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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TMPRSS6-EME1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS6-EME1
FusionPDB ID: 92415
FusionGDB2.0 ID: 92415
HgeneTgene
Gene symbol

TMPRSS6

EME1

Gene ID

164656

146956

Gene nametransmembrane serine protease 6essential meiotic structure-specific endonuclease 1
SynonymsIRIDA|MT2MMS4L|SLX2A
Cytomap

22q12.3

17q21.33

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 6matriptase-2membrane-bound mosaic serine proteinase matriptase-2transmembrane protease, serine 6type II transmembrane serine protease 6crossover junction endonuclease EME1MMS4 homologSLX2 structure-specific endonuclease subunit homolog Aessential meiotic endonuclease 1 homolog 1essential meiotic endonuclease 1 homolog 2hMMS4homolog of yeast EME1 endonuclease
Modification date2020031320200313
UniProtAcc.

Q96AY2

Ensembl transtripts involved in fusion geneENST idsENST00000346753, ENST00000406725, 
ENST00000406856, ENST00000442782, 
ENST00000381792, 
ENST00000338165, 
ENST00000393271, ENST00000511648, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 5 X 2=302 X 5 X 1=10
# samples 53
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/10*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TMPRSS6 [Title/Abstract] AND EME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS6(37485618)-EME1(48455956), # samples:3
Anticipated loss of major functional domain due to fusion event.TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TMPRSS6-EME1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMPRSS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A132-01ATMPRSS6chr22

37485618

-EME1chr17

48455956

+
ChimerDB4BRCATCGA-C8-A132-01ATMPRSS6chr22

37485618

-EME1chr17

48456135

+
ChimerDB4BRCATCGA-C8-A132TMPRSS6chr22

37485617

-EME1chr17

48455955

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000381792TMPRSS6chr2237485618-ENST00000393271EME1chr1748455956+23469771111046311
ENST00000381792TMPRSS6chr2237485618-ENST00000338165EME1chr1748455956+23319771111046311
ENST00000381792TMPRSS6chr2237485618-ENST00000511648EME1chr1748455956+23469771111046311
ENST00000381792TMPRSS6chr2237485617-ENST00000393271EME1chr1748455955+23469771111046311
ENST00000381792TMPRSS6chr2237485617-ENST00000338165EME1chr1748455955+23319771111046311
ENST00000381792TMPRSS6chr2237485617-ENST00000511648EME1chr1748455955+23469771111046311
ENST00000381792TMPRSS6chr2237485618-ENST00000393271EME1chr1748456135+2259977111998295
ENST00000381792TMPRSS6chr2237485618-ENST00000338165EME1chr1748456135+2244977111998295
ENST00000381792TMPRSS6chr2237485618-ENST00000511648EME1chr1748456135+2259977111998295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381792ENST00000393271TMPRSS6chr2237485618-EME1chr1748455956+0.0265904310.97340953
ENST00000381792ENST00000338165TMPRSS6chr2237485618-EME1chr1748455956+0.0266015770.9733984
ENST00000381792ENST00000511648TMPRSS6chr2237485618-EME1chr1748455956+0.0265904310.97340953
ENST00000381792ENST00000393271TMPRSS6chr2237485617-EME1chr1748455955+0.0265904310.97340953
ENST00000381792ENST00000338165TMPRSS6chr2237485617-EME1chr1748455955+0.0266015770.9733984
ENST00000381792ENST00000511648TMPRSS6chr2237485617-EME1chr1748455955+0.0265904310.97340953
ENST00000381792ENST00000393271TMPRSS6chr2237485618-EME1chr1748456135+0.0109487020.9890513
ENST00000381792ENST00000338165TMPRSS6chr2237485618-EME1chr1748456135+0.0108173620.98918265
ENST00000381792ENST00000511648TMPRSS6chr2237485618-EME1chr1748456135+0.0109487020.9890513

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92415_92415_1_TMPRSS6-EME1_TMPRSS6_chr22_37485617_ENST00000381792_EME1_chr17_48455955_ENST00000338165_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_2_TMPRSS6-EME1_TMPRSS6_chr22_37485617_ENST00000381792_EME1_chr17_48455955_ENST00000393271_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_3_TMPRSS6-EME1_TMPRSS6_chr22_37485617_ENST00000381792_EME1_chr17_48455955_ENST00000511648_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_4_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48455956_ENST00000338165_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_5_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48455956_ENST00000393271_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_6_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48455956_ENST00000511648_length(amino acids)=311AA_BP=289
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_7_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48456135_ENST00000338165_length(amino acids)=295AA_BP=
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_8_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48456135_ENST00000393271_length(amino acids)=295AA_BP=
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

>92415_92415_9_TMPRSS6-EME1_TMPRSS6_chr22_37485618_ENST00000381792_EME1_chr17_48456135_ENST00000511648_length(amino acids)=295AA_BP=
MMLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYS
GSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEEL
LSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:37485618/chr17:48455956)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EME1

Q96AY2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-71884_209287.6666666666667812.0DomainSEA
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-71884_209278.6666666666667803.0DomainSEA
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-71884_209287.6666666666667812.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-71884_209278.6666666666667803.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-71884_209287.6666666666667812.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-71884_209278.6666666666667803.0DomainSEA
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-71984_209278.6666666666667825.0DomainSEA
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-7181_55287.6666666666667812.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-7181_55278.6666666666667803.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-7181_55287.6666666666667812.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-7181_55278.6666666666667803.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-7181_55287.6666666666667812.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-7181_55278.6666666666667803.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-7191_55278.6666666666667825.0Topological domainCytoplasmic
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-71856_76287.6666666666667812.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-71856_76278.6666666666667803.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-71856_76287.6666666666667812.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-71856_76278.6666666666667803.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-71856_76287.6666666666667812.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-71856_76278.6666666666667803.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-71956_76278.6666666666667825.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718213_336287.6666666666667812.0DomainCUB 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718335_452287.6666666666667812.0DomainCUB 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718457_489287.6666666666667812.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718490_526287.6666666666667812.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718530_567287.6666666666667812.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-718577_811287.6666666666667812.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718213_336278.6666666666667803.0DomainCUB 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718335_452278.6666666666667803.0DomainCUB 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718457_489278.6666666666667803.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718490_526278.6666666666667803.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718530_567278.6666666666667803.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-718577_811278.6666666666667803.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718213_336287.6666666666667812.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718335_452287.6666666666667812.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718457_489287.6666666666667812.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718490_526287.6666666666667812.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718530_567287.6666666666667812.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-718577_811287.6666666666667812.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718213_336278.6666666666667803.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718335_452278.6666666666667803.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718457_489278.6666666666667803.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718490_526278.6666666666667803.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718530_567278.6666666666667803.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-718577_811278.6666666666667803.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718213_336287.6666666666667812.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718335_452287.6666666666667812.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718457_489287.6666666666667812.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718490_526287.6666666666667812.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718530_567287.6666666666667812.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-718577_811287.6666666666667812.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718213_336278.6666666666667803.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718335_452278.6666666666667803.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718457_489278.6666666666667803.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718490_526278.6666666666667803.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718530_567278.6666666666667803.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-718577_811278.6666666666667803.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719213_336278.6666666666667825.0DomainCUB 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719335_452278.6666666666667825.0DomainCUB 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719457_489278.6666666666667825.0DomainLDL-receptor class A 1
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719490_526278.6666666666667825.0DomainLDL-receptor class A 2
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719530_567278.6666666666667825.0DomainLDL-receptor class A 3
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-719577_811278.6666666666667825.0DomainPeptidase S1
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000346753-71877_811287.6666666666667812.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000381792-71977_811278.6666666666667825.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406725-71877_811278.6666666666667803.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485617chr17:48455955ENST00000406856-71977_811278.6666666666667825.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000346753-71877_811287.6666666666667812.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000381792-71977_811278.6666666666667825.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406725-71877_811278.6666666666667803.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48455956ENST00000406856-71977_811278.6666666666667825.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000346753-71877_811287.6666666666667812.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000381792-71977_811278.6666666666667825.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406725-71877_811278.6666666666667803.0Topological domainExtracellular
HgeneTMPRSS6chr22:37485618chr17:48456135ENST00000406856-71977_811278.6666666666667825.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TMPRSS6
EME1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TMPRSS6-EME1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMPRSS6-EME1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource