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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TMED10-MLH3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TMED10-MLH3
	FusionPDB ID: 91430
	FusionGDB2.0 ID: 91430
		Hgene	Tgene
	Gene symbol	TMED10	MLH3
	Gene ID	10972	27030
	Gene name	transmembrane p24 trafficking protein 10	mutL homolog 3
	Synonyms	P24(DELTA)\|S31I125\|S31III125\|TMP21\|Tmp-21-I\|p23\|p24d1	HNPCC7
	Cytomap	14q24.3	14q24.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21	DNA mismatch repair protein Mlh3
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UHC1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000303575, ENST00000557670,	ENST00000544985, ENST00000555671, ENST00000238662, ENST00000355774, ENST00000380968, ENST00000556257, ENST00000556740,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 12 X 7=1260	1 X 4 X 1=4
	# samples	19	4
	** MAII score	log2(19/1260*10)=-2.72935241005633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/4*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: TMED10 [Title/Abstract] AND MLH3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TMED10(75614366)-MLH3(75497405), # samples:1 TMED10(75614366)-MLH3(75505115), # samples:1 TMED10(75614366)-MLH3(75506718), # samples:1 TMED10(75614367)-MLH3(75497405), # samples:1 TMED10(75614367)-MLH3(75497418), # samples:1 TMED10(75614367)-MLH3(75506718), # samples:1 TMED10(75614367)-MLH3(75505115), # samples:1
Anticipated loss of major functional domain due to fusion event.	TMED10-MLH3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMED10-MLH3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMED10-MLH3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMED10	GO:0006886	intracellular protein transport	20427317
Hgene	TMED10	GO:0035964	COPI-coated vesicle budding	10052452

Fusion gene breakpoints across TMED10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MLH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A452-01A	TMED10	chr14	75614367	-	MLH3	chr14	75505115	-
ChimerDB4	STAD	TCGA-BR-A452-01A	TMED10	chr14	75614367	-	MLH3	chr14	75506718	-
ChimerDB4	STAD	TCGA-BR-A452	TMED10	chr14	75614366	-	MLH3	chr14	75505115	-
ChimerDB4	STAD	TCGA-BR-A452	TMED10	chr14	75614366	-	MLH3	chr14	75506718	-
ChimerDB4	STAD	TCGA-D7-6822-01A	TMED10	chr14	75614367	-	MLH3	chr14	75497405	-
ChimerDB4	STAD	TCGA-D7-6822-01A	TMED10	chr14	75614367	-	MLH3	chr14	75497418	-
ChimerDB4	STAD	TCGA-D7-6822	TMED10	chr14	75614366	-	MLH3	chr14	75497405	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000303575	TMED10	chr14	75614366	-	ENST00000380968	MLH3	chr14	75505115	-	4549	463	52	1230	392
ENST00000303575	TMED10	chr14	75614366	-	ENST00000355774	MLH3	chr14	75505115	-	4573	463	52	1254	400
ENST00000303575	TMED10	chr14	75614366	-	ENST00000238662	MLH3	chr14	75505115	-	1910	463	52	1182	376
ENST00000303575	TMED10	chr14	75614366	-	ENST00000380968	MLH3	chr14	75506718	-	4654	463	52	1335	427
ENST00000303575	TMED10	chr14	75614366	-	ENST00000355774	MLH3	chr14	75506718	-	4678	463	52	1359	435
ENST00000303575	TMED10	chr14	75614366	-	ENST00000238662	MLH3	chr14	75506718	-	2015	463	52	1287	411
ENST00000303575	TMED10	chr14	75614367	-	ENST00000380968	MLH3	chr14	75506718	-	4654	463	52	1335	427
ENST00000303575	TMED10	chr14	75614367	-	ENST00000355774	MLH3	chr14	75506718	-	4678	463	52	1359	435
ENST00000303575	TMED10	chr14	75614367	-	ENST00000238662	MLH3	chr14	75506718	-	2015	463	52	1287	411
ENST00000303575	TMED10	chr14	75614367	-	ENST00000380968	MLH3	chr14	75505115	-	4549	463	52	1230	392
ENST00000303575	TMED10	chr14	75614367	-	ENST00000355774	MLH3	chr14	75505115	-	4573	463	52	1254	400
ENST00000303575	TMED10	chr14	75614367	-	ENST00000238662	MLH3	chr14	75505115	-	1910	463	52	1182	376

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000303575	ENST00000380968	TMED10	chr14	75614366	-	MLH3	chr14	75505115	-	0.000628626	0.99937135
ENST00000303575	ENST00000355774	TMED10	chr14	75614366	-	MLH3	chr14	75505115	-	0.000545557	0.99945444
ENST00000303575	ENST00000238662	TMED10	chr14	75614366	-	MLH3	chr14	75505115	-	0.000638361	0.9993617
ENST00000303575	ENST00000380968	TMED10	chr14	75614366	-	MLH3	chr14	75506718	-	0.000928196	0.9990717
ENST00000303575	ENST00000355774	TMED10	chr14	75614366	-	MLH3	chr14	75506718	-	0.000828052	0.999172
ENST00000303575	ENST00000238662	TMED10	chr14	75614366	-	MLH3	chr14	75506718	-	0.000728136	0.9992718
ENST00000303575	ENST00000380968	TMED10	chr14	75614367	-	MLH3	chr14	75506718	-	0.000928196	0.9990717
ENST00000303575	ENST00000355774	TMED10	chr14	75614367	-	MLH3	chr14	75506718	-	0.000828052	0.999172
ENST00000303575	ENST00000238662	TMED10	chr14	75614367	-	MLH3	chr14	75506718	-	0.000728136	0.9992718
ENST00000303575	ENST00000380968	TMED10	chr14	75614367	-	MLH3	chr14	75505115	-	0.000628626	0.99937135
ENST00000303575	ENST00000355774	TMED10	chr14	75614367	-	MLH3	chr14	75505115	-	0.000545557	0.99945444
ENST00000303575	ENST00000238662	TMED10	chr14	75614367	-	MLH3	chr14	75505115	-	0.000638361	0.9993617

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91430_91430_1_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75505115_ENST00000238662_length(amino acids)=376AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSS
TLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQG
TLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAEC

--------------------------------------------------------------

>91430_91430_2_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75505115_ENST00000355774_length(amino acids)=400AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRL
EQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTV
TKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEK

--------------------------------------------------------------

>91430_91430_3_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75505115_ENST00000380968_length(amino acids)=392AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRL
EQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTV
TKSIVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTK

--------------------------------------------------------------

>91430_91430_4_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75506718_ENST00000238662_length(amino acids)=411AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVERE
ANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLP

--------------------------------------------------------------

>91430_91430_5_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75506718_ENST00000355774_length(amino acids)=435AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLE
FVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESC

--------------------------------------------------------------

>91430_91430_6_TMED10-MLH3_TMED10_chr14_75614366_ENST00000303575_MLH3_chr14_75506718_ENST00000380968_length(amino acids)=427AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLE
FVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSS

--------------------------------------------------------------

>91430_91430_7_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75505115_ENST00000238662_length(amino acids)=376AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSS
TLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQG
TLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAEC

--------------------------------------------------------------

>91430_91430_8_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75505115_ENST00000355774_length(amino acids)=400AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRL
EQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTV
TKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEK

--------------------------------------------------------------

>91430_91430_9_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75505115_ENST00000380968_length(amino acids)=392AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRL
EQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTV
TKSIVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTK

--------------------------------------------------------------

>91430_91430_10_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75506718_ENST00000238662_length(amino acids)=411AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVERE
ANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLP

--------------------------------------------------------------

>91430_91430_11_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75506718_ENST00000355774_length(amino acids)=435AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLE
FVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESC

--------------------------------------------------------------

>91430_91430_12_TMED10-MLH3_TMED10_chr14_75614367_ENST00000303575_MLH3_chr14_75506718_ENST00000380968_length(amino acids)=427AA_BP=0
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDA
TKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNK
FIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLE
FVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:75614366/chr14:75497405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MLH3 Q9UHC1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Probably involved in the repair of mismatches in DNA.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMED10

chr14:75614366

chr14:75505115

ENST00000303575

41_193

137.0

220.0

Domain

GOLD

Hgene

TMED10

chr14:75614366

chr14:75506718

ENST00000303575

41_193

137.0

220.0

Domain

GOLD

Hgene

TMED10

chr14:75614367

chr14:75505115

ENST00000303575

41_193

137.0

220.0

Domain

GOLD

Hgene

TMED10

chr14:75614367

chr14:75506718

ENST00000303575

41_193

137.0

220.0

Domain

GOLD

Hgene

TMED10

chr14:75614366

chr14:75505115

ENST00000303575

211_219

137.0

220.0

Motif

Note=COPI vesicle coat-binding

Hgene

TMED10

chr14:75614366

chr14:75506718

ENST00000303575

211_219

137.0

220.0

Motif

Note=COPI vesicle coat-binding

Hgene

TMED10

chr14:75614367

chr14:75505115

ENST00000303575

211_219

137.0

220.0

Motif

Note=COPI vesicle coat-binding

Hgene

TMED10

chr14:75614367

chr14:75506718

ENST00000303575

211_219

137.0

220.0

Motif

Note=COPI vesicle coat-binding

Hgene

TMED10

chr14:75614366

chr14:75505115

ENST00000303575

147_178

137.0

220.0

Region

Note=Required for TMED10 and TMED2 cis-Golgi network localization

Hgene

TMED10

chr14:75614366

chr14:75506718

ENST00000303575

147_178

137.0

220.0

Region

Note=Required for TMED10 and TMED2 cis-Golgi network localization

Hgene

TMED10

chr14:75614367

chr14:75505115

ENST00000303575

147_178

137.0

220.0

Region

Note=Required for TMED10 and TMED2 cis-Golgi network localization

Hgene

TMED10

chr14:75614367

chr14:75506718

ENST00000303575

147_178

137.0

220.0

Region

Note=Required for TMED10 and TMED2 cis-Golgi network localization

Hgene

TMED10

chr14:75614366

chr14:75505115

ENST00000303575

32_185

137.0

220.0

Topological domain

Lumenal

Hgene

TMED10

chr14:75614366

chr14:75506718

ENST00000303575

32_185

137.0

220.0

Topological domain

Lumenal

Hgene

TMED10

chr14:75614367

chr14:75505115

ENST00000303575

32_185

137.0

220.0

Topological domain

Lumenal

Hgene

TMED10

chr14:75614367

chr14:75506718

ENST00000303575

32_185

137.0

220.0

Topological domain

Lumenal

Hgene

TMED10

chr14:75614366

chr14:75505115

ENST00000303575

186_206

137.0

220.0

Transmembrane

Helical

Hgene

TMED10

chr14:75614366

chr14:75506718

ENST00000303575

186_206

137.0

220.0

Transmembrane

Helical

Hgene

TMED10

chr14:75614367

chr14:75505115

ENST00000303575

186_206

137.0

220.0

Transmembrane

Helical

Hgene

TMED10

chr14:75614367

chr14:75506718

ENST00000303575

186_206

137.0

220.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TMED10
MLH3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TMED10	chr14:75614366	chr14:75505115	ENST00000303575	-	3	5	207_219	137.0	220.0	ARF1 and IL1B
Hgene	TMED10	chr14:75614366	chr14:75506718	ENST00000303575	-	3	5	207_219	137.0	220.0	ARF1 and IL1B
Hgene	TMED10	chr14:75614367	chr14:75505115	ENST00000303575	-	3	5	207_219	137.0	220.0	ARF1 and IL1B
Hgene	TMED10	chr14:75614367	chr14:75506718	ENST00000303575	-	3	5	207_219	137.0	220.0	ARF1 and IL1B
Hgene	TMED10	chr14:75614366	chr14:75505115	ENST00000303575	-	3	5	204_219	137.0	220.0	COPG1
Hgene	TMED10	chr14:75614366	chr14:75506718	ENST00000303575	-	3	5	204_219	137.0	220.0	COPG1
Hgene	TMED10	chr14:75614367	chr14:75505115	ENST00000303575	-	3	5	204_219	137.0	220.0	COPG1
Hgene	TMED10	chr14:75614367	chr14:75506718	ENST00000303575	-	3	5	204_219	137.0	220.0	COPG1

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Related Drugs to TMED10-MLH3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TMED10-MLH3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source