UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
![]() |
|||||||
|
Fusion Protein:TRIM27-RET |
Fusion Protein Summary |
![]() |
Fusion partner gene information | Fusion gene name: TRIM27-RET | FusionPDB ID: 94029 | FusionGDB2.0 ID: 94029 | Hgene | Tgene | Gene symbol | TRIM27 | RET | Gene ID | 5987 | 5979 |
Gene name | tripartite motif containing 27 | ret proto-oncogene | |
Synonyms | RFP|RNF76 | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1 | |
Cytomap | 6p22.1 | 10q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27 | proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary | |
Modification date | 20200327 | 20200322 | |
UniProtAcc | P14373 | RTL1 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000498117, ENST00000377194, ENST00000377199, ENST00000400720, ENST00000412687, ENST00000417660, ENST00000427689, ENST00000431123, ENST00000435528, ENST00000437160, ENST00000437415, ENST00000452265, ENST00000455861, ENST00000459807, ENST00000468047, ENST00000468364, ENST00000485666, ENST00000491158, ENST00000495323, | ENST00000340058, ENST00000355710, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 5 X 9 X 7=315 | 32 X 31 X 11=10912 |
# samples | 9 | 48 | |
** MAII score | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(48/10912*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: TRIM27 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TRIM27(28887789)-RET(43612032), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TRIM27 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10976108 |
Hgene | TRIM27 | GO:0006469 | negative regulation of protein kinase activity | 22128329 |
Hgene | TRIM27 | GO:0032897 | negative regulation of viral transcription | 18248090 |
Hgene | TRIM27 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 23452853 |
Hgene | TRIM27 | GO:0042147 | retrograde transport, endosome to Golgi | 23452853 |
Hgene | TRIM27 | GO:0045087 | innate immune response | 18248090 |
Hgene | TRIM27 | GO:0045814 | negative regulation of gene expression, epigenetic | 10976108 |
Hgene | TRIM27 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 23077300 |
Tgene | RET | GO:0030155 | regulation of cell adhesion | 21357690 |
Tgene | RET | GO:0030335 | positive regulation of cell migration | 20702524 |
Tgene | RET | GO:0033619 | membrane protein proteolysis | 21357690 |
Tgene | RET | GO:0033630 | positive regulation of cell adhesion mediated by integrin | 20702524 |
Tgene | RET | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
Tgene | RET | GO:0043410 | positive regulation of MAPK cascade | 28846099 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
Top |
Fusion Gene Sample Information |
![]() |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | adenocarcinoma | M16029 | TRIM27 | chr6 | 232335 | RET | chr10 | 43608999 | ||
ChimerDB4 | THCA | TCGA-CE-A481-01A | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + |
ChimerDB4 | THCA | TCGA-CE-A481 | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + |
ChimerKB3 | . | . | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + |
ChimerKB3 | . | . | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + |
ChimerKB4 | . | . | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + |
ChiTaRS5.0 | N/A | M16029 | TRIM27 | chr6 | 28875012 | - | RET | chr10 | 43608999 | + |
Top |
Fusion ORF Analysis |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000377194 | TRIM27 | chr6 | 28887788 | - | ENST00000355710 | RET | chr10 | 43612031 | + | 4394 | 1103 | 212 | 2311 | 699 |
ENST00000377194 | TRIM27 | chr6 | 28887788 | - | ENST00000340058 | RET | chr10 | 43612031 | + | 2936 | 1103 | 212 | 2185 | 657 |
ENST00000377199 | TRIM27 | chr6 | 28887788 | - | ENST00000355710 | RET | chr10 | 43612031 | + | 4395 | 1104 | 213 | 2312 | 699 |
ENST00000377199 | TRIM27 | chr6 | 28887788 | - | ENST00000340058 | RET | chr10 | 43612031 | + | 2937 | 1104 | 213 | 2186 | 657 |
ENST00000377194 | TRIM27 | chr6 | 28887789 | - | ENST00000355710 | RET | chr10 | 43612032 | + | 4394 | 1103 | 212 | 2311 | 699 |
ENST00000377194 | TRIM27 | chr6 | 28887789 | - | ENST00000340058 | RET | chr10 | 43612032 | + | 2936 | 1103 | 212 | 2185 | 657 |
ENST00000377199 | TRIM27 | chr6 | 28887789 | - | ENST00000355710 | RET | chr10 | 43612032 | + | 4395 | 1104 | 213 | 2312 | 699 |
ENST00000377199 | TRIM27 | chr6 | 28887789 | - | ENST00000340058 | RET | chr10 | 43612032 | + | 2937 | 1104 | 213 | 2186 | 657 |
ENST00000377194 | TRIM27 | chr6 | 28887789 | - | ENST00000355710 | RET | chr10 | 43612032 | + | 4394 | 1103 | 212 | 2311 | 699 |
ENST00000377194 | TRIM27 | chr6 | 28887789 | - | ENST00000340058 | RET | chr10 | 43612032 | + | 2936 | 1103 | 212 | 2185 | 657 |
ENST00000377199 | TRIM27 | chr6 | 28887789 | - | ENST00000355710 | RET | chr10 | 43612032 | + | 4395 | 1104 | 213 | 2312 | 699 |
ENST00000377199 | TRIM27 | chr6 | 28887789 | - | ENST00000340058 | RET | chr10 | 43612032 | + | 2937 | 1104 | 213 | 2186 | 657 |
ENST00000377194 | TRIM27 | chr6 | 28887788 | - | ENST00000355710 | RET | chr10 | 43612031 | + | 4394 | 1103 | 212 | 2311 | 699 |
ENST00000377194 | TRIM27 | chr6 | 28887788 | - | ENST00000340058 | RET | chr10 | 43612031 | + | 2936 | 1103 | 212 | 2185 | 657 |
ENST00000377199 | TRIM27 | chr6 | 28887788 | - | ENST00000355710 | RET | chr10 | 43612031 | + | 4395 | 1104 | 213 | 2312 | 699 |
ENST00000377199 | TRIM27 | chr6 | 28887788 | - | ENST00000340058 | RET | chr10 | 43612031 | + | 2937 | 1104 | 213 | 2186 | 657 |
ENST00000377194 | TRIM27 | chr6 | 28875012 | - | ENST00000355710 | RET | chr10 | 43608999 | + | 4970 | 1302 | 212 | 2887 | 891 |
ENST00000377194 | TRIM27 | chr6 | 28875012 | - | ENST00000340058 | RET | chr10 | 43608999 | + | 3512 | 1302 | 212 | 2761 | 849 |
ENST00000377199 | TRIM27 | chr6 | 28875012 | - | ENST00000355710 | RET | chr10 | 43608999 | + | 4971 | 1303 | 213 | 2888 | 891 |
ENST00000377199 | TRIM27 | chr6 | 28875012 | - | ENST00000340058 | RET | chr10 | 43608999 | + | 3513 | 1303 | 213 | 2762 | 849 |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000377194 | ENST00000355710 | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + | 0.0036811 | 0.99631894 |
ENST00000377194 | ENST00000340058 | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + | 0.015020659 | 0.98497933 |
ENST00000377199 | ENST00000355710 | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + | 0.003663306 | 0.9963367 |
ENST00000377199 | ENST00000340058 | TRIM27 | chr6 | 28887789 | - | RET | chr10 | 43612032 | + | 0.014964578 | 0.9850354 |
ENST00000377194 | ENST00000355710 | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | 0.0036811 | 0.99631894 |
ENST00000377194 | ENST00000340058 | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | 0.015020659 | 0.98497933 |
ENST00000377199 | ENST00000355710 | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | 0.003663306 | 0.9963367 |
ENST00000377199 | ENST00000340058 | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | 0.014964578 | 0.9850354 |
ENST00000377194 | ENST00000355710 | TRIM27 | chr6 | 28875012 | - | RET | chr10 | 43608999 | + | 0.00204476 | 0.9979552 |
ENST00000377194 | ENST00000340058 | TRIM27 | chr6 | 28875012 | - | RET | chr10 | 43608999 | + | 0.010623794 | 0.9893762 |
ENST00000377199 | ENST00000355710 | TRIM27 | chr6 | 28875012 | - | RET | chr10 | 43608999 | + | 0.002036051 | 0.997964 |
ENST00000377199 | ENST00000340058 | TRIM27 | chr6 | 28875012 | - | RET | chr10 | 43608999 | + | 0.010573481 | 0.9894265 |
Top |
Fusion Amino Acid Sequences |
![]() |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >94029_94029_1_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377194_RET_chr10_43608999_ENST00000340058_length(amino acids)=849AA_BP=360 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL -------------------------------------------------------------- >94029_94029_2_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377194_RET_chr10_43608999_ENST00000355710_length(amino acids)=891AA_BP=360 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL -------------------------------------------------------------- >94029_94029_3_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377199_RET_chr10_43608999_ENST00000340058_length(amino acids)=849AA_BP=360 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL -------------------------------------------------------------- >94029_94029_4_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377199_RET_chr10_43608999_ENST00000355710_length(amino acids)=891AA_BP=360 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL -------------------------------------------------------------- >94029_94029_5_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377194_RET_chr10_43612031_ENST00000340058_length(amino acids)=657AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_6_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377194_RET_chr10_43612031_ENST00000355710_length(amino acids)=699AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_7_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377199_RET_chr10_43612031_ENST00000340058_length(amino acids)=657AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_8_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377199_RET_chr10_43612031_ENST00000355710_length(amino acids)=699AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_9_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377194_RET_chr10_43612032_ENST00000340058_length(amino acids)=657AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_10_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377194_RET_chr10_43612032_ENST00000355710_length(amino acids)=699AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_11_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377199_RET_chr10_43612032_ENST00000340058_length(amino acids)=657AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- >94029_94029_12_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377199_RET_chr10_43612032_ENST00000355710_length(amino acids)=699AA_BP=297 MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:28887789/chr10:43612032) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
