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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TPM2-ACTG1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TPM2-ACTG1
	FusionPDB ID: 93351
	FusionGDB2.0 ID: 93351
		Hgene	Tgene
	Gene symbol	TPM2	ACTG1
	Gene ID	7169	71
	Gene name	tropomyosin 2	actin gamma 1
	Synonyms	AMCD1\|DA1\|DA2B\|DA2B4\|HEL-S-273\|NEM4\|TMSB	ACT\|ACTG\|DFNA20\|DFNA26\|HEL-176
	Cytomap	9p13.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	tropomyosin beta chainepididymis secretory protein Li 273nemaline myopathy type 4tropomyosin 2 (beta)	actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176
	Modification date	20200328	20200327
	UniProtAcc	.	P63261
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000378292, ENST00000329305, ENST00000360958, ENST00000378300,	ENST00000331925, ENST00000573283, ENST00000575087, ENST00000575842,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 15 X 5=1425	40 X 34 X 12=16320
	# samples	21	47
	** MAII score	log2(21/1425*10)=-2.76250068627334 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(47/16320*10)=-5.11783649029386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TPM2 [Title/Abstract] AND ACTG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TPM2(35685061)-ACTG1(79478652), # samples:7
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TPM2	GO:0043462	regulation of ATPase activity	17194691

Fusion gene breakpoints across TPM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	265N	TPM2	chr9	35685060	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-AA-3663-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-BT-A20R-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-CU-A0YN-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-FL-A1YG-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-FP-7829-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-HU-A4GC-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-
ChimerDB4	Non-Cancer	TCGA-HU-A4GP-11A	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378292	TPM2	chr9	35685060	-	ENST00000331925	ACTG1	chr17	79478652	-	3326	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685060	-	ENST00000573283	ACTG1	chr17	79478652	-	3309	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685060	-	ENST00000575842	ACTG1	chr17	79478652	-	3308	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685060	-	ENST00000575087	ACTG1	chr17	79478652	-	3289	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685061	-	ENST00000331925	ACTG1	chr17	79478652	-	3326	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685061	-	ENST00000573283	ACTG1	chr17	79478652	-	3309	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685061	-	ENST00000575842	ACTG1	chr17	79478652	-	3308	1842	1173	2606	477
ENST00000378292	TPM2	chr9	35685061	-	ENST00000575087	ACTG1	chr17	79478652	-	3289	1842	1173	2606	477

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378292	ENST00000331925	TPM2	chr9	35685060	-	ACTG1	chr17	79478652	-	0.005441935	0.9945581
ENST00000378292	ENST00000573283	TPM2	chr9	35685060	-	ACTG1	chr17	79478652	-	0.005384872	0.99461514
ENST00000378292	ENST00000575842	TPM2	chr9	35685060	-	ACTG1	chr17	79478652	-	0.005364479	0.9946355
ENST00000378292	ENST00000575087	TPM2	chr9	35685060	-	ACTG1	chr17	79478652	-	0.005475441	0.9945246
ENST00000378292	ENST00000331925	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-	0.005441935	0.9945581
ENST00000378292	ENST00000573283	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-	0.005384872	0.99461514
ENST00000378292	ENST00000575842	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-	0.005364479	0.9946355
ENST00000378292	ENST00000575087	TPM2	chr9	35685061	-	ACTG1	chr17	79478652	-	0.005475441	0.9945246

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93351_93351_1_TPM2-ACTG1_TPM2_chr9_35685060_ENST00000378292_ACTG1_chr17_79478652_ENST00000331925_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_2_TPM2-ACTG1_TPM2_chr9_35685060_ENST00000378292_ACTG1_chr17_79478652_ENST00000573283_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_3_TPM2-ACTG1_TPM2_chr9_35685060_ENST00000378292_ACTG1_chr17_79478652_ENST00000575087_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_4_TPM2-ACTG1_TPM2_chr9_35685060_ENST00000378292_ACTG1_chr17_79478652_ENST00000575842_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_5_TPM2-ACTG1_TPM2_chr9_35685061_ENST00000378292_ACTG1_chr17_79478652_ENST00000331925_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_6_TPM2-ACTG1_TPM2_chr9_35685061_ENST00000378292_ACTG1_chr17_79478652_ENST00000573283_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_7_TPM2-ACTG1_TPM2_chr9_35685061_ENST00000378292_ACTG1_chr17_79478652_ENST00000575087_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

>93351_93351_8_TPM2-ACTG1_TPM2_chr9_35685061_ENST00000378292_ACTG1_chr17_79478652_ENST00000575842_length(amino acids)=477AA_BP=223
MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD
AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV
ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG
YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP
EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:35685061/chr17:79478652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTG1 P63261
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000305\|PubMed:29581253}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TPM2

chr9:35685060

chr17:79478652

ENST00000360958

1_284

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM2

chr9:35685060

chr17:79478652

ENST00000378292

1_284

213.0

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM2

chr9:35685061

chr17:79478652

ENST00000360958

1_284

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM2

chr9:35685061

chr17:79478652

ENST00000378292

1_284

213.0

285.0

Coiled coil

Ontology_term=ECO:0000250

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1000_TPM2_35685061_ACTG1_79478652_1000_TPM2_35685061_ACTG1_79478652_ranked_0.pdb	TPM2	35685061	35685061	ENST00000575087	ACTG1	chr17	79478652	-	MPAGPPPTAAMDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATD AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLV ILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEG YALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP EALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS	477

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TPM2_pLDDT.png

ACTG1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ACTG1

CFL2, CFL1, ACTG1, ACTB, DSTN, TMSB4X, FHOD1, EPS8L1, EPS8L2, FEZ1, CTNND1, ST3GAL3, SH3GL2, EIF6, PFN2, PRSS23, BCAP31, RBX1, MDK, CAP1, CAP2, RUVBL2, MEPCE, RUVBL1, gag, MORF4L1, MORF4L2, MRGBP, DMAP1, KAT5, POU5F1, UCHL5, YWHAQ, DISC1, TNIK, RPS6KA5, MAPK6, NDRG1, SP1, UBE2Q2, FBXO25, MYOC, LRRK2, APOE, PSEN2, BRCA1, LIG4, TSGA10, TRAF3IP1, GZMK, GZMA, HSP90AA1, HSP90AB1, PPP1CC, MYC, MLH1, UBL4A, ITGA4, ILF3, AICDA, WIPF1, FN1, CTTN, ADRB2, PLD1, CTBP2, GIT2, GRB2, COTL1, WASL, FBXO6, TOPBP1, CDKN2A, ACTA1, ACTBL2, BRK1, HSPA5, UBASH3B, ERRFI1, LGR4, EHHADH, CCDC22, WDYHV1, CCDC101, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, FAF2, RPS6KB2, CORO1B, CORO1C, CAD, EEF1A1, EEF1A2, NCKAP1, RAN, YARS, SFN, HSPB2, SRPK2, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, VCL, IQGAP1, PDLIM7, LIMA1, ANLN, MYO5C, MYO19, MYO18A, Actb, Flot1, Flot2, Myh9, Myo1c, Tpm1, Coro1c, Tmod3, Lima1, Tmed10, Calml3, Myh10, Flnb, TRAF2, VASP, GAN, MCM2, SHC1, ERBB3, RC3H1, Pparg, DUSP19, C17orf89, MCPH1, ACT1, AIP1, SRP1, TAE1, HDAC6, ZNF598, FGFR1, CTNNB1, KRAS, LARS, ACO2, CSNK1A1, TGFB1, PRPF8, EFTUD2, AAR2, PPP5C, CHD3, RIOK1, ESR2, H2AFZ, H3F3A, HIST1H4H, HIST2H2AC, VIM, GPD1, CERS1, HEXIM1, LARP7, CDH1, BIN1, CDK9, TLR9, RC3H2, PSMA3, FAF1, IKBKG, FADD, TANK, USP14, UCHL3, DCTN4, HOOK3, HRAS, MAPT, HIST1H4A, PSMD14, BIRC3, WWP2, HTT, PARK2, CDC37, PLEKHA4, MAGEA3, S, FANCD2, LINC01554, ZC3H18, DOK2, ELK4, MAPK7, PRKCA, PTPN12, PTPRR, RASA1, SH3BGRL, NEK4, DUX4, FASN, LDLR, SREBF2, AIMP2, BRD4, NUPR1, ORF14, Apc2, WDR76, RNF208, EIF3F, INSIG1, INSIG2, RIN3, DDX58, SPOP, ISG15, UFL1, DDRGK1, TP53, NPM1, FXR1, WDR5, BGLT3, SPRTN, BTF3, SLFN11, LHPP, CCNF, MAP1LC3B, NBR1, SQSTM1, OPTN, TOLLIP, NR3C1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TPM2
ACTG1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TPM2-ACTG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TPM2-ACTG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ACTG1	C3711374	Nonsyndromic Deafness	18	CLINGEN
Tgene	ACTG1	C1858172	Deafness, Autosomal Dominant 20	8	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	ACTG1	C3281235	BARAITSER-WINTER SYNDROME 2	4	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	ACTG1	C0001787	Osteoporosis, Age-Related	1	CTD_human
Tgene	ACTG1	C0005745	Blepharoptosis	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0007097	Carcinoma	1	CTD_human
Tgene	ACTG1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	ACTG1	C0009363	Congenital ocular coloboma (disorder)	1	CTD_human
Tgene	ACTG1	C0014544	Epilepsy	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0024433	Macrostomia	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene	ACTG1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene	ACTG1	C0029456	Osteoporosis	1	CTD_human
Tgene	ACTG1	C0029459	Osteoporosis, Senile	1	CTD_human
Tgene	ACTG1	C0033377	Ptosis	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0205696	Anaplastic carcinoma	1	CTD_human
Tgene	ACTG1	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene	ACTG1	C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene	ACTG1	C0205699	Carcinomatosis	1	CTD_human
Tgene	ACTG1	C0240583	Short upturned nose	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0265541	Cranioschisis	1	CTD_human
Tgene	ACTG1	C0266551	Congenital coloboma of iris	1	ORPHANET
Tgene	ACTG1	C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene	ACTG1	C0497552	Congenital neurologic anomalies	1	CTD_human
Tgene	ACTG1	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
Tgene	ACTG1	C0857379	Abnormality of the pinna	1	GENOMICS_ENGLAND
Tgene	ACTG1	C0948089	Acute Coronary Syndrome	1	CTD_human
Tgene	ACTG1	C1257925	Mammary Carcinoma, Animal	1	CTD_human
Tgene	ACTG1	C1384666	hearing impairment	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1843156	Progressive sensorineural hearing impairment	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1844505	Pointed chin	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1849340	Long palpebral fissure	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1855722	Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation	1	ORPHANET
Tgene	ACTG1	C1865014	Long philtrum	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1865017	Thin upper lip vermilion	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1868571	Highly arched eyebrow	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1970280	Hearing loss begins with loss of high frequencies	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1970281	Audiogram shows sloping configuration	1	GENOMICS_ENGLAND
Tgene	ACTG1	C1970282	Deafness, profound, by 6th decade	1	GENOMICS_ENGLAND
Tgene	ACTG1	C3279369	Microphthalmia (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C3549665	Deafness (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C3808883	Short neck (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4012410	Enlarged ventricles (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4229649	Heart defect (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4229650	Pterygium colli (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4229651	Hypertelorism/telecanthus	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4229652	Eye coloboma (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4229653	Trigonocephaly/metopic ridge	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231117	Pectus (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231118	Kyphosis/scoliosis (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231120	Prominent nasal root on profile	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231121	Large, squared nose tip	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231123	Retrognathia (in some patients)	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4231124	Prominent/full/wide cheeks	1	GENOMICS_ENGLAND
Tgene	ACTG1	C4554007	Uveoretinal Coloboma	1	CTD_human
Tgene	ACTG1	C4708599	Coloboma of choroid and retina	1	ORPHANET