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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIM27-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIM27-RET
FusionPDB ID: 94029
FusionGDB2.0 ID: 94029
HgeneTgene
Gene symbol

TRIM27

RET

Gene ID

5987

5979

Gene nametripartite motif containing 27ret proto-oncogene
SynonymsRFP|RNF76CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

6p22.1

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020032720200322
UniProtAcc

P14373

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000498117, ENST00000377194, 
ENST00000377199, ENST00000400720, 
ENST00000412687, ENST00000417660, 
ENST00000427689, ENST00000431123, 
ENST00000435528, ENST00000437160, 
ENST00000437415, ENST00000452265, 
ENST00000455861, ENST00000459807, 
ENST00000468047, ENST00000468364, 
ENST00000485666, ENST00000491158, 
ENST00000495323, 
ENST00000340058, 
ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 9 X 7=31532 X 31 X 11=10912
# samples 948
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIM27 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIM27(28887789)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM27-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM27

GO:0000122

negative regulation of transcription by RNA polymerase II

10976108

HgeneTRIM27

GO:0006469

negative regulation of protein kinase activity

22128329

HgeneTRIM27

GO:0032897

negative regulation of viral transcription

18248090

HgeneTRIM27

GO:0034314

Arp2/3 complex-mediated actin nucleation

23452853

HgeneTRIM27

GO:0042147

retrograde transport, endosome to Golgi

23452853

HgeneTRIM27

GO:0045087

innate immune response

18248090

HgeneTRIM27

GO:0045814

negative regulation of gene expression, epigenetic

10976108

HgeneTRIM27

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across TRIM27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4adenocarcinomaM16029TRIM27chr6

232335

RETchr10

43608999

ChimerDB4THCATCGA-CE-A481-01ATRIM27chr6

28887789

-RETchr10

43612032

+
ChimerDB4THCATCGA-CE-A481TRIM27chr6

28887788

-RETchr10

43612031

+
ChimerKB3..TRIM27chr6

28887788

-RETchr10

43612031

+
ChimerKB3..TRIM27chr6

28887789

-RETchr10

43612032

+
ChimerKB4..TRIM27chr6

28887788

-RETchr10

43612031

+
ChiTaRS5.0N/AM16029TRIM27chr6

28875012

-RETchr10

43608999

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000377194TRIM27chr628887788-ENST00000355710RETchr1043612031+439411032122311699
ENST00000377194TRIM27chr628887788-ENST00000340058RETchr1043612031+293611032122185657
ENST00000377199TRIM27chr628887788-ENST00000355710RETchr1043612031+439511042132312699
ENST00000377199TRIM27chr628887788-ENST00000340058RETchr1043612031+293711042132186657
ENST00000377194TRIM27chr628887789-ENST00000355710RETchr1043612032+439411032122311699
ENST00000377194TRIM27chr628887789-ENST00000340058RETchr1043612032+293611032122185657
ENST00000377199TRIM27chr628887789-ENST00000355710RETchr1043612032+439511042132312699
ENST00000377199TRIM27chr628887789-ENST00000340058RETchr1043612032+293711042132186657
ENST00000377194TRIM27chr628887789-ENST00000355710RETchr1043612032+439411032122311699
ENST00000377194TRIM27chr628887789-ENST00000340058RETchr1043612032+293611032122185657
ENST00000377199TRIM27chr628887789-ENST00000355710RETchr1043612032+439511042132312699
ENST00000377199TRIM27chr628887789-ENST00000340058RETchr1043612032+293711042132186657
ENST00000377194TRIM27chr628887788-ENST00000355710RETchr1043612031+439411032122311699
ENST00000377194TRIM27chr628887788-ENST00000340058RETchr1043612031+293611032122185657
ENST00000377199TRIM27chr628887788-ENST00000355710RETchr1043612031+439511042132312699
ENST00000377199TRIM27chr628887788-ENST00000340058RETchr1043612031+293711042132186657
ENST00000377194TRIM27chr628875012-ENST00000355710RETchr1043608999+497013022122887891
ENST00000377194TRIM27chr628875012-ENST00000340058RETchr1043608999+351213022122761849
ENST00000377199TRIM27chr628875012-ENST00000355710RETchr1043608999+497113032132888891
ENST00000377199TRIM27chr628875012-ENST00000340058RETchr1043608999+351313032132762849

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377194ENST00000355710TRIM27chr628887789-RETchr1043612032+0.00368110.99631894
ENST00000377194ENST00000340058TRIM27chr628887789-RETchr1043612032+0.0150206590.98497933
ENST00000377199ENST00000355710TRIM27chr628887789-RETchr1043612032+0.0036633060.9963367
ENST00000377199ENST00000340058TRIM27chr628887789-RETchr1043612032+0.0149645780.9850354
ENST00000377194ENST00000355710TRIM27chr628887788-RETchr1043612031+0.00368110.99631894
ENST00000377194ENST00000340058TRIM27chr628887788-RETchr1043612031+0.0150206590.98497933
ENST00000377199ENST00000355710TRIM27chr628887788-RETchr1043612031+0.0036633060.9963367
ENST00000377199ENST00000340058TRIM27chr628887788-RETchr1043612031+0.0149645780.9850354
ENST00000377194ENST00000355710TRIM27chr628875012-RETchr1043608999+0.002044760.9979552
ENST00000377194ENST00000340058TRIM27chr628875012-RETchr1043608999+0.0106237940.9893762
ENST00000377199ENST00000355710TRIM27chr628875012-RETchr1043608999+0.0020360510.997964
ENST00000377199ENST00000340058TRIM27chr628875012-RETchr1043608999+0.0105734810.9894265

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94029_94029_1_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377194_RET_chr10_43608999_ENST00000340058_length(amino acids)=849AA_BP=360
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>94029_94029_2_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377194_RET_chr10_43608999_ENST00000355710_length(amino acids)=891AA_BP=360
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>94029_94029_3_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377199_RET_chr10_43608999_ENST00000340058_length(amino acids)=849AA_BP=360
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>94029_94029_4_TRIM27-RET_TRIM27_chr6_28875012_ENST00000377199_RET_chr10_43608999_ENST00000355710_length(amino acids)=891AA_BP=360
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>94029_94029_5_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377194_RET_chr10_43612031_ENST00000340058_length(amino acids)=657AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_6_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377194_RET_chr10_43612031_ENST00000355710_length(amino acids)=699AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_7_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377199_RET_chr10_43612031_ENST00000340058_length(amino acids)=657AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_8_TRIM27-RET_TRIM27_chr6_28887788_ENST00000377199_RET_chr10_43612031_ENST00000355710_length(amino acids)=699AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_9_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377194_RET_chr10_43612032_ENST00000340058_length(amino acids)=657AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_10_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377194_RET_chr10_43612032_ENST00000355710_length(amino acids)=699AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_11_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377199_RET_chr10_43612032_ENST00000340058_length(amino acids)=657AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

>94029_94029_12_TRIM27-RET_TRIM27_chr6_28887789_ENST00000377199_RET_chr10_43612032_ENST00000355710_length(amino acids)=699AA_BP=297
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:28887789/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM27

P14373

RET

RTL1

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377194-79132_172315.3333333333333359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377194-79282_311315.3333333333333359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377199-78132_172315.3333333333333514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377199-78282_311315.3333333333333514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377194-39132_172249.0359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377199-38132_172249.0514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39132_172249.0359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38132_172249.0514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377194-7916_57315.3333333333333359.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377194-7996_127315.3333333333333359.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377199-7816_57315.3333333333333514.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377199-7896_127315.3333333333333514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377194-3916_57249.0359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377194-3996_127249.0359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377199-3816_57249.0514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377199-3896_127249.0514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-3916_57249.0359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-3996_127249.0359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-3816_57249.0514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-3896_127249.0514.0Zinc fingerB box-type
TgeneRETchr6:28875012chr10:43608999ENST00000340058819724_1016586.33333333333341073.0DomainProtein kinase
TgeneRETchr6:28875012chr10:43608999ENST00000355710820724_1016586.33333333333341115.0DomainProtein kinase
TgeneRETchr6:28887788chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr6:28887788chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr6:28887789chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr6:28887789chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr6:28875012chr10:43608999ENST00000340058819730_738586.33333333333341073.0Nucleotide bindingATP
TgeneRETchr6:28875012chr10:43608999ENST00000355710820730_738586.33333333333341115.0Nucleotide bindingATP
TgeneRETchr6:28887788chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr6:28887788chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr6:28887789chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr6:28887789chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr6:28875012chr10:43608999ENST00000340058819805_807586.33333333333341073.0RegionNote=Inhibitors binding
TgeneRETchr6:28875012chr10:43608999ENST00000355710820805_807586.33333333333341115.0RegionNote=Inhibitors binding
TgeneRETchr6:28887788chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr6:28887788chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr6:28887789chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr6:28887789chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr6:28875012chr10:43608999ENST00000340058819658_1114586.33333333333341073.0Topological domainCytoplasmic
TgeneRETchr6:28875012chr10:43608999ENST00000355710820658_1114586.33333333333341115.0Topological domainCytoplasmic
TgeneRETchr6:28875012chr10:43608999ENST00000340058819636_657586.33333333333341073.0TransmembraneHelical
TgeneRETchr6:28875012chr10:43608999ENST00000355710820636_657586.33333333333341115.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM27chr6:28875012chr10:43608999ENST00000400720-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000400720-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000412687-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000412687-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000417660-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000417660-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000427689-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000427689-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000431123-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000431123-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000435528-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000435528-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000437160-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000437160-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000452265-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000452265-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377194-39282_311249.0359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377199-38282_311249.0514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000400720-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000400720-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000412687-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000412687-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000417660-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000417660-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000427689-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000427689-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000431123-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000431123-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000435528-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000435528-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000437160-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000437160-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000452265-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887788chr10:43612031ENST00000452265-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39282_311249.0359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38282_311249.0514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18132_1720514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18282_3110514.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19132_1720359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19282_3110359.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377194-79298_492315.3333333333333359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000377199-78298_492315.3333333333333514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000400720-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000412687-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000417660-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000427689-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000431123-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000435528-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000437160-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000452265-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377194-39298_492249.0359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000377199-38298_492249.0514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000400720-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000412687-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000417660-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000427689-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000431123-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000435528-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000437160-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887788chr10:43612031ENST00000452265-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377194-39298_492249.0359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000377199-38298_492249.0514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-18298_4920514.0DomainB30.2/SPRY
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-19298_4920359.0DomainB30.2/SPRY
HgeneTRIM27chr6:28875012chr10:43608999ENST00000400720-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000400720-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000412687-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000412687-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000417660-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000417660-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000427689-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000427689-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000431123-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000431123-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000435528-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000435528-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000437160-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000437160-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000452265-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28875012chr10:43608999ENST00000452265-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000400720-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000400720-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000412687-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000412687-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000417660-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000417660-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000427689-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000427689-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000431123-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000431123-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000435528-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000435528-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000437160-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000437160-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000452265-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887788chr10:43612031ENST00000452265-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000400720-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000412687-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000417660-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000427689-1996_1270359.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000431123-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000435528-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-1816_570514.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000437160-1896_1270514.0Zinc fingerB box-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-1916_570359.0Zinc fingerRING-type
HgeneTRIM27chr6:28887789chr10:43612032ENST00000452265-1996_1270359.0Zinc fingerB box-type
TgeneRETchr6:28875012chr10:43608999ENST00000340058819168_272586.33333333333341073.0DomainCadherin
TgeneRETchr6:28875012chr10:43608999ENST00000355710820168_272586.33333333333341115.0DomainCadherin
TgeneRETchr6:28887788chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr6:28887788chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr6:28887789chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr6:28887789chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr6:28875012chr10:43608999ENST0000034005881929_635586.33333333333341073.0Topological domainExtracellular
TgeneRETchr6:28875012chr10:43608999ENST0000035571082029_635586.33333333333341115.0Topological domainExtracellular
TgeneRETchr6:28887788chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr6:28887788chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr6:28887788chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr6:28887788chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr6:28887789chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr6:28887789chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr6:28887789chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr6:28887789chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr6:28887788chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr6:28887788chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr6:28887789chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr6:28887789chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (535) >>>535.pdbFusion protein BP residue: 297
CIF file (535) >>>535.cif
TRIM27chr628887788-RETchr1043612031+
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMA
SGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVS
CPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP
LKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKR
VKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLA
RLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDP
KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS
PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK
TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRI
657
3D view using mol* of 535 (AA BP:297)
PDB file (569) >>>569.pdbFusion protein BP residue: 297
CIF file (569) >>>569.cif
TRIM27chr628887788-RETchr1043612031+
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMA
SGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVS
CPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREP
LKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKR
VKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLA
RLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQEDP
KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS
PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK
TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMS
699
3D view using mol* of 569 (AA BP:297)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM27_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM27_RET_535_pLDDT.png (AA BP:297)
all structure
TRIM27_RET_535_pLDDT_and_active_sites.png (AA BP:297)
all structure
TRIM27_RET_535_violinplot.png (AA BP:297)
all structure
TRIM27_RET_569_pLDDT.png (AA BP:297)
all structure
TRIM27_RET_569_pLDDT_and_active_sites.png (AA BP:297)
all structure
TRIM27_RET_569_violinplot.png (AA BP:297)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
TRIM27_RET_535.png
all structure
TRIM27_RET_569.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
5351.0881191.115301.1540.4110.7971.0521.3880.931.4931.153Chain A: 315,316,317,318,319,320,321,323,341,343,3
60,364,373,387,389,390,391,392,393,395,396,463,464
,466,476,477
5691.0751321.117298.0670.4430.7520.9531.4950.841.7791.218Chain A: 313,315,316,317,318,319,320,321,323,341,3
43,360,364,373,387,389,390,391,392,393,394,395,396
,399,400,463,464,466,476,477

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,
TRIM27FBF1, ZBTB16, BEGAIN, MAGEA11, DNMT1, FXYD6, MCOLN1, TRIM27, TRIM11, TRIM23, TRIM29, TRIM32, PRAM1, PML, EIF3E, MBD4, MBD2, MBD3, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2K, UBE2T, UBE2A, UBE2D4, UBE2I, UBE2L6, UBE2J1, UBE2W, UBE2Z, UBE2O, UBE2U, TAL1, GTF2F1, MED21, FBXL19, HR, HDAC1, NFYC, CHD4, PIAS1, PIAS3, PIAS2, PIAS4, UBC, ATXN7, MDM2, TP53, MAGED4B, MAGEF1, MAGEL2, RB1, EID1, UBE2E1, UBE2E3, UBE2E2, UBE2N, NOD2, DAXX, CUL4B, CUL5, IKBKE, TBK1, CHUK, IKBKB, EPC1, GFI1B, UCHL3, UCHL5, USP2, USP7, OTUB2, PIK3C2B, PIK3C2A, HCVgp1, TUBGCP4, HDAC6, RNF25, TRIM43, ARIH2, RBX1, TRIM31, UHRF2, TRIM9, TRAF5, TRIM21, BMI1, TRIM55, LATS2, ARNT2, DGCR6, EIF4E, IQCE, KIF1A, MVP, NDE1, PAX7, MYOD1, AES, BAG1, BMP7, BYSL, CKS1B, CLK2, CSRP2, DCX, DDX6, EHHADH, FHL3, FOXC2, GEM, GFAP, GRB2, ILK, KIFC3, LASP1, LMO1, MCM7, MOS, NEDD9, OAS1, CDK18, POLE2, PPID, PPL, PRKAA1, PSMA1, PSMB1, PSMB3, SDCBP, SRSF2, SIAH1, SNRPA, SNRPB2, TCEA2, TEAD4, TMSB4X, TMSB4XP6, TPM3, TUFT1, XPA, ZNF79, GPANK1, NELFE, ARHGEF5, NCK2, STK16, EIF3D, CDC23, RAB29, MTMR6, EIF4E2, BAG5, POLR1C, SPATA2, JOSD1, NR1D2, SORBS3, TXNDC9, MAD2L2, STK25, KAT5, NEBL, POLR3C, FARS2, NEK6, MID2, NUDT21, MAPKBP1, PTPN23, PRPF31, FOXB1, INPP5J, MAT2B, BABAM1, NME7, ARHGEF3, TPRKB, MEMO1, VPS28, CDKL3, SLC15A3, WT1-AS, AMOTL2, ZNF581, FBXW5, FAM64A, CCHCR1, FAM193B, KCTD9, CHCHD3, WDYHV1, RBM23, C14orf105, CCDC87, RBM41, ABCF3, TBC1D22B, ZNF446, CCDC94, RCOR3, USE1, FAM214A, LGALS14, CSRP2BP, GATAD2B, STAMBPL1, TSHZ3, RNF213, FANCM, ZNF250, DMRT3, SH2D4A, KIF9, AEN, MRPL40, SCNM1, C20orf195, ZFYVE21, LENG1, ARMC7, ZC2HC1C, CCDC102B, CCDC92, FAM214B, KIAA1683, NDEL1, PUS7L, FAM110A, FAM103A1, DTNBP1, PLEKHN1, SPATC1L, TCHP, UTP23, VPS25, GFM2, ZGPAT, BEX2, LINGO1, FAM83A, ATPAF2, RHPN1, PTPMT1, HAUS1, ZMYND19, GLYCTK, GNPDA2, ZNF572, SIRPA, CWF19L2, LINC00526, ZNF417, IQUB, RIBC1, CDC20B, PPP1R18, ZFC3H1, CPNE2, NEIL2, TTLL10, TSGA10IP, KANSL1, FAM126B, TRIM42, ARPIN, MIA3, NOTCH2NL, FLJ38668, BEND7, IDI2, SURF2, ZNF219, FAM170A, RAB11B, ZNF621, FOXD4L6, ARHGAP25, IER2, CEP162, LCA5, RPGRIP1L, ILF2, STK26, C1orf109, UBL5, NIF3L1, ABHD17A, KPNA1, RNF2, TCF20, TSNAX, USP11, CEP135, HMG20A, TINF2, RACGAP1, BCOR, SLAIN2, TCEAL4, ELMSAN1, C10orf2, Cd2ap, Nedd1, Ranbp2, Ring1, Cdc23, Mad2l1, Tmed2, Mllt1, Pcgf1, Taf15, Prkaa1, Gpkow, Cep135, GLI1, BAG6, RIPK1, LGALS3BP, GLTSCR2, IKZF5, MAP7D2, ZNF764, POTEB3, C1orf106, KRBA1, ZNF785, SMARCB1, PRE5, HYM1, PRP4, LSM2, PRP45, YPL077C, BIT61, VID24, SNF1, GCD7, APP1, SQT1, SMP1, BTN2, TRX3, STI1, RRD1, LNX1, TNIP2, REL, ZNF384, USP15, RNF6, RXRB, AXIN1, HGS, AMMECR1, FAM126A, HNRNPLL, ZNF688, ESR2, NEK2, BRCA1, ATG16L1, PPP1CC, BRF1, HIST1H4A, TCF7L2, GSE1, HOXC8, SMARCD1, HDAC4, GPKOW, AP1M1, VPS9D1, TRAF4, THOC1, PIBF1, NCOA1, P2RX7, CDC7, CARD10, RSPH14, HCK, SYT17, SMG9, MAGOHB, INO80B, GRB14, EXOC8, HOXB5, PKN1, ENKD1, PIN1, HIP1R, CAPN7, TNS4, HAPLN2, ZNF414, SYT6, COX5B, VEZF1, TACO1, DTNB, ZFHX3, EIF4A3, CBX8, LMO4, CREB5, TRIM50, BAG3, LONRF1, GNE, UBASH3A, DBF4B, IP6K3, PRR35, ERCC3, IGFN1, PRPF18, CNNM3, FAM161A, KRT75, HOXB9, FAM90A1, QARS, IL16, RIN1, CATSPER1, LMNB2, ACSF3, TCEANC, CCDC185, CPNE7, GADD45GIP1, KRT76, TEX33, KRT3, POM121, ARID5A, LAGE3, SYNGAP1, ZNF587, MSRB1, ZNF580, C6orf165, FASTKD5, UTP14C, MGC50722, MYO15B, GAS2L2, PLEKHA4, PTEN, FYN, nsp12, ESR1, LZTS2, KIAA0355, TNRC6B, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, BRPF3, AIM2, ARHGAP22, NPC1, nsp14, nsp16, DNAJC7, FAM184A, ADNP, OGT, TRIM37, SIX3, PPARG, CDKN1A, PAK1, ARHGAP15, IFI27, MECOM, LHPP, BCCIP, FAM46C, SHANK3, EVA1B, KXD1, TFPT, TGIF2LY, DISC1, NPIPB6, MAP7, ZNF74, GMNN, SYCE2, DHX40, SKOR1, GLI4, ZSCAN29, RGPD1, CBX6, ABT1, ZNF423, NFKBIL1, SIRT6, BCL7C, NT5DC2, MAP3K7, TAB2, TAB3, NFKBIA, RB1CC1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIM27all structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRIM27-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIM27-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TRIM27RETLung AdenocarcinomaMyCancerGenome
TRIM27RETBreast Invasive Ductal CarcinomaMyCancerGenome
TRIM27RETThyroid Gland Papillary CarcinomaMyCancerGenome
TRIM27RETAdenocarcinoma Of Unknown PrimaryMyCancerGenome
TRIM27RETBladder Urothelial CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM27C0238463Papillary thyroid carcinoma2ORPHANET
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human