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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TPM3-DENND4B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TPM3-DENND4B
	FusionPDB ID: 93378
	FusionGDB2.0 ID: 93378
		Hgene	Tgene
	Gene symbol	TPM3	DENND4B
	Gene ID	7170	9909
	Gene name	tropomyosin 3	DENN domain containing 4B
	Synonyms	CAPM1\|CFTD\|HEL-189\|HEL-S-82p\|NEM1\|OK/SW-cl.5\|TM-5\|TM3\|TM30\|TM30nm\|TM5\|TPM3nu\|TPMsk3\|TRK\|hscp30	KIAA0476
	Cytomap	1q21.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi	DENN domain-containing protein 4BDENN/MADD domain containing 4B
	Modification date	20200328	20200313
	UniProtAcc	P06753	O75064
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000323144, ENST00000328159, ENST00000330188, ENST00000341485, ENST00000368531, ENST00000368533, ENST00000469717, ENST00000271850, ENST00000302206, ENST00000341372, ENST00000368530,	ENST00000474386, ENST00000361217,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 22 X 8=2640	2 X 2 X 2=8
	# samples	24	3
	** MAII score	log2(24/2640*10)=-3.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)	PubMed: TPM3 [Title/Abstract] AND DENND4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TPM3(154155463)-DENND4B(153910339), # samples:1 TPM3(154155464)-DENND4B(153910339), # samples:1
Anticipated loss of major functional domain due to fusion event.	TPM3-DENND4B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TPM3-DENND4B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TPM3-DENND4B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TPM3-DENND4B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DENND4B	GO:0032483	regulation of Rab protein signal transduction	20937701

Fusion gene breakpoints across TPM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DENND4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-6822-01A	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-
ChimerDB4	STAD	TCGA-D7-6822	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368533	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3507	185	53	2710	885
ENST00000330188	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3540	218	86	2743	885
ENST00000341485	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3543	221	89	2746	885
ENST00000328159	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3454	132	0	2657	885
ENST00000368531	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3465	143	11	2668	885
ENST00000323144	TPM3	chr1	154155463	-	ENST00000361217	DENND4B	chr1	153910339	-	3499	177	45	2702	885
ENST00000368533	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3507	185	53	2710	885
ENST00000330188	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3540	218	86	2743	885
ENST00000341485	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3543	221	89	2746	885
ENST00000328159	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3454	132	0	2657	885
ENST00000368531	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3465	143	11	2668	885
ENST00000323144	TPM3	chr1	154155464	-	ENST00000361217	DENND4B	chr1	153910339	-	3499	177	45	2702	885

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368533	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.006505083	0.9934949
ENST00000330188	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.006711918	0.9932881
ENST00000341485	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.0068662	0.9931338
ENST00000328159	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.005985224	0.9940148
ENST00000368531	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.005861114	0.99413896
ENST00000323144	ENST00000361217	TPM3	chr1	154155463	-	DENND4B	chr1	153910339	-	0.006410093	0.9935899
ENST00000368533	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.006505083	0.9934949
ENST00000330188	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.006711918	0.9932881
ENST00000341485	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.0068662	0.9931338
ENST00000328159	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.005985224	0.9940148
ENST00000368531	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.005861114	0.99413896
ENST00000323144	ENST00000361217	TPM3	chr1	154155464	-	DENND4B	chr1	153910339	-	0.006410093	0.9935899

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93378_93378_1_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000323144_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

--------------------------------------------------------------

>93378_93378_2_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000328159_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_3_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000330188_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_4_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000341485_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_5_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000368531_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

--------------------------------------------------------------

>93378_93378_6_TPM3-DENND4B_TPM3_chr1_154155463_ENST00000368533_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_7_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000323144_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_8_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000328159_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_9_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000330188_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

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>93378_93378_10_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000341485_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

--------------------------------------------------------------

>93378_93378_11_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000368531_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

--------------------------------------------------------------

>93378_93378_12_TPM3-DENND4B_TPM3_chr1_154155464_ENST00000368533_DENND4B_chr1_153910339_ENST00000361217_length(amino acids)=885AA_BP=0
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQY
CYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQ
ALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVV
LGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQ
PTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARL
QQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLE
ILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLA
LDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHS
QAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154155463/chr1:153910339)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TPM3 P06753	DENND4B O75064
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250\|UniProtKB:P09493}.	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269\|PubMed:20937701}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

1106_1158

655.0

1497.0

Compositional bias

Note=Ser-rich

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

886_923

655.0

1497.0

Compositional bias

Note=Gln-rich

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

1106_1158

655.0

1497.0

Compositional bias

Note=Ser-rich

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

886_923

655.0

1497.0

Compositional bias

Note=Gln-rich

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

775_811

655.0

1497.0

Repeat

Note=PPR 1

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

812_846

655.0

1497.0

Repeat

Note=PPR 2

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

775_811

655.0

1497.0

Repeat

Note=PPR 1

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

812_846

655.0

1497.0

Repeat

Note=PPR 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TPM3

chr1:154155463

chr1:153910339

ENST00000323144

1_285

44.0

248.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155463

chr1:153910339

ENST00000330188

1_285

44.0

249.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155463

chr1:153910339

ENST00000368530

1_285

286.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155463

chr1:153910339

ENST00000368531

1_285

44.0

248.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155463

chr1:153910339

ENST00000368533

1_285

44.0

249.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155464

chr1:153910339

ENST00000323144

1_285

44.0

248.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155464

chr1:153910339

ENST00000330188

1_285

44.0

249.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155464

chr1:153910339

ENST00000368530

1_285

286.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155464

chr1:153910339

ENST00000368531

1_285

44.0

248.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM3

chr1:154155464

chr1:153910339

ENST00000368533

1_285

44.0

249.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

195_369

655.0

1497.0

Domain

uDENN

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

390_526

655.0

1497.0

Domain

cDENN

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

44_203

655.0

1497.0

Domain

MABP

Tgene

DENND4B

chr1:154155463

chr1:153910339

ENST00000361217

528_644

655.0

1497.0

Domain

dDENN

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

195_369

655.0

1497.0

Domain

uDENN

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

390_526

655.0

1497.0

Domain

cDENN

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

44_203

655.0

1497.0

Domain

MABP

Tgene

DENND4B

chr1:154155464

chr1:153910339

ENST00000361217

528_644

655.0

1497.0

Domain

dDENN

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

TPM3

KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, Actb, Itga5, Myh9, Tpm1, Mis12, Calml3, Myh10, Tpm4, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1, TMPO, CTNNB1, LARS, APOE, HDAC4, RXRA, EFTUD2, AAR2, PIH1D1, RPTOR, TNF, FGF11, NOD2, RNF181, AGR2, GPC1, KDM6B, MYC, CDK9, Prkaa1, Prkab1, METTL14, WTAP, ESR2, TET2, DISC1, NR2C2, CSK, AGRN, HOOK3, BMH1, BMH2, VMP1, SNRNP70, BIRC3, ATXN1, TAB2, PSMC5, HSF4, TSKS, NUP54, SNAPIN, TNNI1, PRKCDBP, FGA, PHLDB3, WASH1, THAP7, PLEKHA4, RAD18, PRKD1, SRC, HIST2H2BE, GFM1, MN1, ESR1, MAST2, UNK, DUX4, CIT, AURKB, CHRM3, ECT2, KIF14, KIF20A, SMARCA2, ARHGAP11A, SYDE2, ARHGAP39, Ophn1, MFN2, OPA1, UCHL1, Apc2, FBP1, DTNA, INSIG1, INSIG2, RIN3, TRIM24, PDIA4, SUMO2, MARCKS, CALM1, NEDD4, TKT, CALR, SOD1, FKBP3, TRIM33, RBM8A, PEBP1, PGAM1, CEP78, PTMS, DDX58, CD274, AR, ISG15, UFL1, TMOD1, TRIM37, HTRA4, NAA40, CCDC102A, CCDC6, EXOC4, RBMXL1, TSSC4, KIF5B, EAPP, TPM3P9, PTRF, ZFC3H1, CROCC, NDE1, CCDC96, JUND, ECD, PHF21A, NUF2, NDEL1, HSF1, HOMER2, PRPF8, RCOR1, KDM1A, HOMER1, RCOR3, NES, JUNB, BTF3, TRIM26, FBXW7, DPP4, E, nsp7, ORF7b, ORF8, S, FURIN, nsp4, nsp6, ORF10, CCNF, ANTXR1, FOS, GATA4, KLF10, KLF3, KLF9, ZIC3, NKX2-5, STAT5B,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TPM3
DENND4B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TPM3-DENND4B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TPM3-DENND4B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TPM3	C1836448	Nemaline myopathy 1	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TPM3	C0546264	Congenital Fiber Type Disproportion	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TPM3	C0007097	Carcinoma	2	CTD_human
Hgene	TPM3	C0024667	Animal Mammary Neoplasms	2	CTD_human
Hgene	TPM3	C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Hgene	TPM3	C0205696	Anaplastic carcinoma	2	CTD_human
Hgene	TPM3	C0205697	Carcinoma, Spindle-Cell	2	CTD_human
Hgene	TPM3	C0205698	Undifferentiated carcinoma	2	CTD_human
Hgene	TPM3	C0205699	Carcinomatosis	2	CTD_human
Hgene	TPM3	C0206157	Myopathies, Nemaline	2	GENOMICS_ENGLAND
Hgene	TPM3	C1257925	Mammary Carcinoma, Animal	2	CTD_human
Hgene	TPM3	C0001418	Adenocarcinoma	1	CTD_human
Hgene	TPM3	C0007102	Malignant tumor of colon	1	CTD_human
Hgene	TPM3	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	TPM3	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	TPM3	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	TPM3	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	TPM3	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	TPM3	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Hgene	TPM3	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	TPM3	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	TPM3	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	TPM3	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	TPM3	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	TPM3	C0270960	Congenital myopathy (disorder)	1	GENOMICS_ENGLAND
Hgene	TPM3	C0334121	Inflammatory Myofibroblastic Tumor	1	ORPHANET
Hgene	TPM3	C0546125	Nemaline Myopathy, Childhood Onset	1	ORPHANET
Hgene	TPM3	C0549473	Thyroid carcinoma	1	CTD_human
Hgene	TPM3	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	TPM3	C3710589	Cap Myopathy	1	ORPHANET