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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TRAF3IP2-FYN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TRAF3IP2-FYN
	FusionPDB ID: 93663
	FusionGDB2.0 ID: 93663
		Hgene	Tgene
	Gene symbol	TRAF3IP2	FYN
	Gene ID	10758	2534
	Gene name	TRAF3 interacting protein 2	FYN proto-oncogene, Src family tyrosine kinase
	Synonyms	ACT1\|C6orf2\|C6orf4\|C6orf5\|C6orf6\|CANDF8\|CIKS\|PSORS13	SLK\|SYN\|p59-FYN
	Cytomap	6q21	6q21
	Type of gene	protein-coding	protein-coding
	Description	adapter protein CIKSNFkB-activating protein ACT1connection to IKK and SAPK/JNKnuclear factor NF-kappa-B activator 1symbol withdrawn, see C6orf4	tyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)
	Modification date	20200313	20200327
	UniProtAcc	.	C1orf168
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000340026, ENST00000359831, ENST00000368735, ENST00000368761, ENST00000392556, ENST00000368731,	ENST00000476769, ENST00000229470, ENST00000229471, ENST00000354650, ENST00000356013, ENST00000368667, ENST00000368678, ENST00000368682, ENST00000538466,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 4 X 4=48	19 X 14 X 12=3192
	# samples	4	27
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/3192*10)=-3.56342933917152 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TRAF3IP2 [Title/Abstract] AND FYN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TRAF3IP2(111887647)-FYN(111995833), # samples:2
Anticipated loss of major functional domain due to fusion event.	TRAF3IP2-FYN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRAF3IP2-FYN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRAF3IP2-FYN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRAF3IP2-FYN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRAF3IP2-FYN seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TRAF3IP2-FYN seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRAF3IP2	GO:0002230	positive regulation of defense response to virus by host	23066157
Tgene	FYN	GO:0050852	T cell receptor signaling pathway	7722293

Fusion gene breakpoints across TRAF3IP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8580-01A	TRAF3IP2	chr6	111926979	-	FYN	chr6	111995833	-
ChimerDB4	UCEC	TCGA-D1-A3DG-01A	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000368682	FYN	chr6	111995833	-	3839	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000354650	FYN	chr6	111995833	-	3839	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000229471	FYN	chr6	111995833	-	2889	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000368667	FYN	chr6	111995833	-	2889	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000368678	FYN	chr6	111995833	-	2885	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000229470	FYN	chr6	111995833	-	2877	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000356013	FYN	chr6	111995833	-	2877	2091	588	2228	546
ENST00000392556	TRAF3IP2	chr6	111887647	-	ENST00000538466	FYN	chr6	111995833	-	2877	2091	588	2228	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000368682	FYN	chr6	111995833	-	3846	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000354650	FYN	chr6	111995833	-	3846	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000229471	FYN	chr6	111995833	-	2896	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000368667	FYN	chr6	111995833	-	2896	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000368678	FYN	chr6	111995833	-	2892	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000229470	FYN	chr6	111995833	-	2884	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000356013	FYN	chr6	111995833	-	2884	2098	595	2235	546
ENST00000340026	TRAF3IP2	chr6	111887647	-	ENST00000538466	FYN	chr6	111995833	-	2884	2098	595	2235	546

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392556	ENST00000368682	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.00258892	0.9974111
ENST00000392556	ENST00000354650	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.00258892	0.9974111
ENST00000392556	ENST00000229471	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.01238893	0.987611
ENST00000392556	ENST00000368667	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.01238893	0.987611
ENST00000392556	ENST00000368678	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012327708	0.98767227
ENST00000392556	ENST00000229470	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012919379	0.98708063
ENST00000392556	ENST00000356013	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012919379	0.98708063
ENST00000392556	ENST00000538466	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012919379	0.98708063
ENST00000340026	ENST00000368682	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.002675285	0.9973247
ENST00000340026	ENST00000354650	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.002675285	0.9973247
ENST00000340026	ENST00000229471	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012683788	0.98731625
ENST00000340026	ENST00000368667	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.012683788	0.98731625
ENST00000340026	ENST00000368678	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.01262177	0.9873782
ENST00000340026	ENST00000229470	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.013256474	0.98674357
ENST00000340026	ENST00000356013	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.013256474	0.98674357
ENST00000340026	ENST00000538466	TRAF3IP2	chr6	111887647	-	FYN	chr6	111995833	-	0.013256474	0.98674357

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93663_93663_1_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000229470_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_2_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000229471_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_3_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000354650_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_4_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000356013_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_5_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000368667_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_6_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000368678_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_7_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000368682_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_8_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000340026_FYN_chr6_111995833_ENST00000538466_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_9_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000229470_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_10_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000229471_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_11_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000354650_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_12_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000356013_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_13_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000368667_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_14_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000368678_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_15_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000368682_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

>93663_93663_16_TRAF3IP2-FYN_TRAF3IP2_chr6_111887647_ENST00000392556_FYN_chr6_111995833_ENST00000538466_length(amino acids)=546AA_BP=380
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVT
CLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPW
NYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGI
DIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMVQSSPSSGRPPRQPCTGGSQSSLTCGLLESYSQSWSPKE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111887647/chr6:111995833)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FYN C1orf168
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	728

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRAF3IP2

chr6:111887647

chr6:111995833

ENST00000340026

409_550

501.0

575.0

Domain

SEFIR

Hgene

TRAF3IP2

chr6:111887647

chr6:111995833

ENST00000359831

409_550

491.0

565.0

Domain

SEFIR

Hgene

TRAF3IP2

chr6:111887647

chr6:111995833

ENST00000368735

409_550

36.0

110.0

Domain

SEFIR

Hgene

TRAF3IP2

chr6:111887647

chr6:111995833

ENST00000368761

409_550

492.0

566.0

Domain

SEFIR

Hgene

TRAF3IP2

chr6:111887647

chr6:111995833

ENST00000392556

409_550

80.0

154.0

Domain

SEFIR

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000229471

149_246

369.3333333333333

483.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000229471

271_524

369.3333333333333

483.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000229471

82_143

369.3333333333333

483.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000354650

149_246

424.3333333333333

538.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000354650

271_524

424.3333333333333

538.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000354650

82_143

424.3333333333333

538.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000356013

149_246

369.3333333333333

483.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000356013

271_524

369.3333333333333

483.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000356013

82_143

369.3333333333333

483.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368667

149_246

424.3333333333333

538.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368667

271_524

424.3333333333333

538.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368667

82_143

424.3333333333333

538.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368678

149_246

421.3333333333333

535.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368678

271_524

421.3333333333333

535.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368678

82_143

421.3333333333333

535.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368682

149_246

421.3333333333333

535.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368682

271_524

421.3333333333333

535.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368682

82_143

421.3333333333333

535.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000538466

149_246

421.3333333333333

535.0

Domain

SH2

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000538466

271_524

421.3333333333333

535.0

Domain

Protein kinase

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000538466

82_143

421.3333333333333

535.0

Domain

SH3

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000229471

277_285

369.3333333333333

483.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000354650

277_285

424.3333333333333

538.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000356013

277_285

369.3333333333333

483.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368667

277_285

424.3333333333333

538.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368678

277_285

421.3333333333333

535.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000368682

277_285

421.3333333333333

535.0

Nucleotide binding

ATP

Tgene

FYN

chr6:111887647

chr6:111995833

ENST00000538466

277_285

421.3333333333333

535.0

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TRAF3IP2
FYN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TRAF3IP2-FYN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TRAF3IP2-FYN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source