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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BCAT2-PPP1R12C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BCAT2-PPP1R12C
	FusionPDB ID: 9288
	FusionGDB2.0 ID: 9288
		Hgene	Tgene
	Gene symbol	BCAT2	PPP1R12C
	Gene ID	587	54776
	Gene name	branched chain amino acid transaminase 2	protein phosphatase 1 regulatory subunit 12C
	Synonyms	BCAM\|BCATM\|BCT2\|PP18	AAVS1\|LENG3\|MBS85\|p84\|p85
	Cytomap	19q13.33	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	branched-chain-amino-acid aminotransferase, mitochondrialbranched chain amino-acid transaminase 2, mitochondrialbranched chain aminotransferase 2, mitochondrialplacental protein 18	protein phosphatase 1 regulatory subunit 12Cleukocyte receptor cluster (LRC) encoded novel gene 3leukocyte receptor cluster (LRC) member 3myosin-binding subunit 85protein phosphatase 1 myosin-binding subunit of 85 kDaprotein phosphatase 1 myosin-bind
	Modification date	20200313	20200313
	UniProtAcc	O15382	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000402551, ENST00000601496, ENST00000316273, ENST00000545387, ENST00000598162, ENST00000599246, ENST00000597011,	ENST00000263433, ENST00000376393, ENST00000435544,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 9=810	16 X 6 X 9=864
	# samples	11	16
	** MAII score	log2(11/810*10)=-2.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/864*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BCAT2 [Title/Abstract] AND PPP1R12C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCAT2(49314240)-PPP1R12C(55607703), # samples:1
Anticipated loss of major functional domain due to fusion event.	BCAT2-PPP1R12C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAT2-PPP1R12C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across BCAT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R12C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A3SL	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000263433	PPP1R12C	chr19	55607703	-	1986	29	5	1426	473
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000376393	PPP1R12C	chr19	55607703	-	1795	29	5	1237	410
ENST00000545387	BCAT2	chr19	49314240	-	ENST00000435544	PPP1R12C	chr19	55607703	-	1535	29	5	1423	472
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000263433	PPP1R12C	chr19	55607703	-	1994	37	13	1434	473
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000376393	PPP1R12C	chr19	55607703	-	1803	37	13	1245	410
ENST00000316273	BCAT2	chr19	49314240	-	ENST00000435544	PPP1R12C	chr19	55607703	-	1543	37	13	1431	472
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000263433	PPP1R12C	chr19	55607703	-	2003	46	22	1443	473
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000376393	PPP1R12C	chr19	55607703	-	1812	46	22	1254	410
ENST00000599246	BCAT2	chr19	49314240	-	ENST00000435544	PPP1R12C	chr19	55607703	-	1552	46	22	1440	472
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000263433	PPP1R12C	chr19	55607703	-	2001	44	20	1441	473
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000376393	PPP1R12C	chr19	55607703	-	1810	44	20	1252	410
ENST00000598162	BCAT2	chr19	49314240	-	ENST00000435544	PPP1R12C	chr19	55607703	-	1550	44	20	1438	472

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000545387	ENST00000263433	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.049321603	0.95067835
ENST00000545387	ENST00000376393	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.039440136	0.9605599
ENST00000545387	ENST00000435544	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.06222593	0.9377741
ENST00000316273	ENST00000263433	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.048758004	0.95124197
ENST00000316273	ENST00000376393	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.038338672	0.9616613
ENST00000316273	ENST00000435544	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.06150464	0.9384954
ENST00000599246	ENST00000263433	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.04876436	0.9512356
ENST00000599246	ENST00000376393	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.0387689	0.9612311
ENST00000599246	ENST00000435544	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.060765725	0.9392343
ENST00000598162	ENST00000263433	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.04846785	0.9515322
ENST00000598162	ENST00000376393	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.038284395	0.96171564
ENST00000598162	ENST00000435544	BCAT2	chr19	49314240	-	PPP1R12C	chr19	55607703	-	0.060710058	0.93929

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9288_9288_1_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000316273_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=473AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLN
PEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDL

--------------------------------------------------------------

>9288_9288_2_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000316273_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=410AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAE
PADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALL

--------------------------------------------------------------

>9288_9288_3_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000316273_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=472AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNP
EPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLR

--------------------------------------------------------------

>9288_9288_4_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000545387_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=473AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLN
PEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDL

--------------------------------------------------------------

>9288_9288_5_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000545387_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=410AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAE
PADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALL

--------------------------------------------------------------

>9288_9288_6_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000545387_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=472AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNP
EPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLR

--------------------------------------------------------------

>9288_9288_7_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000598162_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=473AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLN
PEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDL

--------------------------------------------------------------

>9288_9288_8_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000598162_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=410AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAE
PADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALL

--------------------------------------------------------------

>9288_9288_9_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000598162_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=472AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNP
EPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLR

--------------------------------------------------------------

>9288_9288_10_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000599246_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=473AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLN
PEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDL

--------------------------------------------------------------

>9288_9288_11_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000599246_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=410AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAE
PADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALL

--------------------------------------------------------------

>9288_9288_12_BCAT2-PPP1R12C_BCAT2_chr19_49314240_ENST00000599246_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=472AA_BP=7
MAAAALGQLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSS
PPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVT
KPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAP
ESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNP
EPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49314240/chr19:55607703)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCAT2 O15382	.
FUNCTION: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

681_782

317.0

783.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

473_523

317.0

783.0

Compositional bias

Pro-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

297_329

317.0

783.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

100_129

317.0

783.0

Repeat

ANK 1

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

133_162

317.0

783.0

Repeat

ANK 2

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

226_255

317.0

783.0

Repeat

ANK 3

Tgene

PPP1R12C

chr19:49314240

chr19:55607703

ENST00000263433

259_288

317.0

783.0

Repeat

ANK 4

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BCAT2
PPP1R12C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BCAT2-PPP1R12C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BCAT2-PPP1R12C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source