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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNPO1-MEF2C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNPO1-MEF2C
FusionPDB ID: 92783
FusionGDB2.0 ID: 92783
HgeneTgene
Gene symbol

TNPO1

MEF2C

Gene ID

3842

4208

Gene nametransportin 1myocyte enhancer factor 2C
SynonymsIPO2|KPNB2|MIP|MIP1|TRNC5DELq14.3|DEL5q14.3
Cytomap

5q13.2

5q14.3

Type of geneprotein-codingprotein-coding
Descriptiontransportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2myocyte-specific enhancer factor 2CMADS box transcription enhancer factor 2, polypeptide C
Modification date2020031320200329
UniProtAcc.

Q06413

Ensembl transtripts involved in fusion geneENST idsENST00000337273, ENST00000454282, 
ENST00000523768, ENST00000447967, 
ENST00000506351, ENST00000513944, 
ENST00000503554, ENST00000424173, 
ENST00000437473, ENST00000504921, 
ENST00000506554, ENST00000508569, 
ENST00000510942, ENST00000514015, 
ENST00000514028, ENST00000539796, 
ENST00000340208, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 8 X 8=57611 X 9 X 4=396
# samples 1111
** MAII scorelog2(11/576*10)=-2.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNPO1 [Title/Abstract] AND MEF2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNPO1(72112579)-MEF2C(88057145), # samples:4
Anticipated loss of major functional domain due to fusion event.TNPO1-MEF2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNPO1-MEF2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNPO1-MEF2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNPO1-MEF2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNPO1

GO:0006606

protein import into nucleus

9144189

TgeneMEF2C

GO:0000165

MAPK cascade

9858528

TgeneMEF2C

GO:0006355

regulation of transcription, DNA-templated

24008018

TgeneMEF2C

GO:0010628

positive regulation of gene expression

9857019|21556048

TgeneMEF2C

GO:0030279

negative regulation of ossification

17696759

TgeneMEF2C

GO:0045893

positive regulation of transcription, DNA-templated

17696759

TgeneMEF2C

GO:0045944

positive regulation of transcription by RNA polymerase II

8455629|15486975|16043483

TgeneMEF2C

GO:0071374

cellular response to parathyroid hormone stimulus

17696759

TgeneMEF2C

GO:0071560

cellular response to transforming growth factor beta stimulus

9770491

TgeneMEF2C

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

28799067

TgeneMEF2C

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

28799067

TgeneMEF2C

GO:2000727

positive regulation of cardiac muscle cell differentiation

9857019

TgeneMEF2C

GO:2001016

positive regulation of skeletal muscle cell differentiation

21556048


check buttonFusion gene breakpoints across TNPO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEF2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J1-01ATNPO1chr5

72112579

-MEF2Cchr5

88057145

-
ChimerDB4ACCTCGA-OR-A5J1-01ATNPO1chr5

72112579

+MEF2Cchr5

88057145

-
ChimerDB4ACCTCGA-OR-A5J1TNPO1chr5

72112579

+MEF2Cchr5

88057145

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337273TNPO1chr572112579+ENST00000340208MEF2Cchr588057145-60814414261634402
ENST00000454282TNPO1chr572112579+ENST00000340208MEF2Cchr588057145-58021621471355402
ENST00000523768TNPO1chr572112579+ENST00000340208MEF2Cchr588057145-572181661274402

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337273ENST00000340208TNPO1chr572112579+MEF2Cchr588057145-0.0005003080.9994997
ENST00000454282ENST00000340208TNPO1chr572112579+MEF2Cchr588057145-0.0004408770.9995591
ENST00000523768ENST00000340208TNPO1chr572112579+MEF2Cchr588057145-0.0004370060.99956304

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92783_92783_1_TNPO1-MEF2C_TNPO1_chr5_72112579_ENST00000337273_MEF2C_chr5_88057145_ENST00000340208_length(amino acids)=402AA_BP=5
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY

--------------------------------------------------------------

>92783_92783_2_TNPO1-MEF2C_TNPO1_chr5_72112579_ENST00000454282_MEF2C_chr5_88057145_ENST00000340208_length(amino acids)=402AA_BP=5
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY

--------------------------------------------------------------

>92783_92783_3_TNPO1-MEF2C_TNPO1_chr5_72112579_ENST00000523768_MEF2C_chr5_88057145_ENST00000340208_length(amino acids)=402AA_BP=5
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:72112579/chr5:88057145)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEF2C

Q06413

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000340208312146_18386.0484.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000424173011146_1830464.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST000004241730114_310464.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000437473211146_18386.0474.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000510942210146_18386.0466.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514015211146_18386.0442.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000514028211146_18386.0474.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000053979608146_1830.0418.0Compositional biasNote=Ser-rich
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796084_310.0418.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000042417301158_860464.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005397960858_860.0418.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST000004241730113_570464.0DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST00000539796083_570.0418.0DomainMADS-box

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125358_3765.03427.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124358_3765.02688.3333333333335Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125358_3760949.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123358_3765.0849.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12541_1095.03427.0DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12441_1095.02688.3333333333335DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12541_1090949.3333333333334DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12341_1095.0849.0DomainImportin N-terminal
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125137_1745.03427.0RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125181_2115.03427.0RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12519_465.03427.0RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125224_2515.03427.0RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125263_2905.03427.0RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125306_3975.03427.0RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125405_4335.03427.0RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125445_4725.03427.0RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125486_5195.03427.0RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12551_895.03427.0RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125527_5605.03427.0RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125568_6065.03427.0RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125614_6655.03427.0RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125676_7075.03427.0RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125715_7485.03427.0RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125756_7915.03427.0RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125799_8325.03427.0RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125841_8725.03427.0RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+125875_8955.03427.0RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000337273+12598_1315.03427.0RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124137_1745.02688.3333333333335RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124181_2115.02688.3333333333335RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12419_465.02688.3333333333335RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124224_2515.02688.3333333333335RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124263_2905.02688.3333333333335RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124306_3975.02688.3333333333335RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124405_4335.02688.3333333333335RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124445_4725.02688.3333333333335RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124486_5195.02688.3333333333335RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12451_895.02688.3333333333335RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124527_5605.02688.3333333333335RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124568_6065.02688.3333333333335RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124614_6655.02688.3333333333335RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124676_7075.02688.3333333333335RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124715_7485.02688.3333333333335RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124756_7915.02688.3333333333335RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124799_8325.02688.3333333333335RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124841_8725.02688.3333333333335RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+124875_8955.02688.3333333333335RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000454282+12498_1315.02688.3333333333335RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125137_1740949.3333333333334RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125181_2110949.3333333333334RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12519_460949.3333333333334RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125224_2510949.3333333333334RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125263_2900949.3333333333334RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125306_3970949.3333333333334RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125405_4330949.3333333333334RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125445_4720949.3333333333334RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125486_5190949.3333333333334RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12551_890949.3333333333334RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125527_5600949.3333333333334RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125568_6060949.3333333333334RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125614_6650949.3333333333334RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125676_7070949.3333333333334RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125715_7480949.3333333333334RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125756_7910949.3333333333334RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125799_8320949.3333333333334RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125841_8720949.3333333333334RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+125875_8950949.3333333333334RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000506351+12598_1310949.3333333333334RepeatHEAT 3
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123137_1745.0849.0RepeatHEAT 4
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123181_2115.0849.0RepeatHEAT 5
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12319_465.0849.0RepeatHEAT 1
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123224_2515.0849.0RepeatHEAT 6
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123263_2905.0849.0RepeatHEAT 7
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123306_3975.0849.0RepeatHEAT 8
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123405_4335.0849.0RepeatHEAT 9
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123445_4725.0849.0RepeatHEAT 10
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123486_5195.0849.0RepeatHEAT 11
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12351_895.0849.0RepeatHEAT 2
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123527_5605.0849.0RepeatHEAT 12
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123568_6065.0849.0RepeatHEAT 13
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123614_6655.0849.0RepeatHEAT 14
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123676_7075.0849.0RepeatHEAT 15
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123715_7485.0849.0RepeatHEAT 16
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123756_7915.0849.0RepeatHEAT 17
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123799_8325.0849.0RepeatHEAT 18
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123841_8725.0849.0RepeatHEAT 19
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+123875_8955.0849.0RepeatHEAT 20
HgeneTNPO1chr5:72112579chr5:88057145ENST00000523768+12398_1315.0849.0RepeatHEAT 3
TgeneMEF2Cchr5:72112579chr5:88057145ENST000003402083124_3186.0484.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST000004374732114_3186.0474.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005109422104_3186.0466.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005140152114_3186.0442.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005140282114_3186.0474.0Compositional biasNote=Lys-rich (basic)
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000034020831258_8686.0484.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000043747321158_8686.0474.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000051094221058_8686.0466.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000051401521158_8686.0442.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST0000051402821158_8686.0474.0DNA bindingMef2-type
TgeneMEF2Cchr5:72112579chr5:88057145ENST000003402083123_5786.0484.0DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST000004374732113_5786.0474.0DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005109422103_5786.0466.0DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005140152113_5786.0442.0DomainMADS-box
TgeneMEF2Cchr5:72112579chr5:88057145ENST000005140282113_5786.0474.0DomainMADS-box


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>808_TNPO1_72112579_MEF2C_88057145_ranked_0.pdbTNPO17211257972112579ENST00000340208MEF2Cchr588057145-
MVWDRTLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHN
SLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPP
MNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASA
LHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSY
402


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TNPO1_pLDDT.png
all structure
all structure
MEF2C_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNPO1
MEF2C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TNPO1-MEF2C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNPO1-MEF2C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource