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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TP63-TPRG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TP63-TPRG1
FusionPDB ID: 93252
FusionGDB2.0 ID: 93252
HgeneTgene
Gene symbol

TP63

TPRG1

Gene ID

8626

285386

Gene nametumor protein p63tumor protein p63 regulated 1
SynonymsAIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73LFAM79B
Cytomap

3q28

3q28

Type of geneprotein-codingprotein-coding
Descriptiontumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing proteintumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000264731, ENST00000320472, 
ENST00000354600, ENST00000392460, 
ENST00000392461, ENST00000392463, 
ENST00000418709, ENST00000437221, 
ENST00000440651, ENST00000456148, 
ENST00000382063, ENST00000449992, 
ENST00000345063, ENST00000433971, 
ENST00000488841, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=14412 X 7 X 6=504
# samples 916
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/504*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TP63 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TP63(189349366)-TPRG1(189028175), # samples:2
Anticipated loss of major functional domain due to fusion event.TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TP63-TPRG1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

HgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

HgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

HgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

HgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check buttonFusion gene breakpoints across TP63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-1012TP63chr3

189507631

+TPRG1chr3

189038415

+
ChimerDB4LUSCTCGA-63-A5MYTP63chr3

189526315

+TPRG1chr3

188925165

+
ChimerDB4LUSCTCGA-63-A5MYTP63chr3

189590784

+TPRG1chr3

188956522

+
ChimerDB4LUSCTCGA-77-A5G7-01BTP63chr3

189349366

-TPRG1chr3

189028175

+
ChimerDB4LUSCTCGA-77-A5G7TP63chr3

189349366

+TPRG1chr3

189028175

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264731TP63chr3189590784+ENST00000433971TPRG1chr3188956522+22051438801963627
ENST00000264731TP63chr3189590784+ENST00000345063TPRG1chr3188956522+64481438801963627
ENST00000382063TP63chr3189590784+ENST00000433971TPRG1chr3188956522+19501183801708542
ENST00000382063TP63chr3189590784+ENST00000345063TPRG1chr3188956522+61931183801708542
ENST00000418709TP63chr3189590784+ENST00000433971TPRG1chr3188956522+21441377191902627
ENST00000418709TP63chr3189590784+ENST00000345063TPRG1chr3188956522+63871377191902627
ENST00000320472TP63chr3189590784+ENST00000433971TPRG1chr3188956522+21441377191902627
ENST00000320472TP63chr3189590784+ENST00000345063TPRG1chr3188956522+63871377191902627
ENST00000392460TP63chr3189590784+ENST00000433971TPRG1chr3188956522+2116134901874624
ENST00000392460TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6359134901874624
ENST00000440651TP63chr3189590784+ENST00000433971TPRG1chr3188956522+2104133701862620
ENST00000440651TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6347133701862620
ENST00000354600TP63chr3189590784+ENST00000433971TPRG1chr3188956522+19751208931733546
ENST00000354600TP63chr3189590784+ENST00000345063TPRG1chr3188956522+62181208931733546
ENST00000437221TP63chr3189590784+ENST00000433971TPRG1chr3188956522+1834106701592530
ENST00000437221TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6077106701592530
ENST00000392463TP63chr3189590784+ENST00000433971TPRG1chr3188956522+1834106701592530
ENST00000392463TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6077106701592530
ENST00000392461TP63chr3189590784+ENST00000433971TPRG1chr3188956522+1834106701592530
ENST00000392461TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6077106701592530
ENST00000456148TP63chr3189590784+ENST00000433971TPRG1chr3188956522+1822105501580526
ENST00000456148TP63chr3189590784+ENST00000345063TPRG1chr3188956522+6065105501580526
ENST00000449992TP63chr3189590784+ENST00000433971TPRG1chr3188956522+157981201337445
ENST00000449992TP63chr3189590784+ENST00000345063TPRG1chr3188956522+582281201337445
ENST00000264731TP63chr3189349366+ENST00000433971TPRG1chr3189028175+74115180499139
ENST00000264731TP63chr3189349366+ENST00000345063TPRG1chr3189028175+498415180499139
ENST00000382063TP63chr3189349366+ENST00000433971TPRG1chr3189028175+74115180499139
ENST00000382063TP63chr3189349366+ENST00000345063TPRG1chr3189028175+498415180499139
ENST00000418709TP63chr3189349366+ENST00000433971TPRG1chr3189028175+6809019438139
ENST00000418709TP63chr3189349366+ENST00000345063TPRG1chr3189028175+49239019438139
ENST00000320472TP63chr3189349366+ENST00000433971TPRG1chr3189028175+6809019438139
ENST00000320472TP63chr3189349366+ENST00000345063TPRG1chr3189028175+49239019438139
ENST00000392460TP63chr3189349366+ENST00000433971TPRG1chr3189028175+652620410136
ENST00000392460TP63chr3189349366+ENST00000345063TPRG1chr3189028175+4895620410136
ENST00000440651TP63chr3189349366+ENST00000433971TPRG1chr3189028175+652620410136
ENST00000440651TP63chr3189349366+ENST00000345063TPRG1chr3189028175+4895620410136

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264731ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.002026030.997974
ENST00000264731ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0003226310.9996774
ENST00000382063ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.001456770.99854326
ENST00000382063ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004031560.9995969
ENST00000418709ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0028064660.9971935
ENST00000418709ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0003367180.99966323
ENST00000320472ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0028064660.9971935
ENST00000320472ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0003367180.99966323
ENST00000392460ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0028098390.9971902
ENST00000392460ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0003343220.99966574
ENST00000440651ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0031650750.99683493
ENST00000440651ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0003614190.99963856
ENST00000354600ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0026606850.9973393
ENST00000354600ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004458360.9995541
ENST00000437221ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.003316310.99668366
ENST00000437221ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004395250.9995604
ENST00000392463ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.003316310.99668366
ENST00000392463ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004395250.9995604
ENST00000392461ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.003316310.99668366
ENST00000392461ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004395250.9995604
ENST00000456148ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0035562080.9964438
ENST00000456148ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0004523470.99954766
ENST00000449992ENST00000433971TP63chr3189590784+TPRG1chr3188956522+0.0010612310.99893874
ENST00000449992ENST00000345063TP63chr3189590784+TPRG1chr3188956522+0.0002615440.9997384
ENST00000264731ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.196685640.8033143
ENST00000264731ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.089247920.9107521
ENST00000382063ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.196685640.8033143
ENST00000382063ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.089247920.9107521
ENST00000418709ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.170056660.8299434
ENST00000418709ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.088292840.9117071
ENST00000320472ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.170056660.8299434
ENST00000320472ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.088292840.9117071
ENST00000392460ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.183501940.81649804
ENST00000392460ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.090340850.9096591
ENST00000440651ENST00000433971TP63chr3189349366+TPRG1chr3189028175+0.183501940.81649804
ENST00000440651ENST00000345063TP63chr3189349366+TPRG1chr3189028175+0.090340850.9096591

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93252_93252_1_TP63-TPRG1_TP63_chr3_189349366_ENST00000264731_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_2_TP63-TPRG1_TP63_chr3_189349366_ENST00000264731_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_3_TP63-TPRG1_TP63_chr3_189349366_ENST00000320472_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_4_TP63-TPRG1_TP63_chr3_189349366_ENST00000320472_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_5_TP63-TPRG1_TP63_chr3_189349366_ENST00000382063_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_6_TP63-TPRG1_TP63_chr3_189349366_ENST00000382063_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_7_TP63-TPRG1_TP63_chr3_189349366_ENST00000392460_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=136AA_BP=20
MNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKN

--------------------------------------------------------------

>93252_93252_8_TP63-TPRG1_TP63_chr3_189349366_ENST00000392460_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=136AA_BP=20
MNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKN

--------------------------------------------------------------

>93252_93252_9_TP63-TPRG1_TP63_chr3_189349366_ENST00000418709_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_10_TP63-TPRG1_TP63_chr3_189349366_ENST00000418709_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=139AA_BP=23
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA

--------------------------------------------------------------

>93252_93252_11_TP63-TPRG1_TP63_chr3_189349366_ENST00000440651_TPRG1_chr3_189028175_ENST00000345063_length(amino acids)=136AA_BP=20
MNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKN

--------------------------------------------------------------

>93252_93252_12_TP63-TPRG1_TP63_chr3_189349366_ENST00000440651_TPRG1_chr3_189028175_ENST00000433971_length(amino acids)=136AA_BP=20
MNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKN

--------------------------------------------------------------

>93252_93252_13_TP63-TPRG1_TP63_chr3_189590784_ENST00000264731_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_14_TP63-TPRG1_TP63_chr3_189590784_ENST00000264731_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_15_TP63-TPRG1_TP63_chr3_189590784_ENST00000320472_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_16_TP63-TPRG1_TP63_chr3_189590784_ENST00000320472_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_17_TP63-TPRG1_TP63_chr3_189590784_ENST00000354600_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=546AA_BP=372
MEPEERTAALINLTANMLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSN
TDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQI
APPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACP
GRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQ
QQQQHQHLLQKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLL
SRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLA

--------------------------------------------------------------

>93252_93252_18_TP63-TPRG1_TP63_chr3_189590784_ENST00000354600_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=546AA_BP=372
MEPEERTAALINLTANMLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSN
TDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQI
APPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACP
GRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQ
QQQQHQHLLQKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLL
SRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLA

--------------------------------------------------------------

>93252_93252_19_TP63-TPRG1_TP63_chr3_189590784_ENST00000382063_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=542AA_BP=368
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPS
HLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDR
KADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQ
HQHLLQKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWN
PWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLARGSI

--------------------------------------------------------------

>93252_93252_20_TP63-TPRG1_TP63_chr3_189590784_ENST00000382063_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=542AA_BP=368
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPS
HLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDR
KADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQ
HQHLLQKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWN
PWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNAHKNSTGSGRGKKLMVLTEPILIETYTGLMSFIGNRNKLGYSLARGSI

--------------------------------------------------------------

>93252_93252_21_TP63-TPRG1_TP63_chr3_189590784_ENST00000392460_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=624AA_BP=450
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGN
SHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQ
IDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPY

--------------------------------------------------------------

>93252_93252_22_TP63-TPRG1_TP63_chr3_189590784_ENST00000392460_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=624AA_BP=450
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGN
SHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQ
IDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPY

--------------------------------------------------------------

>93252_93252_23_TP63-TPRG1_TP63_chr3_189590784_ENST00000392461_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_24_TP63-TPRG1_TP63_chr3_189590784_ENST00000392461_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_25_TP63-TPRG1_TP63_chr3_189590784_ENST00000392463_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_26_TP63-TPRG1_TP63_chr3_189590784_ENST00000392463_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_27_TP63-TPRG1_TP63_chr3_189590784_ENST00000418709_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_28_TP63-TPRG1_TP63_chr3_189590784_ENST00000418709_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=627AA_BP=453
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRV
EGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADED
SIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLL
QKQIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTE

--------------------------------------------------------------

>93252_93252_29_TP63-TPRG1_TP63_chr3_189590784_ENST00000437221_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_30_TP63-TPRG1_TP63_chr3_189590784_ENST00000437221_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=530AA_BP=356
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_31_TP63-TPRG1_TP63_chr3_189590784_ENST00000440651_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=620AA_BP=446
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGN
SHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
KQQVSDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_32_TP63-TPRG1_TP63_chr3_189590784_ENST00000440651_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=620AA_BP=446
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGN
SHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
KQQVSDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHW
NNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFT

--------------------------------------------------------------

>93252_93252_33_TP63-TPRG1_TP63_chr3_189590784_ENST00000449992_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=445AA_BP=271
MLYLENNAQTQFSEYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEG
NSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
RKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQK
QIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVP

--------------------------------------------------------------

>93252_93252_34_TP63-TPRG1_TP63_chr3_189590784_ENST00000449992_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=445AA_BP=271
MLYLENNAQTQFSEYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEG
NSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
RKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQK
QIDHWNNEKERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVP

--------------------------------------------------------------

>93252_93252_35_TP63-TPRG1_TP63_chr3_189590784_ENST00000456148_TPRG1_chr3_188956522_ENST00000345063_length(amino acids)=526AA_BP=352
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHWNNEK
ERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPM

--------------------------------------------------------------

>93252_93252_36_TP63-TPRG1_TP63_chr3_189590784_ENST00000456148_TPRG1_chr3_188956522_ENST00000433971_length(amino acids)=526AA_BP=352
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQV
SDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQIDHWNNEK
ERILLVTDKTLLICKYDFIMLSCVQLQRIPLSAVYRICLGKFTFPGMSLDKRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPM

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:189349366/chr3:189028175)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+1014437_444449.6666666666667681.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+1012437_444449.6666666666667511.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+1013437_444449.6666666666667556.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+1011437_444449.6666666666667488.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+1014437_444445.6666666666667677.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+1014170_362449.6666666666667681.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+1012170_362449.6666666666667511.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913170_362364.6666666666667596.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+1013170_362449.6666666666667556.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+1011170_362449.6666666666667488.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+1014170_362445.6666666666667677.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+10141_107449.6666666666667681.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+1014394_443449.6666666666667681.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+10121_107449.6666666666667511.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+1012394_443449.6666666666667511.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+8121_107355.6666666666667587.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+9131_107364.6666666666667596.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+10131_107449.6666666666667556.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+1013394_443449.6666666666667556.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+8101_107355.6666666666667417.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+8111_107355.6666666666667462.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+10111_107449.6666666666667488.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+1011394_443449.6666666666667488.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+891_107355.6666666666667394.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+10141_107445.6666666666667677.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+1014394_443445.6666666666667677.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+7111_107270.6666666666667502.0RegionNote=Transcription activation
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+8121_107351.6666666666667583.0RegionNote=Transcription activation

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114437_44420.666666666666668681.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112437_44420.666666666666668511.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112437_4440587.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113437_44420.666666666666668596.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113437_44420.666666666666668556.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110437_4440.0417.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111437_4440.0462.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111437_44420.666666666666668488.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19437_4440.0394.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114437_44420.666666666666668677.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111437_4440.0502.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112437_4440.0583.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812437_444355.6666666666667587.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913437_444364.6666666666667596.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810437_444355.6666666666667417.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811437_444355.6666666666667462.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89437_444355.6666666666667394.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711437_444270.6666666666667502.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812437_444351.6666666666667583.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114170_36220.666666666666668681.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112170_36220.666666666666668511.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112170_3620587.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113170_36220.666666666666668596.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113170_36220.666666666666668556.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110170_3620.0417.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111170_3620.0462.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111170_36220.666666666666668488.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19170_3620.0394.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114170_36220.666666666666668677.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111170_3620.0502.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112170_3620.0583.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812170_362355.6666666666667587.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810170_362355.6666666666667417.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811170_362355.6666666666667462.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89170_362355.6666666666667394.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711170_362270.6666666666667502.0DNA binding.
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812170_362351.6666666666667583.0DNA binding.
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114541_60720.666666666666668681.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112541_60720.666666666666668511.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112541_6070587.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113541_60720.666666666666668596.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113541_60720.666666666666668556.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110541_6070.0417.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111541_6070.0462.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111541_60720.666666666666668488.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19541_6070.0394.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114541_60720.666666666666668677.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111541_6070.0502.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112541_6070.0583.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+1014541_607449.6666666666667681.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+1012541_607449.6666666666667511.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812541_607355.6666666666667587.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913541_607364.6666666666667596.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+1013541_607449.6666666666667556.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810541_607355.6666666666667417.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811541_607355.6666666666667462.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+1011541_607449.6666666666667488.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89541_607355.6666666666667394.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+1014541_607445.6666666666667677.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711541_607270.6666666666667502.0DomainNote=SAM
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812541_607351.6666666666667583.0DomainNote=SAM
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+1141_10720.666666666666668681.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114394_44320.666666666666668681.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114610_68020.666666666666668681.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+1121_10720.666666666666668511.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112394_44320.666666666666668511.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112610_68020.666666666666668511.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+1121_1070587.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112394_4430587.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112610_6800587.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+1131_10720.666666666666668596.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113394_44320.666666666666668596.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113610_68020.666666666666668596.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+1131_10720.666666666666668556.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113394_44320.666666666666668556.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113610_68020.666666666666668556.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+1101_1070.0417.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110394_4430.0417.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110610_6800.0417.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+1111_1070.0462.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111394_4430.0462.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111610_6800.0462.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+1111_10720.666666666666668488.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111394_44320.666666666666668488.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111610_68020.666666666666668488.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+191_1070.0394.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19394_4430.0394.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19610_6800.0394.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+1141_10720.666666666666668677.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114394_44320.666666666666668677.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114610_68020.666666666666668677.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+1111_1070.0502.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111394_4430.0502.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111610_6800.0502.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+1121_1070.0583.0RegionNote=Transcription activation
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112394_4430.0583.0RegionNote=Oligomerization
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112610_6800.0583.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000264731+1014610_680449.6666666666667681.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000320472+1012610_680449.6666666666667511.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812394_443355.6666666666667587.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812610_680355.6666666666667587.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913394_443364.6666666666667596.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913610_680364.6666666666667596.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000392460+1013610_680449.6666666666667556.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810394_443355.6666666666667417.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810610_680355.6666666666667417.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811394_443355.6666666666667462.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811610_680355.6666666666667462.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000418709+1011610_680449.6666666666667488.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89394_443355.6666666666667394.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89610_680355.6666666666667394.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000440651+1014610_680445.6666666666667677.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711394_443270.6666666666667502.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711610_680270.6666666666667502.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812394_443351.6666666666667583.0RegionNote=Oligomerization
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812610_680351.6666666666667583.0RegionNote=Transactivation inhibition
TgeneTPRG1chr3:189349366chr3:189028175ENST000003450633668_240159.66666666666666276.0DomainhSac2
TgeneTPRG1chr3:189349366chr3:189028175ENST0000043397181168_240159.66666666666666276.0DomainhSac2
TgeneTPRG1chr3:189590784chr3:188956522ENST000003450632668_240100.66666666666667276.0DomainhSac2
TgeneTPRG1chr3:189590784chr3:188956522ENST0000043397171168_240100.66666666666667276.0DomainhSac2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>98_TP63_189349366_TPRG1_189028175_ranked_0.pdbTP63189349366189349366ENST00000345063TPRG1chr3189028175+
MKEMNFETSRCATLQYCPDPYIQRRQGEGLRIYWGSPEEQSLLSRWNPWSTEVPYATFTEHPMKYTSEKFLEICKLSGFMSKLVPAIQNA
139


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TP63_pLDDT.png
all structure
all structure
TPRG1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TP63
TPRG1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP63chr3:189349366chr3:189028175ENST00000264731+114352_38820.666666666666668681.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000320472+112352_38820.666666666666668511.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000354600+112352_3880587.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000382063+113352_38820.666666666666668596.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000392460+113352_38820.666666666666668556.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000392461+110352_3880.0417.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000392463+111352_3880.0462.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000418709+111352_38820.666666666666668488.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000437221+19352_3880.0394.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000440651+114352_38820.666666666666668677.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000449992+111352_3880.0502.0HIPK2
HgeneTP63chr3:189349366chr3:189028175ENST00000456148+112352_3880.0583.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000354600+812352_388355.6666666666667587.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000382063+913352_388364.6666666666667596.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000392461+810352_388355.6666666666667417.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000392463+811352_388355.6666666666667462.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000437221+89352_388355.6666666666667394.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000449992+711352_388270.6666666666667502.0HIPK2
HgeneTP63chr3:189590784chr3:188956522ENST00000456148+812352_388351.6666666666667583.0HIPK2


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Related Drugs to TP63-TPRG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TP63-TPRG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource