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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TMBIM4-PBX3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMBIM4-PBX3
FusionPDB ID: 91304
FusionGDB2.0 ID: 91304
HgeneTgene
Gene symbol

TMBIM4

PBX3

Gene ID

51643

5090

Gene nametransmembrane BAX inhibitor motif containing 4PBX homeobox 3
SynonymsCGI-119|GAAP|LFG4|S1R|ZPRO-
Cytomap

12q14.3

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionprotein lifeguard 4Golgi anti-apoptotic proteinZ-proteintransmembrane BAX inhibitor motif-containing protein 4pre-B-cell leukemia transcription factor 3homeobox protein PBX3pre-B-cell leukemia homeobox 3
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000286424, ENST00000358230, 
ENST00000398033, ENST00000539652, 
ENST00000542724, ENST00000556010, 
ENST00000535812, ENST00000544599, 
ENST00000538998, ENST00000373483, 
ENST00000447726, ENST00000342287, 
ENST00000373487, ENST00000373489, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 8 X 8=89610 X 10 X 7=700
# samples 1812
** MAII scorelog2(18/896*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TMBIM4 [Title/Abstract] AND PBX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMBIM4(66563635)-PBX3(128691934), # samples:4
Anticipated loss of major functional domain due to fusion event.TMBIM4-PBX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMBIM4-PBX3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMBIM4-PBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMBIM4-PBX3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMBIM4-PBX3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMBIM4

GO:0050848

regulation of calcium-mediated signaling

19553469


check buttonFusion gene breakpoints across TMBIM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23Z-01ATMBIM4chr12

66563634

-PBX3chr9

128691933

+
ChimerDB4SARCTCGA-DX-A23Z-01ATMBIM4chr12

66563635

-PBX3chr9

128691934

+
ChimerDB4SARCTCGA-QQ-A8VD-01ATMBIM4chr12

66563635

-PBX3chr9

128677965

+
ChimerDB4SARCTCGA-QQ-A8VD-01ATMBIM4chr12

66563635

-PBX3chr9

128691934

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539652TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+226113123670215
ENST00000539652TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+243713123982319
ENST00000539652TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+210113123919298
ENST00000556010TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+226113123670215
ENST00000556010TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+243713123982319
ENST00000556010TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+210113123919298
ENST00000358230TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+2348218110757215
ENST00000358230TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+25242181101069319
ENST00000358230TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+21882181101006298
ENST00000286424TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+22381080647215
ENST00000286424TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+24141080959319
ENST00000286424TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+20781080896298
ENST00000398033TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+227414436683215
ENST00000398033TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+245014436995319
ENST00000398033TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+211414436932298
ENST00000542724TMBIM4chr1266563635-ENST00000342287PBX3chr9128691934+230317365712215
ENST00000542724TMBIM4chr1266563635-ENST00000373487PBX3chr9128691934+2479173651024319
ENST00000542724TMBIM4chr1266563635-ENST00000373489PBX3chr9128691934+214317365961298
ENST00000539652TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+226113123670215
ENST00000539652TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+243713123982319
ENST00000539652TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+210113123919298
ENST00000556010TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+226113123670215
ENST00000556010TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+243713123982319
ENST00000556010TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+210113123919298
ENST00000358230TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+2348218110757215
ENST00000358230TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+25242181101069319
ENST00000358230TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+21882181101006298
ENST00000286424TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+22381080647215
ENST00000286424TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+24141080959319
ENST00000286424TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+20781080896298
ENST00000398033TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+227414436683215
ENST00000398033TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+245014436995319
ENST00000398033TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+211414436932298
ENST00000542724TMBIM4chr1266563634-ENST00000342287PBX3chr9128691933+230317365712215
ENST00000542724TMBIM4chr1266563634-ENST00000373487PBX3chr9128691933+2479173651024319
ENST00000542724TMBIM4chr1266563634-ENST00000373489PBX3chr9128691933+214317365961298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539652ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0036643510.9963356
ENST00000539652ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.0004733260.99952674
ENST00000539652ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.000929520.99907047
ENST00000556010ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0036643510.9963356
ENST00000556010ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.0004733260.99952674
ENST00000556010ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.000929520.99907047
ENST00000358230ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0033384440.99666154
ENST00000358230ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.000439690.9995603
ENST00000358230ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.0009098640.9990902
ENST00000286424ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0040909730.995909
ENST00000286424ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.000448730.99955124
ENST00000286424ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.0009605480.9990395
ENST00000398033ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0036606710.9963393
ENST00000398033ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.0004596550.9995403
ENST00000398033ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.0008958690.9991041
ENST00000542724ENST00000342287TMBIM4chr1266563635-PBX3chr9128691934+0.0025905290.9974095
ENST00000542724ENST00000373487TMBIM4chr1266563635-PBX3chr9128691934+0.0004369240.99956304
ENST00000542724ENST00000373489TMBIM4chr1266563635-PBX3chr9128691934+0.0008731550.99912685
ENST00000539652ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0036643510.9963356
ENST00000539652ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.0004733260.99952674
ENST00000539652ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.000929520.99907047
ENST00000556010ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0036643510.9963356
ENST00000556010ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.0004733260.99952674
ENST00000556010ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.000929520.99907047
ENST00000358230ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0033384440.99666154
ENST00000358230ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.000439690.9995603
ENST00000358230ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.0009098640.9990902
ENST00000286424ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0040909730.995909
ENST00000286424ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.000448730.99955124
ENST00000286424ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.0009605480.9990395
ENST00000398033ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0036606710.9963393
ENST00000398033ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.0004596550.9995403
ENST00000398033ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.0008958690.9991041
ENST00000542724ENST00000342287TMBIM4chr1266563634-PBX3chr9128691933+0.0025905290.9974095
ENST00000542724ENST00000373487TMBIM4chr1266563634-PBX3chr9128691933+0.0004369240.99956304
ENST00000542724ENST00000373489TMBIM4chr1266563634-PBX3chr9128691933+0.0008731550.99912685

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91304_91304_1_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000286424_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_2_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000286424_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_3_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000286424_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_4_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000358230_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_5_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000358230_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_6_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000358230_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_7_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000398033_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_8_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000398033_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_9_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000398033_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_10_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000539652_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_11_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000539652_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_12_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000539652_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_13_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000542724_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_14_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000542724_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_15_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000542724_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_16_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000556010_PBX3_chr9_128691933_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_17_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000556010_PBX3_chr9_128691933_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_18_TMBIM4-PBX3_TMBIM4_chr12_66563634_ENST00000556010_PBX3_chr9_128691933_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_19_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000286424_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_20_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000286424_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_21_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000286424_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
LLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_22_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000358230_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_23_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000358230_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_24_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000358230_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_25_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000398033_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_26_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000398033_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_27_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000398033_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_28_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000539652_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_29_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000539652_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_30_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000539652_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_31_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000542724_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_32_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000542724_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_33_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000542724_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

>91304_91304_34_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000556010_PBX3_chr9_128691934_ENST00000342287_length(amino acids)=215AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA

--------------------------------------------------------------

>91304_91304_35_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000556010_PBX3_chr9_128691934_ENST00000373487_length(amino acids)=319AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT

--------------------------------------------------------------

>91304_91304_36_TMBIM4-PBX3_TMBIM4_chr12_66563635_ENST00000556010_PBX3_chr9_128691934_ENST00000373489_length(amino acids)=298AA_BP=36
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAA
HAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNAN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:66563635/chr9:128691934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePBX3chr12:66563634chr9:128691933ENST0000037348318130_1380254.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563634chr9:128691933ENST0000044772629130_13897.0360.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563635chr9:128691934ENST0000037348318130_1380254.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563635chr9:128691934ENST0000044772629130_13897.0360.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563634chr9:128691933ENST0000034228728235_297172.0764.6666666666666DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563634chr9:128691933ENST0000037348318235_2970254.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563634chr9:128691933ENST0000037348929235_297172.0435.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563634chr9:128691933ENST0000044772629235_29797.0360.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563635chr9:128691934ENST0000034228728235_297172.0764.6666666666666DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563635chr9:128691934ENST0000037348318235_2970254.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563635chr9:128691934ENST0000037348929235_297172.0435.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563635chr9:128691934ENST0000044772629235_29797.0360.0DNA bindingHomeobox%3B TALE-type
TgenePBX3chr12:66563634chr9:128691933ENST000003734831843_2340254.0DomainPBC
TgenePBX3chr12:66563635chr9:128691934ENST000003734831843_2340254.0DomainPBC

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17209_22932.333333333333336239.0IntramembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17209_22932.333333333333336239.0IntramembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17119_12032.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17142_15132.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17173_17532.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17197_20832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-171_3832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17230_23832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-1760_6832.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-1790_9732.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17119_12032.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17142_15132.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17173_17532.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17197_20832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-171_3832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17230_23832.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-1760_6832.333333333333336239.0Topological domainLumenal
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-1790_9732.333333333333336239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17121_14132.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17152_17232.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-17176_19632.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-1739_5932.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-1769_8932.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563634chr9:128691933ENST00000358230-1798_11832.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17121_14132.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17152_17232.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-17176_19632.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-1739_5932.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-1769_8932.333333333333336239.0TransmembraneHelical
HgeneTMBIM4chr12:66563635chr9:128691934ENST00000358230-1798_11832.333333333333336239.0TransmembraneHelical
TgenePBX3chr12:66563634chr9:128691933ENST0000034228728130_138172.0764.6666666666666Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563634chr9:128691933ENST0000037348929130_138172.0435.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563635chr9:128691934ENST0000034228728130_138172.0764.6666666666666Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563635chr9:128691934ENST0000037348929130_138172.0435.0Compositional biasNote=Poly-Ala
TgenePBX3chr12:66563634chr9:128691933ENST000003422872843_234172.0764.6666666666666DomainPBC
TgenePBX3chr12:66563634chr9:128691933ENST000003734892943_234172.0435.0DomainPBC
TgenePBX3chr12:66563634chr9:128691933ENST000004477262943_23497.0360.0DomainPBC
TgenePBX3chr12:66563635chr9:128691934ENST000003422872843_234172.0764.6666666666666DomainPBC
TgenePBX3chr12:66563635chr9:128691934ENST000003734892943_234172.0435.0DomainPBC
TgenePBX3chr12:66563635chr9:128691934ENST000004477262943_23497.0360.0DomainPBC


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>586_TMBIM4_66563635_PBX3_128691934_ranked_0.pdbTMBIM46656363466563635ENST00000373489PBX3chr9128691934+
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVM
ILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGNKRIRYKK
NIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQT
319


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TMBIM4_pLDDT.png
all structure
all structure
PBX3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TMBIM4
PBX3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TMBIM4-PBX3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMBIM4-PBX3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource