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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TRUB2-KCNT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TRUB2-KCNT1
	FusionPDB ID: 94468
	FusionGDB2.0 ID: 94468
		Hgene	Tgene
	Gene symbol	TRUB2	KCNT1
	Gene ID	26995	57582
	Gene name	TruB pseudouridine synthase family member 2	potassium sodium-activated channel subfamily T member 1
	Synonyms	CLONE24922	EIEE14\|ENFL5\|KCa4.1\|SLACK\|Slo2.2\|bA100C15.2
	Cytomap	9q34.11	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	mitochondrial mRNA pseudouridine synthase TRUB2TruB pseudouridine (psi) synthase family member 2TruB pseudouridine (psi) synthase homolog 2probable tRNA pseudouridine synthase 2	potassium channel subfamily T member 1Sequence like a calcium-activated K+ channelpotassium channel, sodium activated subfamily T, member 1potassium channel, subfamily T, member 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q5JUK3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000460320, ENST00000372890, ENST00000546104,	ENST00000263604, ENST00000298480, ENST00000371757, ENST00000486577, ENST00000487664, ENST00000488444, ENST00000490355, ENST00000491806,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 3=108	2 X 4 X 2=16
	# samples	7	4
	** MAII score	log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TRUB2 [Title/Abstract] AND KCNT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TRUB2(131083878)-KCNT1(138641944), # samples:3
Anticipated loss of major functional domain due to fusion event.	TRUB2-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRUB2-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRUB2-KCNT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TRUB2-KCNT1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TRUB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCNT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GD-A3OS-01A	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+
ChimerDB4	BLCA	TCGA-GD-A3OS	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000298480	KCNT1	chr9	138641944	+	4997	495	547	4011	1154
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000487664	KCNT1	chr9	138641944	+	5006	495	547	4020	1157
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000371757	KCNT1	chr9	138641944	+	4891	495	547	3948	1133
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000486577	KCNT1	chr9	138641944	+	4000	495	547	3999	1151
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000491806	KCNT1	chr9	138641944	+	4009	495	547	4005	1152
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000488444	KCNT1	chr9	138641944	+	4009	495	547	4005	1152
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000490355	KCNT1	chr9	138641944	+	4006	495	547	4002	1151
ENST00000546104	TRUB2	chr9	131083878	-	ENST00000263604	KCNT1	chr9	138641944	+	4976	495	547	3990	1147
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000298480	KCNT1	chr9	138641943	+	4997	495	547	4011	1154
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000487664	KCNT1	chr9	138641943	+	5006	495	547	4020	1157
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000371757	KCNT1	chr9	138641943	+	4891	495	547	3948	1133
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000486577	KCNT1	chr9	138641943	+	4000	495	547	3999	1151
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000491806	KCNT1	chr9	138641943	+	4009	495	547	4005	1152
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000488444	KCNT1	chr9	138641943	+	4009	495	547	4005	1152
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000490355	KCNT1	chr9	138641943	+	4006	495	547	4002	1151
ENST00000546104	TRUB2	chr9	131083877	-	ENST00000263604	KCNT1	chr9	138641943	+	4976	495	547	3990	1147

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000546104	ENST00000298480	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.00587914	0.9941209
ENST00000546104	ENST00000487664	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.006314383	0.99368566
ENST00000546104	ENST00000371757	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.008337545	0.9916625
ENST00000546104	ENST00000486577	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.008663585	0.99133635
ENST00000546104	ENST00000491806	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.007325882	0.9926742
ENST00000546104	ENST00000488444	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.007325882	0.9926742
ENST00000546104	ENST00000490355	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.007765671	0.99223435
ENST00000546104	ENST00000263604	TRUB2	chr9	131083878	-	KCNT1	chr9	138641944	+	0.006453227	0.9935468
ENST00000546104	ENST00000298480	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.00587914	0.9941209
ENST00000546104	ENST00000487664	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.006314383	0.99368566
ENST00000546104	ENST00000371757	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.008337545	0.9916625
ENST00000546104	ENST00000486577	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.008663585	0.99133635
ENST00000546104	ENST00000491806	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.007325882	0.9926742
ENST00000546104	ENST00000488444	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.007325882	0.9926742
ENST00000546104	ENST00000490355	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.007765671	0.99223435
ENST00000546104	ENST00000263604	TRUB2	chr9	131083877	-	KCNT1	chr9	138641943	+	0.006453227	0.9935468

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94468_94468_1_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000263604_length(amino acids)=1147AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDP
AEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQD

--------------------------------------------------------------

>94468_94468_2_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000298480_length(amino acids)=1154AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGR
HTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRV

--------------------------------------------------------------

>94468_94468_3_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000371757_length(amino acids)=1133AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGR
HTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLI

--------------------------------------------------------------

>94468_94468_4_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000486577_length(amino acids)=1151AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSED
EVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAY
YRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPS
LSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGS
GYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGG
GDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGY

--------------------------------------------------------------

>94468_94468_5_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000487664_length(amino acids)=1157AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGGCRTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQ
TEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSR
NEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQW
QRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQ
EEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLS
DQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
PLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMF
RLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLD
TTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSS
QGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVM

--------------------------------------------------------------

>94468_94468_6_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000488444_length(amino acids)=1152AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHT
GGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNL

--------------------------------------------------------------

>94468_94468_7_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000490355_length(amino acids)=1151AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSED
EVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAY
YRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPS
LSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGS
GYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTG
GGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLG

--------------------------------------------------------------

>94468_94468_8_TRUB2-KCNT1_TRUB2_chr9_131083877_ENST00000546104_KCNT1_chr9_138641943_ENST00000491806_length(amino acids)=1152AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHT
GGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNL

--------------------------------------------------------------

>94468_94468_9_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000263604_length(amino acids)=1147AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDP
AEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQD

--------------------------------------------------------------

>94468_94468_10_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000298480_length(amino acids)=1154AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGR
HTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRV

--------------------------------------------------------------

>94468_94468_11_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000371757_length(amino acids)=1133AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGR
HTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLI

--------------------------------------------------------------

>94468_94468_12_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000486577_length(amino acids)=1151AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSED
EVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAY
YRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPS
LSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGS
GYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGG
GDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGY

--------------------------------------------------------------

>94468_94468_13_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000487664_length(amino acids)=1157AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGGCRTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQ
TEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSR
NEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQW
QRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQ
EEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLS
DQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
PLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMF
RLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLD
TTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSS
QGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVM

--------------------------------------------------------------

>94468_94468_14_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000488444_length(amino acids)=1152AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHT
GGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNL

--------------------------------------------------------------

>94468_94468_15_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000490355_length(amino acids)=1151AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSED
EVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAY
YRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPS
LSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGS
GYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTG
GGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLG

--------------------------------------------------------------

>94468_94468_16_TRUB2-KCNT1_TRUB2_chr9_131083878_ENST00000546104_KCNT1_chr9_138641944_ENST00000491806_length(amino acids)=1152AA_BP=
MFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETM
LLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLV
FTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEV
DRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRM
YGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEK
RKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQS
EDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLR
AYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLF
PSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP
GSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHT
GGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131083878/chr9:138641944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KCNT1 Q5JUK3
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

475_596

65.66666666666667

1231.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

475_596

84.66666666666667

1257.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

475_596

84.66666666666667

1236.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

475_596

65.66666666666667

1231.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

475_596

84.66666666666667

1257.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

475_596

84.66666666666667

1236.0

Domain

Note=RCK N-terminal

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

282_302

65.66666666666667

1231.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

282_302

84.66666666666667

1257.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

282_302

84.66666666666667

1236.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

282_302

65.66666666666667

1231.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

282_302

84.66666666666667

1257.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

282_302

84.66666666666667

1236.0

Intramembrane

Pore-forming

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

119_155

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

177_187

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

209_213

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

227_251

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

273_281

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

303_304

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

326_1230

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

119_155

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

177_187

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

209_213

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

227_251

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

273_281

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

303_304

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

326_1230

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

119_155

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

177_187

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

209_213

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

227_251

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

273_281

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

303_304

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

326_1230

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

119_155

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

177_187

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

209_213

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

227_251

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

273_281

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

303_304

65.66666666666667

1231.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

326_1230

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

119_155

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

177_187

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

209_213

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

227_251

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

273_281

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

303_304

84.66666666666667

1257.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

326_1230

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

119_155

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

177_187

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

209_213

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

227_251

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

273_281

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

303_304

84.66666666666667

1236.0

Topological domain

Extracellular

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

326_1230

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

156_176

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

188_208

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

214_226

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

252_272

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

305_325

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

98_118

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S1

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

156_176

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

188_208

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

214_226

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

252_272

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

305_325

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

98_118

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S1

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

156_176

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

188_208

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

214_226

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

252_272

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

305_325

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

98_118

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S1

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

156_176

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

188_208

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

214_226

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

252_272

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

305_325

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

98_118

65.66666666666667

1231.0

Transmembrane

Helical%3B Name%3DSegment S1

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

156_176

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

188_208

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

214_226

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

252_272

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

305_325

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

98_118

84.66666666666667

1257.0

Transmembrane

Helical%3B Name%3DSegment S1

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

156_176

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S2

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

188_208

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S3

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

214_226

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S4

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

252_272

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S5

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

305_325

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

98_118

84.66666666666667

1236.0

Transmembrane

Helical%3B Name%3DSegment S1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000263604

1_97

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000298480

1_97

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083877

chr9:138641943

ENST00000371757

1_97

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000263604

1_97

65.66666666666667

1231.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000298480

1_97

84.66666666666667

1257.0

Topological domain

Cytoplasmic

Tgene

KCNT1

chr9:131083878

chr9:138641944

ENST00000371757

1_97

84.66666666666667

1236.0

Topological domain

Cytoplasmic

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TRUB2
KCNT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TRUB2-KCNT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TRUB2-KCNT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source