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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRAF3-ITPK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRAF3-ITPK1
FusionPDB ID: 93667
FusionGDB2.0 ID: 93667
HgeneTgene
Gene symbol

TRAF3

ITPK1

Gene ID

7187

3705

Gene nameTNF receptor associated factor 3inositol-tetrakisphosphate 1-kinase
SynonymsCAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118ITRPK1
Cytomap

14q32.32

14q32.12

Type of geneprotein-codingprotein-coding
DescriptionTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3inositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase
Modification date2020032720200313
UniProtAcc

TRAF3IP1

Q13572

Ensembl transtripts involved in fusion geneENST idsENST00000347662, ENST00000351691, 
ENST00000392745, ENST00000539721, 
ENST00000560371, 		ENST00000556954, 
ENST00000267615, ENST00000354313, 
ENST00000555495, ENST00000556603, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 11 X 11=18159 X 8 X 7=504
# samples 208
** MAII scorelog2(20/1815*10)=-3.18189764310839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/504*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRAF3 [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRAF3(103342862)-ITPK1(93424711), # samples:5
Anticipated loss of major functional domain due to fusion event.TRAF3-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRAF3-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRAF3-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRAF3-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRAF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-S7-A7WM-01ATRAF3chr14

103342861

+ITPK1chr14

93424710

-
ChimerDB4PCPGTCGA-S7-A7WM-01ATRAF3chr14

103342862

-ITPK1chr14

93424711

-
ChimerDB4PCPGTCGA-S7-A7WM-01ATRAF3chr14

103342862

+ITPK1chr14

93424711

-
ChimerDB4PCPGTCGA-S7-A7WMTRAF3chr14

103342862

+ITPK1chr14

93424711

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000560371TRAF3chr14103342862+ENST00000267615ITPK1chr1493424711-6175787401527495
ENST00000560371TRAF3chr14103342862+ENST00000354313ITPK1chr1493424711-2797787401227395
ENST00000560371TRAF3chr14103342862+ENST00000556603ITPK1chr1493424711-3336787401527495
ENST00000560371TRAF3chr14103342862+ENST00000555495ITPK1chr1493424711-3227787401527495
ENST00000347662TRAF3chr14103342862+ENST00000267615ITPK1chr1493424711-63119232931663456
ENST00000347662TRAF3chr14103342862+ENST00000354313ITPK1chr1493424711-29339232931363356
ENST00000347662TRAF3chr14103342862+ENST00000556603ITPK1chr1493424711-34729232931663456
ENST00000347662TRAF3chr14103342862+ENST00000555495ITPK1chr1493424711-33639232931663456
ENST00000392745TRAF3chr14103342862+ENST00000267615ITPK1chr1493424711-62338452151585456
ENST00000392745TRAF3chr14103342862+ENST00000354313ITPK1chr1493424711-28558452151285356
ENST00000392745TRAF3chr14103342862+ENST00000556603ITPK1chr1493424711-33948452151585456
ENST00000392745TRAF3chr14103342862+ENST00000555495ITPK1chr1493424711-32858452151585456
ENST00000539721TRAF3chr14103342862+ENST00000267615ITPK1chr1493424711-6049661431401452
ENST00000539721TRAF3chr14103342862+ENST00000354313ITPK1chr1493424711-2671661431101352
ENST00000539721TRAF3chr14103342862+ENST00000556603ITPK1chr1493424711-3210661431401452
ENST00000539721TRAF3chr14103342862+ENST00000555495ITPK1chr1493424711-3101661431401452
ENST00000351691TRAF3chr14103342862+ENST00000267615ITPK1chr1493424711-6094706761446456
ENST00000351691TRAF3chr14103342862+ENST00000354313ITPK1chr1493424711-2716706761146356
ENST00000351691TRAF3chr14103342862+ENST00000556603ITPK1chr1493424711-3255706761446456
ENST00000351691TRAF3chr14103342862+ENST00000555495ITPK1chr1493424711-3146706761446456
ENST00000560371TRAF3chr14103342861+ENST00000267615ITPK1chr1493424710-6175787401527495
ENST00000560371TRAF3chr14103342861+ENST00000354313ITPK1chr1493424710-2797787401227395
ENST00000560371TRAF3chr14103342861+ENST00000556603ITPK1chr1493424710-3336787401527495
ENST00000560371TRAF3chr14103342861+ENST00000555495ITPK1chr1493424710-3227787401527495
ENST00000347662TRAF3chr14103342861+ENST00000267615ITPK1chr1493424710-63119232931663456
ENST00000347662TRAF3chr14103342861+ENST00000354313ITPK1chr1493424710-29339232931363356
ENST00000347662TRAF3chr14103342861+ENST00000556603ITPK1chr1493424710-34729232931663456
ENST00000347662TRAF3chr14103342861+ENST00000555495ITPK1chr1493424710-33639232931663456
ENST00000392745TRAF3chr14103342861+ENST00000267615ITPK1chr1493424710-62338452151585456
ENST00000392745TRAF3chr14103342861+ENST00000354313ITPK1chr1493424710-28558452151285356
ENST00000392745TRAF3chr14103342861+ENST00000556603ITPK1chr1493424710-33948452151585456
ENST00000392745TRAF3chr14103342861+ENST00000555495ITPK1chr1493424710-32858452151585456
ENST00000539721TRAF3chr14103342861+ENST00000267615ITPK1chr1493424710-6049661431401452
ENST00000539721TRAF3chr14103342861+ENST00000354313ITPK1chr1493424710-2671661431101352
ENST00000539721TRAF3chr14103342861+ENST00000556603ITPK1chr1493424710-3210661431401452
ENST00000539721TRAF3chr14103342861+ENST00000555495ITPK1chr1493424710-3101661431401452
ENST00000351691TRAF3chr14103342861+ENST00000267615ITPK1chr1493424710-6094706761446456
ENST00000351691TRAF3chr14103342861+ENST00000354313ITPK1chr1493424710-2716706761146356
ENST00000351691TRAF3chr14103342861+ENST00000556603ITPK1chr1493424710-3255706761446456
ENST00000351691TRAF3chr14103342861+ENST00000555495ITPK1chr1493424710-3146706761446456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000560371ENST00000267615TRAF3chr14103342862+ITPK1chr1493424711-0.0024270610.99757296
ENST00000560371ENST00000354313TRAF3chr14103342862+ITPK1chr1493424711-0.0029692610.99703074
ENST00000560371ENST00000556603TRAF3chr14103342862+ITPK1chr1493424711-0.0043250170.995675
ENST00000560371ENST00000555495TRAF3chr14103342862+ITPK1chr1493424711-0.0058008740.99419916
ENST00000347662ENST00000267615TRAF3chr14103342862+ITPK1chr1493424711-0.0025349810.997465
ENST00000347662ENST00000354313TRAF3chr14103342862+ITPK1chr1493424711-0.0031693470.99683064
ENST00000347662ENST00000556603TRAF3chr14103342862+ITPK1chr1493424711-0.004551190.99544877
ENST00000347662ENST00000555495TRAF3chr14103342862+ITPK1chr1493424711-0.0060144040.9939856
ENST00000392745ENST00000267615TRAF3chr14103342862+ITPK1chr1493424711-0.0024827350.9975172
ENST00000392745ENST00000354313TRAF3chr14103342862+ITPK1chr1493424711-0.0030874570.9969125
ENST00000392745ENST00000556603TRAF3chr14103342862+ITPK1chr1493424711-0.0043640040.99563605
ENST00000392745ENST00000555495TRAF3chr14103342862+ITPK1chr1493424711-0.0058184540.9941816
ENST00000539721ENST00000267615TRAF3chr14103342862+ITPK1chr1493424711-0.0023421820.9976578
ENST00000539721ENST00000354313TRAF3chr14103342862+ITPK1chr1493424711-0.0027197610.99728024
ENST00000539721ENST00000556603TRAF3chr14103342862+ITPK1chr1493424711-0.0038905640.9961094
ENST00000539721ENST00000555495TRAF3chr14103342862+ITPK1chr1493424711-0.005377180.9946228
ENST00000351691ENST00000267615TRAF3chr14103342862+ITPK1chr1493424711-0.0022968320.99770314
ENST00000351691ENST00000354313TRAF3chr14103342862+ITPK1chr1493424711-0.0026491980.9973508
ENST00000351691ENST00000556603TRAF3chr14103342862+ITPK1chr1493424711-0.00364590.9963541
ENST00000351691ENST00000555495TRAF3chr14103342862+ITPK1chr1493424711-0.005028340.99497163
ENST00000560371ENST00000267615TRAF3chr14103342861+ITPK1chr1493424710-0.0024270610.99757296
ENST00000560371ENST00000354313TRAF3chr14103342861+ITPK1chr1493424710-0.0029692610.99703074
ENST00000560371ENST00000556603TRAF3chr14103342861+ITPK1chr1493424710-0.0043250170.995675
ENST00000560371ENST00000555495TRAF3chr14103342861+ITPK1chr1493424710-0.0058008740.99419916
ENST00000347662ENST00000267615TRAF3chr14103342861+ITPK1chr1493424710-0.0025349810.997465
ENST00000347662ENST00000354313TRAF3chr14103342861+ITPK1chr1493424710-0.0031693470.99683064
ENST00000347662ENST00000556603TRAF3chr14103342861+ITPK1chr1493424710-0.004551190.99544877
ENST00000347662ENST00000555495TRAF3chr14103342861+ITPK1chr1493424710-0.0060144040.9939856
ENST00000392745ENST00000267615TRAF3chr14103342861+ITPK1chr1493424710-0.0024827350.9975172
ENST00000392745ENST00000354313TRAF3chr14103342861+ITPK1chr1493424710-0.0030874570.9969125
ENST00000392745ENST00000556603TRAF3chr14103342861+ITPK1chr1493424710-0.0043640040.99563605
ENST00000392745ENST00000555495TRAF3chr14103342861+ITPK1chr1493424710-0.0058184540.9941816
ENST00000539721ENST00000267615TRAF3chr14103342861+ITPK1chr1493424710-0.0023421820.9976578
ENST00000539721ENST00000354313TRAF3chr14103342861+ITPK1chr1493424710-0.0027197610.99728024
ENST00000539721ENST00000556603TRAF3chr14103342861+ITPK1chr1493424710-0.0038905640.9961094
ENST00000539721ENST00000555495TRAF3chr14103342861+ITPK1chr1493424710-0.005377180.9946228
ENST00000351691ENST00000267615TRAF3chr14103342861+ITPK1chr1493424710-0.0022968320.99770314
ENST00000351691ENST00000354313TRAF3chr14103342861+ITPK1chr1493424710-0.0026491980.9973508
ENST00000351691ENST00000556603TRAF3chr14103342861+ITPK1chr1493424710-0.00364590.9963541
ENST00000351691ENST00000555495TRAF3chr14103342861+ITPK1chr1493424710-0.005028340.99497163

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93667_93667_1_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000347662_ITPK1_chr14_93424710_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_2_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000347662_ITPK1_chr14_93424710_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_3_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000347662_ITPK1_chr14_93424710_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_4_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000347662_ITPK1_chr14_93424710_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_5_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000351691_ITPK1_chr14_93424710_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_6_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000351691_ITPK1_chr14_93424710_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_7_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000351691_ITPK1_chr14_93424710_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_8_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000351691_ITPK1_chr14_93424710_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_9_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000392745_ITPK1_chr14_93424710_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_10_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000392745_ITPK1_chr14_93424710_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_11_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000392745_ITPK1_chr14_93424710_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_12_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000392745_ITPK1_chr14_93424710_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_13_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000539721_ITPK1_chr14_93424710_ENST00000267615_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_14_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000539721_ITPK1_chr14_93424710_ENST00000354313_length(amino acids)=352AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS

--------------------------------------------------------------

>93667_93667_15_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000539721_ITPK1_chr14_93424710_ENST00000555495_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_16_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000539721_ITPK1_chr14_93424710_ENST00000556603_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_17_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000560371_ITPK1_chr14_93424710_ENST00000267615_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

--------------------------------------------------------------

>93667_93667_18_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000560371_ITPK1_chr14_93424710_ENST00000354313_length(amino acids)=395AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG

--------------------------------------------------------------

>93667_93667_19_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000560371_ITPK1_chr14_93424710_ENST00000555495_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

--------------------------------------------------------------

>93667_93667_20_TRAF3-ITPK1_TRAF3_chr14_103342861_ENST00000560371_ITPK1_chr14_93424710_ENST00000556603_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

--------------------------------------------------------------

>93667_93667_21_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000347662_ITPK1_chr14_93424711_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_22_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000347662_ITPK1_chr14_93424711_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_23_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000347662_ITPK1_chr14_93424711_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_24_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000347662_ITPK1_chr14_93424711_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_25_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000351691_ITPK1_chr14_93424711_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_26_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000351691_ITPK1_chr14_93424711_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_27_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000351691_ITPK1_chr14_93424711_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_28_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000351691_ITPK1_chr14_93424711_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_29_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000392745_ITPK1_chr14_93424711_ENST00000267615_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_30_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000392745_ITPK1_chr14_93424711_ENST00000354313_length(amino acids)=356AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI

--------------------------------------------------------------

>93667_93667_31_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000392745_ITPK1_chr14_93424711_ENST00000555495_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_32_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000392745_ITPK1_chr14_93424711_ENST00000556603_length(amino acids)=456AA_BP=209
MAPYSSKDRCPDRRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGH
RFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK
DLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESI
FFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIAT
VLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLA

--------------------------------------------------------------

>93667_93667_33_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000539721_ITPK1_chr14_93424711_ENST00000267615_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_34_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000539721_ITPK1_chr14_93424711_ENST00000354313_length(amino acids)=352AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS

--------------------------------------------------------------

>93667_93667_35_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000539721_ITPK1_chr14_93424711_ENST00000555495_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_36_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000539721_ITPK1_chr14_93424711_ENST00000556603_length(amino acids)=452AA_BP=205
MSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCE
SCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRD
HVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNS
HNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQG
QSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKAS

--------------------------------------------------------------

>93667_93667_37_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000560371_ITPK1_chr14_93424711_ENST00000267615_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

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>93667_93667_38_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000560371_ITPK1_chr14_93424711_ENST00000354313_length(amino acids)=395AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG

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>93667_93667_39_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000560371_ITPK1_chr14_93424711_ENST00000555495_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

--------------------------------------------------------------

>93667_93667_40_TRAF3-ITPK1_TRAF3_chr14_103342862_ENST00000560371_ITPK1_chr14_93424711_ENST00000556603_length(amino acids)=495AA_BP=248
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103342862/chr14:93424711)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRAF3

TRAF3IP1

ITPK1

Q13572

691FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRAF3chr14:103342861chr14:93424710ENST00000392745+612135_190190.0569.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342861chr14:93424710ENST00000392745+61268_77190.0569.0Zinc fingerRING-type
HgeneTRAF3chr14:103342861chr14:93424710ENST00000539721+58135_190190.0486.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342861chr14:93424710ENST00000539721+5868_77190.0486.0Zinc fingerRING-type
HgeneTRAF3chr14:103342861chr14:93424710ENST00000560371+511135_190190.0569.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342861chr14:93424710ENST00000560371+51168_77190.0569.0Zinc fingerRING-type
HgeneTRAF3chr14:103342862chr14:93424711ENST00000392745+612135_190190.0569.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342862chr14:93424711ENST00000392745+61268_77190.0569.0Zinc fingerRING-type
HgeneTRAF3chr14:103342862chr14:93424711ENST00000539721+58135_190190.0486.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342862chr14:93424711ENST00000539721+5868_77190.0486.0Zinc fingerRING-type
HgeneTRAF3chr14:103342862chr14:93424711ENST00000560371+511135_190190.0569.0Zinc fingerTRAF-type 1
HgeneTRAF3chr14:103342862chr14:93424711ENST00000560371+51168_77190.0569.0Zinc fingerRING-type
TgeneITPK1chr14:103342861chr14:93424710ENST00000267615611188_199168.0415.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:103342861chr14:93424710ENST00000354313611188_199168.0315.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:103342861chr14:93424710ENST00000556603611188_199168.0415.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:103342862chr14:93424711ENST00000267615611188_199168.0415.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:103342862chr14:93424711ENST00000354313611188_199168.0315.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:103342862chr14:93424711ENST00000556603611188_199168.0415.0Nucleotide bindingNote=ATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRAF3chr14:103342861chr14:93424710ENST00000392745+612267_338190.0569.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342861chr14:93424710ENST00000539721+58267_338190.0486.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342861chr14:93424710ENST00000560371+511267_338190.0569.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342862chr14:93424711ENST00000392745+612267_338190.0569.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342862chr14:93424711ENST00000539721+58267_338190.0486.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342862chr14:93424711ENST00000560371+511267_338190.0569.0Coiled coilOntology_term=ECO:0000255
HgeneTRAF3chr14:103342861chr14:93424710ENST00000392745+612415_560190.0569.0DomainMATH
HgeneTRAF3chr14:103342861chr14:93424710ENST00000539721+58415_560190.0486.0DomainMATH
HgeneTRAF3chr14:103342861chr14:93424710ENST00000560371+511415_560190.0569.0DomainMATH
HgeneTRAF3chr14:103342862chr14:93424711ENST00000392745+612415_560190.0569.0DomainMATH
HgeneTRAF3chr14:103342862chr14:93424711ENST00000539721+58415_560190.0486.0DomainMATH
HgeneTRAF3chr14:103342862chr14:93424711ENST00000560371+511415_560190.0569.0DomainMATH
HgeneTRAF3chr14:103342861chr14:93424710ENST00000392745+612191_249190.0569.0Zinc fingerTRAF-type 2
HgeneTRAF3chr14:103342861chr14:93424710ENST00000539721+58191_249190.0486.0Zinc fingerTRAF-type 2
HgeneTRAF3chr14:103342861chr14:93424710ENST00000560371+511191_249190.0569.0Zinc fingerTRAF-type 2
HgeneTRAF3chr14:103342862chr14:93424711ENST00000392745+612191_249190.0569.0Zinc fingerTRAF-type 2
HgeneTRAF3chr14:103342862chr14:93424711ENST00000539721+58191_249190.0486.0Zinc fingerTRAF-type 2
HgeneTRAF3chr14:103342862chr14:93424711ENST00000560371+511191_249190.0569.0Zinc fingerTRAF-type 2
TgeneITPK1chr14:103342861chr14:93424710ENST00000267615611117_325168.0415.0DomainATP-grasp
TgeneITPK1chr14:103342861chr14:93424710ENST00000354313611117_325168.0315.0DomainATP-grasp
TgeneITPK1chr14:103342861chr14:93424710ENST00000556603611117_325168.0415.0DomainATP-grasp
TgeneITPK1chr14:103342862chr14:93424711ENST00000267615611117_325168.0415.0DomainATP-grasp
TgeneITPK1chr14:103342862chr14:93424711ENST00000354313611117_325168.0315.0DomainATP-grasp
TgeneITPK1chr14:103342862chr14:93424711ENST00000556603611117_325168.0415.0DomainATP-grasp


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1048_TRAF3_103342862_ITPK1_93424711_1048_TRAF3_103342862_ITPK1_93424711_ranked_0.pdbTRAF3103342861103342862ENST00000555495ITPK1chr1493424711-
MQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRELLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGTPV
FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES
RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQMAIVFNQEGLNAIQPPCVVQN
FINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFG
IDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQD
495


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRAF3_pLDDT.png
all structure
all structure
ITPK1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRAF3
ITPK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRAF3-ITPK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRAF3-ITPK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource