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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TSHR-YAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TSHR-YAP1
	FusionPDB ID: 94584
	FusionGDB2.0 ID: 94584
		Hgene	Tgene
	Gene symbol	TSHR	YAP1
	Gene ID	7253	10413
	Gene name	thyroid stimulating hormone receptor	Yes1 associated transcriptional regulator
	Synonyms	CHNG1\|LGR3\|hTSHR-I	COB1\|YAP\|YAP2\|YAP65\|YKI
	Cytomap	14q31.1	11q22.1
	Type of gene	protein-coding	protein-coding
	Description	thyrotropin receptorTSH receptorseven transmembrane helix receptorthyrotropin receptor-I, hTSHR-I	transcriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
	Modification date	20200329	20200329
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000557096, ENST00000298171, ENST00000342443, ENST00000541158, ENST00000554263, ENST00000554435,	ENST00000282441, ENST00000345877, ENST00000524575, ENST00000526343, ENST00000531439, ENST00000537274, ENST00000528834,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 4 X 2=40	20 X 10 X 13=2600
	# samples	5	21
	** MAII score	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(21/2600*10)=-3.63005039024969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TSHR [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TSHR(81422194)-YAP1(102033186), # samples:2
Anticipated loss of major functional domain due to fusion event.	TSHR-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TSHR-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TSHR-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TSHR-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	YAP1	GO:0006974	cellular response to DNA damage stimulus	18280240
Tgene	YAP1	GO:0008283	cell proliferation	17974916
Tgene	YAP1	GO:0032570	response to progesterone	16772533
Tgene	YAP1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16772533
Tgene	YAP1	GO:0045893	positive regulation of transcription, DNA-templated	20368466
Tgene	YAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	25796446
Tgene	YAP1	GO:0050767	regulation of neurogenesis	25433207
Tgene	YAP1	GO:0050847	progesterone receptor signaling pathway	16772533
Tgene	YAP1	GO:0060242	contact inhibition	17974916
Tgene	YAP1	GO:0065003	protein-containing complex assembly	20368466
Tgene	YAP1	GO:0071480	cellular response to gamma radiation	18280240
Tgene	YAP1	GO:0072091	regulation of stem cell proliferation	25433207

Fusion gene breakpoints across TSHR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-DJ-A2PX	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000541158	TSHR	chr14	81422194	+	ENST00000526343	YAP1	chr11	102033186	+	1925	492	322	1272	316
ENST00000541158	TSHR	chr14	81422194	+	ENST00000282441	YAP1	chr11	102033186	+	4918	492	322	1434	370
ENST00000541158	TSHR	chr14	81422194	+	ENST00000537274	YAP1	chr11	102033186	+	4882	492	322	1398	358
ENST00000541158	TSHR	chr14	81422194	+	ENST00000345877	YAP1	chr11	102033186	+	4768	492	322	1284	320
ENST00000541158	TSHR	chr14	81422194	+	ENST00000531439	YAP1	chr11	102033186	+	1410	492	322	1386	354
ENST00000541158	TSHR	chr14	81422194	+	ENST00000524575	YAP1	chr11	102033186	+	1647	492	322	1434	370
ENST00000342443	TSHR	chr14	81422194	+	ENST00000526343	YAP1	chr11	102033186	+	1853	420	250	1200	316
ENST00000342443	TSHR	chr14	81422194	+	ENST00000282441	YAP1	chr11	102033186	+	4846	420	250	1362	370
ENST00000342443	TSHR	chr14	81422194	+	ENST00000537274	YAP1	chr11	102033186	+	4810	420	250	1326	358
ENST00000342443	TSHR	chr14	81422194	+	ENST00000345877	YAP1	chr11	102033186	+	4696	420	250	1212	320
ENST00000342443	TSHR	chr14	81422194	+	ENST00000531439	YAP1	chr11	102033186	+	1338	420	250	1314	354
ENST00000342443	TSHR	chr14	81422194	+	ENST00000524575	YAP1	chr11	102033186	+	1575	420	250	1362	370
ENST00000298171	TSHR	chr14	81422194	+	ENST00000526343	YAP1	chr11	102033186	+	1759	326	156	1106	316
ENST00000298171	TSHR	chr14	81422194	+	ENST00000282441	YAP1	chr11	102033186	+	4752	326	156	1268	370
ENST00000298171	TSHR	chr14	81422194	+	ENST00000537274	YAP1	chr11	102033186	+	4716	326	156	1232	358
ENST00000298171	TSHR	chr14	81422194	+	ENST00000345877	YAP1	chr11	102033186	+	4602	326	156	1118	320
ENST00000298171	TSHR	chr14	81422194	+	ENST00000531439	YAP1	chr11	102033186	+	1244	326	156	1220	354
ENST00000298171	TSHR	chr14	81422194	+	ENST00000524575	YAP1	chr11	102033186	+	1481	326	156	1268	370
ENST00000554263	TSHR	chr14	81422194	+	ENST00000526343	YAP1	chr11	102033186	+	1629	196	26	976	316
ENST00000554263	TSHR	chr14	81422194	+	ENST00000282441	YAP1	chr11	102033186	+	4622	196	26	1138	370
ENST00000554263	TSHR	chr14	81422194	+	ENST00000537274	YAP1	chr11	102033186	+	4586	196	26	1102	358
ENST00000554263	TSHR	chr14	81422194	+	ENST00000345877	YAP1	chr11	102033186	+	4472	196	26	988	320
ENST00000554263	TSHR	chr14	81422194	+	ENST00000531439	YAP1	chr11	102033186	+	1114	196	26	1090	354
ENST00000554263	TSHR	chr14	81422194	+	ENST00000524575	YAP1	chr11	102033186	+	1351	196	26	1138	370
ENST00000554435	TSHR	chr14	81422194	+	ENST00000526343	YAP1	chr11	102033186	+	1629	196	26	976	316
ENST00000554435	TSHR	chr14	81422194	+	ENST00000282441	YAP1	chr11	102033186	+	4622	196	26	1138	370
ENST00000554435	TSHR	chr14	81422194	+	ENST00000537274	YAP1	chr11	102033186	+	4586	196	26	1102	358
ENST00000554435	TSHR	chr14	81422194	+	ENST00000345877	YAP1	chr11	102033186	+	4472	196	26	988	320
ENST00000554435	TSHR	chr14	81422194	+	ENST00000531439	YAP1	chr11	102033186	+	1114	196	26	1090	354
ENST00000554435	TSHR	chr14	81422194	+	ENST00000524575	YAP1	chr11	102033186	+	1351	196	26	1138	370

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541158	ENST00000526343	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.002840422	0.9971596
ENST00000541158	ENST00000282441	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000146302	0.99985373
ENST00000541158	ENST00000537274	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000157819	0.99984217
ENST00000541158	ENST00000345877	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000148531	0.99985147
ENST00000541158	ENST00000531439	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.005345727	0.9946543
ENST00000541158	ENST00000524575	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.004304797	0.99569523
ENST00000342443	ENST00000526343	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.002992745	0.9970073
ENST00000342443	ENST00000282441	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.00013736	0.9998627
ENST00000342443	ENST00000537274	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000147831	0.9998522
ENST00000342443	ENST00000345877	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000138774	0.99986124
ENST00000342443	ENST00000531439	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.005918373	0.9940817
ENST00000342443	ENST00000524575	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.004667528	0.9953324
ENST00000298171	ENST00000526343	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.002625063	0.9973749
ENST00000298171	ENST00000282441	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000131436	0.9998685
ENST00000298171	ENST00000537274	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000142118	0.9998579
ENST00000298171	ENST00000345877	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.00013316	0.99986684
ENST00000298171	ENST00000531439	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.005915986	0.99408406
ENST00000298171	ENST00000524575	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.004557533	0.9954425
ENST00000554263	ENST00000526343	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.001826201	0.99817383
ENST00000554263	ENST00000282441	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000127094	0.9998729
ENST00000554263	ENST00000537274	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000136556	0.9998634
ENST00000554263	ENST00000345877	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000127427	0.99987257
ENST00000554263	ENST00000531439	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.002640623	0.99735934
ENST00000554263	ENST00000524575	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.00237154	0.9976285
ENST00000554435	ENST00000526343	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.001826201	0.99817383
ENST00000554435	ENST00000282441	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000127094	0.9998729
ENST00000554435	ENST00000537274	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000136556	0.9998634
ENST00000554435	ENST00000345877	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.000127427	0.99987257
ENST00000554435	ENST00000531439	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.002640623	0.99735934
ENST00000554435	ENST00000524575	TSHR	chr14	81422194	+	YAP1	chr11	102033186	+	0.00237154	0.9976285

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94584_94584_1_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000282441_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_2_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000345877_length(amino acids)=320AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNP
VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVD

--------------------------------------------------------------

>94584_94584_3_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000524575_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_4_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000526343_length(amino acids)=316AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSP
GMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTL

--------------------------------------------------------------

>94584_94584_5_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000531439_length(amino acids)=354AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>94584_94584_6_TSHR-YAP1_TSHR_chr14_81422194_ENST00000298171_YAP1_chr11_102033186_ENST00000537274_length(amino acids)=358AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF

--------------------------------------------------------------

>94584_94584_7_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000282441_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_8_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000345877_length(amino acids)=320AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNP
VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVD

--------------------------------------------------------------

>94584_94584_9_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000524575_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_10_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000526343_length(amino acids)=316AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSP
GMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTL

--------------------------------------------------------------

>94584_94584_11_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000531439_length(amino acids)=354AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>94584_94584_12_TSHR-YAP1_TSHR_chr14_81422194_ENST00000342443_YAP1_chr11_102033186_ENST00000537274_length(amino acids)=358AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF

--------------------------------------------------------------

>94584_94584_13_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000282441_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_14_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000345877_length(amino acids)=320AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNP
VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVD

--------------------------------------------------------------

>94584_94584_15_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000524575_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_16_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000526343_length(amino acids)=316AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSP
GMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTL

--------------------------------------------------------------

>94584_94584_17_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000531439_length(amino acids)=354AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>94584_94584_18_TSHR-YAP1_TSHR_chr14_81422194_ENST00000541158_YAP1_chr11_102033186_ENST00000537274_length(amino acids)=358AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF

--------------------------------------------------------------

>94584_94584_19_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000282441_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_20_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000345877_length(amino acids)=320AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNP
VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVD

--------------------------------------------------------------

>94584_94584_21_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000524575_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_22_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000526343_length(amino acids)=316AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSP
GMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTL

--------------------------------------------------------------

>94584_94584_23_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000531439_length(amino acids)=354AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>94584_94584_24_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554263_YAP1_chr11_102033186_ENST00000537274_length(amino acids)=358AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF

--------------------------------------------------------------

>94584_94584_25_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000282441_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_26_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000345877_length(amino acids)=320AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNP
VSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVD

--------------------------------------------------------------

>94584_94584_27_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000524575_length(amino acids)=370AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM
SSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATK

--------------------------------------------------------------

>94584_94584_28_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000526343_length(amino acids)=316AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSP
GMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTL

--------------------------------------------------------------

>94584_94584_29_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000531439_length(amino acids)=354AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV

--------------------------------------------------------------

>94584_94584_30_TSHR-YAP1_TSHR_chr14_81422194_ENST00000554435_YAP1_chr11_102033186_ENST00000537274_length(amino acids)=358AA_BP=57
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNM
MNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME
KERLRLKQQELLRQVRPQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:81422194/chr11:102033186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

298_359

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

298_359

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

298_359

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

86_100

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

298_359

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

298_359

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

298_359

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

230_263

190.66666666666666

505.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

230_263

190.66666666666666

455.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

171_204

12.666666666666666

327.0

Domain

WW 1

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

230_263

12.666666666666666

327.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

230_263

190.66666666666666

451.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

230_263

190.66666666666666

489.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

230_263

190.66666666666666

493.0

Domain

WW 2

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

291_504

190.66666666666666

505.0

Region

Note=Transactivation domain

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

291_504

190.66666666666666

455.0

Region

Note=Transactivation domain

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

291_504

12.666666666666666

327.0

Region

Note=Transactivation domain

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

291_504

190.66666666666666

451.0

Region

Note=Transactivation domain

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

291_504

190.66666666666666

489.0

Region

Note=Transactivation domain

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

291_504

190.66666666666666

493.0

Region

Note=Transactivation domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

762_764

56.666666666666664

254.0

Motif

Note=PDZ-binding

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

762_764

56.666666666666664

275.0

Motif

Note=PDZ-binding

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

100_124

56.666666666666664

254.0

Repeat

Note=LRR 1

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

125_150

56.666666666666664

254.0

Repeat

Note=LRR 2

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

152_174

56.666666666666664

254.0

Repeat

Note=LRR 3

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

176_199

56.666666666666664

254.0

Repeat

Note=LRR 4

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

200_223

56.666666666666664

254.0

Repeat

Note=LRR 5

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

227_248

56.666666666666664

254.0

Repeat

Note=LRR 6

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

250_271

56.666666666666664

254.0

Repeat

Note=LRR 7

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

100_124

56.666666666666664

275.0

Repeat

Note=LRR 1

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

125_150

56.666666666666664

275.0

Repeat

Note=LRR 2

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

152_174

56.666666666666664

275.0

Repeat

Note=LRR 3

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

176_199

56.666666666666664

275.0

Repeat

Note=LRR 4

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

200_223

56.666666666666664

275.0

Repeat

Note=LRR 5

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

227_248

56.666666666666664

275.0

Repeat

Note=LRR 6

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

250_271

56.666666666666664

275.0

Repeat

Note=LRR 7

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

21_413

56.666666666666664

254.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

442_450

56.666666666666664

254.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

474_494

56.666666666666664

254.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

518_537

56.666666666666664

254.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

561_580

56.666666666666664

254.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

603_625

56.666666666666664

254.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

650_660

56.666666666666664

254.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

683_764

56.666666666666664

254.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

21_413

56.666666666666664

275.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

442_450

56.666666666666664

275.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

474_494

56.666666666666664

275.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

518_537

56.666666666666664

275.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

561_580

56.666666666666664

275.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

603_625

56.666666666666664

275.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

650_660

56.666666666666664

275.0

Topological domain

Extracellular

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

683_764

56.666666666666664

275.0

Topological domain

Cytoplasmic

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

414_441

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D1

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

451_473

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D2

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

495_517

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D3

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

538_560

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D4

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

581_602

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D5

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

626_649

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D6

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000342443

661_682

56.666666666666664

254.0

Transmembrane

Helical%3B Name%3D7

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

414_441

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D1

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

451_473

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D2

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

495_517

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D3

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

538_560

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D4

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

581_602

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D5

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

626_649

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D6

Hgene

TSHR

chr14:81422194

chr11:102033186

ENST00000554435

661_682

56.666666666666664

275.0

Transmembrane

Helical%3B Name%3D7

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

86_100

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

86_100

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

86_100

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

86_100

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

86_100

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

3_49

190.66666666666666

505.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

3_49

190.66666666666666

455.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000524575

3_49

12.666666666666666

327.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

3_49

190.66666666666666

451.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

3_49

190.66666666666666

489.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

3_49

190.66666666666666

493.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000282441

171_204

190.66666666666666

505.0

Domain

WW 1

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000345877

171_204

190.66666666666666

455.0

Domain

WW 1

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000526343

171_204

190.66666666666666

451.0

Domain

WW 1

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000531439

171_204

190.66666666666666

489.0

Domain

WW 1

Tgene

YAP1

chr14:81422194

chr11:102033186

ENST00000537274

171_204

190.66666666666666

493.0

Domain

WW 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TSHR
YAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TSHR-YAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TSHR-YAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source