2chr1760613698+THRAchr1738240088+0.0016659290.9983341
ENST00000542523ENST00000546243TLK2chr1760613698+THRAchr1738240088+0.0063361410.9936639
ENST00000582809ENST00000394121TLK2chr1760613698+THRAchr1738240087+0.0166509280.9833491
ENST00000582809ENST00000264637TLK2chr1760613698+THRAchr1738240087+0.0128396120.98716044
ENST00000582809ENST00000584985TLK2chr1760613698+THRAchr1738240087+0.0103003390.98969966
ENST00000582809ENST00000450525TLK2chr1760613698+THRAchr1738240087+0.0021851810.9978148
ENST00000582809ENST00000546243TLK2chr1760613698+THRAchr1738240087+0.0056504430.99434954
ENST00000326270ENST00000394121TLK2chr1760613698+THRAchr1738240087+0.0165586580.98344135
ENST00000326270ENST00000264637TLK2chr1760613698+THRAchr1738240087+0.0112096660.9887903
ENST00000326270ENST00000584985TLK2chr1760613698+THRAchr1738240087+0.0102337490.9897662
ENST00000326270ENST00000450525TLK2chr1760613698+THRAchr1738240087+0.0015432780.9984567
ENST00000326270ENST00000546243TLK2chr1760613698+THRAchr1738240087+0.0065538190.9934462
ENST00000346027ENST00000394121TLK2chr1760613698+THRAchr1738240087+0.0168201660.9831798
ENST00000346027ENST00000264637TLK2chr1760613698+THRAchr1738240087+0.0116079170.98839206
ENST00000346027ENST00000584985TLK2chr1760613698+THRAchr1738240087+0.0105046680.98949534
ENST00000346027ENST00000450525TLK2chr1760613698+THRAchr1738240087+0.0015627950.9984372
ENST00000346027ENST00000546243TLK2chr1760613698+THRAchr1738240087+0.0067721370.9932279
ENST00000343388ENST00000394121TLK2chr1760613698+THRAchr1738240087+0.0153117890.9846882
ENST00000343388ENST00000264637TLK2chr1760613698+THRAchr1738240087+0.0109494370.9890506
ENST00000343388ENST00000584985TLK2chr1760613698+THRAchr1738240087+0.0086909060.99130905
ENST00000343388ENST00000450525TLK2chr1760613698+THRAchr1738240087+0.0016696520.9983304
ENST00000343388ENST00000546243TLK2chr1760613698+THRAchr1738240087+0.0061072390.9938928
ENST00000542523ENST00000394121TLK2chr1760613698+THRAchr1738240087+0.0161907840.98380923
ENST00000542523ENST00000264637TLK2chr1760613698+THRAchr1738240087+0.0112246240.9887754
ENST00000542523ENST00000584985TLK2chr1760613698+THRAchr1738240087+0.0087596980.9912403
ENST00000542523ENST00000450525TLK2chr1760613698+THRAchr1738240087+0.0016659290.9983341
ENST00000542523ENST00000546243TLK2chr1760613698+THRAchr1738240087+0.0063361410.9936639

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91169_91169_1_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240087_ENST00000264637_length(amino acids)=642AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGR
PGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPE

--------------------------------------------------------------

>91169_91169_2_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240087_ENST00000394121_length(amino acids)=642AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGR
PGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPE

--------------------------------------------------------------

>91169_91169_3_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240087_ENST00000450525_length(amino acids)=562AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHM

--------------------------------------------------------------

>91169_91169_4_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240087_ENST00000546243_length(amino acids)=562AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHM

--------------------------------------------------------------

>91169_91169_5_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240087_ENST00000584985_length(amino acids)=603AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSLQ

--------------------------------------------------------------

>91169_91169_6_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240088_ENST00000264637_length(amino acids)=642AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGR
PGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPE

--------------------------------------------------------------

>91169_91169_7_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240088_ENST00000394121_length(amino acids)=642AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGR
PGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPE

--------------------------------------------------------------

>91169_91169_8_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240088_ENST00000450525_length(amino acids)=562AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHM

--------------------------------------------------------------

>91169_91169_9_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240088_ENST00000546243_length(amino acids)=562AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHM

--------------------------------------------------------------

>91169_91169_10_TLK2-THRA_TLK2_chr17_60613698_ENST00000326270_THRA_chr17_38240088_ENST00000584985_length(amino acids)=603AA_BP=226
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAV
GMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD
KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDA
IFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSLQ

--------------------------------------------------------------

>91169_91169_11_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240087_ENST00000264637_length(amino acids)=593AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPK

--------------------------------------------------------------

>91169_91169_12_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240087_ENST00000394121_length(amino acids)=593AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPK

--------------------------------------------------------------

>91169_91169_13_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240087_ENST00000450525_length(amino acids)=513AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL

--------------------------------------------------------------

>91169_91169_14_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240087_ENST00000546243_length(amino acids)=513AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL

--------------------------------------------------------------

>91169_91169_15_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240087_ENST00000584985_length(amino acids)=554AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEE

--------------------------------------------------------------

>91169_91169_16_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240088_ENST00000264637_length(amino acids)=593AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPK

--------------------------------------------------------------

>91169_91169_17_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240088_ENST00000394121_length(amino acids)=593AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPK

--------------------------------------------------------------

>91169_91169_18_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240088_ENST00000450525_length(amino acids)=513AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL

--------------------------------------------------------------

>91169_91169_19_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240088_ENST00000546243_length(amino acids)=513AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL

--------------------------------------------------------------

>91169_91169_20_TLK2-THRA_TLK2_chr17_60613698_ENST00000343388_THRA_chr17_38240088_ENST00000584985_length(amino acids)=554AA_BP=177
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFF
RRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL
IHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME
IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLL
AFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEE

--------------------------------------------------------------

>91169_91169_21_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240087_ENST00000264637_length(amino acids)=643AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEG
RPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEP

--------------------------------------------------------------

>91169_91169_22_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240087_ENST00000394121_length(amino acids)=643AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEG
RPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEP

--------------------------------------------------------------

>91169_91169_23_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240087_ENST00000450525_length(amino acids)=563AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLH

--------------------------------------------------------------

>91169_91169_24_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240087_ENST00000546243_length(amino acids)=563AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLH

--------------------------------------------------------------

>91169_91169_25_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240087_ENST00000584985_length(amino acids)=604AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSL

--------------------------------------------------------------

>91169_91169_26_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240088_ENST00000264637_length(amino acids)=643AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEG
RPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEP

--------------------------------------------------------------

>91169_91169_27_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240088_ENST00000394121_length(amino acids)=643AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEG
RPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEP

--------------------------------------------------------------

>91169_91169_28_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240088_ENST00000450525_length(amino acids)=563AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLH

--------------------------------------------------------------

>91169_91169_29_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240088_ENST00000546243_length(amino acids)=563AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLH

--------------------------------------------------------------

>91169_91169_30_TLK2-THRA_TLK2_chr17_60613698_ENST00000346027_THRA_chr17_38240088_ENST00000584985_length(amino acids)=604AA_BP=227
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIA
VGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDG
DKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSD
AIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAGSL

--------------------------------------------------------------

>91169_91169_31_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240087_ENST00000264637_length(amino acids)=561AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSIL
YKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADS

--------------------------------------------------------------

>91169_91169_32_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240087_ENST00000394121_length(amino acids)=561AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSIL
YKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADS

--------------------------------------------------------------

>91169_91169_33_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240087_ENST00000450525_length(amino acids)=481AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGA

--------------------------------------------------------------

>91169_91169_34_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240087_ENST00000546243_length(amino acids)=481AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGA

--------------------------------------------------------------

>91169_91169_35_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240087_ENST00000584985_length(amino acids)=522AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQ

--------------------------------------------------------------

>91169_91169_36_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240088_ENST00000264637_length(amino acids)=561AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSIL
YKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADS

--------------------------------------------------------------

>91169_91169_37_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240088_ENST00000394121_length(amino acids)=561AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSIL
YKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADS

--------------------------------------------------------------

>91169_91169_38_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240088_ENST00000450525_length(amino acids)=481AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGA

--------------------------------------------------------------

>91169_91169_39_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240088_ENST00000546243_length(amino acids)=481AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGA

--------------------------------------------------------------

>91169_91169_40_TLK2-THRA_TLK2_chr17_60613698_ENST00000542523_THRA_chr17_38240088_ENST00000584985_length(amino acids)=522AA_BP=145
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL
CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQS
PIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN
GGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQ

--------------------------------------------------------------

>91169_91169_41_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240087_ENST00000264637_length(amino acids)=555AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAA
EGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEE

--------------------------------------------------------------

>91169_91169_42_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240087_ENST00000394121_length(amino acids)=555AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAA
EGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEE

--------------------------------------------------------------

>91169_91169_43_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240087_ENST00000450525_length(amino acids)=475AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRF

--------------------------------------------------------------

>91169_91169_44_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240087_ENST00000546243_length(amino acids)=475AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRF

--------------------------------------------------------------

>91169_91169_45_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240087_ENST00000584985_length(amino acids)=516AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAG

--------------------------------------------------------------

>91169_91169_46_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240088_ENST00000264637_length(amino acids)=555AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAA
EGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEE

--------------------------------------------------------------

>91169_91169_47_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240088_ENST00000394121_length(amino acids)=555AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAA
EGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEE

--------------------------------------------------------------

>91169_91169_48_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240088_ENST00000450525_length(amino acids)=475AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRF

--------------------------------------------------------------

>91169_91169_49_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240088_ENST00000546243_length(amino acids)=475AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRF

--------------------------------------------------------------

>91169_91169_50_TLK2-THRA_TLK2_chr17_60613698_ENST00000582809_THRA_chr17_38240088_ENST00000584985_length(amino acids)=516AA_BP=139
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKC
IAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMP
DGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
SDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKGPQVRQLEQQLGEAG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:60613698/chr17:38240088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTHRAchr17:60613698chr17:38240087ENST00000264637310163_40774.0491.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240087ENST00000394121310163_40774.0491.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240087ENST0000045052539163_40774.0411.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240087ENST0000054624339163_40774.0411.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240087ENST00000584985310163_40774.0452.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240088ENST00000264637310163_40774.0491.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240088ENST00000394121310163_40774.0491.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240088ENST0000045052539163_40774.0411.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240088ENST0000054624339163_40774.0411.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240088ENST00000584985310163_40774.0452.0DomainNR LBD
TgeneTHRAchr17:60613698chr17:38240087ENST0000026463731091_11574.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST0000039412131091_11574.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST000004505253991_11574.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST000005462433991_11574.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST0000058498531091_11574.0452.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000026463731091_11574.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000039412131091_11574.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST000004505253991_11574.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST000005462433991_11574.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000058498531091_11574.0452.0Zinc fingerNR C4-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK2chr17:60613698chr17:38240087ENST00000326270+723225_276177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000326270+723317_347177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000326270+723403_451177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000343388+621225_276145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000343388+621317_347145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000343388+621403_451145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000346027+722225_276177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000346027+722317_347177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000346027+722403_451177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000542523+621225_276145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000542523+621317_347145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000542523+621403_451145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000326270+723225_276177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000326270+723317_347177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000326270+723403_451177.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000343388+621225_276145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000343388+621317_347145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000343388+621403_451145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000346027+722225_276177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000346027+722317_347177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000346027+722403_451177.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000542523+621225_276145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000542523+621317_347145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240088ENST00000542523+621403_451145.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60613698chr17:38240087ENST00000326270+723462_741177.0773.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240087ENST00000343388+621462_741145.0719.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240087ENST00000346027+722462_741177.0751.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240087ENST00000542523+621462_741145.0719.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240088ENST00000326270+723462_741177.0773.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240088ENST00000343388+621462_741145.0719.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240088ENST00000346027+722462_741177.0751.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240088ENST00000542523+621462_741145.0719.0DomainProtein kinase
HgeneTLK2chr17:60613698chr17:38240087ENST00000326270+723468_476177.0773.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240087ENST00000343388+621468_476145.0719.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240087ENST00000346027+722468_476177.0751.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240087ENST00000542523+621468_476145.0719.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240088ENST00000326270+723468_476177.0773.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240088ENST00000343388+621468_476145.0719.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240088ENST00000346027+722468_476177.0751.0Nucleotide bindingATP
HgeneTLK2chr17:60613698chr17:38240088ENST00000542523+621468_476145.0719.0Nucleotide bindingATP
TgeneTHRAchr17:60613698chr17:38240087ENST0000026463731053_12774.0491.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240087ENST0000039412131053_12774.0491.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240087ENST000004505253953_12774.0411.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240087ENST000005462433953_12774.0411.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240087ENST0000058498531053_12774.0452.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240088ENST0000026463731053_12774.0491.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240088ENST0000039412131053_12774.0491.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240088ENST000004505253953_12774.0411.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240088ENST000005462433953_12774.0411.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240088ENST0000058498531053_12774.0452.0DNA bindingNuclear receptor
TgeneTHRAchr17:60613698chr17:38240087ENST000002646373101_5274.0491.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240087ENST000003941213101_5274.0491.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240087ENST00000450525391_5274.0411.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240087ENST00000546243391_5274.0411.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240087ENST000005849853101_5274.0452.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240088ENST000002646373101_5274.0491.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240088ENST000003941213101_5274.0491.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240088ENST00000450525391_5274.0411.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240088ENST00000546243391_5274.0411.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240088ENST000005849853101_5274.0452.0RegionNote=Modulating
TgeneTHRAchr17:60613698chr17:38240087ENST0000026463731053_7374.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST0000039412131053_7374.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST000004505253953_7374.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST000005462433953_7374.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240087ENST0000058498531053_7374.0452.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000026463731053_7374.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000039412131053_7374.0491.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST000004505253953_7374.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST000005462433953_7374.0411.0Zinc fingerNR C4-type
TgeneTHRAchr17:60613698chr17:38240088ENST0000058498531053_7374.0452.0Zinc fingerNR C4-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TLK2
THRA


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TLK2-THRA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TLK2-THRA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource