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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BCAS3-GIT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BCAS3-GIT1
	FusionPDB ID: 9210
	FusionGDB2.0 ID: 9210
		Hgene	Tgene
	Gene symbol	BCAS3	GIT1
	Gene ID	54828	28964
	Gene name	BCAS3 microtubule associated cell migration factor	GIT ArfGAP 1
	Synonyms	GAOB1\|MAAB	-
	Cytomap	17q23.2	17q11.2
	Type of gene	protein-coding	protein-coding
	Description	breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1	ARF GTPase-activating protein GIT1ARF GAP GIT1CAT-1CAT1G protein-coupled receptor kinase interacting ArfGAP 1G protein-coupled receptor kinase-interactor 1GRK-interacting protein 1cool-associated and tyrosine-phosphorylated protein 1
	Modification date	20200313	20200327
	UniProtAcc	Q9H6U6	Q9Y2X7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000390652, ENST00000407086, ENST00000408905, ENST00000588462, ENST00000589222, ENST00000585744, ENST00000585812, ENST00000588874,	ENST00000225394, ENST00000394869, ENST00000579937, ENST00000581348,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	53 X 35 X 17=31535	3 X 3 X 2=18
	# samples	61	3
	** MAII score	log2(61/31535*10)=-5.69200088030826 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BCAS3 [Title/Abstract] AND GIT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCAS3(58946044)-GIT1(27905797), # samples:4
Anticipated loss of major functional domain due to fusion event.	BCAS3-GIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAS3-GIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAS3-GIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCAS3-GIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BCAS3	GO:0043085	positive regulation of catalytic activity	17505058
Hgene	BCAS3	GO:0045944	positive regulation of transcription by RNA polymerase II	17505058
Hgene	BCAS3	GO:0071391	cellular response to estrogen stimulus	17505058
Tgene	GIT1	GO:0032465	regulation of cytokinesis	23108400

Fusion gene breakpoints across BCAS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GIT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-91-6847-01A	BCAS3	chr17	58946044	-	GIT1	chr17	27905797	-
ChimerDB4	LUAD	TCGA-91-6847-01A	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-
ChimerDB4	LUAD	TCGA-91-6847	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000589222	BCAS3	chr17	58946044	+	ENST00000225394	GIT1	chr17	27905797	-	3410	652	68	2176	702
ENST00000589222	BCAS3	chr17	58946044	+	ENST00000394869	GIT1	chr17	27905797	-	3404	652	68	2176	702
ENST00000589222	BCAS3	chr17	58946044	+	ENST00000581348	GIT1	chr17	27905797	-	2638	652	68	2107	679
ENST00000589222	BCAS3	chr17	58946044	+	ENST00000579937	GIT1	chr17	27905797	-	2475	652	68	1975	635
ENST00000407086	BCAS3	chr17	58946044	+	ENST00000225394	GIT1	chr17	27905797	-	3390	632	48	2156	702
ENST00000407086	BCAS3	chr17	58946044	+	ENST00000394869	GIT1	chr17	27905797	-	3384	632	48	2156	702
ENST00000407086	BCAS3	chr17	58946044	+	ENST00000581348	GIT1	chr17	27905797	-	2618	632	48	2087	679
ENST00000407086	BCAS3	chr17	58946044	+	ENST00000579937	GIT1	chr17	27905797	-	2455	632	48	1955	635
ENST00000390652	BCAS3	chr17	58946044	+	ENST00000225394	GIT1	chr17	27905797	-	3373	615	31	2139	702
ENST00000390652	BCAS3	chr17	58946044	+	ENST00000394869	GIT1	chr17	27905797	-	3367	615	31	2139	702
ENST00000390652	BCAS3	chr17	58946044	+	ENST00000581348	GIT1	chr17	27905797	-	2601	615	31	2070	679
ENST00000390652	BCAS3	chr17	58946044	+	ENST00000579937	GIT1	chr17	27905797	-	2438	615	31	1938	635
ENST00000408905	BCAS3	chr17	58946044	+	ENST00000225394	GIT1	chr17	27905797	-	3342	584	0	2108	702
ENST00000408905	BCAS3	chr17	58946044	+	ENST00000394869	GIT1	chr17	27905797	-	3336	584	0	2108	702
ENST00000408905	BCAS3	chr17	58946044	+	ENST00000581348	GIT1	chr17	27905797	-	2570	584	0	2039	679
ENST00000408905	BCAS3	chr17	58946044	+	ENST00000579937	GIT1	chr17	27905797	-	2407	584	0	1907	635
ENST00000588462	BCAS3	chr17	58946044	+	ENST00000225394	GIT1	chr17	27905797	-	3342	584	0	2108	702
ENST00000588462	BCAS3	chr17	58946044	+	ENST00000394869	GIT1	chr17	27905797	-	3336	584	0	2108	702
ENST00000588462	BCAS3	chr17	58946044	+	ENST00000581348	GIT1	chr17	27905797	-	2570	584	0	2039	679
ENST00000588462	BCAS3	chr17	58946044	+	ENST00000579937	GIT1	chr17	27905797	-	2407	584	0	1907	635

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000589222	ENST00000225394	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004738603	0.9952614
ENST00000589222	ENST00000394869	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004783644	0.99521637
ENST00000589222	ENST00000581348	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.012539269	0.9874607
ENST00000589222	ENST00000579937	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.01250404	0.9874959
ENST00000407086	ENST00000225394	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004799285	0.99520075
ENST00000407086	ENST00000394869	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004845284	0.99515474
ENST00000407086	ENST00000581348	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.012757783	0.9872422
ENST00000407086	ENST00000579937	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.01271085	0.9872892
ENST00000390652	ENST00000225394	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004697559	0.99530244
ENST00000390652	ENST00000394869	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004738568	0.9952615
ENST00000390652	ENST00000581348	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.012675108	0.98732483
ENST00000390652	ENST00000579937	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.012676529	0.98732346
ENST00000408905	ENST00000225394	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004821291	0.9951787
ENST00000408905	ENST00000394869	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004874995	0.995125
ENST00000408905	ENST00000581348	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.013270142	0.98672986
ENST00000408905	ENST00000579937	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.013305364	0.9866946
ENST00000588462	ENST00000225394	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004821291	0.9951787
ENST00000588462	ENST00000394869	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.004874995	0.995125
ENST00000588462	ENST00000581348	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.013270142	0.98672986
ENST00000588462	ENST00000579937	BCAS3	chr17	58946044	+	GIT1	chr17	27905797	-	0.013305364	0.9866946

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9210_9210_1_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000390652_GIT1_chr17_27905797_ENST00000225394_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_2_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000390652_GIT1_chr17_27905797_ENST00000394869_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_3_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000390652_GIT1_chr17_27905797_ENST00000579937_length(amino acids)=635AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_4_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000390652_GIT1_chr17_27905797_ENST00000581348_length(amino acids)=679AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYREGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEE
DFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRL

--------------------------------------------------------------

>9210_9210_5_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000407086_GIT1_chr17_27905797_ENST00000225394_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_6_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000407086_GIT1_chr17_27905797_ENST00000394869_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_7_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000407086_GIT1_chr17_27905797_ENST00000579937_length(amino acids)=635AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_8_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000407086_GIT1_chr17_27905797_ENST00000581348_length(amino acids)=679AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYREGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEE
DFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRL

--------------------------------------------------------------

>9210_9210_9_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000408905_GIT1_chr17_27905797_ENST00000225394_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_10_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000408905_GIT1_chr17_27905797_ENST00000394869_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_11_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000408905_GIT1_chr17_27905797_ENST00000579937_length(amino acids)=635AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_12_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000408905_GIT1_chr17_27905797_ENST00000581348_length(amino acids)=679AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYREGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEE
DFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRL

--------------------------------------------------------------

>9210_9210_13_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000588462_GIT1_chr17_27905797_ENST00000225394_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_14_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000588462_GIT1_chr17_27905797_ENST00000394869_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_15_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000588462_GIT1_chr17_27905797_ENST00000579937_length(amino acids)=635AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_16_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000588462_GIT1_chr17_27905797_ENST00000581348_length(amino acids)=679AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYREGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEE
DFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRL

--------------------------------------------------------------

>9210_9210_17_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000589222_GIT1_chr17_27905797_ENST00000225394_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_18_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000589222_GIT1_chr17_27905797_ENST00000394869_length(amino acids)=702AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_19_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000589222_GIT1_chr17_27905797_ENST00000579937_length(amino acids)=635AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE
NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF

--------------------------------------------------------------

>9210_9210_20_BCAS3-GIT1_BCAS3_chr17_58946044_ENST00000589222_GIT1_chr17_27905797_ENST00000581348_length(amino acids)=679AA_BP=195
MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP
LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS
IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR
QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG
AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM
YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYREGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEE
DFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:58946044/chr17:27905797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCAS3 Q9H6U6	GIT1 Q9Y2X7
FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250\|UniProtKB:Q8CCN5, ECO:0000269\|PubMed:17505058}.	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity). {ECO:0000250\|UniProtKB:Q68FF6, ECO:0000269\|PubMed:11896197}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

251_415

253.66666666666666

762.0

Region

PTK2/FAK1-binding

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

254_367

253.66666666666666

762.0

Region

ARHGEF6-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

1_124

253.66666666666666

762.0

Domain

Arf-GAP

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

1_124

262.6666666666667

771.0

Domain

Arf-GAP

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

1_124

262.6666666666667

748.0

Domain

Arf-GAP

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

251_415

262.6666666666667

771.0

Region

PTK2/FAK1-binding

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

254_367

262.6666666666667

771.0

Region

ARHGEF6-binding

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

251_415

262.6666666666667

748.0

Region

PTK2/FAK1-binding

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

254_367

262.6666666666667

748.0

Region

ARHGEF6-binding

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

132_161

253.66666666666666

762.0

Repeat

Note=ANK 1

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

166_195

253.66666666666666

762.0

Repeat

Note=ANK 2

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

199_228

253.66666666666666

762.0

Repeat

Note=ANK 3

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

132_161

262.6666666666667

771.0

Repeat

Note=ANK 1

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

166_195

262.6666666666667

771.0

Repeat

Note=ANK 2

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

199_228

262.6666666666667

771.0

Repeat

Note=ANK 3

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

132_161

262.6666666666667

748.0

Repeat

Note=ANK 1

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

166_195

262.6666666666667

748.0

Repeat

Note=ANK 2

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

199_228

262.6666666666667

748.0

Repeat

Note=ANK 3

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000225394

11_34

253.66666666666666

762.0

Zinc finger

C4-type

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000394869

11_34

262.6666666666667

771.0

Zinc finger

C4-type

Tgene

GIT1

chr17:58946044

chr17:27905797

ENST00000581348

11_34

262.6666666666667

748.0

Zinc finger

C4-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1441_BCAS3_58946044_GIT1_27905797_ranked_0.pdb	BCAS3	58946044	58946044	ENST00000579937	GIT1	chr17	27905797	-	MNEAMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGTPLTEEKEKIVWVRFENADLNDTSRNLEFHEIHSTGNEPP LLIMIGYSDGMQVWSIPISGEAQELFSVRHGPIRAARILPAPQFGAQKCDNFAEKRPLLGVCKSIGSSGTSPPYCCVDLYSLRTGEMVKS IQFKTPIYDLHCNKRLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGR QKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDG AVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSM YEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYE NTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLF	702

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

BCAS3_pLDDT.png

GIT1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BCAS3
GIT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BCAS3-GIT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BCAS3-GIT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source