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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TP53BP1-DAPK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TP53BP1-DAPK2
FusionPDB ID: 93182
FusionGDB2.0 ID: 93182
HgeneTgene
Gene symbol

TP53BP1

DAPK2

Gene ID

7158

23604

Gene nametumor protein p53 binding protein 1death associated protein kinase 2
Synonyms53BP1|TDRD30|p202|p53BP1DRP-1|DRP1
Cytomap

15q15.3

15q22.31

Type of geneprotein-codingprotein-coding
DescriptionTP53-binding protein 1p53-binding protein 1tumor protein 53-binding protein, 1tumor suppressor p53-binding protein 1death-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform
Modification date2020032220200313
UniProtAcc

Q12888

Q9UIK4

Ensembl transtripts involved in fusion geneENST idsENST00000263801, ENST00000382039, 
ENST00000382044, ENST00000450115, 
ENST00000605155, 		ENST00000558482, 
ENST00000261891, ENST00000457488, 
ENST00000558069, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 7=9248 X 9 X 8=576
# samples 1313
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TP53BP1 [Title/Abstract] AND DAPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TP53BP1(43771595)-DAPK2(64263760), # samples:3
Anticipated loss of major functional domain due to fusion event.TP53BP1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP53BP1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP53BP1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP53BP1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP53BP1

GO:0006303

double-strand break repair via nonhomologous end joining

23333306|23760478|28241136

HgeneTP53BP1

GO:0006974

cellular response to DNA damage stimulus

17500065|28241136

HgeneTP53BP1

GO:0045830

positive regulation of isotype switching

23345425

HgeneTP53BP1

GO:0051260

protein homooligomerization

23345425

HgeneTP53BP1

GO:2000042

negative regulation of double-strand break repair via homologous recombination

23333306|23345425

TgeneDAPK2

GO:0006468

protein phosphorylation

10376525

TgeneDAPK2

GO:0035556

intracellular signal transduction

10376525


check buttonFusion gene breakpoints across TP53BP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DAPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A7TC-01ATP53BP1chr15

43771595

-DAPK2chr15

64263760

-
ChimerDB4LGGTCGA-DU-A7TCTP53BP1chr15

43771594

-DAPK2chr15

64263760

-
ChimerDB4LGGTCGA-DU-A7TCTP53BP1chr15

43771595

-DAPK2chr15

64263760

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263801TP53BP1chr1543771595-ENST00000261891DAPK2chr1564263760-330910262531824523
ENST00000263801TP53BP1chr1543771595-ENST00000457488DAPK2chr1564263760-242210262531824523
ENST00000263801TP53BP1chr1543771595-ENST00000558069DAPK2chr1564263760-217910262532178642
ENST00000382039TP53BP1chr1543771595-ENST00000261891DAPK2chr1564263760-3133850621648528
ENST00000382039TP53BP1chr1543771595-ENST00000457488DAPK2chr1564263760-2246850621648528
ENST00000382039TP53BP1chr1543771595-ENST00000558069DAPK2chr1564263760-2003850622002647
ENST00000382044TP53BP1chr1543771595-ENST00000261891DAPK2chr1564263760-31999161281714528
ENST00000382044TP53BP1chr1543771595-ENST00000457488DAPK2chr1564263760-23129161281714528
ENST00000382044TP53BP1chr1543771595-ENST00000558069DAPK2chr1564263760-20699161282068647
ENST00000450115TP53BP1chr1543771595-ENST00000261891DAPK2chr1564263760-3155872841670528
ENST00000450115TP53BP1chr1543771595-ENST00000457488DAPK2chr1564263760-2268872841670528
ENST00000450115TP53BP1chr1543771595-ENST00000558069DAPK2chr1564263760-2025872842024646
ENST00000263801TP53BP1chr1543771594-ENST00000261891DAPK2chr1564263760-330910262531824523
ENST00000263801TP53BP1chr1543771594-ENST00000457488DAPK2chr1564263760-242210262531824523
ENST00000263801TP53BP1chr1543771594-ENST00000558069DAPK2chr1564263760-217910262532178642
ENST00000382039TP53BP1chr1543771594-ENST00000261891DAPK2chr1564263760-3133850621648528
ENST00000382039TP53BP1chr1543771594-ENST00000457488DAPK2chr1564263760-2246850621648528
ENST00000382039TP53BP1chr1543771594-ENST00000558069DAPK2chr1564263760-2003850622002647
ENST00000382044TP53BP1chr1543771594-ENST00000261891DAPK2chr1564263760-31999161281714528
ENST00000382044TP53BP1chr1543771594-ENST00000457488DAPK2chr1564263760-23129161281714528
ENST00000382044TP53BP1chr1543771594-ENST00000558069DAPK2chr1564263760-20699161282068647
ENST00000450115TP53BP1chr1543771594-ENST00000261891DAPK2chr1564263760-3155872841670528
ENST00000450115TP53BP1chr1543771594-ENST00000457488DAPK2chr1564263760-2268872841670528
ENST00000450115TP53BP1chr1543771594-ENST00000558069DAPK2chr1564263760-2025872842024646

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263801ENST00000261891TP53BP1chr1543771595-DAPK2chr1564263760-0.001023860.9989761
ENST00000263801ENST00000457488TP53BP1chr1543771595-DAPK2chr1564263760-0.0012997280.99870026
ENST00000263801ENST00000558069TP53BP1chr1543771595-DAPK2chr1564263760-0.0029270230.99707294
ENST00000382039ENST00000261891TP53BP1chr1543771595-DAPK2chr1564263760-0.0023681550.9976318
ENST00000382039ENST00000457488TP53BP1chr1543771595-DAPK2chr1564263760-0.0039828110.99601716
ENST00000382039ENST00000558069TP53BP1chr1543771595-DAPK2chr1564263760-0.0077376440.99226236
ENST00000382044ENST00000261891TP53BP1chr1543771595-DAPK2chr1564263760-0.0023258360.99767417
ENST00000382044ENST00000457488TP53BP1chr1543771595-DAPK2chr1564263760-0.0037705510.99622947
ENST00000382044ENST00000558069TP53BP1chr1543771595-DAPK2chr1564263760-0.0071743690.9928256
ENST00000450115ENST00000261891TP53BP1chr1543771595-DAPK2chr1564263760-0.0024340540.997566
ENST00000450115ENST00000457488TP53BP1chr1543771595-DAPK2chr1564263760-0.0040357190.9959643
ENST00000450115ENST00000558069TP53BP1chr1543771595-DAPK2chr1564263760-0.0080075390.9919925
ENST00000263801ENST00000261891TP53BP1chr1543771594-DAPK2chr1564263760-0.001023860.9989761
ENST00000263801ENST00000457488TP53BP1chr1543771594-DAPK2chr1564263760-0.0012997280.99870026
ENST00000263801ENST00000558069TP53BP1chr1543771594-DAPK2chr1564263760-0.0029270230.99707294
ENST00000382039ENST00000261891TP53BP1chr1543771594-DAPK2chr1564263760-0.0023681550.9976318
ENST00000382039ENST00000457488TP53BP1chr1543771594-DAPK2chr1564263760-0.0039828110.99601716
ENST00000382039ENST00000558069TP53BP1chr1543771594-DAPK2chr1564263760-0.0077376440.99226236
ENST00000382044ENST00000261891TP53BP1chr1543771594-DAPK2chr1564263760-0.0023258360.99767417
ENST00000382044ENST00000457488TP53BP1chr1543771594-DAPK2chr1564263760-0.0037705510.99622947
ENST00000382044ENST00000558069TP53BP1chr1543771594-DAPK2chr1564263760-0.0071743690.9928256
ENST00000450115ENST00000261891TP53BP1chr1543771594-DAPK2chr1564263760-0.0024340540.997566
ENST00000450115ENST00000457488TP53BP1chr1543771594-DAPK2chr1564263760-0.0040357190.9959643
ENST00000450115ENST00000558069TP53BP1chr1543771594-DAPK2chr1564263760-0.0080075390.9919925

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93182_93182_1_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000263801_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=523AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRR

--------------------------------------------------------------

>93182_93182_2_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000263801_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=523AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRR

--------------------------------------------------------------

>93182_93182_3_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000263801_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=642AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGRAPEQR
KTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESARHDLSQ
LRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSELLSRS

--------------------------------------------------------------

>93182_93182_4_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382039_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_5_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382039_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_6_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382039_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=647AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

--------------------------------------------------------------

>93182_93182_7_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382044_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_8_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382044_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_9_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000382044_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=647AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

--------------------------------------------------------------

>93182_93182_10_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000450115_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_11_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000450115_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_12_TP53BP1-DAPK2_TP53BP1_chr15_43771594_ENST00000450115_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=646AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

--------------------------------------------------------------

>93182_93182_13_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000263801_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=523AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRR

--------------------------------------------------------------

>93182_93182_14_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000263801_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=523AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRR

--------------------------------------------------------------

>93182_93182_15_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000263801_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=642AA_BP=257
MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVA
DPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD
VEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELFDFLAQ
KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLE
ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGRAPEQR
KTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESARHDLSQ
LRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSELLSRS

--------------------------------------------------------------

>93182_93182_16_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382039_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_17_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382039_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_18_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382039_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=647AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

--------------------------------------------------------------

>93182_93182_19_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382044_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_20_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382044_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_21_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000382044_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=647AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

--------------------------------------------------------------

>93182_93182_22_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000450115_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_23_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000450115_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=528AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQ

--------------------------------------------------------------

>93182_93182_24_TP53BP1-DAPK2_TP53BP1_chr15_43771595_ENST00000450115_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=646AA_BP=262
MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLK
ENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLEL
SQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARVSGGELF
DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE
PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITSKGEGR
APEQRKTEPTQLKTKHLREYTLKCHSSMPPNNSYVNFERFACVVEDVARVDLGCRALVEAHDTIQDDVEALVSIFNEKEAWYREENESAR
HDLSQLRYEFRKVESLKKLLREDIQATGCSLGSMARKLDHLQAQFEILRQELSADLQWIQELVGSFQLESGSSEGLGSTFYQDTSESLSE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:43771595/chr15:64263760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TP53BP1

Q12888

DAPK2

Q9UIK4

FUNCTION: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:27153538, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306, PubMed:27153538). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:27153538, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136}.FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDAPK2chr15:43771594chr15:64263760ENST00000261891111277_344104.66666666666667371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771594chr15:64263760ENST00000261891111292_301104.66666666666667371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:43771594chr15:64263760ENST00000457488212277_344104.66666666666667371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771594chr15:64263760ENST00000457488212292_301104.66666666666667371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:43771594chr15:64263760ENST00000558069210277_344104.66666666666667489.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771594chr15:64263760ENST00000558069210292_301104.66666666666667489.0RegionAutoinhibitory domain
TgeneDAPK2chr15:43771595chr15:64263760ENST00000261891111277_344104.66666666666667371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771595chr15:64263760ENST00000261891111292_301104.66666666666667371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:43771595chr15:64263760ENST00000457488212277_344104.66666666666667371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771595chr15:64263760ENST00000457488212292_301104.66666666666667371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:43771595chr15:64263760ENST00000558069210277_344104.66666666666667489.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:43771595chr15:64263760ENST00000558069210292_301104.66666666666667489.0RegionAutoinhibitory domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281642_1646257.66666666666671973.0Compositional biasNote=Poly-Ser
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281760_1764257.66666666666671973.0Compositional biasNote=Poly-Glu
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281642_1646262.66666666666671978.0Compositional biasNote=Poly-Ser
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281760_1764262.66666666666671978.0Compositional biasNote=Poly-Glu
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281642_1646257.66666666666671973.0Compositional biasNote=Poly-Ser
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281760_1764257.66666666666671973.0Compositional biasNote=Poly-Glu
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281642_1646262.66666666666671978.0Compositional biasNote=Poly-Ser
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281760_1764262.66666666666671978.0Compositional biasNote=Poly-Glu
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281724_1848257.66666666666671973.0DomainBRCT 1
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281864_1964257.66666666666671973.0DomainBRCT 2
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281724_1848262.66666666666671978.0DomainBRCT 1
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281864_1964262.66666666666671978.0DomainBRCT 2
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281724_1848257.66666666666671973.0DomainBRCT 1
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281864_1964257.66666666666671973.0DomainBRCT 2
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281724_1848262.66666666666671978.0DomainBRCT 1
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281864_1964262.66666666666671978.0DomainBRCT 2
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281396_1403257.66666666666671973.0MotifGAR
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281604_1631257.66666666666671973.0MotifUDR
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281396_1403262.66666666666671978.0MotifGAR
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281604_1631262.66666666666671978.0MotifUDR
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281396_1403257.66666666666671973.0MotifGAR
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281604_1631257.66666666666671973.0MotifUDR
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281396_1403262.66666666666671978.0MotifGAR
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281604_1631262.66666666666671978.0MotifUDR
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281484_1603257.66666666666671973.0RegionTudor-like
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281484_1603262.66666666666671978.0RegionTudor-like
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281484_1603257.66666666666671973.0RegionTudor-like
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281484_1603262.66666666666671978.0RegionTudor-like
TgeneDAPK2chr15:43771594chr15:64263760ENST0000026189111123_285104.66666666666667371.0DomainProtein kinase
TgeneDAPK2chr15:43771594chr15:64263760ENST0000045748821223_285104.66666666666667371.0DomainProtein kinase
TgeneDAPK2chr15:43771594chr15:64263760ENST0000055806921023_285104.66666666666667489.0DomainProtein kinase
TgeneDAPK2chr15:43771595chr15:64263760ENST0000026189111123_285104.66666666666667371.0DomainProtein kinase
TgeneDAPK2chr15:43771595chr15:64263760ENST0000045748821223_285104.66666666666667371.0DomainProtein kinase
TgeneDAPK2chr15:43771595chr15:64263760ENST0000055806921023_285104.66666666666667489.0DomainProtein kinase
TgeneDAPK2chr15:43771594chr15:64263760ENST0000026189111129_37104.66666666666667371.0Nucleotide bindingATP
TgeneDAPK2chr15:43771594chr15:64263760ENST0000045748821229_37104.66666666666667371.0Nucleotide bindingATP
TgeneDAPK2chr15:43771594chr15:64263760ENST0000055806921029_37104.66666666666667489.0Nucleotide bindingATP
TgeneDAPK2chr15:43771595chr15:64263760ENST0000026189111129_37104.66666666666667371.0Nucleotide bindingATP
TgeneDAPK2chr15:43771595chr15:64263760ENST0000045748821229_37104.66666666666667371.0Nucleotide bindingATP
TgeneDAPK2chr15:43771595chr15:64263760ENST0000055806921029_37104.66666666666667489.0Nucleotide bindingATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TP53BP1_pLDDT.png
all structure
all structure
DAPK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TP53BP1TP53, RPA2, BLM, H2AFX, H2afx, PAXIP1, CHEK1, DYNLL1, ATM, DCLRE1A, NFKB1, RPA1, Trp53, E2F1, TFDP1, BRCA1, CHEK2, RAD18, USP28, UBE2I, PIAS4, RNF8, RNF168, MDC1, MCPH1, HDAC4, TP53I3, vpr, EP300, SETD8, Dynll1, HIST1H4A, HIST1H3A, ARAP1, NCOA3, SIRT7, COPS5, NEK1, NUP107, CCNT1, ACAA2, LIG4, ACR, PCNT, PSMD8, SDHB, SPAG9, GALNTL5, AAMP, CAPZA1, CAPZB, CDC27, CUX1, ARID3A, FASN, FLNA, XRCC6, KPNA1, KPNB1, KPNA3, MCM6, NUMA1, PCMT1, MAPK1, MAPK3, PSMC5, PTPN9, DPF2, RFC2, SAFB, SRSF1, SMARCD1, TMPO, TP73, TRPS1, DNAJC7, XRCC5, YWHAZ, DEK, HAT1, CDC23, CDC16, MTA2, ANAPC10, GNB2L1, PAICS, MYL12A, NUDC, STRAP, CBX3, CLASP2, RCOR1, SUN2, DHRS7B, CACYBP, ANAPC2, ANAPC4, ANAPC5, ANAPC7, PELO, UGGT1, BEND3, ANAPC1, ZBTB10, ANAPC16, FLCN, VCP, CDK1, CCNB1, PLK1, HIST2H4A, MEOX2, VAC14, UBE2L3, ENO1, SHMT2, MOV10, NXF1, MSL1, EED, SUMO2, KDM1A, THAP10, NUP50, POLR1C, SUB1, SMC6, Cenpf, Scai, FOXK1, FOXK2, UBC, TRIM28, PCGF1, DPPA4, NANOG, POU5F1, NFATC2, NUDT16L1, MRPS7, PRPF38A, BUB1, KAT8, LMNA, CFTR, TRIM14, RNF4, SPDL1, ESR2, UBE4A, EZH2, TNRC6A, RIF1, MYC, HIST1H2BB, CDK8, SFXN1, MGST3, COX4I1, PLGRKT, AURKAIP1, FUS, FAM175A, HUS1, BRCC3, UIMC1, TOPBP1, TP53BP1, ATR, BABAM1, BRE, RAD50, CDKN1A, ZEB1, NBN, RAD9A, MRE11A, RAD1, POT1, OBFC1, TINF2, MAD2L2, SETX, ARID1A, SLX4, CREBBP, ERCC4, ZNF207, GTF2H1, ATRIP, RECQL, ARID1B, RHNO1, HNRNPA2B1, ERCC1, RNF169, TERF1, ACD, TLK1, RECQL5, HNRNPUL1, GTF2H3, BARD1, WRNIP1, ERCC3, TERF2, CTC1, ATF3, SMC5, MUS81, JMJD1C, SMN1, BRCA2, MNAT1, C11orf30, ZNF827, NDNL2, SFPQ, USP34, GTF2H4, HMBOX1, USP3, PIAS3, NSMCE1, UBR5, PSPC1, PSMD14, CIRBP, NONO, BUB3, RAD52, MAU2, EP400, AEN, AKAP8L, ANXA11, ANXA7, API5, ASH2L, ASUN, EWSR1, BHLHE40, C18orf25, CABIN1, CARM1, KHSRP, SUMO1, CCDC101, CCNC, CD2BP2, CDK19, ZNF451, CPSF6, CPSF7, CSTF3, CXorf67, DAZAP1, DBR1, DDX20, DDX39B, DDX42, DDX46, DGCR8, DHX38, PML, DIS3, DNPEP, DPY30, ILF2, EGR1, ETV6, EXOSC5, FAM103A1, FAM98B, SMARCC1, SMARCC2, TRIM33, FBXO22, FUBP1, GEMIN4, GTF2IRD1, GTF3C1, GTF3C3, GTF3C4, GTF3C5, HEXIM1, HNRNPAB, HNRNPD, HNRNPDL, HSPA1A, IFI16, INTS9, KAT2A, ZBTB48, LSM3, LSM4, HIRA, SMARCB1, MBNL1, MDN1, MED1, MED10, MED12, MED13, MED13L, MED14, ILF3, MED15, MED17, MED18, MED20, SMARCE1, MED22, MED25, MED27, MED30, MED31, MED4, MED6, SF3B1, MED7, MED8, MED9, MORC3, MSANTD3, NELFB, NFIC, NOSIP, NR2C1, NR2C2, NSUN2, NUDT21, SMARCD2, OGT, PARN, PPM1G, PPP1R10, PPP1R8, PRAME, PRCC, PRR12, PSMC1, PSMC3, PSMC4, PSMD13, PSMD2, PSMD4, PSMD6, PSME3, PTGS2, RAD54L2, RBM10, RBM5, RFX1, RNGTT, RNMT, INTS3, SAGE1, SAP130, SETD1A, SIN3A, SLX4IP, SNAPC1, SP110, SRRT, SS18L1, TADA1, TADA3, TAF10, TAF15, TAF5L, TAF6L, TCEB2, TCF12, TEX10, THOC2, THOC7, TOPORS, TRIM22, TRMT1L, TRMT2A, TSPYL1, UPP1, VWA9, WDR26, WTAP, ZBTB2, ZBTB25, ZBTB9, ZC3H4, ZFC3H1, ZFR, ZHX2, ZNF316, ZNF609, ZZZ3, KIAA1429, KDM2A, E2F4, RBL1, RBL2, SIRT3, PPP5C, EXOC4, ACTC1, ESR1, C20orf196, RAD51, SCAI, MAP1LC3A, PELI1, ANKS1A, PITX1, POU6F2, BCL6, KLHDC7B, UBAP2, CREB5, CCDC120, OXER1, TLX3, HGS, C10orf55, CIC, NUDT16, PARP1, Arrb1, ARRB1, PTEN, DNAJB6, SLIT2, RPS21, CSNK1E, HIST1H1T, PIP4K2A, METTL1, BCKDK, SPRR2E, TMA16, LRPAP1, PHF6, DDX58, HIST1H2AB, SKA3, NAA40, DYNLL2, CDKN3, SLFN11, KIFAP3, BIRC5, TOP3B, CTSL, nsp15, nsp9, ORF7b, TOLLIP, SIRT6, Paxip1, MEF2A, SPOP, NPLOC4, RB1CC1, Kpna2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TP53BP1all structure
DAPK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000263801-7281495_1523257.66666666666671973.0dimethylated histone H4
HgeneTP53BP1chr15:43771594chr15:64263760ENST00000382044-7281495_1523262.66666666666671978.0dimethylated histone H4
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000263801-7281495_1523257.66666666666671973.0dimethylated histone H4
HgeneTP53BP1chr15:43771595chr15:64263760ENST00000382044-7281495_1523262.66666666666671978.0dimethylated histone H4


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Related Drugs to TP53BP1-DAPK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TP53BP1-DAPK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTP53BP1C0006142Malignant neoplasm of breast1CTD_human
HgeneTP53BP1C0007102Malignant tumor of colon1CTD_human
HgeneTP53BP1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneTP53BP1C0009375Colonic Neoplasms1CTD_human
HgeneTP53BP1C0017636Glioblastoma1CTD_human
HgeneTP53BP1C0024232Lymphatic Metastasis1CTD_human
HgeneTP53BP1C0334588Giant Cell Glioblastoma1CTD_human
HgeneTP53BP1C0678222Breast Carcinoma1CTD_human
HgeneTP53BP1C0919267ovarian neoplasm1CTD_human
HgeneTP53BP1C1140680Malignant neoplasm of ovary1CTD_human
HgeneTP53BP1C1257931Mammary Neoplasms, Human1CTD_human
HgeneTP53BP1C1458155Mammary Neoplasms1CTD_human
HgeneTP53BP1C1621958Glioblastoma Multiforme1CTD_human
HgeneTP53BP1C4704874Mammary Carcinoma, Human1CTD_human