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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIM24-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIM24-RET
FusionPDB ID: 94010
FusionGDB2.0 ID: 94010
HgeneTgene
Gene symbol

TRIM24

RET

Gene ID

8805

5979

Gene nametripartite motif containing 24ret proto-oncogene
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

7q33-q34

10q11.21

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc

O15164

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000343526, ENST00000415680, 
ENST00000497516, 		ENST00000340058, 
ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 7=63032 X 31 X 11=10912
# samples 1048
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIM24 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across TRIM24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..TRIM24chr7

138239711

+RETchr10

43612031

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343526TRIM24chr7138239711+ENST00000355710RETchr1043612031+50361745922953953
ENST00000343526TRIM24chr7138239711+ENST00000340058RETchr1043612031+35781745922827911

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94010_94010_1_TRIM24-RET_TRIM24_chr7_138239711_ENST00000343526_RET_chr10_43612031_ENST00000340058_length(amino acids)=911AA_BP=551
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>94010_94010_2_TRIM24-RET_TRIM24_chr7_138239711_ENST00000343526_RET_chr10_43612031_ENST00000355710_length(amino acids)=953AA_BP=551
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:/chr10:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM24

O15164

RET

RTL1

FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (709) >>>709.pdbFusion protein BP residue: 551
CIF file (709) >>>709.cif		TRIM24chr7138239711+RETchr1043612031+
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAV
AAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVC
HQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPG
SPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKS
NQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVS
PEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFI
EEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDI
KVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHV
MHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKF
PTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISH
QEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG
MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF
NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL
911
3D view using mol* of 709 (AA BP:551)
PDB file (729) >>>729.pdbFusion protein BP residue: 551
CIF file (729) >>>729.cif		TRIM24chr7138239711+RETchr1043612031+
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAV
AAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVC
HQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPG
SPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKS
NQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVS
PEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFI
EEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDI
KVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHV
MHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKF
PTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISH
QEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG
MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF
NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL
YGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDT
953
3D view using mol* of 729 (AA BP:551)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM24_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM24_RET_709_pLDDT.png (AA BP:551)
all structure
TRIM24_RET_709_pLDDT_and_active_sites.png (AA BP:551)
all structure
TRIM24_RET_709_violinplot.png (AA BP:551)
all structure
TRIM24_RET_729_pLDDT.png (AA BP:551)
all structure
TRIM24_RET_729_pLDDT_and_active_sites.png (AA BP:551)
all structure
TRIM24_RET_729_violinplot.png (AA BP:551)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
TRIM24_RET_709.png
all structure
TRIM24_RET_729.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
7090.9671840.995518.9590.6640.6380.820.4281.0060.4250.625Chain A: 348,351,352,355,356,358,359,362,363,366,5
74,606,609,610,612,613,616,617,620,707,709,712,733
,734,735,736,737,740,741,742,743,744,745,746,747,7
48,764,765
7291.1171131.169310.4150.4510.7891.0121.5180.7492.0281.306Chain A: 569,570,571,572,573,574,575,577,595,597,6
14,618,627,641,643,644,645,646,647,649,650,717,718
,720,730,731,732

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
729ZINC000019632917DB00475Chlordiazepoxide-8.74715-8.79505
729ZINC000008214418DB09135Ioxilan-8.06983-8.06983
729ZINC000009212427DB11596Levoleucovorin-7.98019-7.98029
729BaricitinibDB11596-7.97009-7.97009
729ZINC000001530639DB01095Fluvastatin-7.81648-7.81828
729ZINC000004213946DB04861Nebivolol-7.71146-7.73126
729ZINC000003798064DB00242Cladribine-7.72339-7.72339
729ZINC000001999441DB04861Nebivolol-7.68243-7.70223
729ZINC000013537284DB00969Alosetron-6.75757-7.66087
729ZINC000253632968DB06290Simeprevir-7.6264-7.633
729ZINC000003827556DB11943Delafloxacin-6.04017-7.60597
729ZINC000000897089DB00358Mefloquine-7.58672-7.58922
729ZINC000003944422DB00503Ritonavir-7.51379-7.51379
729PexidartinibDB00503-7.26074-7.47754
729ZINC000011681534DB04861Nebivolol-7.45089-7.47069
729ZINC000043100953DB09042Tedizolid phosphate-7.34095-7.42595
729ZINC000019203912DB00623Fluphenazine-6.85219-7.39949
729EncorafenibDB00623-6.93691-7.37071
729ZINC000028232750DB00385Valrubicin-7.35374-7.35404
729ZINC000009224016DB00235Milrinone-7.32759-7.34609

