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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BCL3-GRIK4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BCL3-GRIK4
FusionPDB ID: 9406
FusionGDB2.0 ID: 9406
HgeneTgene
Gene symbol

BCL3

GRIK4

Gene ID

602

2900

Gene nameBCL3 transcription coactivatorglutamate ionotropic receptor kainate type subunit 4
SynonymsBCL4|D19S37EAA1|GRIK|GluK4|KA1
Cytomap

19q13.32

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma 3 proteinB cell CLL/lymphoma 3B-cell leukemia/lymphoma 3B-cell lymphoma 3-encoded proteinBCL-3chronic lymphatic leukemia proteinproto-oncogene BCL3glutamate receptor ionotropic, kainate 4excitatory amino acid receptor 1glutamate receptor KA1glutamate receptor, ionotropic, kainate 4
Modification date2020031320200320
UniProtAcc

P20749

Q16099

Ensembl transtripts involved in fusion geneENST idsENST00000164227, ENST00000487394, 
ENST00000527130, ENST00000438375, 
ENST00000527524, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 6=4327 X 11 X 6=462
# samples 910
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/462*10)=-2.20789285164133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BCL3 [Title/Abstract] AND GRIK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BCL3(45252303)-GRIK4(120686087), # samples:2
GRIK4(120686167)-BCL3(45260979), # samples:1
Anticipated loss of major functional domain due to fusion event.BCL3-GRIK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL3-GRIK4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL3-GRIK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL3-GRIK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL3-GRIK4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BCL3-GRIK4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL3

GO:0006351

transcription, DNA-templated

16306601

HgeneBCL3

GO:0006974

cellular response to DNA damage stimulus

16384933

HgeneBCL3

GO:0007249

I-kappaB kinase/NF-kappaB signaling

8196632

HgeneBCL3

GO:0009615

response to virus

16306601

HgeneBCL3

GO:0010225

response to UV-C

16384933

HgeneBCL3

GO:0042981

regulation of apoptotic process

16732314

HgeneBCL3

GO:0043066

negative regulation of apoptotic process

16384933

HgeneBCL3

GO:0045892

negative regulation of transcription, DNA-templated

16306601

HgeneBCL3

GO:0045893

positive regulation of transcription, DNA-templated

16384933


check buttonFusion gene breakpoints across BCL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-JX-A5QV-01ABCL3chr19

45252303

+GRIK4chr11

120686087

+
ChimerDB4CESCTCGA-JX-A5QV-01ABCL3chr19

45261670

+GRIK4chr11

120686087

+
ChimerDB4CESCTCGA-JX-A5QVBCL3chr19

45252303

+GRIK4chr11

120686086

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000164227BCL3chr1945252303+ENST00000527524GRIK4chr11120686087+57685006431231019
ENST00000164227BCL3chr1945252303+ENST00000438375GRIK4chr11120686087+41255006431231019
ENST00000164227BCL3chr1945252303+ENST00000527524GRIK4chr11120686086+57685006431231019
ENST00000164227BCL3chr1945252303+ENST00000438375GRIK4chr11120686086+41255006431231019

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000164227ENST00000527524BCL3chr1945252303+GRIK4chr11120686087+0.0007280990.9992719
ENST00000164227ENST00000438375BCL3chr1945252303+GRIK4chr11120686087+0.0014968470.9985032
ENST00000164227ENST00000527524BCL3chr1945252303+GRIK4chr11120686086+0.0007280990.9992719
ENST00000164227ENST00000438375BCL3chr1945252303+GRIK4chr11120686086+0.0014968470.9985032

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9406_9406_1_BCL3-GRIK4_BCL3_chr19_45252303_ENST00000164227_GRIK4_chr11_120686086_ENST00000438375_length(amino acids)=1019AA_BP=145
MGRTGGPGGAGGGEAGGRHRPGRQKSLQFSRLQGKSRRPAKPPSRAAEPSRSPAAVPGGPMPRCPAGAMDEGPVDLRTRPKAAGLPGAAL
PLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPVCQILPKGVVAVLGPSSSPASSSIISNICGEKEVP
HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEI
RDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVP
FTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFR
QIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE
ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR
LTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVD
DLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTK
GYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEAT
EVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRR

--------------------------------------------------------------

>9406_9406_2_BCL3-GRIK4_BCL3_chr19_45252303_ENST00000164227_GRIK4_chr11_120686086_ENST00000527524_length(amino acids)=1019AA_BP=145
MGRTGGPGGAGGGEAGGRHRPGRQKSLQFSRLQGKSRRPAKPPSRAAEPSRSPAAVPGGPMPRCPAGAMDEGPVDLRTRPKAAGLPGAAL
PLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPVCQILPKGVVAVLGPSSSPASSSIISNICGEKEVP
HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEI
RDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVP
FTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFR
QIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE
ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR
LTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVD
DLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTK
GYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEAT
EVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRR

--------------------------------------------------------------

>9406_9406_3_BCL3-GRIK4_BCL3_chr19_45252303_ENST00000164227_GRIK4_chr11_120686087_ENST00000438375_length(amino acids)=1019AA_BP=145
MGRTGGPGGAGGGEAGGRHRPGRQKSLQFSRLQGKSRRPAKPPSRAAEPSRSPAAVPGGPMPRCPAGAMDEGPVDLRTRPKAAGLPGAAL
PLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPVCQILPKGVVAVLGPSSSPASSSIISNICGEKEVP
HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEI
RDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVP
FTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFR
QIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE
ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR
LTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVD
DLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTK
GYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEAT
EVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRR

--------------------------------------------------------------

>9406_9406_4_BCL3-GRIK4_BCL3_chr19_45252303_ENST00000164227_GRIK4_chr11_120686087_ENST00000527524_length(amino acids)=1019AA_BP=145
MGRTGGPGGAGGGEAGGRHRPGRQKSLQFSRLQGKSRRPAKPPSRAAEPSRSPAAVPGGPMPRCPAGAMDEGPVDLRTRPKAAGLPGAAL
PLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPVCQILPKGVVAVLGPSSSPASSSIISNICGEKEVP
HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEI
RDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVP
FTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFR
QIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE
ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR
LTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVD
DLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTK
GYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEAT
EVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45252303/chr11:120686087)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL3

P20749

GRIK4

Q16099

FUNCTION: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}.FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220862_86582.33333333333333957.0Compositional biasNote=Poly-Arg
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321862_86582.33333333333333957.0Compositional biasNote=Poly-Arg
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220862_86582.33333333333333957.0Compositional biasNote=Poly-Arg
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321862_86582.33333333333333957.0Compositional biasNote=Poly-Arg
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220567_62382.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220645_80482.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220826_95682.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321567_62382.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321645_80482.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321826_95682.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220567_62382.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220645_80482.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220826_95682.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321567_62382.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321645_80482.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321826_95682.33333333333333957.0Topological domainCytoplasmic
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220546_56682.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220624_64482.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686086ENST00000438375220805_82582.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321546_56682.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321624_64482.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686086ENST00000527524321805_82582.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220546_56682.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220624_64482.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000438375220805_82582.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321546_56682.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321624_64482.33333333333333957.0TransmembraneHelical
TgeneGRIK4chr19:45252303chr11:120686087ENST00000527524321805_82582.33333333333333957.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19365_45485.33333333333333455.0Compositional biasNote=Pro/Ser-rich
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+199_12085.33333333333333455.0Compositional biasNote=Pro-rich
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19365_45485.33333333333333455.0Compositional biasNote=Pro/Ser-rich
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+199_12085.33333333333333455.0Compositional biasNote=Pro-rich
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19134_16385.33333333333333455.0RepeatNote=ANK 1
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19171_20085.33333333333333455.0RepeatNote=ANK 2
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19204_23585.33333333333333455.0RepeatNote=ANK 3
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19241_27085.33333333333333455.0RepeatNote=ANK 4
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19275_30485.33333333333333455.0RepeatNote=ANK 5
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19308_33785.33333333333333455.0RepeatNote=ANK 6
HgeneBCL3chr19:45252303chr11:120686086ENST00000164227+19338_36785.33333333333333455.0RepeatNote=ANK 7
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19134_16385.33333333333333455.0RepeatNote=ANK 1
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19171_20085.33333333333333455.0RepeatNote=ANK 2
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19204_23585.33333333333333455.0RepeatNote=ANK 3
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19241_27085.33333333333333455.0RepeatNote=ANK 4
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19275_30485.33333333333333455.0RepeatNote=ANK 5
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19308_33785.33333333333333455.0RepeatNote=ANK 6
HgeneBCL3chr19:45252303chr11:120686087ENST00000164227+19338_36785.33333333333333455.0RepeatNote=ANK 7
TgeneGRIK4chr19:45252303chr11:120686086ENST0000043837522021_54582.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686086ENST0000052752432121_54582.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686087ENST0000043837522021_54582.33333333333333957.0Topological domainExtracellular
TgeneGRIK4chr19:45252303chr11:120686087ENST0000052752432121_54582.33333333333333957.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BCL3
GRIK4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BCL3-GRIK4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BCL3-GRIK4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource