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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TRAPPC8-SS18

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TRAPPC8-SS18
	FusionPDB ID: 93833
	FusionGDB2.0 ID: 93833
		Hgene	Tgene
	Gene symbol	TRAPPC8	SS18
	Gene ID	22878	6760
	Gene name	trafficking protein particle complex 8	SS18 subunit of BAF chromatin remodeling complex
	Synonyms	GSG1\|HsT2706\|KIAA1012\|TRS85	SSXT\|SYT
	Cytomap	18q12.1	18q11.2
	Type of gene	protein-coding	protein-coding
	Description	trafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homolog	protein SSXTSS18, nBAF chromatin remodeling complex subunitsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosome
	Modification date	20200313	20200329
	UniProtAcc	.	O75177
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000283351, ENST00000582513, ENST00000582539, ENST00000584876,	ENST00000269137, ENST00000539849, ENST00000545952, ENST00000585241, ENST00000415083, ENST00000542420, ENST00000542743,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 16 X 5=1520	14 X 18 X 5=1260
	# samples	21	15
	** MAII score	log2(21/1520*10)=-2.85561009066483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TRAPPC8 [Title/Abstract] AND SS18 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TRAPPC8(29487423)-SS18(23637706), # samples:3
Anticipated loss of major functional domain due to fusion event.	TRAPPC8-SS18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRAPPC8-SS18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRAPPC8-SS18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRAPPC8-SS18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRAPPC8-SS18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TRAPPC8-SS18 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SS18	GO:0045944	positive regulation of transcription by RNA polymerase II	15919756

Fusion gene breakpoints across TRAPPC8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SS18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A4SE-01A	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000283351	TRAPPC8	chr18	29487423	-	ENST00000415083	SS18	chr18	23637706	-	4491	1725	336	2750	804
ENST00000283351	TRAPPC8	chr18	29487423	-	ENST00000542420	SS18	chr18	23637706	-	3762	1725	336	2750	804
ENST00000283351	TRAPPC8	chr18	29487423	-	ENST00000542743	SS18	chr18	23637706	-	3127	1725	336	2657	773
ENST00000582513	TRAPPC8	chr18	29487423	-	ENST00000415083	SS18	chr18	23637706	-	4497	1731	342	2756	804
ENST00000582513	TRAPPC8	chr18	29487423	-	ENST00000542420	SS18	chr18	23637706	-	3768	1731	342	2756	804
ENST00000582513	TRAPPC8	chr18	29487423	-	ENST00000542743	SS18	chr18	23637706	-	3133	1731	342	2663	773

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000283351	ENST00000415083	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.000585651	0.9994143
ENST00000283351	ENST00000542420	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.000937456	0.9990626
ENST00000283351	ENST00000542743	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.002880628	0.9971194
ENST00000582513	ENST00000415083	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.000569689	0.99943024
ENST00000582513	ENST00000542420	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.000915203	0.99908483
ENST00000582513	ENST00000542743	TRAPPC8	chr18	29487423	-	SS18	chr18	23637706	-	0.002797999	0.99720204

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93833_93833_1_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000283351_SS18_chr18_23637706_ENST00000415083_length(amino acids)=804AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQD

--------------------------------------------------------------

>93833_93833_2_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000283351_SS18_chr18_23637706_ENST00000542420_length(amino acids)=804AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQD

--------------------------------------------------------------

>93833_93833_3_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000283351_SS18_chr18_23637706_ENST00000542743_length(amino acids)=773AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGY

--------------------------------------------------------------

>93833_93833_4_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000582513_SS18_chr18_23637706_ENST00000415083_length(amino acids)=804AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQD

--------------------------------------------------------------

>93833_93833_5_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000582513_SS18_chr18_23637706_ENST00000542420_length(amino acids)=804AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQD

--------------------------------------------------------------

>93833_93833_6_TRAPPC8-SS18_TRAPPC8_chr18_29487423_ENST00000582513_SS18_chr18_23637706_ENST00000542743_length(amino acids)=773AA_BP=377
MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLN
DVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSN
KNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDF
LNDQAMLYAAGALPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPS
SSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHM
MGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGY

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:29487423/chr18:23637706)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	SS18 O75177
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

175_418

77.0

388.0

Compositional bias

Note=Gln-rich

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

95_99

77.0

388.0

Compositional bias

Note=Poly-Pro

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

175_418

77.0

419.0

Compositional bias

Note=Gln-rich

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

95_99

77.0

419.0

Compositional bias

Note=Poly-Pro

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

374_377

77.0

388.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

392_401

77.0

388.0

Motif

SH3-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

413_416

77.0

388.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

374_377

77.0

419.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

392_401

77.0

419.0

Motif

SH3-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

413_416

77.0

419.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

344_369

77.0

388.0

Region

Note=2 X 13 AA imperfect tandem repeats

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

344_369

77.0

419.0

Region

Note=2 X 13 AA imperfect tandem repeats

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

344_356

77.0

388.0

Repeat

Note=1

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

357_369

77.0

388.0

Repeat

Note=2

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

344_356

77.0

419.0

Repeat

Note=1

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

357_369

77.0

419.0

Repeat

Note=2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

50_53

77.0

388.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

50_53

77.0

419.0

Motif

SH2-binding

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000269137

2_186

77.0

388.0

Region

Note=Transcriptional activation

Tgene

SS18

chr18:29487423

chr18:23637706

ENST00000415083

2_186

77.0

419.0

Region

Note=Transcriptional activation

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

SS18

SMARCA2, SMARCB1, EP300, MLLT10, GRB2, Bcl7b, SMARCD1, RBM14, YWHAG, ELAVL1, CUL3, CST11, ATF2, TLE1, SMARCA5, HDAC1, HDAC2, EED, SUZ12, EZH2, SS18, NFKBID, DPF3, DPF2, SMARCE1, ARID1B, ARID1A, PHF10, SMARCC2, SMARCC1, GLTSCR1, SMARCD3, SMARCD2, SMARCA4, ARID2, DPF1, ACTL6A, ACTL6B, BCL7A, BCL7C, BCL7B, BRD9, CDKN1A, NEFM, RAB5C, SYNCRIP, Wash, FUS, DDIT3, FLI1, nsp13ab, BRD3, NR3C1, SS18L1, BRD7, PBRM1, ACTC1, STK11IP, DDX58, UBQLN2, PTPRR, T, ELF5, ERG, ETV4, FOS, GATA2, GCM1, HNF4A, IRF1, IRF4, KLF3, KLF5, LHX2, MYOD1, PAX7, SOX17, SOX2, SP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TRAPPC8
SS18

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TRAPPC8-SS18

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TRAPPC8-SS18

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SS18	C0039101	synovial sarcoma	2	CTD_human;ORPHANET