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000019632917DB00475ChlordiazepoxideSmall moleculeCNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1Approved|Illicit|Investigational
ZINC000008214418DB09135IoxilanSmall moleculeCC(=O)N(CC(O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCCO)=C1IApproved
ZINC000009212427DB11596LevoleucovorinSmall moleculeNC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1Approved|Investigational
ZINC000003798064DB00242CladribineSmall moleculeNC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1Approved|Investigational
ZINC000013537284DB00969AlosetronSmall moleculeCN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2Approved|Withdrawn
ZINC000253632968DB06290SimeprevirSmall molecule[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1Approved
ZINC000003827556DB11943DelafloxacinSmall moleculeNC1=NC(N2C=C(C(O)=O)C(=O)C3=CC(F)=C(N4CC(O)C4)C(Cl)=C23)=C(F)C=C1FApproved|Investigational
ZINC000003944422DB00503RitonavirSmall moleculeCC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1Approved|Investigational
ZINC000011681534DB04861NebivololSmall moleculeOC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2Approved|Investigational
ZINC000043100953DB09042Tedizolid phosphateSmall moleculeCN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=OApproved
ZINC000019203912DB00623FluphenazineSmall moleculeOCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1Approved
ZINC000009224016DB00235MilrinoneSmall moleculeCC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1Approved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000019632917299.7594.645553.04137.02264.707279.78871.524941.819138.565310000
ZINC000019632917299.7595.502549.003118.96574.766283.8271.453935.577138.408310000
ZINC000008214418791.1161.945763.111318.983317.0489.77117.311418.936716.59.19911.20931
ZINC000009212427473.44416.012788.553155.209480.878152.46601386.2177.2514.258.2841021
ZINC000001530639411.4722.606736.515244.402177.684267.60146.8281317.38524.48.258275.70510
ZINC000004213946405.4415.213712.775270.54687.695260.77393.7611260.0136.49.251394.55500
ZINC000004213946405.4413.313660.255261.06875.583229.84493.761216.09336.49.124395.53300
ZINC000003798064285.6898.439477.736141.855198.60961.28175.991805.57649.18.398362.39200
ZINC000001999441405.4414.722712.226273.48884.211260.77493.7531256.14736.49.229395.14300
ZINC000001999441405.4410.513723.645269.65591.189269.03293.7681265.84436.49.27394.03900
ZINC000013537284294.35511.018558.659261.63964.423232.5970975.98514.58.467310000
ZINC000013537284294.3552.688556.854260.96665.507230.3810971.56114.58.221310000
ZINC000013537284294.35511.062555.086259.10266.238229.7460970.70114.58.471310000
ZINC000253632968749.9396.9571148.652820.732134.162154.91538.8422228.6291.2513.758.419162.52532
ZINC000253632968749.93911.1351103.653772.655146.278144.58240.1382184.3831.2513.758.499157.80432
ZINC000253632968749.9399.2981114.226794.485125.878154.69239.172200.51.2513.758.41163.80632
ZINC000253632968749.9398.171081.392774.076143.601146.31117.4042179.1541.2513.758.604161.00632
ZINC000003827556440.7657.343641.991114.171269.717120.689137.4141132.35936.78.856257.44801
ZINC000003827556440.7659.028639.547117.652265.215120.459136.2211128.10136.79.031258.22101
ZINC000000897089378.3177.024589.936192.76554.441122.198220.5321034.58724.29.632310000
ZINC000003944422720.9435.1711056.641444.158125.027430.69256.7642164.0523.2510.959.179172.02532
ZINC000011681534405.4412.335727.789280.70885.7267.62193.761272.95136.49.228395.43300
ZINC000011681534405.4416.385707.131273.32277.744262.30193.7651256.16536.49.073396.54300
ZINC000043100953450.3228.428720.625174.492308.419199.97437.7411252.9792139.192117.34511
ZINC000043100953450.3228.806708.392174.655291.009204.37638.3521241.0022139.026120.70611
ZINC000019203912437.5221.866667.705280.39337.632229.684119.9961257.68116.28.126395.4401
ZINC000019203912437.5223.481669.797259.98957.21232.5120.0981250.57516.28.155391.65701
ZINC000019203912437.5223.695710.047257.01859.375274.093119.5611303.38216.28.086392.08701
ZINC000028232750723.6536.89972.28461.942279.783143.56186.9941913.981316.69.109236.82323
ZINC000009224016211.2239.241456.01678.254179.616198.1460733.27115.59.427371.63500
ZINC000009224016211.2239.627456.21378.003179.401198.8090733.31615.59.463371.68500


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000019632917CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C10.1473206730.447326601
ZINC000008214418CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000009212427Nc1nc2c(c(=O)[nH]1)N(C=O)[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN20.0637430910.499740832
ZINC000001530639CC(C)n1c(/C=C/[C@H](O)C[C@H](O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc210.1011703060.183209327
ZINC000004213946O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000003798064Nc1nc(Cl)nc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O10.072600780.352494439
ZINC000001999441O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000013537284Cc1nc[nH]c1CN1CCc2c(c3ccccc3n2C)C1=O0.1673991990.254688426
ZINC000253632968COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C0.0148452150.273382605
ZINC000003827556Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(O)C4)c(Cl)c32)c(F)cc1F0.1372155140.181774775
ZINC000000897089O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000003944422CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs10.0411619360.407340083
ZINC000011681534O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000043100953Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n10.0928451070.135775423
ZINC000019203912OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC10.2416067250.269532671
ZINC000028232750CCCCC(=O)OCC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@@H]2C[C@H](NC(=O)C(F)(F)F)[C@@H](O)[C@@H](C)O2)C1)C(=O)c1c(OC)cccc1C3=O0.0230569920.246049783
ZINC000009224016Cc1[nH]c(=O)c(C#N)cc1-c1ccncc10.2541192710.265270344


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,
TRIM24ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B, DTNBP1, STAT3, NR1I3, SOX2, TNRC6A, UBE2I, MYC, MCM2, SUPT6H, MCM4, PEX5, MCM6, MCM7, SUPT16H, SSRP1, SPOP, FBXO38, PLEKHA4, CREBBP, SMG7, H2AFY, NPM1, H2AFY2, BRD2, SET, ZC3H18, RSF1, MBD1, E2F2, TOP2A, BRPF1, AFF4, PADI2, TFDP2, ZCCHC8, MLKL, PPIH, TFDP1, VPS72, ENPP6, GADD45GIP1, SEZ6L, RAD18, PSD, CDH16, YEATS4, DSC2, MLLT1, RNF43, C10orf71, RCOR2, TANC1, ACTR6, RIBC2, FMN2, RBM7, NOLC1, SRCAP, RNPS1, XPC, MFAP1, DNASE2B, XPO1, TRAF3, UBE2D1, DNAJC19, CEP78, CALM1, SUMO2, SOD1, MARCKS, CALR, PDIA4, DPP7, PTMA, RPS28, PDIA3, HSPE1, CSTB, ALDOA, MOB2, MIF, DDTL, RPRD1B, TPM3, CYCS, STMN1, BASP1, SSB, LCE3D, PGK1, PFN1, TKT, NPC2, PA2G4, TAB1, MARCKSL1, CNPY2, MYL12B, ARHGDIA, MTPN, TPI1, MDH1, PGAM1, TBCA, HMGN1, GGH, PTMS, HSP90B1, MAT2A, ANXA5, PPIB, FABP5, PDIA6, DDX39B, CMBL, TALDO1, TPM4, NUDC, CKB, NUCKS1, GSTO1, HDGF, TAGLN2, PRDX5, PARK7, PEBP1, MYL6, AHSG, SOD2, TRIM37, APEX1, ASF1A, CBX3, HIST1H2BG, TERF2IP, ZNF330, HORMAD2, MAD2L1, ZNF418, ZNF776, CRYAA, ZNF287, ABTB2, CCT8L2, ZNF17, ZNF718, ZNF484, KRT37, NUP62, PIAS4, KXD1, KNSTRN, MAGEA9, NUP62CL, ZNF726, LURAP1, ZNF383, KRT39, TGM7, ZNF460, ZNF543, KRT38, TRIM52, NLRP3, T, ELF1, ELF3, ELF4, ELF5, ERG, ETS1, ETV4, FEV, FOS, GATA2, HNF1B, HNF4A, KLF15, KLF5, KLF6, KLF8, LHX1, LHX2, LHX3, LHX4, MYOD1, NFIC, NFIX, PAX6, SOX17, SOX5, SP7, TLX3, YY1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIM24all structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRIM24-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIM24-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TRIM24RETLung AdenocarcinomaMyCancerGenome
TRIM24RETThyroid Gland Papillary CarcinomaMyCancerGenome
TRIM24RETBreast Invasive Ductal CarcinomaMyCancerGenome
TRIM24RETAdenocarcinoma Of Unknown PrimaryMyCancerGenome
TRIM24RETBladder Urothelial CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM24C0238463Papillary thyroid carcinoma2ORPHANET
HgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTRIM24C2239176Liver carcinoma1CTD_human
HgeneTRIM24C3658266Prostatic Cancer, Castration-Resistant1CTD_human
HgeneTRIM24C3658267Prostatic Neoplasms, Castration-Resistant1CTD_human
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human