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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIT1-ABCA10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIT1-ABCA10
FusionPDB ID: 94265
FusionGDB2.0 ID: 94265
HgeneTgene
Gene symbol

TRIT1

ABCA10

Gene ID

54802

10349

Gene nametRNA isopentenyltransferase 1ATP binding cassette subfamily A member 10
SynonymsCOXPD35|GRO1|IPPT|IPT|IPTase|MOD5|hGRO1EST698739
Cytomap

1p34.2

17q24.3

Type of geneprotein-codingprotein-coding
DescriptiontRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferaseATP-binding cassette sub-family A member 10ATP-binding cassette A10ATP-binding cassette, sub-family A (ABC1), member 10
Modification date2020031320200313
UniProtAcc.

Q8WWZ4

Ensembl transtripts involved in fusion geneENST idsENST00000316891, ENST00000372818, 
ENST00000441669, ENST00000544981, 
ENST00000491865, ENST00000537223, 
ENST00000537440, ENST00000541099, 
ENST00000545233, 		ENST00000423818, 
ENST00000519732, ENST00000269081, 
ENST00000416101, ENST00000432313, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 2 X 4=565 X 5 X 4=100
# samples 65
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIT1 [Title/Abstract] AND ABCA10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIT1(40348990)-ABCA10(67193263), # samples:1
Anticipated loss of major functional domain due to fusion event.TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TRIT1-ABCA10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCA10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-PD-A5DF-01ATRIT1chr1

40348990

-ABCA10chr17

67193263

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441669TRIT1chr140348990-ENST00000416101ABCA10chr1767193263-427517432934541041
ENST00000316891TRIT1chr140348990-ENST00000416101ABCA10chr1767193263-429018934434691041
ENST00000372818TRIT1chr140348990-ENST00000416101ABCA10chr1767193263-429018934434691041
ENST00000544981TRIT1chr140348990-ENST00000416101ABCA10chr1767193263-428818734234671041

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441669ENST00000416101TRIT1chr140348990-ABCA10chr1767193263-0.0002825320.9997174
ENST00000316891ENST00000416101TRIT1chr140348990-ABCA10chr1767193263-0.0002951950.9997048
ENST00000372818ENST00000416101TRIT1chr140348990-ABCA10chr1767193263-0.0002951950.9997048
ENST00000544981ENST00000416101TRIT1chr140348990-ABCA10chr1767193263-0.0002902280.9997098

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94265_94265_1_TRIT1-ABCA10_TRIT1_chr1_40348990_ENST00000316891_ABCA10_chr17_67193263_ENST00000416101_length(amino acids)=1041AA_BP=729
MFLQKVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADIL
ADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ
GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERR
ALLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRNGSD
DPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGM
SSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWR
KNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFV
IRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAI
RNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLG
KEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSE
AEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEA

--------------------------------------------------------------

>94265_94265_2_TRIT1-ABCA10_TRIT1_chr1_40348990_ENST00000372818_ABCA10_chr17_67193263_ENST00000416101_length(amino acids)=1041AA_BP=729
MFLQKVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADIL
ADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ
GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERR
ALLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRNGSD
DPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGM
SSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWR
KNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFV
IRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAI
RNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLG
KEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSE
AEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEA

--------------------------------------------------------------

>94265_94265_3_TRIT1-ABCA10_TRIT1_chr1_40348990_ENST00000441669_ABCA10_chr17_67193263_ENST00000416101_length(amino acids)=1041AA_BP=729
MFLQKVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADIL
ADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ
GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERR
ALLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRNGSD
DPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGM
SSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWR
KNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFV
IRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAI
RNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLG
KEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSE
AEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEA

--------------------------------------------------------------

>94265_94265_4_TRIT1-ABCA10_TRIT1_chr1_40348990_ENST00000544981_ABCA10_chr17_67193263_ENST00000416101_length(amino acids)=1041AA_BP=729
MFLQKVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADIL
ADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ
GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERR
ALLCLLLVLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEIDDFRNRNGSD
DPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGM
SSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWR
KNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFV
IRCLEMKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAI
RNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLG
KEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSE
AEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:40348990/chr17:67193263)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCA10

Q8WWZ4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:12821155}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-11132_3758.0468.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-11032_3758.0442.0RegionSubstrate binding
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-1932_3758.0386.0RegionSubstrate binding
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401206_1440391.66666666666671544.0DomainABC transporter 2
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040391_626391.66666666666671544.0DomainABC transporter 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391206_1440391.6666666666667449.0DomainABC transporter 2
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039391_626391.6666666666667449.0DomainABC transporter 1
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051206_1440093.0DomainABC transporter 2
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805391_626093.0DomainABC transporter 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131206_1440391.6666666666667453.0DomainABC transporter 2
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013391_626391.6666666666667453.0DomainABC transporter 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401239_1246391.66666666666671544.0Nucleotide bindingATP 2
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040427_434391.66666666666671544.0Nucleotide bindingATP 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391239_1246391.6666666666667449.0Nucleotide bindingATP 2
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039427_434391.6666666666667449.0Nucleotide bindingATP 1
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051239_1246093.0Nucleotide bindingATP 2
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805427_434093.0Nucleotide bindingATP 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131239_1246391.6666666666667453.0Nucleotide bindingATP 2
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013427_434391.6666666666667453.0Nucleotide bindingATP 1
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401014_1034391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401046_1066391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401073_1093391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000026908110401113_1133391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040774_794391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040890_910391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040926_946391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040985_1005391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391014_1034391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391046_1066391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391073_1093391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000041610110391113_1133391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039774_794391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039890_910391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039926_946391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039985_1005391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051014_1034093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051046_1066093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051073_1093093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000423818051113_1133093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805135_155093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805185_205093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805210_230093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805240_260093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805264_284093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805310_330093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805774_794093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004238180583_103093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805890_910093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805926_946093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000042381805985_1005093.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131014_1034391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131046_1066391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131073_1093391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST0000043231310131113_1133391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013774_794391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013890_910391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013926_946391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013985_1005391.6666666666667453.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111395_42558.0468.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110395_42558.0442.0Zinc fingerNote=Matrin-type
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19395_42558.0386.0Zinc fingerNote=Matrin-type
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040135_155391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040185_205391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040210_230391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040240_260391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040264_284391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000002690811040310_330391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000269081104083_103391.66666666666671544.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039135_155391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039185_205391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039210_230391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039240_260391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039264_284391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004161011039310_330391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000416101103983_103391.6666666666667449.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013135_155391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013185_205391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013210_230391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013240_260391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013264_284391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST000004323131013310_330391.6666666666667453.0TransmembraneHelical
TgeneABCA10chr1:40348990chr17:67193263ENST00000432313101383_103391.6666666666667453.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIT1
ABCA10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111233_25558.0468.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110233_25558.0442.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19233_25558.0386.0isopentenylpyrophosphate transferase
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111183_18758.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111281_28358.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111313_33158.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000316891-111323_33058.0468.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110183_18758.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110281_28358.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110313_33158.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000372818-110323_33058.0442.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19183_18758.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19281_28358.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19313_33158.0386.0substrate tRNA
HgeneTRIT1chr1:40348990chr17:67193263ENST00000441669-19323_33058.0386.0substrate tRNA


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Related Drugs to TRIT1-ABCA10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIT1-ABCA10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource