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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TNKS2-HECTD2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TNKS2-HECTD2
	FusionPDB ID: 92736
	FusionGDB2.0 ID: 92736
		Hgene	Tgene
	Gene symbol	TNKS2	HECTD2
	Gene ID	80351	143279
	Gene name	tankyrase 2	HECT domain E3 ubiquitin protein ligase 2
	Synonyms	ARTD6\|PARP-5b\|PARP-5c\|PARP5B\|PARP5C\|TANK2\|TNKL\|pART6	-
	Cytomap	10q23.32	10q23.32
	Type of gene	protein-coding	protein-coding
	Description	poly [ADP-ribose] polymerase tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Bprotein poly-ADP-ribosyltransferase tankyrase-2tankyrase IItankyrase,	probable E3 ubiquitin-protein ligase HECTD2HECT domain containing E3 ubiquitin protein ligase 2HECT domain-containing protein 2HECT-type E3 ubiquitin transferase HECTD2
	Modification date	20200313	20200313
	UniProtAcc	.	Q5U5R9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371627,	ENST00000371667, ENST00000498446, ENST00000536715, ENST00000298068, ENST00000371681, ENST00000446394,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 4=320	5 X 6 X 6=180
	# samples	10	7
	** MAII score	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TNKS2 [Title/Abstract] AND HECTD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TNKS2(93602148)-HECTD2(93220184), # samples:3
Anticipated loss of major functional domain due to fusion event.	TNKS2-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TNKS2-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TNKS2-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TNKS2-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNKS2	GO:0000209	protein polyubiquitination	19759537\|21478859
Hgene	TNKS2	GO:0006471	protein ADP-ribosylation	11739745
Hgene	TNKS2	GO:0070212	protein poly-ADP-ribosylation	25043379
Hgene	TNKS2	GO:0070213	protein auto-ADP-ribosylation	19759537\|21478859
Hgene	TNKS2	GO:1904355	positive regulation of telomere capping	21531765

Fusion gene breakpoints across TNKS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HECTD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-YL-A9WH-01A	TNKS2	chr10	93602148	-	HECTD2	chr10	93220184	+
ChimerDB4	PRAD	TCGA-YL-A9WH-01A	TNKS2	chr10	93602148	+	HECTD2	chr10	93220184	+
ChimerDB4	PRAD	TCGA-YL-A9WH	TNKS2	chr10	93602148	+	HECTD2	chr10	93220184	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000371627

TNKS2

chr10

93602148

ENST00000446394

HECTD2

chr10

93220184

6890

2438

4512

1472

ENST00000371627

TNKS2

chr10

93602148

ENST00000371681

HECTD2

chr10

93220184

4250

2438

2793

899

ENST00000371627

TNKS2

chr10

93602148

ENST00000298068

HECTD2

chr10

93220184

6878

2438

4500

1468

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371627	ENST00000446394	TNKS2	chr10	93602148	+	HECTD2	chr10	93220184	+	0.000123023	0.999877
ENST00000371627	ENST00000371681	TNKS2	chr10	93602148	+	HECTD2	chr10	93220184	+	0.000301094	0.9996989
ENST00000371627	ENST00000298068	TNKS2	chr10	93602148	+	HECTD2	chr10	93220184	+	9.06E-05	0.9999094

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92736_92736_1_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000298068_length(amino acids)=1468AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP
VLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTV
LKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPA
KPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDS
EQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYG
MFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE
LLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVE
ILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQL

--------------------------------------------------------------

>92736_92736_2_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000371681_length(amino acids)=899AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP

--------------------------------------------------------------

>92736_92736_3_TNKS2-HECTD2_TNKS2_chr10_93602148_ENST00000371627_HECTD2_chr10_93220184_ENST00000446394_length(amino acids)=1472AA_BP=781
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP
VLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTV
LKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLR
LFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIII
QRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH
PDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAH
GLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRP
EEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93602148/chr10:93220184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HECTD2 Q5U5R9
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269\|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269\|PubMed:28584101}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

545_553

686.3333333333334

1167.0

Region

HIF1AN-binding

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

123_155

686.3333333333334

1167.0

Repeat

Note=ANK 3

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

210_242

686.3333333333334

1167.0

Repeat

Note=ANK 4

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

243_275

686.3333333333334

1167.0

Repeat

Note=ANK 5

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

276_308

686.3333333333334

1167.0

Repeat

Note=ANK 6

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

363_398

686.3333333333334

1167.0

Repeat

Note=ANK 7

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

399_431

686.3333333333334

1167.0

Repeat

Note=ANK 8

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

432_464

686.3333333333334

1167.0

Repeat

Note=ANK 9

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

525_557

686.3333333333334

1167.0

Repeat

Note=ANK 10

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

558_590

686.3333333333334

1167.0

Repeat

Note=ANK 11

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

57_89

686.3333333333334

1167.0

Repeat

Note=ANK 1

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

591_623

686.3333333333334

1167.0

Repeat

Note=ANK 12

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

90_122

686.3333333333334

1167.0

Repeat

Note=ANK 2

Tgene

HECTD2

chr10:93602148

chr10:93220184

ENST00000298068

437_776

89.33333333333333

777.0

Domain

HECT

Tgene

HECTD2

chr10:93602148

chr10:93220184

ENST00000371681

437_776

89.33333333333333

208.0

Domain

HECT

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

873_936

686.3333333333334

1167.0

Domain

SAM

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

959_1164

686.3333333333334

1167.0

Domain

PARP catalytic

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

678_710

686.3333333333334

1167.0

Repeat

Note=ANK 13

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

711_743

686.3333333333334

1167.0

Repeat

Note=ANK 14

Hgene

TNKS2

chr10:93602148

chr10:93220184

ENST00000371627

744_776

686.3333333333334

1167.0

Repeat

Note=ANK 15

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2066_TNKS2_93602148_HECTD2_93220184_ranked_0.pdb	TNKS2	93602148	93602148	ENST00000298068	HECTD2	chr10	93220184	+	MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAVREPPPICLDVRQKQRTSMDASSSEMKAP VLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTV LKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLR LFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIII QRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH PDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAH GLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRP EEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTC	1472

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TNKS2_pLDDT.png

HECTD2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TNKS2
HECTD2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TNKS2-HECTD2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TNKS2-HECTD2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source