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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIM33-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIM33-RET
FusionPDB ID: 94080
FusionGDB2.0 ID: 94080
HgeneTgene
Gene symbol

TRIM33

RET

Gene ID

51592

5979

Gene nametripartite motif containing 33ret proto-oncogene
SynonymsECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMACDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

1p13.2

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gammaproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc

Q9UPN9

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000358465, ENST00000369543, 
ENST00000450349, ENST00000476908, 
ENST00000340058, ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 18 X 10=306032 X 31 X 11=10912
# samples 2148
** MAII scorelog2(21/3060*10)=-3.86507041991389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIM33 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIM33(114964058)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM33

GO:0016567

protein ubiquitination

19135894

HgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

HgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across TRIM33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6543-01ATRIM33chr1

114964058

-RETchr10

43612032

+
ChimerDB4LUADTCGA-55-6543TRIM33chr1

114964057

-RETchr10

43612031

+
ChimerKB3..TRIM33chr1

114944010

-RETchr10

43609927

+
ChimerKB3..TRIM33chr1

114945381

-RETchr10

43612031

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358465TRIM33chr1114945381-ENST00000355710RETchr1043612031+62672976041841394
ENST00000358465TRIM33chr1114945381-ENST00000340058RETchr1043612031+48092976040581352
ENST00000369543TRIM33chr1114945381-ENST00000355710RETchr1043612031+62672976041841394
ENST00000369543TRIM33chr1114945381-ENST00000340058RETchr1043612031+48092976040581352
ENST00000358465TRIM33chr1114964058-ENST00000355710RETchr1043612032+54362145033531117
ENST00000358465TRIM33chr1114964058-ENST00000340058RETchr1043612032+39782145032271075
ENST00000369543TRIM33chr1114964058-ENST00000355710RETchr1043612032+54362145033531117
ENST00000369543TRIM33chr1114964058-ENST00000340058RETchr1043612032+39782145032271075
ENST00000358465TRIM33chr1114964057-ENST00000355710RETchr1043612031+54362145033531117
ENST00000358465TRIM33chr1114964057-ENST00000340058RETchr1043612031+39782145032271075
ENST00000369543TRIM33chr1114964057-ENST00000355710RETchr1043612031+54362145033531117
ENST00000369543TRIM33chr1114964057-ENST00000340058RETchr1043612031+39782145032271075

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358465ENST00000355710TRIM33chr1114964058-RETchr1043612032+0.0007377930.99926215
ENST00000358465ENST00000340058TRIM33chr1114964058-RETchr1043612032+0.0033106510.9966893
ENST00000369543ENST00000355710TRIM33chr1114964058-RETchr1043612032+0.0007377930.99926215
ENST00000369543ENST00000340058TRIM33chr1114964058-RETchr1043612032+0.0033106510.9966893
ENST00000358465ENST00000355710TRIM33chr1114964057-RETchr1043612031+0.0007377930.99926215
ENST00000358465ENST00000340058TRIM33chr1114964057-RETchr1043612031+0.0033106510.9966893
ENST00000369543ENST00000355710TRIM33chr1114964057-RETchr1043612031+0.0007377930.99926215
ENST00000369543ENST00000340058TRIM33chr1114964057-RETchr1043612031+0.0033106510.9966893

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94080_94080_1_TRIM33-RET_TRIM33_chr1_114945381_ENST00000358465_RET_chr10_43612031_ENST00000340058_length(amino acids)=1352AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QREDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT

--------------------------------------------------------------

>94080_94080_2_TRIM33-RET_TRIM33_chr1_114945381_ENST00000358465_RET_chr10_43612031_ENST00000355710_length(amino acids)=1394AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QREDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP

--------------------------------------------------------------

>94080_94080_3_TRIM33-RET_TRIM33_chr1_114945381_ENST00000369543_RET_chr10_43612031_ENST00000340058_length(amino acids)=1352AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QREDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT

--------------------------------------------------------------

>94080_94080_4_TRIM33-RET_TRIM33_chr1_114945381_ENST00000369543_RET_chr10_43612031_ENST00000355710_length(amino acids)=1394AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QREDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL
LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI
SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEM
YRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP

--------------------------------------------------------------

>94080_94080_5_TRIM33-RET_TRIM33_chr1_114964057_ENST00000358465_RET_chr10_43612031_ENST00000340058_length(amino acids)=1075AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

>94080_94080_6_TRIM33-RET_TRIM33_chr1_114964057_ENST00000358465_RET_chr10_43612031_ENST00000355710_length(amino acids)=1117AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------

>94080_94080_7_TRIM33-RET_TRIM33_chr1_114964057_ENST00000369543_RET_chr10_43612031_ENST00000340058_length(amino acids)=1075AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

>94080_94080_8_TRIM33-RET_TRIM33_chr1_114964057_ENST00000369543_RET_chr10_43612031_ENST00000355710_length(amino acids)=1117AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------

>94080_94080_9_TRIM33-RET_TRIM33_chr1_114964058_ENST00000358465_RET_chr10_43612032_ENST00000340058_length(amino acids)=1075AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

>94080_94080_10_TRIM33-RET_TRIM33_chr1_114964058_ENST00000358465_RET_chr10_43612032_ENST00000355710_length(amino acids)=1117AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------

>94080_94080_11_TRIM33-RET_TRIM33_chr1_114964058_ENST00000369543_RET_chr10_43612032_ENST00000340058_length(amino acids)=1075AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

>94080_94080_12_TRIM33-RET_TRIM33_chr1_114964058_ENST00000369543_RET_chr10_43612032_ENST00000355710_length(amino acids)=1117AA_BP=715
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114964058/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM33

Q9UPN9

RET

RTL1

FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120299_401687.01128.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119299_401687.01111.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120299_401687.01128.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119299_401687.01111.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-112013_18687.01128.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-112044_49687.01128.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120545_550687.01128.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-111913_18687.01111.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-111944_49687.01111.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119545_550687.01111.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112013_18687.01128.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112044_49687.01128.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120545_550687.01128.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111913_18687.01111.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111944_49687.01111.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119545_550687.01111.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-11201_147687.01128.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-11191_147687.01111.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-11201_147687.01128.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-11191_147687.01111.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120125_154687.01128.0Zinc fingerRING-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120212_259687.01128.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120271_312687.01128.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119125_154687.01111.0Zinc fingerRING-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119212_259687.01111.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119271_312687.01111.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120125_154687.01128.0Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120212_259687.01128.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120271_312687.01128.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119125_154687.01111.0Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119212_259687.01111.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119271_312687.01111.0Zinc fingerB box-type 2
TgeneRETchr1:114964057chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr1:114964057chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr1:114964057chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr1:114964057chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr1:114964057chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr1:114964057chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr1:114964058chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr1:114964058chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120974_1046687.01128.0DomainBromo
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119974_1046687.01111.0DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120974_1046687.01128.0DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119974_1046687.01111.0DomainBromo
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120887_934687.01128.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119887_934687.01111.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120887_934687.01128.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119887_934687.01111.0Zinc fingerPHD-type
TgeneRETchr1:114964057chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr1:114964057chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr1:114964057chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr1:114964057chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr1:114964057chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr1:114964057chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr1:114964057chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr1:114964057chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr1:114964058chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr1:114964058chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (895)CIF file (895) >>>895.cifTRIM33chr1114945381-RETchr1043612031+
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPV
TAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASS
GSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLL
DTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGD
IQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCED
NASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQR
PVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGA
IENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINE
INKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVN
LGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQ
VYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISV
QTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHS
NPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVT
NPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQ
VKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNL
HLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP
SGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQREDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR
DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR
KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAI
ESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM
ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFT
1352
3D view using mol* of 895 (AA BP:)
PDB file (907)CIF file (907) >>>907.cifTRIM33chr1114945381-RETchr1043612031+
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPV
TAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASS
GSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLL
DTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGD
IQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCED
NASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQR
PVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGA
IENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINE
INKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVN
LGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQ
VYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISV
QTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHS
NPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVT
NPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQ
VKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNL
HLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP
SGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQREDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR
DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR
KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAI
ESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM
ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWP
1394
3D view using mol* of 907 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM33_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM33_RET_895_pLDDT_and_active_sites.png (AA BP:)
all structure
TRIM33_RET_895_violinplot.png (AA BP:)
all structure
TRIM33_RET_907_pLDDT_and_active_sites.png (AA BP:)
all structure
TRIM33_RET_907_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
8951.081161.118290.5210.4770.7670.9841.4030.8661.6211.467Chain A: 1010,1011,1012,1013,1014,1015,1016,1018,1
036,1038,1055,1059,1068,1082,1084,1085,1086,1087,1
088,1090,1091,1094,1158,1159,1161,1171,1172
9071.0731331.109363.2370.50.7641.0241.2110.8891.3631.172Chain A: 1010,1011,1012,1013,1014,1015,1016,1017,1
018,1036,1038,1055,1059,1068,1082,1084,1085,1086,1
087,1088,1090,1091,1154,1158,1159,1161,1171,1172,1
173,1175,1187,1191,1192,1193,1194

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
895ZINC000003938686DB09073Palbociclib-7.5107-7.9176
895AsciminibDB09073-7.38856-7.85356
895ZINC000253632968DB06290Simeprevir-7.60114-7.60774
895ZINC000001530886DB00966Telmisartan-5.40141-7.55821
895ZINC000019418959DB00831Trifluoperazine-7.26891-7.54901
895ZINC000001995484DB01610Valganciclovir-7.25025-7.46355
895ZINC000001543475DB14126Tenofovir-7.17426-7.45086
895ZINC000000006300DB00962Zaleplon-7.3931-7.3931
895ZINC000003787097DB06771Besifloxacin-7.24121-7.30721
895ZINC000000020220DB00537Ciprofloxacin-7.18263-7.28243
895ZINC000019203912DB00623Fluphenazine-6.92827-7.26447
895ZINC000000897089DB00358Mefloquine-7.14111-7.14361
895ZINC000084668739DB11611Lifitegrast-7.09415-7.09415
895UpadacitinibDB11611-7.06692-7.06792
895ZINC000000896543DB01195Flecainide-7.06553-7.06553
895ZINC000019632618DB00619Imatinib-6.30862-7.06332
895ZINC000043100953DB09042Tedizolid phosphate-6.97366-7.05866
895ZINC000001530697DB00679Thioridazine-7.04066-7.04106
895ZINC000000009073DB00714Apomorphine-6.93049-6.97439
895ZINC000000137884DB00649Stavudine-6.96836-6.96976

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000003938686DB09073PalbociclibSmall moleculeCC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=OApproved|Investigational
ZINC000253632968DB06290SimeprevirSmall molecule[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1Approved
ZINC000001530886DB00966TelmisartanSmall moleculeCCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=OApproved|Investigational
ZINC000019418959DB00831TrifluoperazineSmall moleculeCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1Approved|Investigational
ZINC000001543475DB14126TenofovirSmall moleculeC[C@H](CN1C=NC2=C1N=CN=C2N)OCP(O)(O)=OExperimental|Investigational
ZINC000000006300DB00962ZaleplonSmall moleculeCCN(C(C)=O)C1=CC=CC(=C1)C1=CC=NC2=C(C=NN12)C#NApproved|Illicit|Investigational
ZINC000003787097DB06771BesifloxacinSmall moleculeN[C@@H]1CCCCN(C1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1Cl)C(O)=OApproved
ZINC000000020220DB00537CiprofloxacinSmall moleculeOC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=OApproved|Investigational
ZINC000019203912DB00623FluphenazineSmall moleculeOCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1Approved
ZINC000084668739DB11611LifitegrastSmall moleculeCS(=O)(=O)C1=CC(C[C@H](NC(=O)C2=C(Cl)C3=C(CN(CC3)C(=O)C3=CC=C4C=COC4=C3)C=C2Cl)C(O)=O)=CC=C1Approved
ZINC000000896543DB01195FlecainideSmall moleculeFC(F)(F)COC1=CC(C(=O)NCC2CCCCN2)=C(OCC(F)(F)F)C=C1Approved|Withdrawn
ZINC000019632618DB00619ImatinibSmall moleculeCN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1Approved
ZINC000043100953DB09042Tedizolid phosphateSmall moleculeCN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=OApproved
ZINC000000009073DB00714ApomorphineSmall molecule[H][C@]12CC3=C(C(O)=C(O)C=C3)C3=CC=CC(CCN1C)=C23Approved|Investigational
ZINC000000137884DB00649StavudineSmall moleculeCC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=OApproved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000003938686447.5398.82766.315477.598137.176151.54101402.5882118.081376.62700
ZINC000003938686447.5398.648773.964490.638134.585148.74101410.0512118.181377.38600
ZINC000003938686447.5399.527761.155473.791137.885149.47801397.3732118.061376.300
ZINC000253632968749.9396.9571148.652820.732134.162154.91538.8422228.6291.2513.758.419162.52532
ZINC000253632968749.93911.1351103.653772.655146.278144.58240.1382184.3831.2513.758.499157.80432
ZINC000253632968749.9399.2981114.226794.485125.878154.69239.172200.51.2513.758.41163.80632
ZINC000253632968749.9398.171081.392774.076143.601146.31117.4042179.1541.2513.758.604161.00632
ZINC000001530886514.6267.48850.985294.329111.948444.70901601.819158.498186.97921
ZINC000001530886514.6263.392898.781323.212100.491475.07801648.918158.623191.31421
ZINC000001530886514.6266.83830.587285.837116.397428.35301580.24158.44185.14421
ZINC000001530886514.6268.764825.335324.05451.458449.82301592.388158.537110021
ZINC000019418959407.4963.166685.963284.0386.797242.502152.6261250.66904.58.057392.21310
ZINC000019418959407.4962.336654.93278.08511.45232.074133.3211198.50904.58.184310000
ZINC000019418959407.4963.508684.003297.47.942225.738152.9231221.05604.58.132310000
ZINC000001995484354.3659.631568.054246.752278.13743.16601064.885611.98.54215.89521
ZINC000001995484354.36511.53614.893262.115314.10338.67501087.654611.98.4541021
ZINC000001543475287.2148.348504.272135.683258.29105.9154.383848.06410.78.314131.42801
ZINC000001543475287.2148.376485.449129.583251.84599.7254.296831.981410.78.324132.55201
ZINC000000006300305.3387.755592.047183.731150.968257.34801021.54206.59.379384.51300
ZINC000003787097393.8454.658626.791306.654201.43960.43658.2621137.68725.58.886248.67901
ZINC000003787097393.8458.875614.969305.177195.95359.53854.3011129.72125.59.012249.49601
ZINC000000020220331.3468.67578.412299.833178.53968.48731.5531017.371168.925248.3301
ZINC000000020220331.3468.111575.511298.04176.66769.24631.5581012.813168.79248.64801
ZINC000019203912437.5221.866667.705280.39337.632229.684119.9961257.68116.28.126395.4401
ZINC000019203912437.5223.481669.797259.98957.21232.5120.0981250.57516.28.155391.65701
ZINC000019203912437.5223.695710.047257.01859.375274.093119.5611303.38216.28.086392.08701
ZINC000000897089378.3177.024589.936192.76554.441122.198220.5321034.58724.29.632310000
ZINC000084668739615.48413.795897.582209.576215.175373.77199.061665.0091.2511.259.285166.22612
ZINC000000896543414.3476.232700.531313.39139.1495.239252.7631202.487249.04310001
ZINC000019632618493.617.136910.98331.716108.169471.09401624.49210.58.418279.901
ZINC000019632618493.615.838905.381330.366105.96469.05501622.541210.58.399280.30201
ZINC000019632618493.614.324915.779339.063103.299473.41701628.421210.58.414281.06801
ZINC000043100953450.3228.428720.625174.492308.419199.97437.7411252.9792139.192117.34511
ZINC000043100953450.3228.806708.392174.655291.009204.37638.3521241.0022139.026120.70611
ZINC000001530697370.571.897689.826351.7844.029263.06670.9461232.378037.845310011
ZINC000001530697370.572.15660.267308.5816.715269.02375.9471206.162037.963310011
ZINC000000009073267.3272.782497.054198.41689.209209.4290864.1823.58.732385.24200
ZINC000000009073267.3273.056495.924195.69289.933210.30861.91423.58.758385.01500
ZINC000000009073267.3272.7496.286197.17288.825210.2890858.90623.58.722385.13100
ZINC000000137884224.2167.279414.925165.009163.54486.3710698.28826.99.342370.13900


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000003938686CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O0.1541407730.105977064
ZINC000253632968COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C0.0148452150.273382605
ZINC000001530886CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc10.2177627810.303280041
ZINC000019418959CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC10.2588259950.284976043
ZINC000001995484CC(C)[C@H](N)C(=O)OC[C@H](CO)OCn1cnc2c(=O)[nH]c(N)nc210.0662231610.39718523
ZINC000001543475C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O0.0923712960.318784803
ZINC000000006300CCN(C(C)=O)c1cccc(-c2ccnc3c(C#N)cnn23)c10.205370370.301287055
ZINC000003787097N[C@@H]1CCCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C10.1258950860.168671155
ZINC000000020220O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O0.2310316290.323908212
ZINC000019203912OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC10.2416067250.269532671
ZINC000000897089O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000084668739CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3c(c2Cl)CCN(C(=O)c2ccc4ccoc4c2)C3)C(=O)O)c10.0976790350.229936056
ZINC000000896543O=C(NC[C@H]1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F0.1344937580.265746877
ZINC000019632618Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n10.2640386550.265356679
ZINC000043100953Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n10.0928451070.135775423
ZINC000001530697CSc1ccc2c(c1)N(CC[C@H]1CCCCN1C)c1ccccc1S20.1432805140.391555547
ZINC000000009073CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-30.1403815320.423432224
ZINC000000137884Cc1cn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]c1=O0.075621740.490280424


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,
TRIM33NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, Trim24, Nfe2l2, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25, MAPK6, TRIM28, UBE2D2, ESR2, EZH2, CYLD, TP53BP1, BRCA1, MDC1, KIAA1429, MYC, RPS6KA6, PLEKHA4, ESR1, IMMP1L, THOC1, BRD1, SP100, VCP, PNMA2, NID2, ERC1, KPNA6, BCKDHB, BCKDHA, KPNA1, SKIV2L, KIAA1551, CALU, TTC37, DBT, PNMA1, RCN1, GNB2L1, RCN2, FBN2, NIN, PEX5, DNAJC10, ANGEL1, DCAF7, ASS1, AOX1, TRAF2, ADCK3, UNC80, CHAMP1, GCDH, FAM53C, NT5DC2, SKI, FHL3, MLKL, LRP2, PELO, BAG2, TMX3, EDEM3, HDAC6, UACA, GPX1, NELL2, BTBD18, SDF4, CAV1, ZNF43, TRIM4, GFOD1, POLR2C, KDM5C, SLFN11, PJA2, SCO2, ZFP82, CHEK1, PER1, SAT1, DGKE, TIMM50, POGZ, ANKRD28, TUBG1, RNF31, GGCX, EGFR, BRD4, CEP78, SUMO2, PDIA4, SOD1, DPP7, CALM1, TPM3, LCE3D, TRIM37, ASF1A, CBX3, NUP50, TERF2IP, Pias1, THRSP, ZNF484, TRIM52, HSPB2, ZNF776, KRT37, PYCRL, ZNF418, TGM7, CCT8L2, KRT39, MAGEA9, NUP62, MAD2L1, ZNF460, CRYAA, SHARPIN, KRT38, SSSCA1, FOXF2, ZNF333, ZNF747, SOHLH1, HSPA8, ZNF44, LOXL4, KCTD17, ZNF764, C12orf74, ELF4, ELF5, FOS, HNF4A, KLF8, LHX4, MYOD1, SOX17, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIM33all structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRIM33-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIM33-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
TRIM33RETLung AdenocarcinomaMyCancerGenome
TRIM33RETBreast Invasive Ductal CarcinomaMyCancerGenome
TRIM33RETThyroid Gland Papillary CarcinomaMyCancerGenome
TRIM33RETAdenocarcinoma Of Unknown PrimaryMyCancerGenome
TRIM33RETBladder Urothelial CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM33C0238463Papillary thyroid carcinoma2ORPHANET
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human