TRIM27 | RET |
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}. | 1358 |
![]() |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377194 | - | 7 | 9 | 132_172 | 315.3333333333333 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377194 | - | 7 | 9 | 282_311 | 315.3333333333333 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377199 | - | 7 | 8 | 132_172 | 315.3333333333333 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377199 | - | 7 | 8 | 282_311 | 315.3333333333333 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377194 | - | 3 | 9 | 132_172 | 249.0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377199 | - | 3 | 8 | 132_172 | 249.0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377194 | - | 3 | 9 | 132_172 | 249.0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377199 | - | 3 | 8 | 132_172 | 249.0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377194 | - | 7 | 9 | 16_57 | 315.3333333333333 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377194 | - | 7 | 9 | 96_127 | 315.3333333333333 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377199 | - | 7 | 8 | 16_57 | 315.3333333333333 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377199 | - | 7 | 8 | 96_127 | 315.3333333333333 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377194 | - | 3 | 9 | 16_57 | 249.0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377194 | - | 3 | 9 | 96_127 | 249.0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377199 | - | 3 | 8 | 16_57 | 249.0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377199 | - | 3 | 8 | 96_127 | 249.0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377194 | - | 3 | 9 | 16_57 | 249.0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377194 | - | 3 | 9 | 96_127 | 249.0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377199 | - | 3 | 8 | 16_57 | 249.0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377199 | - | 3 | 8 | 96_127 | 249.0 | 514.0 | Zinc finger | B box-type |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 724_1016 | 586.3333333333334 | 1073.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 724_1016 | 586.3333333333334 | 1115.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 724_1016 | 712.0 | 1073.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 724_1016 | 712.0 | 1115.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 724_1016 | 712.0 | 1073.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 724_1016 | 712.0 | 1115.0 | Domain | Protein kinase | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 730_738 | 586.3333333333334 | 1073.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 730_738 | 586.3333333333334 | 1115.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 730_738 | 712.0 | 1073.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 730_738 | 712.0 | 1115.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 730_738 | 712.0 | 1073.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 730_738 | 712.0 | 1115.0 | Nucleotide binding | ATP | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 805_807 | 586.3333333333334 | 1073.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 805_807 | 586.3333333333334 | 1115.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 805_807 | 712.0 | 1073.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 805_807 | 712.0 | 1115.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 805_807 | 712.0 | 1073.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 805_807 | 712.0 | 1115.0 | Region | Note=Inhibitors binding | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 658_1114 | 586.3333333333334 | 1073.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 658_1114 | 586.3333333333334 | 1115.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 636_657 | 586.3333333333334 | 1073.0 | Transmembrane | Helical | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 636_657 | 586.3333333333334 | 1115.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000400720 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000400720 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000412687 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000412687 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000417660 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000417660 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000427689 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000427689 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000431123 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000431123 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000435528 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000435528 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000437160 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000437160 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000452265 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000452265 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377194 | - | 3 | 9 | 282_311 | 249.0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377199 | - | 3 | 8 | 282_311 | 249.0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000400720 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000400720 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000412687 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000412687 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000417660 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000417660 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000427689 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000427689 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000431123 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000431123 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000435528 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000435528 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000437160 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000437160 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000452265 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000452265 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377194 | - | 3 | 9 | 282_311 | 249.0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377199 | - | 3 | 8 | 282_311 | 249.0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000400720 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000400720 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000412687 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000412687 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000417660 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000417660 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000427689 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000427689 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000431123 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000431123 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000435528 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000435528 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000437160 | - | 1 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000437160 | - | 1 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000452265 | - | 1 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000452265 | - | 1 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377194 | - | 7 | 9 | 298_492 | 315.3333333333333 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000377199 | - | 7 | 8 | 298_492 | 315.3333333333333 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000400720 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000412687 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000417660 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000427689 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000431123 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000435528 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000437160 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000452265 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377194 | - | 3 | 9 | 298_492 | 249.0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000377199 | - | 3 | 8 | 298_492 | 249.0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000400720 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000412687 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000417660 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000427689 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000431123 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000435528 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000437160 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000452265 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377194 | - | 3 | 9 | 298_492 | 249.0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000377199 | - | 3 | 8 | 298_492 | 249.0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000400720 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000412687 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000417660 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000427689 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000431123 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000435528 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000437160 | - | 1 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000452265 | - | 1 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000400720 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000400720 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000412687 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000412687 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000417660 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000417660 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000427689 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000427689 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000431123 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000431123 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000435528 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000435528 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000437160 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000437160 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000452265 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28875012 | chr10:43608999 | ENST00000452265 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000400720 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000400720 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000412687 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000412687 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000417660 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000417660 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000427689 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000427689 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000431123 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000431123 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000435528 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000435528 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000437160 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000437160 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000452265 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887788 | chr10:43612031 | ENST00000452265 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000400720 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000400720 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000412687 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000412687 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000417660 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000417660 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000427689 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000427689 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000431123 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000431123 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000435528 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000435528 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000437160 | - | 1 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000437160 | - | 1 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000452265 | - | 1 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type |
Hgene | TRIM27 | chr6:28887789 | chr10:43612032 | ENST00000452265 | - | 1 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 168_272 | 586.3333333333334 | 1073.0 | Domain | Cadherin | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 168_272 | 586.3333333333334 | 1115.0 | Domain | Cadherin | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 168_272 | 712.0 | 1073.0 | Domain | Cadherin | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 168_272 | 712.0 | 1115.0 | Domain | Cadherin | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 168_272 | 712.0 | 1073.0 | Domain | Cadherin | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 168_272 | 712.0 | 1115.0 | Domain | Cadherin | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000340058 | 8 | 19 | 29_635 | 586.3333333333334 | 1073.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28875012 | chr10:43608999 | ENST00000355710 | 8 | 20 | 29_635 | 586.3333333333334 | 1115.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 29_635 | 712.0 | 1073.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 658_1114 | 712.0 | 1073.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 29_635 | 712.0 | 1115.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 658_1114 | 712.0 | 1115.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 29_635 | 712.0 | 1073.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 658_1114 | 712.0 | 1073.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 29_635 | 712.0 | 1115.0 | Topological domain | Extracellular | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 658_1114 | 712.0 | 1115.0 | Topological domain | Cytoplasmic | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000340058 | 10 | 19 | 636_657 | 712.0 | 1073.0 | Transmembrane | Helical | |
Tgene | RET | chr6:28887788 | chr10:43612031 | ENST00000355710 | 10 | 20 | 636_657 | 712.0 | 1115.0 | Transmembrane | Helical | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000340058 | 10 | 19 | 636_657 | 712.0 | 1073.0 | Transmembrane | Helical | |
Tgene | RET | chr6:28887789 | chr10:43612032 | ENST00000355710 | 10 | 20 | 636_657 | 712.0 | 1115.0 | Transmembrane | Helical |
Top |
Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file (535) >>>535.pdbFusion protein BP residue: 297 CIF file (535) >>>535.cif | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMA SGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVS CPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP LKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKR VKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLA RLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDP KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRI | 657 |
3D view using mol* of 535 (AA BP:297) | ||||||||||
![]() | ||||||||||
PDB file (569) >>>569.pdbFusion protein BP residue: 297 CIF file (569) >>>569.cif | TRIM27 | chr6 | 28887788 | - | RET | chr10 | 43612031 | + | MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMA SGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVS CPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP LKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKR VKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLA RLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDP KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMS | 699 |
3D view using mol* of 569 (AA BP:297) | ||||||||||
![]() |
Top |
pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
TRIM27_pLDDT.png![]() |
RET_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
Top |
Ramachandran Plot of Fusion Protein Structure |
![]() |
Fusion AA seq ID in FusionPDB and their Ramachandran plots |
TRIM27_RET_535.png |
![]() |
TRIM27_RET_569.png |
![]() |
Top |
Potential Active Site Information |
![]() |
Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
535 | 1.088 | 119 | 1.115 | 301.154 | 0.411 | 0.797 | 1.052 | 1.388 | 0.93 | 1.493 | 1.153 | Chain A: 315,316,317,318,319,320,321,323,341,343,3 60,364,373,387,389,390,391,392,393,395,396,463,464 ,466,476,477 |
569 | 1.075 | 132 | 1.117 | 298.067 | 0.443 | 0.752 | 0.953 | 1.495 | 0.84 | 1.779 | 1.218 | Chain A: 313,315,316,317,318,319,320,321,323,341,3 43,360,364,373,387,389,390,391,392,393,394,395,396 ,399,400,463,464,466,476,477 |
Top |
Potentially Interacting Small Molecules through Virtual Screening |
![]() |
Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
Top |
![]() |
ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
Top |
Biochemical Features of Small Molecules |
![]() |
ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
Top |
Drug Toxicity Information |
![]() |
ZINC ID | Smile | Surface Accessibility | Toxicity |
Top |
Fusion Protein-Protein Interaction |
![]() |
![]() |
Gene | PPI interactors |
RET | STAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A, |
TRIM27 | FBF1, ZBTB16, BEGAIN, MAGEA11, DNMT1, FXYD6, MCOLN1, TRIM27, TRIM11, TRIM23, TRIM29, TRIM32, PRAM1, PML, EIF3E, MBD4, MBD2, MBD3, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2K, UBE2T, UBE2A, UBE2D4, UBE2I, UBE2L6, UBE2J1, UBE2W, UBE2Z, UBE2O, UBE2U, TAL1, GTF2F1, MED21, FBXL19, HR, HDAC1, NFYC, CHD4, PIAS1, PIAS3, PIAS2, PIAS4, UBC, ATXN7, MDM2, TP53, MAGED4B, MAGEF1, MAGEL2, RB1, EID1, UBE2E1, UBE2E3, UBE2E2, UBE2N, NOD2, DAXX, CUL4B, CUL5, IKBKE, TBK1, CHUK, IKBKB, EPC1, GFI1B, UCHL3, UCHL5, USP2, USP7, OTUB2, PIK3C2B, PIK3C2A, HCVgp1, TUBGCP4, HDAC6, RNF25, TRIM43, ARIH2, RBX1, TRIM31, UHRF2, TRIM9, TRAF5, TRIM21, BMI1, TRIM55, LATS2, ARNT2, DGCR6, EIF4E, IQCE, KIF1A, MVP, NDE1, PAX7, MYOD1, AES, BAG1, BMP7, BYSL, CKS1B, CLK2, CSRP2, DCX, DDX6, EHHADH, FHL3, FOXC2, GEM, GFAP, GRB2, ILK, KIFC3, LASP1, LMO1, MCM7, MOS, NEDD9, OAS1, CDK18, POLE2, PPID, PPL, PRKAA1, PSMA1, PSMB1, PSMB3, SDCBP, SRSF2, SIAH1, SNRPA, SNRPB2, TCEA2, TEAD4, TMSB4X, TMSB4XP6, TPM3, TUFT1, XPA, ZNF79, GPANK1, NELFE, ARHGEF5, NCK2, STK16, EIF3D, CDC23, RAB29, MTMR6, EIF4E2, BAG5, POLR1C, SPATA2, JOSD1, NR1D2, SORBS3, TXNDC9, MAD2L2, STK25, KAT5, NEBL, POLR3C, FARS2, NEK6, MID2, NUDT21, MAPKBP1, PTPN23, PRPF31, FOXB1, INPP5J, MAT2B, BABAM1, NME7, ARHGEF3, TPRKB, MEMO1, VPS28, CDKL3, SLC15A3, WT1-AS, AMOTL2, ZNF581, FBXW5, FAM64A, CCHCR1, FAM193B, KCTD9, CHCHD3, WDYHV1, RBM23, C14orf105, CCDC87, RBM41, ABCF3, TBC1D22B, ZNF446, CCDC94, RCOR3, USE1, FAM214A, LGALS14, CSRP2BP, GATAD2B, STAMBPL1, TSHZ3, RNF213, FANCM, ZNF250, DMRT3, SH2D4A, KIF9, AEN, MRPL40, SCNM1, C20orf195, ZFYVE21, LENG1, ARMC7, ZC2HC1C, CCDC102B, CCDC92, FAM214B, KIAA1683, NDEL1, PUS7L, FAM110A, FAM103A1, DTNBP1, PLEKHN1, SPATC1L, TCHP, UTP23, VPS25, GFM2, ZGPAT, BEX2, LINGO1, FAM83A, ATPAF2, RHPN1, PTPMT1, HAUS1, ZMYND19, GLYCTK, GNPDA2, ZNF572, SIRPA, CWF19L2, LINC00526, ZNF417, IQUB, RIBC1, CDC20B, PPP1R18, ZFC3H1, CPNE2, NEIL2, TTLL10, TSGA10IP, KANSL1, FAM126B, TRIM42, ARPIN, MIA3, NOTCH2NL, FLJ38668, BEND7, IDI2, SURF2, ZNF219, FAM170A, RAB11B, ZNF621, FOXD4L6, ARHGAP25, IER2, CEP162, LCA5, RPGRIP1L, ILF2, STK26, C1orf109, UBL5, NIF3L1, ABHD17A, KPNA1, RNF2, TCF20, TSNAX, USP11, CEP135, HMG20A, TINF2, RACGAP1, BCOR, SLAIN2, TCEAL4, ELMSAN1, C10orf2, Cd2ap, Nedd1, Ranbp2, Ring1, Cdc23, Mad2l1, Tmed2, Mllt1, Pcgf1, Taf15, Prkaa1, Gpkow, Cep135, GLI1, BAG6, RIPK1, LGALS3BP, GLTSCR2, IKZF5, MAP7D2, ZNF764, POTEB3, C1orf106, KRBA1, ZNF785, SMARCB1, PRE5, HYM1, PRP4, LSM2, PRP45, YPL077C, BIT61, VID24, SNF1, GCD7, APP1, SQT1, SMP1, BTN2, TRX3, STI1, RRD1, LNX1, TNIP2, REL, ZNF384, USP15, RNF6, RXRB, AXIN1, HGS, AMMECR1, FAM126A, HNRNPLL, ZNF688, ESR2, NEK2, BRCA1, ATG16L1, PPP1CC, BRF1, HIST1H4A, TCF7L2, GSE1, HOXC8, SMARCD1, HDAC4, GPKOW, AP1M1, VPS9D1, TRAF4, THOC1, PIBF1, NCOA1, P2RX7, CDC7, CARD10, RSPH14, HCK, SYT17, SMG9, MAGOHB, INO80B, GRB14, EXOC8, HOXB5, PKN1, ENKD1, PIN1, HIP1R, CAPN7, TNS4, HAPLN2, ZNF414, SYT6, COX5B, VEZF1, TACO1, DTNB, ZFHX3, EIF4A3, CBX8, LMO4, CREB5, TRIM50, BAG3, LONRF1, GNE, UBASH3A, DBF4B, IP6K3, PRR35, ERCC3, IGFN1, PRPF18, CNNM3, FAM161A, KRT75, HOXB9, FAM90A1, QARS, IL16, RIN1, CATSPER1, LMNB2, ACSF3, TCEANC, CCDC185, CPNE7, GADD45GIP1, KRT76, TEX33, KRT3, POM121, ARID5A, LAGE3, SYNGAP1, ZNF587, MSRB1, ZNF580, C6orf165, FASTKD5, UTP14C, MGC50722, MYO15B, GAS2L2, PLEKHA4, PTEN, FYN, nsp12, ESR1, LZTS2, KIAA0355, TNRC6B, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, BRPF3, AIM2, ARHGAP22, NPC1, nsp14, nsp16, DNAJC7, FAM184A, ADNP, OGT, TRIM37, SIX3, PPARG, CDKN1A, PAK1, ARHGAP15, IFI27, MECOM, LHPP, BCCIP, FAM46C, SHANK3, EVA1B, KXD1, TFPT, TGIF2LY, DISC1, NPIPB6, MAP7, ZNF74, GMNN, SYCE2, DHX40, SKOR1, GLI4, ZSCAN29, RGPD1, CBX6, ABT1, ZNF423, NFKBIL1, SIRT6, BCL7C, NT5DC2, MAP3K7, TAB2, TAB3, NFKBIA, RB1CC1, |
![]() |
Gene | STRING network |
TRIM27 | ![]() |
RET | ![]() |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to TRIM27-RET |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to TRIM27-RET |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
TRIM27 | RET | Lung Adenocarcinoma | MyCancerGenome | |
TRIM27 | RET | Breast Invasive Ductal Carcinoma | MyCancerGenome | |
TRIM27 | RET | Thyroid Gland Papillary Carcinoma | MyCancerGenome | |
TRIM27 | RET | Adenocarcinoma Of Unknown Primary | MyCancerGenome | |
TRIM27 | RET | Bladder Urothelial Carcinoma | MyCancerGenome |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TRIM27 | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET |
Tgene | RET | C1833921 | Familial medullary thyroid carcinoma | 23 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | RET | C3888239 | HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1 | 16 | GENOMICS_ENGLAND;UNIPROT |
Tgene | RET | C0025268 | Multiple Endocrine Neoplasia Type 2a | 15 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | RET | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 12 | CLINGEN |
Tgene | RET | C0025269 | Multiple Endocrine Neoplasia Type 2b | 10 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | RET | C0238463 | Papillary thyroid carcinoma | 3 | CTD_human;ORPHANET |
Tgene | RET | C1275808 | Congenital central hypoventilation | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | RET | C1859049 | CCHS WITH HIRSCHSPRUNG DISEASE | 3 | CTD_human;ORPHANET |
Tgene | RET | C0009402 | Colorectal Carcinoma | 2 | CTD_human;UNIPROT |
Tgene | RET | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | RET | C0019569 | Hirschsprung Disease | 2 | CTD_human |
Tgene | RET | C0027662 | Multiple Endocrine Neoplasia | 2 | CTD_human;GENOMICS_ENGLAND |
Tgene | RET | C0085758 | Aganglionosis, Colonic | 2 | CTD_human |
Tgene | RET | C0266294 | Unilateral agenesis of kidney | 2 | ORPHANET |
Tgene | RET | C1257840 | Aganglionosis, Rectosigmoid Colon | 2 | CTD_human |
Tgene | RET | C3661523 | Congenital Intestinal Aganglionosis | 2 | CTD_human |
Tgene | RET | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Tgene | RET | C0031511 | Pheochromocytoma | 1 | CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | RET | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | RET | C0040136 | Thyroid Neoplasm | 1 | CGI;CTD_human |
Tgene | RET | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
Tgene | RET | C0206693 | Medullary carcinoma | 1 | CTD_human |
Tgene | RET | C0238462 | Medullary carcinoma of thyroid | 1 | CGI;CTD_human |
Tgene | RET | C0270823 | Petit mal status | 1 | CTD_human |
Tgene | RET | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
Tgene | RET | C0343640 | African Burkitt's lymphoma | 1 | CTD_human |
Tgene | RET | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
Tgene | RET | C0549473 | Thyroid carcinoma | 1 | CGI;CTD_human;UNIPROT |
Tgene | RET | C0740340 | Amyloidosis, Familial | 1 | CTD_human |
Tgene | RET | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
Tgene | RET | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
Tgene | RET | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
Tgene | RET | C1257877 | Pheochromocytoma, Extra-Adrenal | 1 | CTD_human |
Tgene | RET | C1609433 | Congenital absence of kidneys syndrome | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Tgene | RET | C3501843 | Nonmedullary Thyroid Carcinoma | 1 | CTD_human |
Tgene | RET | C3501844 | Familial Nonmedullary Thyroid Cancer | 1 | CTD_human |
Tgene | RET | C4721444 | Burkitt Leukemia | 1 | CTD_human |