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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TPM3-ROS1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TPM3-ROS1
FusionPDB ID: 93389
FusionGDB2.0 ID: 93389
HgeneTgene
Gene symbol

TPM3

ROS1

Gene ID

7170

6098

Gene nametropomyosin 3ROS proto-oncogene 1, receptor tyrosine kinase
SynonymsCAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30MCF3|ROS|c-ros-1
Cytomap

1q21.3

6q22.1

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosiproto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
Modification date2020032820200314
UniProtAcc

P06753

P08922

Ensembl transtripts involved in fusion geneENST idsENST00000469717, ENST00000271850, 
ENST00000302206, ENST00000323144, 
ENST00000328159, ENST00000330188, 
ENST00000341372, ENST00000341485, 
ENST00000368530, ENST00000368531, 
ENST00000368533, 		ENST00000368507, 
ENST00000368508, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 22 X 8=264018 X 20 X 5=1800
# samples 2420
** MAII scorelog2(24/2640*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1800*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TPM3 [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TPM3(154142876)-ROS1(117642559), # samples:2
Anticipated loss of major functional domain due to fusion event.TPM3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TPM3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TPM3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TPM3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TPM3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TPM3-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TPM3-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TPM3-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROS1

GO:0001558

regulation of cell growth

16885344

TgeneROS1

GO:0006468

protein phosphorylation

16885344

TgeneROS1

GO:0032006

regulation of TOR signaling

16885344


check buttonFusion gene breakpoints across TPM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..TPM3chr1

154145559

-ROS1chr6

117641193

-
ChiTaRS5.0N/AAB795239TPM3chr1

154142876

-ROS1chr6

117642559

-
ChiTaRS5.0N/AJB625501TPM3chr1

154142876

-ROS1chr6

117642559

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368533TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2312717532119688
ENST00000368533TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2312717532119688
ENST00000330188TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2345750862152688
ENST00000330188TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2345750862152688
ENST00000341485TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2300705892107672
ENST00000341485TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2300705892107672
ENST00000341372TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2246651622053663
ENST00000341372TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2246651622053663
ENST00000328159TPM3chr1154142876-ENST00000368508ROS1chr6117642559-225966402066688
ENST00000328159TPM3chr1154142876-ENST00000368507ROS1chr6117642559-225966402066688
ENST00000271850TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2410815342217727
ENST00000271850TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2410815342217727
ENST00000368531TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2270675112077688
ENST00000368531TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2270675112077688
ENST00000323144TPM3chr1154142876-ENST00000368508ROS1chr6117642559-2304709452111688
ENST00000323144TPM3chr1154142876-ENST00000368507ROS1chr6117642559-2304709452111688
ENST00000368530TPM3chr1154142876-ENST00000368508ROS1chr6117642559-25639681872370727
ENST00000368530TPM3chr1154142876-ENST00000368507ROS1chr6117642559-25639681872370727

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368533ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0064653460.9935347
ENST00000368533ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0064653460.9935347
ENST00000330188ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0060325990.9939674
ENST00000330188ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0060325990.9939674
ENST00000341485ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0054612820.9945387
ENST00000341485ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0054612820.9945387
ENST00000341372ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0045980690.99540186
ENST00000341372ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0045980690.99540186
ENST00000328159ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0058691210.9941309
ENST00000328159ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0058691210.9941309
ENST00000271850ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0046168110.9953832
ENST00000271850ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0046168110.9953832
ENST00000368531ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0057411780.99425876
ENST00000368531ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0057411780.99425876
ENST00000323144ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0059658370.99403423
ENST00000323144ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0059658370.99403423
ENST00000368530ENST00000368508TPM3chr1154142876-ROS1chr6117642559-0.0043132240.9956867
ENST00000368530ENST00000368507TPM3chr1154142876-ROS1chr6117642559-0.0043132240.9956867

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93389_93389_1_TPM3-ROS1_TPM3_chr1_154142876_ENST00000271850_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=727AA_BP=260
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQK
SAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL
ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDV
ICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS

--------------------------------------------------------------

>93389_93389_2_TPM3-ROS1_TPM3_chr1_154142876_ENST00000271850_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=727AA_BP=260
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQK
SAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL
ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDV
ICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS

--------------------------------------------------------------

>93389_93389_3_TPM3-ROS1_TPM3_chr1_154142876_ENST00000323144_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_4_TPM3-ROS1_TPM3_chr1_154142876_ENST00000323144_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_5_TPM3-ROS1_TPM3_chr1_154142876_ENST00000328159_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_6_TPM3-ROS1_TPM3_chr1_154142876_ENST00000328159_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_7_TPM3-ROS1_TPM3_chr1_154142876_ENST00000330188_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_8_TPM3-ROS1_TPM3_chr1_154142876_ENST00000330188_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_9_TPM3-ROS1_TPM3_chr1_154142876_ENST00000341372_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=663AA_BP=196
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGESRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA
KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF
AERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSG
AFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA
TFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLM
DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN
SIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKD

--------------------------------------------------------------

>93389_93389_10_TPM3-ROS1_TPM3_chr1_154142876_ENST00000341372_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=663AA_BP=196
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGESRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA
KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF
AERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSG
AFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA
TFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLM
DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN
SIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKD

--------------------------------------------------------------

>93389_93389_11_TPM3-ROS1_TPM3_chr1_154142876_ENST00000341485_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=672AA_BP=205
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADEEKME
LQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKL
KEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKL
TLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLL
TYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV
RWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
QLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKE

--------------------------------------------------------------

>93389_93389_12_TPM3-ROS1_TPM3_chr1_154142876_ENST00000341485_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=672AA_BP=205
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADEEKME
LQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKL
KEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKL
TLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLL
TYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV
RWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
QLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKE

--------------------------------------------------------------

>93389_93389_13_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368530_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=727AA_BP=260
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQK
SAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL
ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDV
ICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS

--------------------------------------------------------------

>93389_93389_14_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368530_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=727AA_BP=260
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQK
SAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL
ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDV
ICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS

--------------------------------------------------------------

>93389_93389_15_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368531_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_16_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368531_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_17_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368533_ROS1_chr6_117642559_ENST00000368507_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

>93389_93389_18_TPM3-ROS1_TPM3_chr1_154142876_ENST00000368533_ROS1_chr6_117642559_ENST00000368508_length(amino acids)=688AA_BP=221
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLP
TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN
EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI
YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWA
QEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154142876/chr6:117642559)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPM3

P06753

ROS1

P08922

FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431945_22221880.33333333333332348.0DomainProtein kinase
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431951_19591880.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431883_23471880.33333333333332348.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPM3chr1:154142876chr6:117642559ENST00000323144-781_285221.33333333333334248.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154142876chr6:117642559ENST00000330188-781_285221.33333333333334249.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154142876chr6:117642559ENST00000368530-8101_285258.3333333333333286.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154142876chr6:117642559ENST00000368531-781_285221.33333333333334248.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154142876chr6:117642559ENST00000368533-781_285221.33333333333334249.0Coiled coilOntology_term=ECO:0000250
TgeneROS1chr1:154142876chr6:117642559ENST000003685083343101_1961880.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431043_11501880.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431450_15561880.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431557_16561880.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431658_17511880.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431752_18541880.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr1:154142876chr6:117642559ENST000003685083343197_2851880.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr1:154142876chr6:117642559ENST000003685083343557_6711880.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr1:154142876chr6:117642559ENST000003685083343947_10421880.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr1:154142876chr6:117642559ENST00000368508334328_18591880.33333333333332348.0Topological domainExtracellular
TgeneROS1chr1:154142876chr6:117642559ENST0000036850833431860_18821880.33333333333332348.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TPM3_pLDDT.png
all structure
all structure
ROS1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TPM3KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, Actb, Itga5, Myh9, Tpm1, Mis12, Calml3, Myh10, Tpm4, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1, TMPO, CTNNB1, LARS, APOE, HDAC4, RXRA, EFTUD2, AAR2, PIH1D1, RPTOR, TNF, FGF11, NOD2, RNF181, AGR2, GPC1, KDM6B, MYC, CDK9, Prkaa1, Prkab1, METTL14, WTAP, ESR2, TET2, DISC1, NR2C2, CSK, AGRN, HOOK3, BMH1, BMH2, VMP1, SNRNP70, BIRC3, ATXN1, TAB2, PSMC5, HSF4, TSKS, NUP54, SNAPIN, TNNI1, PRKCDBP, FGA, PHLDB3, WASH1, THAP7, PLEKHA4, RAD18, PRKD1, SRC, HIST2H2BE, GFM1, MN1, ESR1, MAST2, UNK, DUX4, CIT, AURKB, CHRM3, ECT2, KIF14, KIF20A, SMARCA2, ARHGAP11A, SYDE2, ARHGAP39, Ophn1, MFN2, OPA1, UCHL1, Apc2, FBP1, DTNA, INSIG1, INSIG2, RIN3, TRIM24, PDIA4, SUMO2, MARCKS, CALM1, NEDD4, TKT, CALR, SOD1, FKBP3, TRIM33, RBM8A, PEBP1, PGAM1, CEP78, PTMS, DDX58, CD274, AR, ISG15, UFL1, TMOD1, TRIM37, HTRA4, NAA40, CCDC102A, CCDC6, EXOC4, RBMXL1, TSSC4, KIF5B, EAPP, TPM3P9, PTRF, ZFC3H1, CROCC, NDE1, CCDC96, JUND, ECD, PHF21A, NUF2, NDEL1, HSF1, HOMER2, PRPF8, RCOR1, KDM1A, HOMER1, RCOR3, NES, JUNB, BTF3, TRIM26, FBXW7, DPP4, E, nsp7, ORF7b, ORF8, S, FURIN, nsp4, nsp6, ORF10, CCNF, ANTXR1, FOS, GATA4, KLF10, KLF3, KLF9, ZIC3, NKX2-5, STAT5B,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TPM3all structure
ROS1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TPM3-ROS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TPM3-ROS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM3C1836448Nemaline myopathy 19CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM3C0546264Congenital Fiber Type Disproportion4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM3C0007097Carcinoma2CTD_human
HgeneTPM3C0024667Animal Mammary Neoplasms2CTD_human
HgeneTPM3C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneTPM3C0205696Anaplastic carcinoma2CTD_human
HgeneTPM3C0205697Carcinoma, Spindle-Cell2CTD_human
HgeneTPM3C0205698Undifferentiated carcinoma2CTD_human
HgeneTPM3C0205699Carcinomatosis2CTD_human
HgeneTPM3C0206157Myopathies, Nemaline2GENOMICS_ENGLAND
HgeneTPM3C1257925Mammary Carcinoma, Animal2CTD_human
HgeneTPM3C0001418Adenocarcinoma1CTD_human
HgeneTPM3C0007102Malignant tumor of colon1CTD_human
HgeneTPM3C0009375Colonic Neoplasms1CTD_human
HgeneTPM3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM3C0024623Malignant neoplasm of stomach1CTD_human
HgeneTPM3C0038356Stomach Neoplasms1CTD_human
HgeneTPM3C0040136Thyroid Neoplasm1CTD_human
HgeneTPM3C0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneTPM3C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneTPM3C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneTPM3C0205643Carcinoma, Cribriform1CTD_human
HgeneTPM3C0205644Carcinoma, Granular Cell1CTD_human
HgeneTPM3C0205645Adenocarcinoma, Tubular1CTD_human
HgeneTPM3C0270960Congenital myopathy (disorder)1GENOMICS_ENGLAND
HgeneTPM3C0334121Inflammatory Myofibroblastic Tumor1ORPHANET
HgeneTPM3C0546125Nemaline Myopathy, Childhood Onset1ORPHANET
HgeneTPM3C0549473Thyroid carcinoma1CTD_human
HgeneTPM3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneTPM3C3710589Cap Myopathy1ORPHANET
TgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneROS1C0017638Glioma1CTD_human
TgeneROS1C0025202melanoma1CTD_human
TgeneROS1C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
TgeneROS1C0259783mixed gliomas1CTD_human
TgeneROS1C0555198Malignant Glioma1CTD_human