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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BCAR3-ABCA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BCAR3-ABCA4
FusionPDB ID: 9162
FusionGDB2.0 ID: 9162
HgeneTgene
Gene symbol

BCAR3

ABCA4

Gene ID

8412

24

Gene nameBCAR3 adaptor protein, NSP family memberATP binding cassette subfamily A member 4
SynonymsAND-34|NSP2|SH2D3BABC10|ABCR|ARMD2|CORD3|FFM|RMP|RP19|STGD|STGD1
Cytomap

1p22.1

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistancretinal-specific phospholipid-transporting ATPase ABCA4ATP binding cassette transporterATP-binding cassette sub-family A member 4ATP-binding cassette transporter, retinal-specificATP-binding cassette, sub-family A (ABC1), member 4ATP-binding transpor
Modification date2020031320200315
UniProtAcc

O75815

P78363

Ensembl transtripts involved in fusion geneENST idsENST00000260502, ENST00000370243, 
ENST00000370244, ENST00000370247, 
ENST00000466632, ENST00000539242, 
ENST00000465352, ENST00000535735, 
ENST00000535881, ENST00000536513, 
ENST00000370225, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 9=11884 X 5 X 5=100
# samples 127
** MAII scorelog2(12/1188*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BCAR3 [Title/Abstract] AND ABCA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BCAR3(94054534)-ABCA4(94495187), # samples:3
Anticipated loss of major functional domain due to fusion event.BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCA4

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-ZS-A9CF-02ABCAR3chr1

94079404

-ABCA4chr1

94505683

-
ChimerDB4UCECTCGA-AJ-A3EJ-01ABCAR3chr1

94054534

-ABCA4chr1

94495187

-
ChimerDB4UCECTCGA-AJ-A3EJBCAR3chr1

94054533

-ABCA4chr1

94495187

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370243BCAR3chr194054534-ENST00000370225ABCA4chr194495187-407412046836731201
ENST00000370247BCAR3chr194054534-ENST00000370225ABCA4chr194495187-369382316732921041
ENST00000370243BCAR3chr194054533-ENST00000370225ABCA4chr194495187-407412046836731201
ENST00000370247BCAR3chr194054533-ENST00000370225ABCA4chr194495187-369382316732921041
ENST00000370247BCAR3chr194079404-ENST00000370225ABCA4chr194505683-395125116735501127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370243ENST00000370225BCAR3chr194054534-ABCA4chr194495187-0.0018555680.9981444
ENST00000370247ENST00000370225BCAR3chr194054534-ABCA4chr194495187-0.0012947020.99870527
ENST00000370243ENST00000370225BCAR3chr194054533-ABCA4chr194495187-0.0018555680.9981444
ENST00000370247ENST00000370225BCAR3chr194054533-ABCA4chr194495187-0.0012947020.99870527
ENST00000370247ENST00000370225BCAR3chr194079404-ABCA4chr194505683-0.0014844650.99851555

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9162_9162_1_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1201AA_BP=378
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI
NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL
TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL
QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE
DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI
QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY
VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM
VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG
VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV
YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG
TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD

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>9162_9162_2_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1041AA_BP=218
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS
SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG
QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC
PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG
PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV
AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW
AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG
EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS
PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV
PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE
CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL

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>9162_9162_3_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1201AA_BP=378
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI
NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL
TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL
QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE
DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI
QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY
VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM
VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG
VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV
YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG
TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD

--------------------------------------------------------------

>9162_9162_4_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1041AA_BP=218
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS
SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG
QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC
PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG
PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV
AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW
AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG
EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS
PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV
PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE
CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL

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>9162_9162_5_BCAR3-ABCA4_BCAR3_chr1_94079404_ENST00000370247_ABCA4_chr1_94505683_ENST00000370225_length(amino acids)=1127AA_BP=28
MPKECSAFHALSAALCCFYHRKSFIGVKGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNK
NFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPA
AHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTF
FSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGA
GGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITR
EASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICV
IFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIP
MMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHS
ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVD
RLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEE
IEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEAL
CTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94054534/chr1:94495187)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAR3

O75815

ABCA4

P78363

FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.FUNCTION: Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO:0000269|PubMed:10075733, ECO:0000269|PubMed:24097981}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714154_253309.6666666666667826.0DomainSH2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501938_21701450.66666666666672274.0DomainABC transporter 2
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501938_21701450.66666666666672274.0DomainABC transporter 2
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501938_21701174.02274.0DomainABC transporter 2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501972_19791450.66666666666672274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501972_19791450.66666666666672274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501972_19791174.02274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501895_22731450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501895_22731450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501398_17271174.02274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501895_22731174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501728_17481450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501760_17801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501793_18131450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501832_18521450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501874_18941450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501728_17481450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501760_17801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501793_18131450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501832_18521450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501874_18941450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501377_13971174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501728_17481174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501760_17801174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501793_18131174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501832_18521174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501874_18941174.02274.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310479_482218.66666666666666735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310479_482218.66666666666666735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110479_48228.0735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310154_253218.66666666666666735.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310548_818218.66666666666666735.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18548_8180502.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310154_253218.66666666666666735.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310548_818218.66666666666666735.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18548_8180502.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110154_25328.0735.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110548_81828.0735.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18548_8180502.0DomainRas-GEF
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850929_11601450.66666666666672274.0DomainABC transporter 1
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850929_11601450.66666666666672274.0DomainABC transporter 1
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250929_11601174.02274.0DomainABC transporter 1
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850963_9701450.66666666666672274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850963_9701450.66666666666672274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250963_9701174.02274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501398_17271450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501_211450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST00000370225285043_6461450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850857_13761450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501398_17271450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501_211450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST00000370225285043_6461450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850857_13761450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501_211174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST00000370225225043_6461174.02274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250857_13761174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501377_13971450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST00000370225285022_421450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850647_6671450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850700_7201450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850731_7511450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850760_7801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850836_8561450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501377_13971450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST00000370225285022_421450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850647_6671450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850700_7201450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850731_7511450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850760_7801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850836_8561450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST00000370225225022_421174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250647_6671174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250700_7201174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250731_7511174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250760_7801174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250836_8561174.02274.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BCAR3
ABCA4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BCAR3-ABCA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BCAR3-ABCA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource