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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BCAS3-CA10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BCAS3-CA10
	FusionPDB ID: 9197
	FusionGDB2.0 ID: 9197
		Hgene	Tgene
	Gene symbol	BCAS3	CA10
	Gene ID	54828	56934
	Gene name	BCAS3 microtubule associated cell migration factor	carbonic anhydrase 10
	Synonyms	GAOB1\|MAAB	CA-RPX\|CARPX\|HUCEP-15
	Cytomap	17q23.2	17q21.33-q22
	Type of gene	protein-coding	protein-coding
	Description	breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1	carbonic anhydrase-related protein 10CA-RP XCARP Xcarbonic anhydrase Xcarbonic anhydrase-related protein Xcerebral protein-15epididymis secretory sperm binding protein
	Modification date	20200313	20200313
	UniProtAcc	Q9H6U6	Q9NS85
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000390652, ENST00000407086, ENST00000408905, ENST00000585744, ENST00000588462, ENST00000588874, ENST00000589222, ENST00000585812,	ENST00000571918, ENST00000285273, ENST00000340813, ENST00000442502, ENST00000451037, ENST00000570565,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	53 X 35 X 17=31535	21 X 12 X 9=2268
	# samples	61	24
	** MAII score	log2(61/31535*10)=-5.69200088030826 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/2268*10)=-3.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BCAS3 [Title/Abstract] AND CA10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCAS3(58967132)-CA10(49731097), # samples:3
Anticipated loss of major functional domain due to fusion event.	BCAS3-CA10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAS3-CA10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BCAS3	GO:0043085	positive regulation of catalytic activity	17505058
Hgene	BCAS3	GO:0045944	positive regulation of transcription by RNA polymerase II	17505058
Hgene	BCAS3	GO:0071391	cellular response to estrogen stimulus	17505058

Fusion gene breakpoints across BCAS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CA10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-A6-5657-01A	BCAS3	chr17	58967132	-	CA10	chr17	49731097	-
ChimerDB4	COAD	TCGA-A6-5657-01A	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-
ChimerDB4	COAD	TCGA-A6-5657	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000589222	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2599	806	68	1327	419
ENST00000589222	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2599	806	68	1327	419
ENST00000589222	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2591	806	68	1327	419
ENST00000589222	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2589	806	68	1327	419
ENST00000589222	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	2143	806	68	1327	419
ENST00000407086	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2579	786	48	1307	419
ENST00000407086	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2579	786	48	1307	419
ENST00000407086	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2571	786	48	1307	419
ENST00000407086	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2569	786	48	1307	419
ENST00000407086	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	2123	786	48	1307	419
ENST00000390652	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2562	769	31	1290	419
ENST00000390652	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2562	769	31	1290	419
ENST00000390652	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2554	769	31	1290	419
ENST00000390652	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2552	769	31	1290	419
ENST00000390652	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	2106	769	31	1290	419
ENST00000408905	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2531	738	0	1259	419
ENST00000408905	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2531	738	0	1259	419
ENST00000408905	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2523	738	0	1259	419
ENST00000408905	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2521	738	0	1259	419
ENST00000408905	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	2075	738	0	1259	419
ENST00000588462	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2531	738	0	1259	419
ENST00000588462	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2531	738	0	1259	419
ENST00000588462	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2523	738	0	1259	419
ENST00000588462	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2521	738	0	1259	419
ENST00000588462	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	2075	738	0	1259	419
ENST00000585744	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	1947	154	13	675	220
ENST00000585744	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	1947	154	13	675	220
ENST00000585744	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	1939	154	13	675	220
ENST00000585744	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	1937	154	13	675	220
ENST00000585744	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	1491	154	13	675	220
ENST00000588874	BCAS3	chr17	58967132	+	ENST00000570565	CA10	chr17	49731097	-	2032	239	188	760	190
ENST00000588874	BCAS3	chr17	58967132	+	ENST00000442502	CA10	chr17	49731097	-	2032	239	188	760	190
ENST00000588874	BCAS3	chr17	58967132	+	ENST00000340813	CA10	chr17	49731097	-	2024	239	188	760	190
ENST00000588874	BCAS3	chr17	58967132	+	ENST00000451037	CA10	chr17	49731097	-	2022	239	188	760	190
ENST00000588874	BCAS3	chr17	58967132	+	ENST00000285273	CA10	chr17	49731097	-	1576	239	188	760	190

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000589222	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000571802	0.9994282
ENST00000589222	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000571802	0.9994282
ENST00000589222	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000567185	0.99943274
ENST00000589222	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000567222	0.99943274
ENST00000589222	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000802589	0.9991974
ENST00000407086	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00057871	0.99942136
ENST00000407086	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00057871	0.99942136
ENST00000407086	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000578761	0.99942124
ENST00000407086	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000579453	0.9994205
ENST00000407086	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000811266	0.9991887
ENST00000390652	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000547831	0.9994522
ENST00000390652	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000547831	0.9994522
ENST00000390652	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000545916	0.9994541
ENST00000390652	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00054653	0.9994535
ENST00000390652	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000747496	0.9992525
ENST00000408905	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000587031	0.999413
ENST00000408905	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000587031	0.999413
ENST00000408905	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000580594	0.99941945
ENST00000408905	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00058118	0.99941885
ENST00000408905	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000810573	0.99918944
ENST00000588462	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000587031	0.999413
ENST00000588462	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000587031	0.999413
ENST00000588462	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000580594	0.99941945
ENST00000588462	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00058118	0.99941885
ENST00000588462	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.000810573	0.99918944
ENST00000585744	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.003002807	0.99699724
ENST00000585744	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.003002807	0.99699724
ENST00000585744	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.002879759	0.99712026
ENST00000585744	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.002905371	0.99709463
ENST00000585744	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00267094	0.9973291
ENST00000588874	ENST00000570565	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00284783	0.9971521
ENST00000588874	ENST00000442502	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00284783	0.9971521
ENST00000588874	ENST00000340813	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.00274274	0.9972573
ENST00000588874	ENST00000451037	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.002765575	0.9972344
ENST00000588874	ENST00000285273	BCAS3	chr17	58967132	+	CA10	chr17	49731097	-	0.002844081	0.9971559

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9197_9197_1_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000390652_CA10_chr17_49731097_ENST00000285273_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

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>9197_9197_2_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000390652_CA10_chr17_49731097_ENST00000340813_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_3_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000390652_CA10_chr17_49731097_ENST00000442502_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_4_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000390652_CA10_chr17_49731097_ENST00000451037_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_5_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000390652_CA10_chr17_49731097_ENST00000570565_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_6_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000407086_CA10_chr17_49731097_ENST00000285273_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_7_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000407086_CA10_chr17_49731097_ENST00000340813_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_8_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000407086_CA10_chr17_49731097_ENST00000442502_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_9_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000407086_CA10_chr17_49731097_ENST00000451037_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_10_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000407086_CA10_chr17_49731097_ENST00000570565_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_11_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000408905_CA10_chr17_49731097_ENST00000285273_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_12_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000408905_CA10_chr17_49731097_ENST00000340813_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_13_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000408905_CA10_chr17_49731097_ENST00000442502_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_14_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000408905_CA10_chr17_49731097_ENST00000451037_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_15_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000408905_CA10_chr17_49731097_ENST00000570565_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_16_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000585744_CA10_chr17_49731097_ENST00000285273_length(amino acids)=220AA_BP=47
MISDCCAGNQRDSVGVGPSEPGCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNR
MLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRP

--------------------------------------------------------------

>9197_9197_17_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000585744_CA10_chr17_49731097_ENST00000340813_length(amino acids)=220AA_BP=47
MISDCCAGNQRDSVGVGPSEPGCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNR
MLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRP

--------------------------------------------------------------

>9197_9197_18_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000585744_CA10_chr17_49731097_ENST00000442502_length(amino acids)=220AA_BP=47
MISDCCAGNQRDSVGVGPSEPGCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNR
MLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRP

--------------------------------------------------------------

>9197_9197_19_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000585744_CA10_chr17_49731097_ENST00000451037_length(amino acids)=220AA_BP=47
MISDCCAGNQRDSVGVGPSEPGCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNR
MLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRP

--------------------------------------------------------------

>9197_9197_20_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000585744_CA10_chr17_49731097_ENST00000570565_length(amino acids)=220AA_BP=47
MISDCCAGNQRDSVGVGPSEPGCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNR
MLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRP

--------------------------------------------------------------

>9197_9197_21_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588462_CA10_chr17_49731097_ENST00000285273_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_22_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588462_CA10_chr17_49731097_ENST00000340813_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_23_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588462_CA10_chr17_49731097_ENST00000442502_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_24_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588462_CA10_chr17_49731097_ENST00000451037_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_25_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588462_CA10_chr17_49731097_ENST00000570565_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_26_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588874_CA10_chr17_49731097_ENST00000285273_length(amino acids)=190AA_BP=17
MNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPE
TSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKL

--------------------------------------------------------------

>9197_9197_27_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588874_CA10_chr17_49731097_ENST00000340813_length(amino acids)=190AA_BP=17
MNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPE
TSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKL

--------------------------------------------------------------

>9197_9197_28_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588874_CA10_chr17_49731097_ENST00000442502_length(amino acids)=190AA_BP=17
MNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPE
TSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKL

--------------------------------------------------------------

>9197_9197_29_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588874_CA10_chr17_49731097_ENST00000451037_length(amino acids)=190AA_BP=17
MNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPE
TSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKL

--------------------------------------------------------------

>9197_9197_30_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000588874_CA10_chr17_49731097_ENST00000570565_length(amino acids)=190AA_BP=17
MNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPE
TSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKL

--------------------------------------------------------------

>9197_9197_31_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000589222_CA10_chr17_49731097_ENST00000285273_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_32_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000589222_CA10_chr17_49731097_ENST00000340813_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_33_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000589222_CA10_chr17_49731097_ENST00000442502_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_34_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000589222_CA10_chr17_49731097_ENST00000451037_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

>9197_9197_35_BCAS3-CA10_BCAS3_chr17_58967132_ENST00000589222_CA10_chr17_49731097_ENST00000570565_length(amino acids)=419AA_BP=246
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL
VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:58967132/chr17:49731097)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCAS3 Q9H6U6	CA10 Q9NS85
FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250\|UniProtKB:Q8CCN5, ECO:0000269\|PubMed:17505058}.	FUNCTION: Does not have a catalytic activity.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CA10

chr17:58967132

chr17:49731097

ENST00000285273

31_301

155.0

329.0

Domain

Alpha-carbonic anhydrase

Tgene

CA10

chr17:58967132

chr17:49731097

ENST00000442502

31_301

155.0

329.0

Domain

Alpha-carbonic anhydrase

Tgene

CA10

chr17:58967132

chr17:49731097

ENST00000451037

31_301

155.0

329.0

Domain

Alpha-carbonic anhydrase

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>865_BCAS3_58967132_CA10_49731097_865_BCAS3_58967132_CA10_49731097_ranked_0.pdb	BCAS3	58967132	58967132	ENST00000285273	CA10	chr17	49731097	-	MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS IQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKVQLIHYNHELYTNVTEAAKSPNGL VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRL	419

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BCAS3_pLDDT.png

CA10_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BCAS3
CA10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BCAS3-CA10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BCAS3-CA10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source