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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TMPRSS2-ETV4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS2-ETV4
FusionPDB ID: 92379
FusionGDB2.0 ID: 92379
HgeneTgene
Gene symbol

TMPRSS2

ETV4

Gene ID

7113

2118

Gene nametransmembrane serine protease 2ETS variant transcription factor 4
SynonymsPP9284|PRSS10E1A-F|E1AF|PEA3|PEAS3
Cytomap

21q22.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2ETS translocation variant 4ETS variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog
Modification date2020031320200313
UniProtAcc

O15393

P43268

Ensembl transtripts involved in fusion geneENST idsENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000319349, ENST00000393664, 
ENST00000538265, ENST00000545089, 
ENST00000545954, ENST00000586826, 
ENST00000591713, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 73 X 10=2920014 X 28 X 6=2352
# samples 13024
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2352*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TMPRSS2 [Title/Abstract] AND ETV4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42880008)-ETV4(41622735), # samples:14
Anticipated loss of major functional domain due to fusion event.TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneETV4

GO:0045944

positive regulation of transcription by RNA polymerase II

24983502


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5763-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-CH-5763TMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-CH-5763TMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-G9-6351-01ATMPRSS2chr21

42866283

-ETV4chr17

41607549

-
ChimerDB4PRADTCGA-G9-6371-01ATMPRSS2chr21

42879876

-ETV4chr17

41622734

-
ChimerDB4PRADTCGA-G9-6371-01ATMPRSS2chr21

42879877

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-G9-6371-01ATMPRSS2chr21

42880007

-ETV4chr17

41622734

-
ChimerDB4PRADTCGA-G9-6371-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-G9-6371TMPRSS2chr21

42879876

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-G9-6371TMPRSS2chr21

42880007

-ETV4chr17

41613847

-
ChimerDB4PRADTCGA-G9-6371TMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-G9-6371TMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42870045

-ETV4chr17

41622734

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42870045

-ETV4chr17

41623035

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42870046

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42880007

-ETV4chr17

41622734

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42880007

-ETV4chr17

41623035

-
ChimerDB4PRADTCGA-HC-7077-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42870045

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42870045

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42870046

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42870046

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42880007

-ETV4chr17

41613847

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42880007

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-HC-7077TMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-HC-7079-01ATMPRSS2chr21

42870046

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-KC-A7FD-01ATMPRSS2chr21

42880007

-ETV4chr17

41622734

-
ChimerDB4PRADTCGA-KC-A7FD-01ATMPRSS2chr21

42880007

-ETV4chr17

41622737

-
ChimerDB4PRADTCGA-KC-A7FD-01ATMPRSS2chr21

42880007

-ETV4chr17

41623035

-
ChimerDB4PRADTCGA-KC-A7FD-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KC-A7FD-01ATMPRSS2chr21

42880008

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42879876

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880007

-ETV4chr17

41613847

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880007

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880008

-ETV4chr17

41622738

-
ChimerDB4PRADTCGA-KC-A7FDTMPRSS2chr21

42880008

-ETV4chr17

41623036

-
ChimerDB4PRADTCGA-KK-A7AW-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KK-A7AWTMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-KK-A7AWTMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-M7-A725-01ATMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-M7-A725TMPRSS2chr21

42880007

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-M7-A725TMPRSS2chr21

42880008

-ETV4chr17

41622735

-
ChimerDB4PRADTCGA-M7-A725TMPRSS2chr21

42880008

-ETV4chr17

41622738

-
ChimerDB4prostate cancerEU693079TMPRSS2chr21

42880085

ETV4chr17

41622350
ChimerKB3..TMPRSS2chr21

42870045

-ETV4chr17

41623305

-
ChiTaRS5.0N/AEU693079TMPRSS2chr21

42870044

-ETV4chr17

41623036

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332149TMPRSS2chr2142866283-ENST00000319349ETV4chr1741607549-16923731351016293
ENST00000332149TMPRSS2chr2142866283-ENST00000393664ETV4chr1741607549-16903731351016293
ENST00000332149TMPRSS2chr2142866283-ENST00000538265ETV4chr1741607549-16073731351016293
ENST00000332149TMPRSS2chr2142866283-ENST00000545954ETV4chr1741607549-12583731351016293
ENST00000332149TMPRSS2chr2142866283-ENST00000545089ETV4chr1741607549-12563731351016293
ENST00000332149TMPRSS2chr2142866283-ENST00000591713ETV4chr1741607549-11993731351016293
ENST00000398585TMPRSS2chr2142866283-ENST00000319349ETV4chr1741607549-1729410401053337
ENST00000398585TMPRSS2chr2142866283-ENST00000393664ETV4chr1741607549-1727410401053337
ENST00000398585TMPRSS2chr2142866283-ENST00000538265ETV4chr1741607549-1644410401053337
ENST00000398585TMPRSS2chr2142866283-ENST00000545954ETV4chr1741607549-1295410401053337
ENST00000398585TMPRSS2chr2142866283-ENST00000545089ETV4chr1741607549-1293410401053337
ENST00000398585TMPRSS2chr2142866283-ENST00000591713ETV4chr1741607549-1236410401053337
ENST00000398585TMPRSS2chr2142879876-ENST00000319349ETV4chr1741622735-2186116261510494
ENST00000398585TMPRSS2chr2142879876-ENST00000393664ETV4chr1741622735-2184116261510494
ENST00000332149TMPRSS2chr2142870045-ENST00000319349ETV4chr1741622735-22201501351544469
ENST00000332149TMPRSS2chr2142870045-ENST00000393664ETV4chr1741622735-22181501351544469
ENST00000398585TMPRSS2chr2142870045-ENST00000319349ETV4chr1741622735-2257187401581513
ENST00000398585TMPRSS2chr2142870045-ENST00000393664ETV4chr1741622735-2255187401581513
ENST00000332149TMPRSS2chr2142870046-ENST00000319349ETV4chr1741622735-22201501351544469
ENST00000332149TMPRSS2chr2142870046-ENST00000393664ETV4chr1741622735-22181501351544469
ENST00000398585TMPRSS2chr2142870046-ENST00000319349ETV4chr1741622735-2257187401581513
ENST00000398585TMPRSS2chr2142870046-ENST00000393664ETV4chr1741622735-2255187401581513
ENST00000398585TMPRSS2chr2142879877-ENST00000319349ETV4chr1741622735-2186116261510494
ENST00000398585TMPRSS2chr2142879877-ENST00000393664ETV4chr1741622735-2184116261510494
ENST00000332149TMPRSS2chr2142870045-ENST00000319349ETV4chr1741622734-22201501351544469
ENST00000332149TMPRSS2chr2142870045-ENST00000393664ETV4chr1741622734-22181501351544469
ENST00000398585TMPRSS2chr2142870045-ENST00000319349ETV4chr1741622734-2257187401581513
ENST00000398585TMPRSS2chr2142870045-ENST00000393664ETV4chr1741622734-2255187401581513
ENST00000398585TMPRSS2chr2142879876-ENST00000319349ETV4chr1741622734-2186116261510494
ENST00000398585TMPRSS2chr2142879876-ENST00000393664ETV4chr1741622734-2184116261510494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332149ENST00000319349TMPRSS2chr2142866283-ETV4chr1741607549-0.0055180340.99448204
ENST00000332149ENST00000393664TMPRSS2chr2142866283-ETV4chr1741607549-0.0055430440.9944569
ENST00000332149ENST00000538265TMPRSS2chr2142866283-ETV4chr1741607549-0.0057961480.99420387
ENST00000332149ENST00000545954TMPRSS2chr2142866283-ETV4chr1741607549-0.0060316950.99396825
ENST00000332149ENST00000545089TMPRSS2chr2142866283-ETV4chr1741607549-0.0060484060.9939516
ENST00000332149ENST00000591713TMPRSS2chr2142866283-ETV4chr1741607549-0.005446470.99455357
ENST00000398585ENST00000319349TMPRSS2chr2142866283-ETV4chr1741607549-0.0044367720.99556327
ENST00000398585ENST00000393664TMPRSS2chr2142866283-ETV4chr1741607549-0.0044799980.99552
ENST00000398585ENST00000538265TMPRSS2chr2142866283-ETV4chr1741607549-0.0046777270.9953223
ENST00000398585ENST00000545954TMPRSS2chr2142866283-ETV4chr1741607549-0.0048813090.99511874
ENST00000398585ENST00000545089TMPRSS2chr2142866283-ETV4chr1741607549-0.0048469870.99515295
ENST00000398585ENST00000591713TMPRSS2chr2142866283-ETV4chr1741607549-0.0044719840.99552804
ENST00000398585ENST00000319349TMPRSS2chr2142879876-ETV4chr1741622735-0.0026342130.9973658
ENST00000398585ENST00000393664TMPRSS2chr2142879876-ETV4chr1741622735-0.0026600430.9973399
ENST00000332149ENST00000319349TMPRSS2chr2142870045-ETV4chr1741622735-0.0059731740.9940268
ENST00000332149ENST00000393664TMPRSS2chr2142870045-ETV4chr1741622735-0.0060176550.9939824
ENST00000398585ENST00000319349TMPRSS2chr2142870045-ETV4chr1741622735-0.0049578860.9950421
ENST00000398585ENST00000393664TMPRSS2chr2142870045-ETV4chr1741622735-0.005003830.9949962
ENST00000332149ENST00000319349TMPRSS2chr2142870046-ETV4chr1741622735-0.0059731740.9940268
ENST00000332149ENST00000393664TMPRSS2chr2142870046-ETV4chr1741622735-0.0060176550.9939824
ENST00000398585ENST00000319349TMPRSS2chr2142870046-ETV4chr1741622735-0.0049578860.9950421
ENST00000398585ENST00000393664TMPRSS2chr2142870046-ETV4chr1741622735-0.005003830.9949962
ENST00000398585ENST00000319349TMPRSS2chr2142879877-ETV4chr1741622735-0.0026342130.9973658
ENST00000398585ENST00000393664TMPRSS2chr2142879877-ETV4chr1741622735-0.0026600430.9973399
ENST00000332149ENST00000319349TMPRSS2chr2142870045-ETV4chr1741622734-0.0059731740.9940268
ENST00000332149ENST00000393664TMPRSS2chr2142870045-ETV4chr1741622734-0.0060176550.9939824
ENST00000398585ENST00000319349TMPRSS2chr2142870045-ETV4chr1741622734-0.0049578860.9950421
ENST00000398585ENST00000393664TMPRSS2chr2142870045-ETV4chr1741622734-0.005003830.9949962
ENST00000398585ENST00000319349TMPRSS2chr2142879876-ETV4chr1741622734-0.0026342130.9973658
ENST00000398585ENST00000393664TMPRSS2chr2142879876-ETV4chr1741622734-0.0026600430.9973399

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92379_92379_1_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_2_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_3_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_4_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_5_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_6_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000332149_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=293AA_BP=80
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLH
TEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKL
IEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDE

--------------------------------------------------------------

>92379_92379_7_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_8_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_9_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_10_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_11_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_12_TMPRSS2-ETV4_TMPRSS2_chr21_42866283_ENST00000398585_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=337AA_BP=124
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVG
AFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYV

--------------------------------------------------------------

>92379_92379_13_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000332149_ETV4_chr17_41622734_ENST00000319349_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_14_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000332149_ETV4_chr17_41622734_ENST00000393664_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_15_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000332149_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_16_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000332149_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_17_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000398585_ETV4_chr17_41622734_ENST00000319349_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_18_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000398585_ETV4_chr17_41622734_ENST00000393664_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_19_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000398585_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_20_TMPRSS2-ETV4_TMPRSS2_chr21_42870045_ENST00000398585_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_21_TMPRSS2-ETV4_TMPRSS2_chr21_42870046_ENST00000332149_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_22_TMPRSS2-ETV4_TMPRSS2_chr21_42870046_ENST00000332149_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=469AA_BP=5
MALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTD
PALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSF
TSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGF
SGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPE
EVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAY

--------------------------------------------------------------

>92379_92379_23_TMPRSS2-ETV4_TMPRSS2_chr21_42870046_ENST00000398585_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_24_TMPRSS2-ETV4_TMPRSS2_chr21_42870046_ENST00000398585_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=513AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQ
ETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPL
QPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPA
VDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFRE
GPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFV

--------------------------------------------------------------

>92379_92379_25_TMPRSS2-ETV4_TMPRSS2_chr21_42879876_ENST00000398585_ETV4_chr17_41622734_ENST00000319349_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

>92379_92379_26_TMPRSS2-ETV4_TMPRSS2_chr21_42879876_ENST00000398585_ETV4_chr17_41622734_ENST00000393664_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

>92379_92379_27_TMPRSS2-ETV4_TMPRSS2_chr21_42879876_ENST00000398585_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

>92379_92379_28_TMPRSS2-ETV4_TMPRSS2_chr21_42879876_ENST00000398585_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

>92379_92379_29_TMPRSS2-ETV4_TMPRSS2_chr21_42879877_ENST00000398585_ETV4_chr17_41622735_ENST00000319349_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

>92379_92379_30_TMPRSS2-ETV4_TMPRSS2_chr21_42879877_ENST00000398585_ETV4_chr17_41622735_ENST00000393664_length(amino acids)=494AA_BP=29
MGRGTWAPGTRRCPLPRPEVKAGVRSAARQKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPD
FHSENLAFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQ
PHPGHGYLGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIK
QEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPAL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42880008/chr17:41622735)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

ETV4

P43268

FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.FUNCTION: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneETV4chr21:42870045chr17:41622734ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622734ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622734ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622734ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622734ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622734ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622734ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622734ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622734ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622734ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622735ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622735ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622735ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622735ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622735ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622735ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622735ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622735ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870045chr17:41622735ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870045chr17:41622735ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870046chr17:41622735ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870046chr17:41622735ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870046chr17:41622735ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870046chr17:41622735ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870046chr17:41622735ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870046chr17:41622735ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870046chr17:41622735ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870046chr17:41622735ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42870046chr17:41622735ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42870046chr17:41622735ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622734ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622734ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622734ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622734ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622734ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622734ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622734ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622734ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622734ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622734ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622735ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622735ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622735ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622735ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622735ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622735ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622735ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622735ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879876chr17:41622735ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879876chr17:41622735ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879877chr17:41622735ENST00000319349113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879877chr17:41622735ENST0000031934911349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879877chr17:41622735ENST00000393664012148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879877chr17:41622735ENST0000039366401249_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879877chr17:41622735ENST00000538265012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879877chr17:41622735ENST0000053826501249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879877chr17:41622735ENST00000545954012148_2440446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879877chr17:41622735ENST0000054595401249_750446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42879877chr17:41622735ENST00000591713113148_24420.0485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42879877chr17:41622735ENST0000059171311349_7520.0485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42866283chr17:41607549ENST00000319349713341_421270.3333333333333485.0DNA bindingETS
TgeneETV4chr21:42866283chr17:41607549ENST00000393664612341_421270.3333333333333485.0DNA bindingETS
TgeneETV4chr21:42866283chr17:41607549ENST00000538265612341_421231.33333333333334446.0DNA bindingETS
TgeneETV4chr21:42866283chr17:41607549ENST00000545954612341_421231.33333333333334446.0DNA bindingETS
TgeneETV4chr21:42866283chr17:41607549ENST00000591713713341_421270.3333333333333485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622734ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622734ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622734ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622734ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622734ENST00000591713113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622735ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622735ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622735ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622735ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870045chr17:41622735ENST00000591713113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870046chr17:41622735ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870046chr17:41622735ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42870046chr17:41622735ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870046chr17:41622735ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42870046chr17:41622735ENST00000591713113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622734ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622734ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622734ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622734ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622734ENST00000591713113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622735ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622735ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622735ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622735ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879876chr17:41622735ENST00000591713113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879877chr17:41622735ENST00000319349113341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879877chr17:41622735ENST00000393664012341_42120.0485.0DNA bindingETS
TgeneETV4chr21:42879877chr17:41622735ENST00000538265012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879877chr17:41622735ENST00000545954012341_4210446.0DNA bindingETS
TgeneETV4chr21:42879877chr17:41622735ENST00000591713113341_42120.0485.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-114112_14918.333333333333332530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-114150_24218.333333333333332530.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-114256_48918.333333333333332530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-114112_14918.333333333333332530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-114150_24218.333333333333332530.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-114256_48918.333333333333332530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-114112_14918.333333333333332530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-114150_24218.333333333333332530.0DomainSRCR
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-114256_48918.333333333333332530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-114112_1490493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-114150_2420493.0DomainSRCR
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-114256_4890493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-114106_49218.333333333333332530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-1141_8418.333333333333332530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-114106_49218.333333333333332530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-1141_8418.333333333333332530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-114106_49218.333333333333332530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-1141_8418.333333333333332530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-114106_4920493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-1141_840493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr17:41607549ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622734ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr17:41622735ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr17:41622735ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000332149-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000398585-11485_10518.333333333333332530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622734ENST00000458356-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000332149-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000398585-11485_10518.333333333333332530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879876chr17:41622735ENST00000458356-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000332149-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000398585-11485_10518.333333333333332530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42879877chr17:41622735ENST00000458356-11485_1050493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneETV4chr21:42866283chr17:41607549ENST00000319349713148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42866283chr17:41607549ENST0000031934971349_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42866283chr17:41607549ENST00000393664612148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42866283chr17:41607549ENST0000039366461249_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42866283chr17:41607549ENST00000538265612148_244231.33333333333334446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42866283chr17:41607549ENST0000053826561249_75231.33333333333334446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42866283chr17:41607549ENST00000545954612148_244231.33333333333334446.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42866283chr17:41607549ENST0000054595461249_75231.33333333333334446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr21:42866283chr17:41607549ENST00000591713713148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr21:42866283chr17:41607549ENST0000059171371349_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TMPRSS2CLK1, HNRNPL, DCAF4, S, ACE2, STX7, SCD, PLP2, PLLP, MOSPD3, UPK2, SELK, C3orf52, IGFBP5, SEC22A, PLP1, CLN6, TMEM128, C14orf1, CFHR5, TMEM243, TMEM60, CXCL9, BNIP2, CNIH3, PGAP2, TMEM218, TMEM86A, CMTM7, ZFPL1, BMP10, TMEM79, SLC35A1, SFTPC, VAMP5, FAXDC2, STX8, NINJ2, CLEC7A, C2CD2L, CNIH2, BNIP3, DEFB103A, DEFB103B, TMEM11, C17orf62, TMEM86B, ADIPOQ, EDDM3B, BRICD5, PTTG1IP, PTCH1, ANKRD46, TMEM222, C1QL4, TMEM120B, FAM3C, TMEM229B, PLN, CTXN3, TNF, SMIM1, AQP1, TMPRSS2, DNASE2, MYO1C, PGRMC1, NDUFA4, ADAM10, CLGN, SEC16A, SPINT2, COCH, B4GAT1, XPOT, MYO1B, LANCL1, CALU, PLXNA2, GPC4, BANF1, CPD, CLPX, STC2, SLIT2, MYO1D, ERLIN2, BAG2, TFRC, HLA-A, TP53, RPN1, RPN2, GNAI2, APP, ITGB1, INSR, GLA, GPI, ITGAV, CTSD, APRT, IGF1R, MET, GNAI3, CLTA, CALM2, HLA-C, DLAT, HSPA5, LAMC1, LAMP1, IGF2R, PDIA4, P4HA1, HSP90B1, PVR, RPA2, ATP2A2, PFKL, CDH2, MSH3, RPA1, CALR, RPA3, LONP1, TGFBR1, DDOST, HADHA, ECE1, DNM2, FXR2, PLXNA3, ATP1B3, HADHB, SEC61A1, GNB1, NOMO3, PRKDC, TFAM, SLC7A5, PFKP, KIF23, FMR1, PTK7, ADAM15, CUL2, SCARB2, WRN, DSC3, ITIH4, GANAB, KARS, RCN1, SAFB, IMMT, HSD17B12, UBR4, QSOX2, RRM2B, MON2, YTHDF3, PABPN1, PLD3, PELP1, TTC13, CNNM3, IPO4, FAR1, GGH, ERLEC1, RBM33, DNAJA3, RBM14, PPP1R9B, SDF2, NEU1, GRWD1, AIF1L, NTPCR, FUCA2, EDEM3, RACGAP1, RAB18, TMEM106B, CHPF2, GNG12, DNAJB11, EGFL7, DDX20, ADAMTS1, LNPEP, ITM2B, MRPL11, HYOU1, AFG3L2, YTHDF2, SUPT16H, PDHX, IPO5, SAP18, HGS, SPTBN2, PLXNB2, ARPC3, ACTN4, TRIM13, PDCD6, MPDU1, SEC22B, ATP6AP2, STAM2, ARL6IP5, UFL1, SEC31A, STBD1, SMC2, SEC24A, SEC24B, ACSL3, CDK1, SRPR, SPTB, MTHFD1, ACTN1, ETFA, RAB6A, VDAC1, HMOX2, MYH10, DEK, ATP5C1, NAMPT, VDAC2, QARS, TUFM, SERPINH1, BCAP31, PSMD7, CLCN7, SLC25A1, YARS, EPPK1, RAB10, ABCE1, RHOA, CNBP, TPM4, SLC25A11, LMNB2, CKAP4, GOLGA3, TWF1, TRAP1, STX5, DDX39B, RAB3GAP1, PON2, PPA1, SEC23A, SEC23B, NDUFA9, ATP6V1F, INF2, ANO6, ACTBL2, MIA3, CDKAL1, KIAA0368, C19orf70, SLC25A24, HUWE1, MEGF8, KTN1, COMTD1, ANKLE2, VRK2, ZDHHC17, DNAH10, NUP93, MMGT1, TMEM199, ATPAF2, EMC1, PDZD8, NBEA, MOSPD2, PDCD6IP, SYNE2, UBXN4, CCDC47, LRRC59, C7orf55, DDRGK1, NGLY1, CDK5RAP3, CCDC115, CLCC1, OSBPL9, RBM15, CGRRF1, ESYT1, NDC1, EFHD1, OSBPL8, KIAA1715, LSG1, RAB1B, TMX1, GORASP2, SFXN1, XPO5, VEZT, JPH1, BIRC6, AAAS, TOMM22, DDX19A, SMPD4, TMOD3, EMC3, VAPA, CEP72, LARS, DPM3, DHCR7, UBA2, AASS, ATP6V1H, SLC25A13, STOML2, RAB21, MYO6, VDAC3, AUP1, SEC23IP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TMPRSS2all structure
ETV4all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TMPRSS2-ETV4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMPRSS2-ETV4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneETV4C0033578Prostatic Neoplasms2CTD_human
TgeneETV4C0376358Malignant neoplasm of prostate2CTD_human
TgeneETV4C0006142Malignant neoplasm of breast1CTD_human
TgeneETV4C0027627Neoplasm Metastasis1CTD_human
TgeneETV4C0678222Breast Carcinoma1CTD_human
TgeneETV4C1257931Mammary Neoplasms, Human1CTD_human
TgeneETV4C1458155Mammary Neoplasms1CTD_human
TgeneETV4C4704874Mammary Carcinoma, Human1CTD_human