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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TMEM14B-TFAP2A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TMEM14B-TFAP2A
	FusionPDB ID: 91711
	FusionGDB2.0 ID: 91711
		Hgene	Tgene
	Gene symbol	TMEM14B	TFAP2A
	Gene ID	81853	7020
	Gene name	transmembrane protein 14B	transcription factor AP-2 alpha
	Synonyms	-	AP-2\|AP-2alpha\|AP2TF\|BOFS\|TFAP2
	Cytomap	6p24.2	6p24.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 14B	transcription factor AP-2-alphaAP-2 transcription factoractivating enhancer-binding protein 2-alphaactivator protein 2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
	Modification date	20200320	20200328
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000491103, ENST00000379530, ENST00000379542, ENST00000461342, ENST00000467317, ENST00000475942, ENST00000481240, ENST00000473276,	ENST00000319516, ENST00000379604, ENST00000379608, ENST00000379613, ENST00000482890, ENST00000497266,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	4 X 6 X 3=72
	# samples	4	5
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TMEM14B [Title/Abstract] AND TFAP2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TMEM14B(10749931)-TFAP2A(10400822), # samples:2
Anticipated loss of major functional domain due to fusion event.	TMEM14B-TFAP2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM14B-TFAP2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM14B	GO:0061351	neural precursor cell proliferation	29033352
Hgene	TMEM14B	GO:2000045	regulation of G1/S transition of mitotic cell cycle	29033352
Tgene	TFAP2A	GO:0000122	negative regulation of transcription by RNA polymerase II	8321221\|9520389\|20066163
Tgene	TFAP2A	GO:0008285	negative regulation of cell proliferation	20607706
Tgene	TFAP2A	GO:0030501	positive regulation of bone mineralization	19578371
Tgene	TFAP2A	GO:0043066	negative regulation of apoptotic process	20066163
Tgene	TFAP2A	GO:0043525	positive regulation of neuron apoptotic process	20607706
Tgene	TFAP2A	GO:0045595	regulation of cell differentiation	20607706
Tgene	TFAP2A	GO:0045892	negative regulation of transcription, DNA-templated	20607706
Tgene	TFAP2A	GO:0045893	positive regulation of transcription, DNA-templated	12586840
Tgene	TFAP2A	GO:0045944	positive regulation of transcription by RNA polymerase II	7555706\|7559606\|11278550\|20808827
Tgene	TFAP2A	GO:0070172	positive regulation of tooth mineralization	19578371
Tgene	TFAP2A	GO:0071281	cellular response to iron ion	20808827
Tgene	TFAP2A	GO:2000378	negative regulation of reactive oxygen species metabolic process	20066163

Fusion gene breakpoints across TMEM14B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFAP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-EW-A6SD-01A	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000379542	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2438	267	1036	467	189
ENST00000379542	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2432	267	1036	467	189
ENST00000379542	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1243	267	1036	467	189
ENST00000379542	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1200	267	1036	467	189
ENST00000379542	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1102	267	1036	467	189
ENST00000461342	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2392	221	990	421	189
ENST00000461342	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2386	221	990	421	189
ENST00000461342	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1197	221	990	421	189
ENST00000461342	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1154	221	990	421	189
ENST00000461342	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1056	221	990	421	189
ENST00000475942	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2392	221	990	421	189
ENST00000475942	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2386	221	990	421	189
ENST00000475942	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1197	221	990	421	189
ENST00000475942	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1154	221	990	421	189
ENST00000475942	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1056	221	990	421	189
ENST00000379530	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2386	215	984	415	189
ENST00000379530	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2380	215	984	415	189
ENST00000379530	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1191	215	984	415	189
ENST00000379530	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1148	215	984	415	189
ENST00000379530	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1050	215	984	415	189
ENST00000481240	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2366	195	964	395	189
ENST00000481240	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2360	195	964	395	189
ENST00000481240	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1171	195	964	395	189
ENST00000481240	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1128	195	964	395	189
ENST00000481240	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1030	195	964	395	189
ENST00000467317	TMEM14B	chr6	10749931	+	ENST00000379613	TFAP2A	chr6	10400822	-	2366	195	964	395	189
ENST00000467317	TMEM14B	chr6	10749931	+	ENST00000379604	TFAP2A	chr6	10400822	-	2360	195	964	395	189
ENST00000467317	TMEM14B	chr6	10749931	+	ENST00000319516	TFAP2A	chr6	10400822	-	1171	195	964	395	189
ENST00000467317	TMEM14B	chr6	10749931	+	ENST00000379608	TFAP2A	chr6	10400822	-	1128	195	964	395	189
ENST00000467317	TMEM14B	chr6	10749931	+	ENST00000482890	TFAP2A	chr6	10400822	-	1030	195	964	395	189

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379542	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000570184	0.99942976
ENST00000379542	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00059335	0.9994067
ENST00000379542	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002272031	0.99772793
ENST00000379542	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002694114	0.99730587
ENST00000379542	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.003362121	0.9966378
ENST00000461342	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000562754	0.9994373
ENST00000461342	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000594674	0.9994054
ENST00000461342	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.001828653	0.9981713
ENST00000461342	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00214581	0.9978542
ENST00000461342	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002710688	0.9972893
ENST00000475942	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000562754	0.9994373
ENST00000475942	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000594674	0.9994054
ENST00000475942	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.001828653	0.9981713
ENST00000475942	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00214581	0.9978542
ENST00000475942	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002710688	0.9972893
ENST00000379530	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000850915	0.9991491
ENST00000379530	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000861566	0.99913836
ENST00000379530	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00243531	0.9975647
ENST00000379530	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002739643	0.99726033
ENST00000379530	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.003437192	0.9965628
ENST00000481240	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00067829	0.9993217
ENST00000481240	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000712145	0.9992879
ENST00000481240	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002096244	0.9979037
ENST00000481240	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002400233	0.9975998
ENST00000481240	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002875935	0.997124
ENST00000467317	ENST00000379613	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.00067829	0.9993217
ENST00000467317	ENST00000379604	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.000712145	0.9992879
ENST00000467317	ENST00000319516	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002096244	0.9979037
ENST00000467317	ENST00000379608	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002400233	0.9975998
ENST00000467317	ENST00000482890	TMEM14B	chr6	10749931	+	TFAP2A	chr6	10400822	-	0.002875935	0.997124

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91711_91711_1_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379530_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_2_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379530_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_3_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379530_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_4_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379530_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_5_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379530_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_6_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379542_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_7_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379542_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_8_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379542_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_9_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379542_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_10_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000379542_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_11_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000461342_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_12_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000461342_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_13_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000461342_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_14_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000461342_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_15_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000461342_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_16_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000467317_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_17_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000467317_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_18_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000467317_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_19_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000467317_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_20_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000467317_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_21_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000475942_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_22_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000475942_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_23_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000475942_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_24_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000475942_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_25_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000475942_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_26_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000481240_TFAP2A_chr6_10400822_ENST00000319516_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_27_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000481240_TFAP2A_chr6_10400822_ENST00000379604_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_28_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000481240_TFAP2A_chr6_10400822_ENST00000379608_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_29_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000481240_TFAP2A_chr6_10400822_ENST00000379613_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

>91711_91711_30_TMEM14B-TFAP2A_TMEM14B_chr6_10749931_ENST00000481240_TFAP2A_chr6_10400822_ENST00000482890_length(amino acids)=189AA_BP=
MFKKKRVHKLGRTFLCWLHGLFCSLRLHMRAQGCGSGWGGRGGCRVGEAAPLTVERAVPETRGDPRAAAAAAAAAAAAVAAAGRVADPGA
VTRRRVGARGAGEAWEGRGGRRASLSVLLLFVTAFGVVVRVAVGVVAEVHFVHGLEGLGEIVLQGRDRGTHRGAAEAVGDEVEVGQAALD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:10749931/chr6:10400822)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379530

8_28

33.333333333333336

81.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379542

8_28

33.333333333333336

115.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379530

34_54

33.333333333333336

81.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379530

60_80

33.333333333333336

81.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379530

83_103

33.333333333333336

81.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379542

34_54

33.333333333333336

115.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379542

60_80

33.333333333333336

115.0

Transmembrane

Helical

Hgene

TMEM14B

chr6:10749931

chr6:10400822

ENST00000379542

83_103

33.333333333333336

115.0

Transmembrane

Helical

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000319516

29_117

290.3333333333333

434.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379604

29_117

294.3333333333333

438.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379608

29_117

288.3333333333333

432.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000482890

29_117

294.3333333333333

438.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000319516

57_62

290.3333333333333

434.0

Motif

Note=PPxY motif

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379604

57_62

294.3333333333333

438.0

Motif

Note=PPxY motif

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379608

57_62

288.3333333333333

432.0

Motif

Note=PPxY motif

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000482890

57_62

294.3333333333333

438.0

Motif

Note=PPxY motif

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000319516

280_410

290.3333333333333

434.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379604

280_410

294.3333333333333

438.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000379608

280_410

288.3333333333333

432.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Tgene

TFAP2A

chr6:10749931

chr6:10400822

ENST00000482890

280_410

294.3333333333333

438.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TMEM14B
TFAP2A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TMEM14B-TFAP2A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TMEM14B-TFAP2A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source