UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TROVE2-CDC73

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TROVE2-CDC73
	FusionPDB ID: 94333
	FusionGDB2.0 ID: 94333
		Hgene	Tgene
	Gene symbol	TROVE2	CDC73
	Gene ID	6738	79577
	Gene name	Ro60, Y RNA binding protein	cell division cycle 73
	Synonyms	RORNP\|SSA2\|TROVE2	C1orf28\|FIHP\|HPTJT\|HRPT1\|HRPT2\|HYX
	Cytomap	1q31.2	1q31.2
	Type of gene	protein-coding	protein-coding
	Description	60 kDa SS-A/Ro ribonucleoprotein60 kDa ribonucleoprotein RoRo/SSA 60kDaSjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)TROVE domain family member 2gastric cancer multi-drug resistance proteinro60 autoantigensjoegren syndrom	parafibrominFamilial isolated hyperparathyroidismPaf1/RNA polymerase II complex componentcell division cycle 73 Paf1/RNA polymerase II complex component-like proteincell division cycle 73, Paf1/RNA polymerase II complex component, homologcell divisio
	Modification date	20200313	20200313
	UniProtAcc	.	Q6P1J9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000460715, ENST00000367441, ENST00000367443, ENST00000367444, ENST00000367445, ENST00000367446, ENST00000400968, ENST00000416058, ENST00000432079,	ENST00000367435, ENST00000477868,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 3 X 2=12	7 X 7 X 4=196
	# samples	2	7
	** MAII score	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TROVE2 [Title/Abstract] AND CDC73 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDC73(193121574)-TROVE2(193060781), # samples:2 TROVE2(193053785)-CDC73(193218858), # samples:1 TROVE2(193053787)-CDC73(193218860), # samples:1
Anticipated loss of major functional domain due to fusion event.	TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TROVE2-CDC73 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TROVE2-CDC73 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TROVE2	GO:0010468	regulation of gene expression	26382853
Hgene	TROVE2	GO:0035457	cellular response to interferon-alpha	26382853
Tgene	CDC73	GO:0008285	negative regulation of cell proliferation	16989776
Tgene	CDC73	GO:0010390	histone monoubiquitination	16307923
Tgene	CDC73	GO:0030177	positive regulation of Wnt signaling pathway	16630820
Tgene	CDC73	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742
Tgene	CDC73	GO:0033523	histone H2B ubiquitination	16307923
Tgene	CDC73	GO:0045638	negative regulation of myeloid cell differentiation	20541477
Tgene	CDC73	GO:0045944	positive regulation of transcription by RNA polymerase II	20178742
Tgene	CDC73	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	16989776

Fusion gene breakpoints across TROVE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDC73 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D9-A4Z3-01A	TROVE2	chr1	193053785	+	CDC73	chr1	193218858	+
ChimerDB4	SKCM	TCGA-D9-A4Z3-01A	TROVE2	chr1	193053787	+	CDC73	chr1	193218860	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367444

TROVE2

chr1

193053785

ENST00000367435

CDC73

chr1

193218858

5098

1730

187

1908

573

ENST00000367443

TROVE2

chr1

193053785

ENST00000367435

CDC73

chr1

193218858

5098

1730

187

1908

573

ENST00000367444

TROVE2

chr1

193053787

ENST00000367435

CDC73

chr1

193218860

5098

1730

187

1908

573

ENST00000367443

TROVE2

chr1

193053787

ENST00000367435

CDC73

chr1

193218860

5098

1730

187

1908

573

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367444	ENST00000367435	TROVE2	chr1	193053785	+	CDC73	chr1	193218858	+	0.000180168	0.9998198
ENST00000367443	ENST00000367435	TROVE2	chr1	193053785	+	CDC73	chr1	193218858	+	0.000180168	0.9998198
ENST00000367444	ENST00000367435	TROVE2	chr1	193053787	+	CDC73	chr1	193218860	+	0.000180168	0.9998198
ENST00000367443	ENST00000367435	TROVE2	chr1	193053787	+	CDC73	chr1	193218860	+	0.000180168	0.9998198

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94333_94333_1_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367443_CDC73_chr1_193218858_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------

>94333_94333_2_TROVE2-CDC73_TROVE2_chr1_193053785_ENST00000367444_CDC73_chr1_193218858_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------

>94333_94333_3_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367443_CDC73_chr1_193218860_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------

>94333_94333_4_TROVE2-CDC73_TROVE2_chr1_193053787_ENST00000367444_CDC73_chr1_193218860_ENST00000367435_length(amino acids)=573AA_BP=0
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQE
PMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHK
DLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWK
ALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKT
FKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRVKAFHLKYDEVRLDPNVQKWDVTVLE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:193121574/chr1:193060781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CDC73 Q6P1J9
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269\|PubMed:15580289, ECO:0000269\|PubMed:15632063, ECO:0000269\|PubMed:15923622, ECO:0000269\|PubMed:16630820, ECO:0000269\|PubMed:16989776, ECO:0000269\|PubMed:19136632, ECO:0000269\|PubMed:19952111, ECO:0000269\|PubMed:20178742, ECO:0000269\|PubMed:20541477, ECO:0000269\|PubMed:21329879}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367443

16_369

514.3333333333334

506.0

Domain

TROVE

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367443

16_369

514.3333333333334

506.0

Domain

TROVE

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367443

120_284

514.3333333333334

506.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367443

361_538

514.3333333333334

506.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367443

120_284

514.3333333333334

506.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367443

361_538

514.3333333333334

506.0

Region

VWFA-like domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367441

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367445

16_369

535.0

Domain

TROVE

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367446

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000400968

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367441

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367445

16_369

535.0

Domain

TROVE

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367446

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000400968

16_369

539.0

Domain

TROVE

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367441

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367441

361_538

539.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367445

120_284

535.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367445

361_538

535.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367446

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000367446

361_538

539.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000400968

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053785

chr1:193218858

ENST00000400968

361_538

539.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367441

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367441

361_538

539.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367445

120_284

535.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367445

361_538

535.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367446

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000367446

361_538

539.0

Region

VWFA-like domain

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000400968

120_284

539.0

Region

RNA-binding

Hgene

TROVE2

chr1:193053787

chr1:193218860

ENST00000400968

361_538

539.0

Region

VWFA-like domain

Tgene

CDC73

chr1:193053785

chr1:193218858

ENST00000367435

361_364

472.3333333333333

532.0

Compositional bias

Note=Poly-Ile

Tgene

CDC73

chr1:193053787

chr1:193218860

ENST00000367435

361_364

472.3333333333333

532.0

Compositional bias

Note=Poly-Ile

Tgene

CDC73

chr1:193053785

chr1:193218858

ENST00000367435

125_139

472.3333333333333

532.0

Motif

Note=Nuclear localization signal

Tgene

CDC73

chr1:193053787

chr1:193218860

ENST00000367435

125_139

472.3333333333333

532.0

Motif

Note=Nuclear localization signal

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TROVE2
CDC73

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CDC73	chr1:193053785	chr1:193218858	ENST00000367435		14	17	200_250	472.3333333333333	532.0	CTNNB1
Tgene	CDC73	chr1:193053787	chr1:193218860	ENST00000367435		14	17	200_250	472.3333333333333	532.0	CTNNB1
Tgene	CDC73	chr1:193053785	chr1:193218858	ENST00000367435		14	17	200_531	472.3333333333333	532.0	POLR2A and PAF1
Tgene	CDC73	chr1:193053787	chr1:193218860	ENST00000367435		14	17	200_531	472.3333333333333	532.0	POLR2A and PAF1

Top

Related Drugs to TROVE2-CDC73

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TROVE2-CDC73

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source