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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TM9SF4-ZNF423

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TM9SF4-ZNF423
FusionPDB ID: 91285
FusionGDB2.0 ID: 91285
HgeneTgene
Gene symbol

TM9SF4

ZNF423

Gene ID

9777

23090

Gene nametransmembrane 9 superfamily member 4zinc finger protein 423
SynonymsdJ836N17.2Ebfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZ
Cytomap

20q11.21

16q12.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1zinc finger protein 423OLF-1/EBF associated zinc fingerSmad- and Olf-interacting zinc finger proteinearly B-cell factor associated zinc finger proteinolf1/EBF-associated zinc finger protein
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000217315, ENST00000398022, 
ENST00000562520, ENST00000563137, 
ENST00000262383, ENST00000535559, 
ENST00000562871, ENST00000567169, 
ENST00000561648, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 19 X 14=53206 X 5 X 6=180
# samples 287
** MAII scorelog2(28/5320*10)=-4.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TM9SF4 [Title/Abstract] AND ZNF423 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TM9SF4(30723976)-ZNF423(49823457), # samples:3
Anticipated loss of major functional domain due to fusion event.TM9SF4-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TM9SF4-ZNF423 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTM9SF4

GO:0001666

response to hypoxia

25961573

TgeneZNF423

GO:0045892

negative regulation of transcription, DNA-templated

10660046

TgeneZNF423

GO:0045893

positive regulation of transcription, DNA-templated

10660046


check buttonFusion gene breakpoints across TM9SF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF423 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-A632-01ATM9SF4chr20

30723976

-ZNF423chr16

49823457

-
ChimerDB4PRADTCGA-HC-A632-01ATM9SF4chr20

30723976

+ZNF423chr16

49823457

-
ChimerDB4PRADTCGA-HC-A632TM9SF4chr20

30723976

+ZNF423chr16

49823457

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398022TM9SF4chr2030723976+ENST00000561648ZNF423chr1649823457-805446423543021355
ENST00000217315TM9SF4chr2030723976+ENST00000561648ZNF423chr1649823457-810851814843561402

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398022ENST00000561648TM9SF4chr2030723976+ZNF423chr1649823457-0.0012569330.9987431
ENST00000217315ENST00000561648TM9SF4chr2030723976+ZNF423chr1649823457-0.001392470.9986076

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91285_91285_1_TM9SF4-ZNF423_TM9SF4_chr20_30723976_ENST00000217315_ZNF423_chr16_49823457_ENST00000561648_length(amino acids)=1402AA_BP=123
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDME
DESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSY
LKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQ
AHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQF
SSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFNSL
AVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPSD
GNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAE
QSPVSSDVEVSSPKRQRLSASANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHY
VCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHK
CIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAATENGTANGVPPMATKKAEPADLQGMLLKNPEAPNSH
EASEDDVDASEPMYGCDICGAAYTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCP
ICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAA
SSPNGQGLQKLYKCALCLKEFRSKQDLVKLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESHMQVD
HRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCP

--------------------------------------------------------------

>91285_91285_2_TM9SF4-ZNF423_TM9SF4_chr20_30723976_ENST00000398022_ZNF423_chr16_49823457_ENST00000561648_length(amino acids)=1355AA_BP=76
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLVEEGEASDFSLAWD
SSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSS
KDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHEC
EAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQL
SEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVE
RGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFNSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAY
PVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAKLESPVVQPTQSF
MEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSASANSISNGEYPCNQCDLKFSNFESFQT
HLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHL
AVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREK
HCVFDAATENGTANGVPPMATKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRLRDHNIRPGEDDGS
RKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQM
HPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLVKLDVNGLPYGLCAGCMARS
ANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESHMQVDHRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVAN
HMIEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQEDKIYDCSQCPQKFFFQTELQNHTM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30723976/chr16:49823457)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191020_10425.3333333333333331285.0Zinc fingerC2H2-type 24
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191064_10825.3333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191120_11435.3333333333333331285.0Zinc fingerC2H2-type 26
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191168_11905.3333333333333331285.0Zinc fingerC2H2-type 27
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191198_12205.3333333333333331285.0Zinc fingerC2H2-type 28
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191229_12525.3333333333333331285.0Zinc fingerC2H2-type 29
TgeneZNF423chr20:30723976chr16:49823457ENST00000262383191259_12825.3333333333333331285.0Zinc fingerC2H2-type 30
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319138_1605.3333333333333331285.0Zinc fingerC2H2-type 2
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319166_1885.3333333333333331285.0Zinc fingerC2H2-type 3
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319194_2165.3333333333333331285.0Zinc fingerC2H2-type 4
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319222_2445.3333333333333331285.0Zinc fingerC2H2-type 5
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319263_2865.3333333333333331285.0Zinc fingerC2H2-type 6
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319295_3185.3333333333333331285.0Zinc fingerC2H2-type 7
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319323_3455.3333333333333331285.0Zinc fingerC2H2-type 8
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319409_4335.3333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319441_4645.3333333333333331285.0Zinc fingerC2H2-type 10
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319480_5035.3333333333333331285.0Zinc fingerC2H2-type 11
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319517_5405.3333333333333331285.0Zinc fingerC2H2-type 12
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319563_5885.3333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319632_6545.3333333333333331285.0Zinc fingerC2H2-type 14
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319662_6845.3333333333333331285.0Zinc fingerC2H2-type 15
TgeneZNF423chr20:30723976chr16:49823457ENST000002623831967_935.3333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319692_7155.3333333333333331285.0Zinc fingerC2H2-type 16
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319720_7435.3333333333333331285.0Zinc fingerC2H2-type 17
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319750_7735.3333333333333331285.0Zinc fingerC2H2-type 18
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319781_8035.3333333333333331285.0Zinc fingerC2H2-type 19
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319807_8305.3333333333333331285.0Zinc fingerC2H2-type 20
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319886_9085.3333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319930_9525.3333333333333331285.0Zinc fingerC2H2-type 22
TgeneZNF423chr20:30723976chr16:49823457ENST0000026238319959_9815.3333333333333331285.0Zinc fingerC2H2-type 23
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081020_10425.3333333333333331285.0Zinc fingerC2H2-type 24
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081064_10825.3333333333333331285.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081120_11435.3333333333333331285.0Zinc fingerC2H2-type 26
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081168_11905.3333333333333331285.0Zinc fingerC2H2-type 27
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081198_12205.3333333333333331285.0Zinc fingerC2H2-type 28
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081229_12525.3333333333333331285.0Zinc fingerC2H2-type 29
TgeneZNF423chr20:30723976chr16:49823457ENST00000561648081259_12825.3333333333333331285.0Zinc fingerC2H2-type 30
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808138_1605.3333333333333331285.0Zinc fingerC2H2-type 2
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808166_1885.3333333333333331285.0Zinc fingerC2H2-type 3
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808194_2165.3333333333333331285.0Zinc fingerC2H2-type 4
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808222_2445.3333333333333331285.0Zinc fingerC2H2-type 5
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808263_2865.3333333333333331285.0Zinc fingerC2H2-type 6
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808295_3185.3333333333333331285.0Zinc fingerC2H2-type 7
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808323_3455.3333333333333331285.0Zinc fingerC2H2-type 8
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808409_4335.3333333333333331285.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808441_4645.3333333333333331285.0Zinc fingerC2H2-type 10
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808480_5035.3333333333333331285.0Zinc fingerC2H2-type 11
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808517_5405.3333333333333331285.0Zinc fingerC2H2-type 12
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808563_5885.3333333333333331285.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808632_6545.3333333333333331285.0Zinc fingerC2H2-type 14
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808662_6845.3333333333333331285.0Zinc fingerC2H2-type 15
TgeneZNF423chr20:30723976chr16:49823457ENST000005616480867_935.3333333333333331285.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808692_7155.3333333333333331285.0Zinc fingerC2H2-type 16
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808720_7435.3333333333333331285.0Zinc fingerC2H2-type 17
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808750_7735.3333333333333331285.0Zinc fingerC2H2-type 18
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808781_8035.3333333333333331285.0Zinc fingerC2H2-type 19
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808807_8305.3333333333333331285.0Zinc fingerC2H2-type 20
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808886_9085.3333333333333331285.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808930_9525.3333333333333331285.0Zinc fingerC2H2-type 22
TgeneZNF423chr20:30723976chr16:49823457ENST0000056164808959_9815.3333333333333331285.0Zinc fingerC2H2-type 23
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081020_104201225.0Zinc fingerC2H2-type 24
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081064_108201225.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081120_114301225.0Zinc fingerC2H2-type 26
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081168_119001225.0Zinc fingerC2H2-type 27
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081198_122001225.0Zinc fingerC2H2-type 28
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081229_125201225.0Zinc fingerC2H2-type 29
TgeneZNF423chr20:30723976chr16:49823457ENST00000562520081259_128201225.0Zinc fingerC2H2-type 30
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008138_16001225.0Zinc fingerC2H2-type 2
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008166_18801225.0Zinc fingerC2H2-type 3
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008194_21601225.0Zinc fingerC2H2-type 4
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008222_24401225.0Zinc fingerC2H2-type 5
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008263_28601225.0Zinc fingerC2H2-type 6
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008295_31801225.0Zinc fingerC2H2-type 7
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008323_34501225.0Zinc fingerC2H2-type 8
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008409_43301225.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008441_46401225.0Zinc fingerC2H2-type 10
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008480_50301225.0Zinc fingerC2H2-type 11
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008517_54001225.0Zinc fingerC2H2-type 12
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008563_58801225.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008632_65401225.0Zinc fingerC2H2-type 14
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008662_68401225.0Zinc fingerC2H2-type 15
TgeneZNF423chr20:30723976chr16:49823457ENST000005625200867_9301225.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008692_71501225.0Zinc fingerC2H2-type 16
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008720_74301225.0Zinc fingerC2H2-type 17
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008750_77301225.0Zinc fingerC2H2-type 18
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008781_80301225.0Zinc fingerC2H2-type 19
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008807_83001225.0Zinc fingerC2H2-type 20
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008886_90801225.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008930_95201225.0Zinc fingerC2H2-type 22
TgeneZNF423chr20:30723976chr16:49823457ENST0000056252008959_98101225.0Zinc fingerC2H2-type 23
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071020_104201225.0Zinc fingerC2H2-type 24
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071064_108201225.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071120_114301225.0Zinc fingerC2H2-type 26
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071168_119001225.0Zinc fingerC2H2-type 27
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071198_122001225.0Zinc fingerC2H2-type 28
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071229_125201225.0Zinc fingerC2H2-type 29
TgeneZNF423chr20:30723976chr16:49823457ENST00000562871071259_128201225.0Zinc fingerC2H2-type 30
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107138_16001225.0Zinc fingerC2H2-type 2
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107166_18801225.0Zinc fingerC2H2-type 3
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107194_21601225.0Zinc fingerC2H2-type 4
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107222_24401225.0Zinc fingerC2H2-type 5
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107263_28601225.0Zinc fingerC2H2-type 6
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107295_31801225.0Zinc fingerC2H2-type 7
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107323_34501225.0Zinc fingerC2H2-type 8
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107409_43301225.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107441_46401225.0Zinc fingerC2H2-type 10
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107480_50301225.0Zinc fingerC2H2-type 11
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107517_54001225.0Zinc fingerC2H2-type 12
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107563_58801225.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107632_65401225.0Zinc fingerC2H2-type 14
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107662_68401225.0Zinc fingerC2H2-type 15
TgeneZNF423chr20:30723976chr16:49823457ENST000005628710767_9301225.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107692_71501225.0Zinc fingerC2H2-type 16
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107720_74301225.0Zinc fingerC2H2-type 17
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107750_77301225.0Zinc fingerC2H2-type 18
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107781_80301225.0Zinc fingerC2H2-type 19
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107807_83001225.0Zinc fingerC2H2-type 20
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107886_90801225.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107930_95201225.0Zinc fingerC2H2-type 22
TgeneZNF423chr20:30723976chr16:49823457ENST0000056287107959_98101225.0Zinc fingerC2H2-type 23
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081020_104201225.0Zinc fingerC2H2-type 24
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081064_108201225.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081120_114301225.0Zinc fingerC2H2-type 26
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081168_119001225.0Zinc fingerC2H2-type 27
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081198_122001225.0Zinc fingerC2H2-type 28
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081229_125201225.0Zinc fingerC2H2-type 29
TgeneZNF423chr20:30723976chr16:49823457ENST00000563137081259_128201225.0Zinc fingerC2H2-type 30
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708138_16001225.0Zinc fingerC2H2-type 2
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708166_18801225.0Zinc fingerC2H2-type 3
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708194_21601225.0Zinc fingerC2H2-type 4
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708222_24401225.0Zinc fingerC2H2-type 5
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708263_28601225.0Zinc fingerC2H2-type 6
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708295_31801225.0Zinc fingerC2H2-type 7
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708323_34501225.0Zinc fingerC2H2-type 8
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708409_43301225.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708441_46401225.0Zinc fingerC2H2-type 10
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708480_50301225.0Zinc fingerC2H2-type 11
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708517_54001225.0Zinc fingerC2H2-type 12
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708563_58801225.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708632_65401225.0Zinc fingerC2H2-type 14
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708662_68401225.0Zinc fingerC2H2-type 15
TgeneZNF423chr20:30723976chr16:49823457ENST000005631370867_9301225.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708692_71501225.0Zinc fingerC2H2-type 16
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708720_74301225.0Zinc fingerC2H2-type 17
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708750_77301225.0Zinc fingerC2H2-type 18
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708781_80301225.0Zinc fingerC2H2-type 19
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708807_83001225.0Zinc fingerC2H2-type 20
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708886_90801225.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708930_95201225.0Zinc fingerC2H2-type 22
TgeneZNF423chr20:30723976chr16:49823457ENST0000056313708959_98101225.0Zinc fingerC2H2-type 23

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+31824_28159.333333333333336626.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318303_34659.333333333333336626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318368_37659.333333333333336626.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318398_41659.333333333333336626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318438_44959.333333333333336626.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318471_50159.333333333333336626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318523_53559.333333333333336626.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318557_57059.333333333333336626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318592_59859.333333333333336626.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318620_64259.333333333333336626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+31824_28176.33333333333333643.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318303_34676.33333333333333643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318368_37676.33333333333333643.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318398_41676.33333333333333643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318438_44976.33333333333333643.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318471_50176.33333333333333643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318523_53576.33333333333333643.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318557_57076.33333333333333643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318592_59876.33333333333333643.0Topological domainExtracellular
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318620_64276.33333333333333643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318282_30259.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318347_36759.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318377_39759.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318417_43759.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318450_47059.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318502_52259.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318536_55659.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318571_59159.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000217315+318599_61959.333333333333336626.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318282_30276.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318347_36776.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318377_39776.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318417_43776.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318450_47076.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318502_52276.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318536_55676.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318571_59176.33333333333333643.0TransmembraneHelical
HgeneTM9SF4chr20:30723976chr16:49823457ENST00000398022+318599_61976.33333333333333643.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2042_TM9SF4_30723976_ZNF423_49823457_ranked_0.pdbTM9SF43072397630723976ENST00000561648ZNF423chr1649823457-
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDEDME
DESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSY
LKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQ
AHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQF
SSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFNSL
AVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPSD
GNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAE
QSPVSSDVEVSSPKRQRLSASANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHY
VCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHK
CIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAATENGTANGVPPMATKKAEPADLQGMLLKNPEAPNSH
EASEDDVDASEPMYGCDICGAAYTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCP
ICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAA
SSPNGQGLQKLYKCALCLKEFRSKQDLVKLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESHMQVD
HRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCP
1402


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TM9SF4_pLDDT.png
all structure
all structure
ZNF423_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TM9SF4
ZNF423


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TM9SF4-ZNF423


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TM9SF4-ZNF423


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource