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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TPM3-RPS11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TPM3-RPS11
FusionPDB ID: 93390
FusionGDB2.0 ID: 93390
HgeneTgene
Gene symbol

TPM3

RPS11

Gene ID

7170

6205

Gene nametropomyosin 3ribosomal protein S11
SynonymsCAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30S11
Cytomap

1q21.3

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi40S ribosomal protein S11small ribosomal subunit protein uS17
Modification date2020032820200327
UniProtAcc

P06753

.
Ensembl transtripts involved in fusion geneENST idsENST00000271850, ENST00000302206, 
ENST00000323144, ENST00000328159, 
ENST00000330188, ENST00000341372, 
ENST00000341485, ENST00000368530, 
ENST00000368531, ENST00000368533, 
ENST00000469717, 		ENST00000594493, 
ENST00000599561, ENST00000270625, 
ENST00000596873, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 22 X 8=264014 X 51 X 16=11424
# samples 2488
** MAII scorelog2(24/2640*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(88/11424*10)=-3.69842055050444
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TPM3 [Title/Abstract] AND RPS11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TPM3(154143125)-RPS11(50000777), # samples:1
Anticipated loss of major functional domain due to fusion event.TPM3-RPS11 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TPM3-RPS11 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TPM3-RPS11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TPM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8372-01ATPM3chr1

154143125

-RPS11chr19

50000777

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368533TPM3chr1154143125-ENST00000270625RPS11chr1950000777+103164753976307
ENST00000368533TPM3chr1154143125-ENST00000596873RPS11chr1950000777+105864753856267
ENST00000330188TPM3chr1154143125-ENST00000270625RPS11chr1950000777+1064680861009307
ENST00000330188TPM3chr1154143125-ENST00000596873RPS11chr1950000777+109168086889267
ENST00000341485TPM3chr1154143125-ENST00000270625RPS11chr1950000777+10196359912330
ENST00000341485TPM3chr1154143125-ENST00000596873RPS11chr1950000777+10466358922297
ENST00000341372TPM3chr1154143125-ENST00000270625RPS11chr1950000777+96558162910282
ENST00000341372TPM3chr1154143125-ENST00000596873RPS11chr1950000777+99258162790242
ENST00000328159TPM3chr1154143125-ENST00000270625RPS11chr1950000777+9785940923307
ENST00000328159TPM3chr1154143125-ENST00000596873RPS11chr1950000777+10055940803267
ENST00000271850TPM3chr1154143125-ENST00000270625RPS11chr1950000777+1129745341074346
ENST00000271850TPM3chr1154143125-ENST00000596873RPS11chr1950000777+115674534954306
ENST00000368531TPM3chr1154143125-ENST00000270625RPS11chr1950000777+98960511934307
ENST00000368531TPM3chr1154143125-ENST00000596873RPS11chr1950000777+101660511814267
ENST00000323144TPM3chr1154143125-ENST00000270625RPS11chr1950000777+102363945968307
ENST00000323144TPM3chr1154143125-ENST00000596873RPS11chr1950000777+105063945848267
ENST00000368530TPM3chr1154143125-ENST00000270625RPS11chr1950000777+12828981871227346
ENST00000368530TPM3chr1154143125-ENST00000596873RPS11chr1950000777+13098981871107306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368533ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0045233640.99547666
ENST00000368533ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0041791850.99582076
ENST00000330188ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0065700790.99342996
ENST00000330188ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0055829560.9944171
ENST00000341485ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0031790580.9968209
ENST00000341485ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0028797060.9971204
ENST00000341372ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0038261480.9961739
ENST00000341372ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0031142940.9968857
ENST00000328159ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.004927140.9950728
ENST00000328159ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0046253430.99537474
ENST00000271850ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0023229590.997677
ENST00000271850ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0020046020.9979954
ENST00000368531ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0052331440.99476683
ENST00000368531ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0047470150.99525297
ENST00000323144ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0066501410.99334985
ENST00000323144ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0059344440.9940655
ENST00000368530ENST00000270625TPM3chr1154143125-RPS11chr1950000777+0.0032613040.99673873
ENST00000368530ENST00000596873TPM3chr1154143125-RPS11chr1950000777+0.0028315240.9971685

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93390_93390_1_TPM3-RPS11_TPM3_chr1_154143125_ENST00000271850_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=346AA_BP=228
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKM

--------------------------------------------------------------

>93390_93390_2_TPM3-RPS11_TPM3_chr1_154143125_ENST00000271850_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=306AA_BP=228
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKM

--------------------------------------------------------------

>93390_93390_3_TPM3-RPS11_TPM3_chr1_154143125_ENST00000323144_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=307AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQ

--------------------------------------------------------------

>93390_93390_4_TPM3-RPS11_TPM3_chr1_154143125_ENST00000323144_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=267AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ

--------------------------------------------------------------

>93390_93390_5_TPM3-RPS11_TPM3_chr1_154143125_ENST00000328159_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=307AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQ

--------------------------------------------------------------

>93390_93390_6_TPM3-RPS11_TPM3_chr1_154143125_ENST00000328159_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=267AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ

--------------------------------------------------------------

>93390_93390_7_TPM3-RPS11_TPM3_chr1_154143125_ENST00000330188_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=307AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
KEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQ

--------------------------------------------------------------

>93390_93390_8_TPM3-RPS11_TPM3_chr1_154143125_ENST00000330188_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=267AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ

--------------------------------------------------------------

>93390_93390_9_TPM3-RPS11_TPM3_chr1_154143125_ENST00000341372_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=282AA_BP=164
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGESRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA
KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAIEGTYI
DKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVT

--------------------------------------------------------------

>93390_93390_10_TPM3-RPS11_TPM3_chr1_154143125_ENST00000341372_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=242AA_BP=164
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGESRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA
KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAIEGTYI

--------------------------------------------------------------

>93390_93390_11_TPM3-RPS11_TPM3_chr1_154143125_ENST00000341485_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=330AA_BP=1
MWGAGRCPASELLELLLGAGSLGDLEHVEAHCLAQRPALAHCDDVTDLDVPEAGGQVYRHVLVALLEAVVLADVVQIVSADDNGPLHLHL
GHHAREDPPSNGHITSEGAFLVNVGALNSLLEFISKNLDFFLIFIFFLRVLFFSSTQTLQVLVHQSNLLIHLSATGLCQLSSFLCAFQVS
FNDHQLTSHLFILPICLFCNVLSFFELDFLEFHLFFISSFFSFFQLLQGSGQALLSTVQLFFNQLDPTVQGGHLSLSLFPGPPFSLNFSL

--------------------------------------------------------------

>93390_93390_12_TPM3-RPS11_TPM3_chr1_154143125_ENST00000341485_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=297AA_BP=1
MKAERAWPEQPDGPLRSPEAGGQVYRHVLVALLEAVVLADVVQIVSADDNGPLHLHLGHHAREDPPSNGHITSEGAFLVNVGALNSLLEF
ISKNLDFFLIFIFFLRVLFFSSTQTLQVLVHQSNLLIHLSATGLCQLSSFLCAFQVSFNDHQLTSHLFILPICLFCNVLSFFELDFLEFH
LFFISSFFSFFQLLQGSGQALLSTVQLFFNQLDPTVQGGHLSLSLFPGPPFSLNFSLEALSSLLCIICLLLQNLDLALHRLDGGDPSHGA

--------------------------------------------------------------

>93390_93390_13_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368530_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=346AA_BP=228
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKM

--------------------------------------------------------------

>93390_93390_14_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368530_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=306AA_BP=228
MLMMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVAS
LNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLE
RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKM

--------------------------------------------------------------

>93390_93390_15_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368531_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=307AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQ

--------------------------------------------------------------

>93390_93390_16_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368531_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=267AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ

--------------------------------------------------------------

>93390_93390_17_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368533_RPS11_chr19_50000777_ENST00000270625_length(amino acids)=307AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
KEDKYEEEIKILTDKLKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQ

--------------------------------------------------------------

>93390_93390_18_TPM3-RPS11_TPM3_chr1_154143125_ENST00000368533_RPS11_chr19_50000777_ENST00000596873_length(amino acids)=267AA_BP=189
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERG
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154143125/chr19:50000777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPM3

P06753

.
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPM3chr1:154143125chr19:50000777ENST00000323144-681_285198.0248.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154143125chr19:50000777ENST00000330188-681_285198.0249.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154143125chr19:50000777ENST00000368530-7101_285235.0286.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154143125chr19:50000777ENST00000368531-681_285198.0248.0Coiled coilOntology_term=ECO:0000250
HgeneTPM3chr1:154143125chr19:50000777ENST00000368533-681_285198.0249.0Coiled coilOntology_term=ECO:0000250


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TPM3KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, Actb, Itga5, Myh9, Tpm1, Mis12, Calml3, Myh10, Tpm4, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1, TMPO, CTNNB1, LARS, APOE, HDAC4, RXRA, EFTUD2, AAR2, PIH1D1, RPTOR, TNF, FGF11, NOD2, RNF181, AGR2, GPC1, KDM6B, MYC, CDK9, Prkaa1, Prkab1, METTL14, WTAP, ESR2, TET2, DISC1, NR2C2, CSK, AGRN, HOOK3, BMH1, BMH2, VMP1, SNRNP70, BIRC3, ATXN1, TAB2, PSMC5, HSF4, TSKS, NUP54, SNAPIN, TNNI1, PRKCDBP, FGA, PHLDB3, WASH1, THAP7, PLEKHA4, RAD18, PRKD1, SRC, HIST2H2BE, GFM1, MN1, ESR1, MAST2, UNK, DUX4, CIT, AURKB, CHRM3, ECT2, KIF14, KIF20A, SMARCA2, ARHGAP11A, SYDE2, ARHGAP39, Ophn1, MFN2, OPA1, UCHL1, Apc2, FBP1, DTNA, INSIG1, INSIG2, RIN3, TRIM24, PDIA4, SUMO2, MARCKS, CALM1, NEDD4, TKT, CALR, SOD1, FKBP3, TRIM33, RBM8A, PEBP1, PGAM1, CEP78, PTMS, DDX58, CD274, AR, ISG15, UFL1, TMOD1, TRIM37, HTRA4, NAA40, CCDC102A, CCDC6, EXOC4, RBMXL1, TSSC4, KIF5B, EAPP, TPM3P9, PTRF, ZFC3H1, CROCC, NDE1, CCDC96, JUND, ECD, PHF21A, NUF2, NDEL1, HSF1, HOMER2, PRPF8, RCOR1, KDM1A, HOMER1, RCOR3, NES, JUNB, BTF3, TRIM26, FBXW7, DPP4, E, nsp7, ORF7b, ORF8, S, FURIN, nsp4, nsp6, ORF10, CCNF, ANTXR1, FOS, GATA4, KLF10, KLF3, KLF9, ZIC3, NKX2-5, STAT5B,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TPM3all structure
RPS11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TPM3-RPS11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TPM3-RPS11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM3C1836448Nemaline myopathy 19CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM3C0546264Congenital Fiber Type Disproportion4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM3C0007097Carcinoma2CTD_human
HgeneTPM3C0024667Animal Mammary Neoplasms2CTD_human
HgeneTPM3C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneTPM3C0205696Anaplastic carcinoma2CTD_human
HgeneTPM3C0205697Carcinoma, Spindle-Cell2CTD_human
HgeneTPM3C0205698Undifferentiated carcinoma2CTD_human
HgeneTPM3C0205699Carcinomatosis2CTD_human
HgeneTPM3C0206157Myopathies, Nemaline2GENOMICS_ENGLAND
HgeneTPM3C1257925Mammary Carcinoma, Animal2CTD_human
HgeneTPM3C0001418Adenocarcinoma1CTD_human
HgeneTPM3C0007102Malignant tumor of colon1CTD_human
HgeneTPM3C0009375Colonic Neoplasms1CTD_human
HgeneTPM3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM3C0024623Malignant neoplasm of stomach1CTD_human
HgeneTPM3C0038356Stomach Neoplasms1CTD_human
HgeneTPM3C0040136Thyroid Neoplasm1CTD_human
HgeneTPM3C0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneTPM3C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneTPM3C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneTPM3C0205643Carcinoma, Cribriform1CTD_human
HgeneTPM3C0205644Carcinoma, Granular Cell1CTD_human
HgeneTPM3C0205645Adenocarcinoma, Tubular1CTD_human
HgeneTPM3C0270960Congenital myopathy (disorder)1GENOMICS_ENGLAND
HgeneTPM3C0334121Inflammatory Myofibroblastic Tumor1ORPHANET
HgeneTPM3C0546125Nemaline Myopathy, Childhood Onset1ORPHANET
HgeneTPM3C0549473Thyroid carcinoma1CTD_human
HgeneTPM3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneTPM3C3710589Cap Myopathy1ORPHANET